Chemicals Associated with Site-Specific Neoplasia

http://ntp.niehs.nih.gov/go/SA-pos

Numbers of Chemicals Associated with Site-Specific Neoplasia
Chemicals that produced "clear" and "some" evidence of Carcinogenicity are listed below. *
	Response of "Clear" or "Some" Evidence *
Site	Male Rats	Female Rats	Male Mice	Female Mice	Totals
Adrenal Gland (Combined)	14	10	6	4	24
Adrenal Gland Cortex	0	2	0	0	2
Adrenal Gland Medulla	14	8	6	4	22
Bone	1	0	0	0	1
Brain	2	2	2	1	3
Clitoral Gland	0	14	0	0	14
Epididymis	0	0	0	0	0
Esophagus	3	3	0	0	3
Forestomach	20	14	23	25	35
Glandular Stomach	1	1	1	0	1
Harderian Gland	0	0	12	13	14
Heart	0	0	3	2	3
Hematopoietic System	15	16	12	18	40
Intestines	13	10	4	3	18
Kidney (Combined)	50	17	12	1	62
Kidney Mesenchymal Cell	0	0	0	0	0
Kidney Transitional Cell	6	4	0	0	9
Kidney Tubular Cell	47	13	12	1	56
Liver	46	48	91	117	159
Lung	14	20	36	38	62
Mammary Gland	7	29	0	12	37
Mesothelium (Abdominal Cavity/Tunica Vaginalis)	13	2	1	2	14
Nasal Cavity	14	10	3	3	15
Oral Cavity	13	18	0	1	20
Ovary	0	0	0	11	11
Pancreas (Combined)	9	3	0	0	11
Pancreas Acinar Cell	8	2	0	0	10
Pancreas Islet Cell	1	1	0	0	2
Parathyroid Gland	0	0	0	0	0
Pituitary Gland	0	1	2	3	4
Preputial Gland	8	0	4	0	12
Seminal Vesicle	1	0	1	0	2
Skin	18	10	4	4	21
Spleen	6	3	0	1	8
Subcutaneous Tissue	7	3	0	5	11
Testis	2	0	0	0	2
Thyroid (Combined)	19	17	9	10	28
Thyroid Gland C-Cell	2	2	0	1	5
Thyroid Gland Follicular Cell	18	16	9	9	26
Ureter	2	1	0	0	2
Urinary Bladder	15	14	2	3	20
Uterus/Cervix	0	10	0	9	19
Vagina	0	0	0	1	1
Vascular System (Combined)	7	4	16	16	26
Vascular System (Heart)	0	0	2	2	2
Vascular System (Liver)	1	2	5	4	8
Vascular System (Nasal Cavity)	0	0	1	1	1
Vascular System (Spleen)	2	0	1	2	5
Vascular System (Unspecified)	4	2	8	9	13
Zymbal Gland	19	17	1	3	22
Note: Totals represents the number of individual chemicals that caused positive responses.

Web page last updated on May 14, 2008

National Toxicology Program