Summaries & Associations of Study Results
| Levels of Evidence of Carcinogenicity | May Have Been Related | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TR | Chemical | Salmonella Results | Route | Male Rats | Female Rats | Male Mice | Female Mice | Sex/Species | Multiple Tumor Sites | |||
| TR-506 | Acrylonitrile | + | Gavage | (CE) | (CE) | Yes | ||||||
| TR-073 | Allyl chloride | + | Gavage | N | N | (E) | (E) | No | ||||
| TR-383 | 1-Amino-2,4-dibromoanthraquinone | + | Dosed-Feed | CE | CE | (CE) | (CE) | Yes | ||||
| TR-378 | Benzaldehyde | -,- | Gavage | NE | NE | (SE) | (SE) | No | ||||
| TR-370 | Benzofuran | - | Gavage | NE | SE | (CE) | (CE) | Yes | ||||
| TR-250 | Benzyl acetate | - | Gavage | EE | NE | (SE) | (SE) | Yes | ||||
| TR-452 | 2,2-bis(Bromomethyl)-1,3-propanediol | +,+,- | Dosed-Feed | (CE) | CE | CE | CE | (MM) | (FM) | Yes | ||
| TR-239 | bis(2-Chloro-1-methylethyl) ether | +W,+,+,+,+,+ | Gavage | P | P | (FM) | Yes | |||||
| TR-288 | 1,3-Butadiene | + | Inhalation | (CE) | (CE) | Yes | ||||||
| TR-434 | 1,3-Butadiene | + | Inhalation | (CE) | (CE) | Yes | ||||||
| TR-484 | 2-Butoxyethanol (ethylene glycol monobutyl ether) | - | Inhalation | NE | EE | SE | (SE) | (MM) | Yes | |||
| TR-300 | 3-Chloro-2-methylpropene | -,+W,- | Gavage | (CE) | (CE) | (CE) | (CE) | No | ||||
| TR-095 | 3-Chloromethylpyridine hydrochloride | + | Gavage | (P) | (E) | (P) | (P) | No | ||||
| TR-063 | 4-Chloro-o-phenylenediamine | + | Dosed-Feed | (P) | (P) | P | P | Yes | ||||
| TR-467 | Chloroprene | - | Inhalation | CE | CE | (CE) | (CE) | Yes | ||||
| TR-430 | C.I. Direct blue 218 | - | Dosed-Feed | SE | NE | CE | CE | (MR) | Yes | |||
| TR-222 | C.I. Disperse yellow 3 | +,+ | Dosed-Feed | P | N | N | P | (MR) | Yes | |||
| TR-422 | Coumarin | + | Gavage | SE | EE | SE | CE | (MM) | (FM) | Yes | ||
| TR-550 | Cresols | -,- | Dosed-Feed | EE | (SE) | Yes | ||||||
| TR-100 | Cupferron | + | Dosed-Feed | (P) | (P) | P | P | Yes | ||||
| TR-242 | Diallyl phthalate | -,- | Gavage | (E) | (E) | Yes | ||||||
| TR-028 | 1,2-Dibromo-3-chloropropane | + | Gavage | (P) | (P) | (P) | (P) | Yes | ||||
| TR-086 | 1,2-Dibromoethane | + | Gavage | (P) | (P) | (P) | (P) | Yes | ||||
| TR-400 | 2,3-Dibromo-1-propanol | + | Topical Application | (CE) | (CE) | (CE) | (CE) | Yes | ||||
| TR-055 | 1,2-Dichloroethane | + | Gavage | (P) | P | P | P | Yes | ||||
| TR-269 | 1,3-Dichloropropene (Telone II) | + | Gavage | (CE) | (SE) | IS | (CE) | Yes | ||||
| TR-342 | Dichlorvos | + | Gavage | SE | EE | (SE) | (CE) | Yes | ||||
| TR-257 | Diglycidyl resorcinol ether (DGRE) | + | Gavage | (P) | (P) | (P) | (P) | No | ||||
| TR-354 | Dimethoxane | + | Gavage | NE | NE | (EE) | NE | No | ||||
| TR-360 | N,N-Dimethylaniline | - | Gavage | SE | NE | NE | (EE) | Yes | ||||
| TR-287 | Dimethyl hydrogen phosphite | ?,+W | Gavage | (CE) | (EE) | NE | NE | Yes | ||||
| TR-316 | Dimethylvinyl chloride (DMVC) | -,+ | Gavage | (CE) | (CE) | (CE) | (CE) | Yes | ||||
| TR-059 | Estradiol mustard | Gavage | N | N | (P) | (P) | Yes | |||||
| TR-259 | Ethyl acrylate | -,-,+W,- | Gavage | (P) | (P) | (P) | (P) | No | ||||
| TR-382 | Furfural | -,?,? | Gavage | SE | NE | CE | SE | (FM) | Yes | |||
| TR-374 | Glycidol | +,+ | Gavage | (CE) | (CE) | (CE) | CE | Yes | ||||
| TR-509 | 2,4-Hexadienal | +,+ | Gavage | (CE) | (CE) | (CE) | (CE) | Yes | ||||
| TR-340 | Iodinated glycerol | + | Gavage | SE | NE | NE | SE | (FM) | Yes | |||
| TR-408 | Mercuric chloride | - | Gavage | (SE) | (EE) | EE | NE | Yes | ||||
| TR-491 | Methyleugenol | - | Gavage | CE | CE | CE | CE | (FR) | Yes | |||
| TR-416 | o-Nitroanisole | +,+ | Dosed-Feed | CE | CE | CE | SE | (MR) | (FR) | Yes | ||
| TR-140 | Pivalolactone | Gavage | (P) | (P) | N | N | No | |||||
| TR-495 | Sodium nitrite | + | Dosed-Water | NE | NE | NE | EE | (FM) | No | |||
| TR-115 | Sulfallate | + | Dosed-Feed | (P) | P | P | P | Yes | ||||
| TR-399 | Titanocene dichloride | + | Gavage | (EE) | (EE) | No | ||||||
| TR-384 | 1,2,3-Trichloropropane | +,+ | Gavage | (CE) | (CE) | (CE) | (CE) | Yes | ||||
| TR-034 | Trifluralin | + | Dosed-Feed | N | N | N | (P) | Yes | ||||
| TR-076 | tris(2,3-Dibromopropyl) phosphate | Dosed-Feed | P | P | (P) | (P) | Yes | |||||
| TR-510 | Urethane | ?,+ | Dosed-Water | (CE) | CE | Yes | ||||||
| Totals | 24 | 20 | 29 | 34 | ||||||||
| The number of chemicals causing tumors in Forestomach is 48. | ||||||||||||
Levels of Evidence of Carcinogenicity: CE or P = Clear Evidence, SE = Some Evidence, EE or E = Equivocal Evidence, NE or N = No Evidence, IS = Inadequate Experiment Salmonella Results: + = Positive, +W = Weakly Positive, ? = Inconclusive, - = Negative Parentheses indicate the animal group in which a tumor occurred in the organ specified. Sex/Species: MR = Male Rats, FR = Female Rats, MM = Male Mice, FM = Female Mice Totals include positive, equivocal and may-have-been-related responses where a tumor occurred in the organ specified. NOTE: Blank space under the animal groups indicates no experiments were done. | ||||||||||||
Web page last updated on May 14, 2008
