Summaries & Associations of Study Results
| Levels of Evidence of Carcinogenicity | May Have Been Related | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TR | Chemical | Salmonella Results | Route | Male Rats | Female Rats | Male Mice | Female Mice | Sex/Species | Multiple Tumor Sites | |||
| TR-334 | 2-Amino-5-nitrophenol | + | Gavage | SE | NE | NE | NE | (MR) | Yes | |||
| TR-116 | p-Anisidine hydrochloride | Dosed-Feed | (E) | N | N | N | No | |||||
| TR-289 | Benzene | - | Gavage | CE | CE | (CE) | CE | Yes | ||||
| TR-288 | 1,3-Butadiene | + | Inhalation | CE | CE | (MM) | Yes | |||||
| TR-434 | 1,3-Butadiene | + | Inhalation | (CE) | CE | Yes | ||||||
| TR-304 | Chlorendic acid | - | Dosed-Feed | CE | CE | CE | NE | (MR) | Yes | |||
| TR-397 | C.I. Direct blue 15 | - | Dosed-Water | (CE) | CE | Yes | ||||||
| TR-084 | 2,4-Diaminoanisole sulfate | + | Dosed-Feed | (P) | P | P | P | Yes | ||||
| TR-372 | 3,3'-Dimethoxybenzidine dihydrochloride | Dosed-Water | (CE) | CE | Yes | |||||||
| TR-390 | 3,3'-Dimethylbenzidine dihydrochloride | + | Dosed-Water | (CE) | CE | Yes | ||||||
| TR-316 | Dimethylvinyl chloride (DMVC) | -,+ | Gavage | CE | CE | (CE) | CE | Yes | ||||
| TR-548 | Endocrine disruptor (Ethinyl estradiol) | Dosed-Feed | ||||||||||
| TR-291 | Isophorone | - | Gavage | (SE) | NE | EE | NE | Yes | ||||
| TR-332 | 2-Mercaptobenzothiazole | ?,- | Gavage | (SE) | SE | NE | EE | Yes | ||||
| TR-368 | Nalidixic acid | -,+W | Dosed-Feed | (CE) | CE | EE | NE | Yes | ||||
| TR-337 | Nitrofurazone | + | Dosed-Feed | (EE) | CE | NE | CE | Yes | ||||
| TR-240 | Propyl gallate | - | Dosed-Feed | (E) | N | E | N | Yes | ||||
| TR-384 | 1,2,3-Trichloropropane | +,+ | Gavage | (CE) | CE | CE | CE | Yes | ||||
| TR-058 | tris(Aziridinyl)-phosphine sulfide (thio-tepa) | + | Intraperitoneal Injection | P | P | (P) | P | Yes | ||||
| Totals | 13 | 0 | 5 | 0 | ||||||||
| The number of chemicals causing tumors in Preputial Gland is 18. | ||||||||||||
Levels of Evidence of Carcinogenicity: CE or P = Clear Evidence, SE = Some Evidence, EE or E = Equivocal Evidence, NE or N = No Evidence, IS = Inadequate Experiment Salmonella Results: + = Positive, +W = Weakly Positive, ? = Inconclusive, - = Negative Parentheses indicate the animal group in which a tumor occurred in the organ specified. Sex/Species: MR = Male Rats, FR = Female Rats, MM = Male Mice, FM = Female Mice Totals include positive, equivocal and may-have-been-related responses where a tumor occurred in the organ specified. NOTE: Blank space under the animal groups indicates no experiments were done. | ||||||||||||
Web page last updated on May 14, 2008
