Summaries & Associations of Study Results
| Levels of Evidence of Carcinogenicity | May Have Been Related | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TR | Chemical | Salmonella Results | Route | Male Rats | Female Rats | Male Mice | Female Mice | Sex/Species | Multiple Tumor Sites | |||
| TR-093 | 3-Amino-9-ethylcarbazole HCl | + | Dosed-Feed | (P) | P | P | P | Yes | ||||
| TR-289 | Benzene | - | Gavage | (CE) | CE | CE | CE | Yes | ||||
| TR-452 | 2,2-bis(Bromomethyl)-1,3-propanediol | +,+,- | Dosed-Feed | (CE) | CE | CE | CE | Yes | ||||
| TR-346 | Chloroethane | + | Inhalation | (EE) | EE | IS | CE | Yes | ||||
| TR-405 | C.I. Acid red 114 | + | Dosed-Water | (CE) | (CE) | Yes | ||||||
| TR-397 | C.I. Direct blue 15 | - | Dosed-Water | (CE) | (CE) | Yes | ||||||
| TR-407 | C.I. Pigment red 3 | + | Dosed-Feed | SE | SE | SE | NE | (MR) | Yes | |||
| TR-285 | C.I. Basic red 9 monohydrochloride | + | Dosed-Feed | (CE) | CE | CE | CE | Yes | ||||
| TR-084 | 2,4-Diaminoanisole sulfate | + | Dosed-Feed | (P) | P | P | P | Yes | ||||
| TR-400 | 2,3-Dibromo-1-propanol | + | Topical Application | (CE) | (CE) | (CE) | (CE) | Yes | ||||
| TR-310 | Diesel fuel marine | - | Topical Application | (EE) | (EE) | No | ||||||
| TR-372 | 3,3'-Dimethoxybenzidine dihydrochloride | Dosed-Water | (CE) | (CE) | Yes | |||||||
| TR-128 | 3,3'-Dimethoxybenzidine-4,4'-diisocyanate | + | Dosed-Feed | (P) | P | N | N | Yes | ||||
| TR-390 | 3,3'-Dimethylbenzidine dihydrochloride | + | Dosed-Water | (CE) | (CE) | Yes | ||||||
| TR-054 | 2,4-Dinitrotoluene | + | Dosed-Feed | (P) | P | N | N | Yes | ||||
| TR-103 | Fenthion | -,+W | Dosed-Feed | N | N | (E) | N | No | ||||
| TR-252 | Geranyl acetate | - | Gavage | N | N | N | N | (MR) | Yes | |||
| TR-374 | Glycidol | +,+ | Gavage | (CE) | CE | (CE) | (CE) | Yes | ||||
| TR-499 | Indium phosphide | Inhalation | CE | CE | CE | CE | (MR) | Yes | ||||
| TR-491 | Methyleugenol | - | Gavage | (CE) | CE | CE | CE | Yes | ||||
| TR-146 | Nithiazide | + | Dosed-Feed | N | (P) | P | E | Yes | ||||
| TR-127 | 5-Nitro-o-anisidine | + | Dosed-Feed | (P) | P | E | P | Yes | ||||
| TR-337 | Nitrofurazone | + | Dosed-Feed | (EE) | CE | NE | CE | Yes | ||||
| TR-504 | o-Nitrotoluene | -,- | Dosed-Feed | (CE) | (CE) | CE | CE | Yes | ||||
| TR-498 | p-Nitrotoluene | - | Dosed-Feed | (EE) | SE | EE | NE | Yes | ||||
| TR-485 | Oxymetholone | - | Gavage | EE | (CE) | (MR) | Yes | |||||
| TR-364 | Rhodamine 6G | - | Dosed-Feed | (EE) | EE | NE | NE | Yes | ||||
| TR-464 | Sodium xylenesulfonate | - | Topical Application | NE | NE | NE | NE | (FR) | (MM) | No | ||
| TR-058 | tris(Aziridinyl)-phosphine sulfide (thio-tepa) | + | Intraperitoneal Injection | (P) | (P) | (P) | P | Yes | ||||
| TR-510 | Urethane | ?,+ | Dosed-Water | CE | (CE) | Yes | ||||||
| TR-510 | Urethane + ethanol (combination) | Dosed-Water | ||||||||||
| TR-362 | 4-Vinyl-1-cyclohexene diepoxide | + | Topical Application | (CE) | (CE) | (CE) | (CE) | Yes | ||||
| Totals | 26 | 11 | 7 | 5 | ||||||||
| The number of chemicals causing tumors in Skin is 32. | ||||||||||||
Levels of Evidence of Carcinogenicity: CE or P = Clear Evidence, SE = Some Evidence, EE or E = Equivocal Evidence, NE or N = No Evidence, IS = Inadequate Experiment Salmonella Results: + = Positive, +W = Weakly Positive, ? = Inconclusive, - = Negative Parentheses indicate the animal group in which a tumor occurred in the organ specified. Sex/Species: MR = Male Rats, FR = Female Rats, MM = Male Mice, FM = Female Mice Totals include positive, equivocal and may-have-been-related responses where a tumor occurred in the organ specified. NOTE: Blank space under the animal groups indicates no experiments were done. | ||||||||||||
Web page last updated on May 14, 2008
