Chemicals Associated with Site-Specific Tumor Induction in Kidney Transitional Cell

http://ntp.niehs.nih.gov/go/SA-30

Chemicals Associated with Site-Specific Tumor Induction in Kidney Transitional Cell
				Levels of Evidence of Carcinogenicity				May Have Been Related
TR	Chemical	Salmonella Results	Route	Male Rats	Female Rats	Male Mice	Female Mice	Sex/Species	Multiple Tumor Sites
TR-089	o-Anisidine hydrochloride		Dosed-Feed	(P)	P	P	P		Yes
TR-494	Anthraquinone	+,-,-,-,+,-	Dosed-Feed	(SE)	CE	CE	CE		Yes
TR-067	Aspirin, phenacetin, and caffeine		Dosed-Feed	N	(E)	N	N		Yes
TR-424	o-Benzyl-p-chlorophenol	-,-	Gavage	NE	(EE)	SE	NE		Yes
TR-335	C.I. Acid orange 3	+	Gavage	NE	(CE)	NE	NE		No
TR-423	3,4-Dihydrocoumarin	-	Gavage	SE	NE	NE	SE	(MR)	Yes
TR-323	Dimethyl methylphosphonate	-	Gavage	(SE)	NE	IS	NE		Yes
TR-313	Mirex	-	Dosed-Feed	(CE)	CE				Yes
TR-006	Nitrilotriacetic acid trisodium monohydrate	-	Dosed-Feed	(E)	E	N	N		Yes
TR-006	Nitrilotriacetic acid trisodium monohydrate	-	Dosed-Feed	(P)	P				Yes
TR-416	o-Nitroanisole	+,+	Dosed-Feed	(CE)	(CE)	CE	SE		Yes
TR-367	Phenylbutazone	-	Gavage	EE	(SE)	SE	NE		Yes
TR-457	Salicylazosulfapyridine	-	Gavage	SE	(SE)	CE	CE		Yes
			Totals	8	6	0	0
The number of chemicals causing tumors in Kidney Transitional Cell is 12.
Levels of Evidence of Carcinogenicity: CE or P = Clear Evidence, SE = Some Evidence, EE or E = Equivocal Evidence, NE or N = No Evidence, IS = Inadequate Experiment Salmonella Results: + = Positive, +W = Weakly Positive, ? = Inconclusive, - = Negative Parentheses indicate the animal group in which a tumor occurred in the organ specified. Sex/Species: MR = Male Rats, FR = Female Rats, MM = Male Mice, FM = Female Mice Totals include positive, equivocal and may-have-been-related responses where a tumor occurred in the organ specified. NOTE: Blank space under the animal groups indicates no experiments were done.

Web page last updated on May 14, 2008

National Toxicology Program