Summaries & Associations of Study Results
| Levels of Evidence of Carcinogenicity | May Have Been Related | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TR | Chemical | Salmonella Results | Route | Male Rats | Female Rats | Male Mice | Female Mice | Sex/Species | Multiple Tumor Sites | |||
| TR-447 | Acetonitrile | -,- | Inhalation | (EE) | NE | NE | NE | No | ||||
| TR-021 | Aldrin | - | Dosed-Feed | E | E | (P) | N | Yes | ||||
| TR-144 | 2-Aminoanthraquinone | + | Dosed-Feed | (P) | IS | (P) | (P) | Yes | ||||
| TR-383 | 1-Amino-2,4-dibromoanthraquinone | + | Dosed-Feed | (CE) | (CE) | (CE) | (CE) | Yes | ||||
| TR-093 | 3-Amino-9-ethylcarbazole HCl | + | Dosed-Feed | (P) | (P) | (P) | (P) | Yes | ||||
| TR-111 | 1-Amino-2-methylanthraquinone | + | Dosed-Feed | (P) | (P) | N | (P) | Yes | ||||
| TR-216 | 11-Aminoundecanoic acid | - | Dosed-Feed | (P) | N | E | N | Yes | ||||
| TR-494 | Anthraquinone | +,-,-,-,+,- | Dosed-Feed | SE | (CE) | (CE) | (CE) | (MR) | Yes | |||
| TR-038 | Aroclor 1254 | - | Dosed-Feed | (E) | (E) | Yes | ||||||
| TR-370 | Benzofuran | - | Gavage | NE | SE | (CE) | (CE) | Yes | ||||
| TR-533 | Benzophenone | - | Dosed-Feed | SE | EE | (SE) | SE | (FM) | Yes | |||
| TR-250 | Benzyl acetate | - | Gavage | EE | NE | (SE) | (SE) | Yes | ||||
| TR-239 | bis(2-Chloro-1-methylethyl) ether | +W,+,+,+,+,+ | Gavage | (P) | P | Yes | ||||||
| TR-321 | Bromodichloromethane | -,- | Gavage | CE | CE | CE | (CE) | Yes | ||||
| TR-288 | 1,3-Butadiene | + | Inhalation | CE | (CE) | Yes | ||||||
| TR-434 | 1,3-Butadiene | + | Inhalation | (CE) | (CE) | Yes | ||||||
| TR-484 | 2-Butoxyethanol (ethylene glycol monobutyl ether) | - | Inhalation | NE | EE | SE | SE | (MM) | Yes | |||
| TR-503 | Chloral hydrate | + | Gavage | (SE) | No | |||||||
| TR-025 | Chloramben | + | Dosed-Feed | N | N | (E) | (P) | No | ||||
| TR-008 | Chlordane (analytical grade) | - | Dosed-Feed | N | N | (P) | (P) | No | ||||
| TR-000 (143-50-0) | Chlordecone (kepone) | -,- | Dosed-Feed | (P) | (P) | (P) | (P) | No | ||||
| TR-304 | Chlorendic acid | - | Dosed-Feed | (CE) | (CE) | (CE) | NE | Yes | ||||
| TR-308 | Chlorinated paraffins: C12, 60% chlorine | - | Gavage | (CE) | (CE) | (CE) | (CE) | Yes | ||||
| TR-305 | Chlorinated paraffins: C23, 43% chlorine | - | Gavage | NE | EE | CE | (EE) | Yes | ||||
| TR-351 | p-Chloroaniline hydrochloride | Gavage | CE | EE | (SE) | NE | Yes | |||||
| TR-261 | Chlorobenzene | -,- | Gavage | (E) | N | N | N | No | ||||
| TR-075 | Chlorobenzilate | -,-,- | Dosed-Feed | E | E | (P) | (P) | Yes | ||||
| TR-282 | Chlorodibromomethane | -,+W | Gavage | NE | NE | (EE) | (SE) | No | ||||
| TR-346 | Chloroethane | + | Inhalation | EE | EE | IS | CE | (FM) | Yes | |||
| TR-000 (67-66-3) | Chloroform | - | Gavage | P | N | (P) | (P) | Yes | ||||
| TR-085 | 4-Chloro-m-phenylenediamine | + | Dosed-Feed | P | N | N | (P) | Yes | ||||
| TR-063 | 4-Chloro-o-phenylenediamine | + | Dosed-Feed | P | P | (P) | (P) | Yes | ||||
| TR-467 | Chloroprene | - | Inhalation | CE | CE | CE | (CE) | Yes | ||||
| TR-187 | 5-Chloro-o-toluidine | -,-,- | Dosed-Feed | N | N | (P) | (P) | Yes | ||||
| TR-405 | C.I. Acid red 114 | + | Dosed-Water | (CE) | (CE) | Yes | ||||||
| TR-397 | C.I. Direct blue 15 | - | Dosed-Water | (CE) | (CE) | Yes | ||||||
| TR-430 | C.I. Direct blue 218 | - | Dosed-Feed | SE | NE | (CE) | (CE) | Yes | ||||
| TR-299 | C.I. Disperse blue 1 | + | Dosed-Feed | CE | CE | (EE) | NE | Yes | ||||
| TR-222 | C.I. Disperse yellow 3 | +,+ | Dosed-Feed | (P) | N | N | (P) | Yes | ||||
| TR-407 | C.I. Pigment red 3 | + | Dosed-Feed | SE | (SE) | SE | NE | Yes | ||||
| TR-285 | C.I. Basic red 9 monohydrochloride | + | Dosed-Feed | (CE) | CE | (CE) | (CE) | Yes | ||||
| TR-196 | Cinnamyl anthranilate | - | Dosed-Feed | P | N | (P) | (P) | Yes | ||||
| TR-226 | C.I. Solvent yellow 14 | +,+ | Dosed-Feed | (P) | (P) | N | N | No | ||||
| TR-479 | Coconut oil acid diethanolamine condensate | - | Topical Application | NE | EE | (CE) | (CE) | Yes | ||||
| TR-422 | Coumarin | + | Gavage | SE | EE | SE | (CE) | Yes | ||||
| TR-142 | p-Cresidine | + | Dosed-Feed | (P) | P | P | (P) | Yes | ||||
| TR-542 | Cumene | - | Inhalation | CE | SE | CE | (CE) | Yes | ||||
| TR-100 | Cupferron | + | Dosed-Feed | (P) | (P) | P | (P) | Yes | ||||
| TR-083 | Daminozide | - | Dosed-Feed | N | P | (E) | N | Yes | ||||
| TR-225 | D & C red no. 9 | +W | Dosed-Feed | (P) | (E) | N | N | Yes | ||||
| TR-463 | D & C yellow no. 11 | +W,? | Dosed-Feed | (SE) | (SE) | Yes | ||||||
| TR-309 | Decabromodiphenyl oxide | - | Dosed-Feed | (SE) | (SE) | (EE) | NE | Yes | ||||
| TR-513 | Decalin | - | Inhalation | CE | NE | NE | EE | (FM) | Yes | |||
| TR-162 | 2,4-Diaminotoluene (2,4-toluene diamine) | + | Dosed-Feed | (P) | (P) | N | (P) | Yes | ||||
| TR-086 | 1,2-Dibromoethane | + | Gavage | P | (P) | P | P | Yes | ||||
| TR-400 | 2,3-Dibromo-1-propanol | + | Topical Application | (CE) | (CE) | (CE) | CE | Yes | ||||
| TR-319 | 1,4-Dichlorobenzene (p-dichlorobenzene) | - | Gavage | CE | NE | (CE) | (CE) | Yes | ||||
| TR-123 | 2,7-Dichlorodibenzo-p-dioxin | - | Dosed-Feed | N | N | (E) | N | Yes | ||||
| TR-131 | p,p'-Dichlorodiphenyl dichloroethylene | -,- | Dosed-Feed | N | N | (P) | (P) | No | ||||
| TR-219 | 2,6-Dichloro-p-phenylenediamine | +,+ | Dosed-Feed | N | N | (P) | (P) | No | ||||
| TR-263 | 1,2-Dichloropropane (propylene dichloride) | +W,+W | Gavage | NE | EE | (SE) | (SE) | Yes | ||||
| TR-269 | 1,3-Dichloropropene (Telone II) | + | Gavage | (CE) | SE | IS | CE | Yes | ||||
| TR-090 | Dicofol | - | Dosed-Feed | N | N | (P) | N | No | ||||
| TR-021 | Dieldrin | - | Dosed-Feed | N | N | (E) | N | No | ||||
| TR-478 | Diethanolamine | - | Topical Application | NE | NE | (CE) | (CE) | Yes | ||||
| TR-212 | Di(2-ethylhexyl)adipate | -,-,- | Dosed-Feed | N | N | (P) | (P) | No | ||||
| TR-217 | Di(2-ethylhexyl) phthalate | -,-,-,-,-,- | Dosed-Feed | (P) | (P) | (P) | (P) | No | ||||
| TR-156 | Di(p-ethylphenyl)dichloroethane | + | Dosed-Feed | N | N | N | (E) | No | ||||
| TR-429 | Diethyl phthalate | -,- | Topical Application | NE | NE | (EE) | (EE) | No | ||||
| TR-423 | 3,4-Dihydrocoumarin | - | Gavage | SE | NE | NE | (SE) | Yes | ||||
| TR-372 | 3,3'-Dimethoxybenzidine dihydrochloride | Dosed-Water | (CE) | (CE) | Yes | |||||||
| TR-390 | 3,3'-Dimethylbenzidine dihydrochloride | + | Dosed-Water | (CE) | (CE) | Yes | ||||||
| TR-080 | 1,4-Dioxane | -,-,- | Dosed-Water | P | (P) | (P) | (P) | Yes | ||||
| TR-404 | 5,5-Diphenylhydantoin (phenytoin) | -,- | Dosed-Feed | (EE) | NE | NE | (CE) | No | ||||
| TR-132 | 2,5-Dithiobiurea | - | Dosed-Feed | N | N | N | (E) | No | ||||
| TR-512 | Elmiron (sodium pentosanpolysulfate) | - | Gavage | NE | NE | (SE) | (SE) | (MM) | Yes | |||
| TR-466 | Ethylbenzene | - | Inhalation | CE | SE | SE | (SE) | Yes | ||||
| TR-388 | Ethylene thiourea (ETU) | -,+W | Dosed-Feed | CE | CE | (CE) | (CE) | Yes | ||||
| TR-223 | Eugenol | - | Dosed-Feed | N | N | (E) | (E) | No | ||||
| TR-195 | Fluometuron | - | Dosed-Feed | N | N | (E) | N | No | ||||
| TR-541 | Formamide | -,-,- | Gavage | NE | NE | (CE) | EE | (FM) | No | |||
| TR-496 | Fumonisin B1 | Dosed-Feed | CE | NE | NE | (CE) | Yes | |||||
| TR-402 | Furan | -,+W | Gavage | (CE) | (CE) | (CE) | (CE) | Yes | ||||
| TR-382 | Furfural | -,?,? | Gavage | (SE) | NE | (CE) | (SE) | Yes | ||||
| TR-374 | Glycidol | +,+ | Gavage | CE | CE | (CE) | CE | Yes | ||||
| TR-271 | HC blue 1 | + | Dosed-Feed | (EE) | SE | (CE) | (CE) | Yes | ||||
| TR-281 | HC red 3 | + | Gavage | NE | NE | (EE) | IS | No | ||||
| TR-009 | Heptachlor | -,- | Dosed-Feed | N | E | (P) | (P) | Yes | ||||
| TR-198 | 1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin | Gavage | (E) | (P) | (P) | (P) | No | |||||
| TR-068 | Hexachloroethane | -,- | Gavage | N | N | (P) | (P) | No | ||||
| TR-092 | Hydrazobenzene | + | Dosed-Feed | (P) | (P) | N | (P) | Yes | ||||
| TR-357 | Hydrochlorothiazide | - | Dosed-Feed | NE | NE | (EE) | NE | No | ||||
| TR-366 | Hydroquinone | - | Gavage | SE | SE | NE | (SE) | Yes | ||||
| TR-499 | Indium phosphide | Inhalation | CE | CE | (CE) | (CE) | Yes | |||||
| TR-291 | Isophorone | - | Gavage | SE | NE | (EE) | NE | Yes | ||||
| TR-480 | Lauric acid diethanolamine condensate | - | Topical Application | NE | NE | NE | (SE) | No | ||||
| TR-527 | Leucomalachite green | Dosed-Feed | EE | (EE) | (SE) | Yes | ||||||
| TR-527 | Malachite green | - | Dosed-Feed | (EE) | NE | Yes | ||||||
| TR-332 | 2-Mercaptobenzothiazole | ?,- | Gavage | SE | SE | NE | (EE) | Yes | ||||
| TR-328 | Methyl carbamate | - | Gavage | (CE) | (CE) | NE | NE | No | ||||
| TR-186 | 4,4'-Methylenebis(N,N-dimethyl)benzenamine | + | Dosed-Feed | P | P | (E) | (P) | Yes | ||||
| TR-306 | Methylene chloride | +,+,- | Inhalation | SE | CE | (CE) | (CE) | Yes | ||||
| TR-248 | 4,4'-Methylenedianiline dihydrochloride | +,+ | Dosed-Water | (P) | P | (P) | (P) | Yes | ||||
| TR-491 | Methyleugenol | - | Gavage | (CE) | (CE) | (CE) | (CE) | Yes | ||||
| TR-516 | 2-Methylimidazole | - | Dosed-Feed | SE | CE | (SE) | (SE) | (MR) | (FR) | Yes | ||
| TR-538 | Methyl isobutyl ketone | - | Inhalation | SE | EE | (SE) | (SE) | Yes | ||||
| TR-029 | 2-Methyl-1-nitroanthraquinone | + | Dosed-Feed | (P) | (P) | P | P | Yes | ||||
| TR-352 | N-Methylolacrylamide | - | Gavage | NE | NE | (CE) | (CE) | Yes | ||||
| TR-439 | Methylphenidate hydrochloride | -,- | Dosed-Feed | NE | NE | (SE) | (SE) | No | ||||
| TR-543 | alpha-Methylstyrene | - | Inhalation | SE | NE | EE | (CE) | (MM) | Yes | |||
| TR-181 | Michler's ketone | + | Dosed-Feed | (P) | (P) | P | (P) | Yes | ||||
| TR-313 | Mirex | - | Dosed-Feed | (CE) | (CE) | Yes | ||||||
| TR-266 | Monuron | - | Dosed-Feed | (CE) | NE | NE | NE | Yes | ||||
| TR-143 | 1,5-Naphthalenediamine | + | Dosed-Feed | N | P | P | (P) | Yes | ||||
| TR-146 | Nithiazide | + | Dosed-Feed | N | P | (P) | (E) | Yes | ||||
| TR-118 | 5-Nitroacenaphthene | + | Dosed-Feed | P | P | N | (P) | Yes | ||||
| TR-133 | 3-Nitro-p-acetophenetide | + | Dosed-Feed | N | N | (P) | N | No | ||||
| TR-127 | 5-Nitro-o-anisidine | + | Dosed-Feed | P | P | (E) | (P) | Yes | ||||
| TR-416 | o-Nitroanisole | +,+ | Dosed-Feed | CE | CE | (CE) | (SE) | Yes | ||||
| TR-117 | 6-Nitrobenzimidazole | + | Dosed-Feed | N | N | (P) | (P) | No | ||||
| TR-026 | Nitrofen | Dosed-Feed | IS | P | (P) | (P) | Yes | |||||
| TR-184 | Nitrofen | Dosed-Feed | N | N | (P) | (P) | No | |||||
| TR-461 | Nitromethane | - | Inhalation | NE | CE | CE | (CE) | Yes | ||||
| TR-169 | 2-Nitro-p-phenylenediamine | + | Dosed-Feed | N | N | N | (P) | No | ||||
| TR-052 | 3-Nitropropionic acid | + | Gavage | (E) | N | N | N | Yes | ||||
| TR-190 | p-Nitrosodiphenylamine | +W | Dosed-Feed | (P) | N | (P) | N | No | ||||
| TR-504 | o-Nitrotoluene | -,- | Dosed-Feed | (CE) | CE | CE | (CE) | (FR) | Yes | |||
| TR-107 | 5-Nitro-o-toluidine | + | Dosed-Feed | N | N | (P) | (P) | Yes | ||||
| TR-443 | Oxazepam | - | Dosed-Feed | (CE) | (CE) | Yes | ||||||
| TR-205 | 4,4'-Oxydianiline | + | Dosed-Feed | (P) | (P) | (P) | (P) | Yes | ||||
| TR-485 | Oxymetholone | - | Gavage | EE | (CE) | Yes | ||||||
| TR-232 | Pentachloroethane | - | Gavage | E | N | (P) | (P) | Yes | ||||
| TR-349 | Pentachlorophenol, Dowicide EC-7 | Dosed-Feed | (CE) | (CE) | Yes | |||||||
| TR-349 | Pentachlorophenol, technical | - | Dosed-Feed | (CE) | (SE) | Yes | ||||||
| TR-099 | Phenazopyridine hydrochloride | ?,+ | Dosed-Feed | P | P | N | (P) | Yes | ||||
| TR-367 | Phenylbutazone | - | Gavage | EE | SE | (SE) | NE | Yes | ||||
| TR-023 | Picloram | - | Dosed-Feed | N | (E) | N | N | No | ||||
| TR-124 | Piperonyl sulfoxide | -,- | Dosed-Feed | N | N | (P) | N | No | ||||
| TR-244 | Polybrominated biphenyl mixture (Firemaster FF-1) | Gavage | (P) | (P) | (P) | (P) | No | |||||
| TR-398 | Polybrominated biphenyl mixture (Firemaster FF-1) | Dosed-Feed | (CE) | (CE) | (CE) | (CE) | No | |||||
| TR-476 | Primidone (primaclone) | + | Dosed-Feed | EE | NE | (CE) | (CE) | Yes | ||||
| TR-395 | Probenecid | - | Gavage | NE | NE | NE | (SE) | No | ||||
| TR-005 | Proflavin hydrochloride | Dosed-Feed | E | N | (E) | (E) | Yes | |||||
| TR-515 | Propylene glycol mono-t-butyl ether | + | Inhalation | EE | NE | (CE) | (CE) | (MR) | Yes | |||
| TR-470 | Pyridine | - | Dosed-Water | SE | EE | (CE) | (CE) | Yes | ||||
| TR-508 | Riddelliine | + | Gavage | (CE) | (CE) | (CE) | CE | Yes | ||||
| TR-457 | Salicylazosulfapyridine | - | Gavage | SE | SE | (CE) | (CE) | Yes | ||||
| TR-194 | Selenium sulfide | + | Gavage | (P) | (P) | N | (P) | Yes | ||||
| TR-519 | Stoddard solvent (type lIC) | - | Inhalation | SE | NE | NE | EE | (FM) | Yes | |||
| TR-530 | TEF evaluation (Binary mixture; PCB 126/PCB 153) | Gavage | (CE) | Yes | ||||||||
| TR-525 | TEF evaluation (PECDF (Pentachlorodibenzofuran)) | Gavage | (SE) | Yes | ||||||||
| TR-531 | Tef Evaluation (Pcb Mixture; Pcb 126/Pcb 118) | Gavage | (CE) | (FR) | Yes | |||||||
| TR-521 | TEF evaluation (TCDD) | Gavage | (CE) | (FR) | Yes | |||||||
| TR-209 | 2,3,7,8-Tetrachlorodibenzo-p-dioxin | - | Gavage | P | (P) | (P) | (P) | Yes | ||||
| TR-237 | 1,1,1,2-Tetrachloroethane | -,- | Gavage | (E) | N | (P) | (P) | No | ||||
| TR-027 | 1,1,2,2-Tetrachloroethane | -,- | Gavage | (E) | N | (P) | (P) | No | ||||
| TR-013 | Tetrachloroethylene | - | Gavage | IS | IS | (P) | (P) | No | ||||
| TR-311 | Tetrachloroethylene | - | Inhalation | CE | SE | (CE) | (CE) | Yes | ||||
| TR-033 | Tetrachlorvinphos | - | Dosed-Feed | N | P | (P) | (P) | Yes | ||||
| TR-450 | Tetrafluoroethylene | Inhalation | (CE) | (CE) | (CE) | (CE) | Yes | |||||
| TR-475 | Tetrahydrofuran | -,- | Inhalation | SE | NE | NE | (CE) | Yes | ||||
| TR-047 | 4,4'-Thiodianiline | + | Dosed-Feed | (P) | P | (P) | (P) | Yes | ||||
| TR-251 | 2,4- & 2,6-Toluene diisocyanate | + | Gavage | P | (P) | N | (P) | Yes | ||||
| TR-153 | o-Toluidine hydrochloride | +,- | Dosed-Feed | P | P | P | (P) | Yes | ||||
| TR-037 | Toxaphene | + | Dosed-Feed | E | E | (P) | (P) | Yes | ||||
| TR-526 | TEF evaluation (Dioxin mixture) | Gavage | (CE) | Yes | ||||||||
| TR-529 | Toxic equivalency factor evaluation (PCB 153- 2,2'-4,4',5,5'-hexachlorobiphenyl) | Gavage | (EE) | No | ||||||||
| TR-520 | Toxic equivalency factor evaluation ((PCB 126) 3,3',4,4',5-pentachlorobiphenyl) | Gavage | (CE) | (FR) | Yes | |||||||
| TR-420 | Triamterene | -,- | Dosed-Feed | (EE) | NE | (SE) | (SE) | No | ||||
| TR-074 | 1,1,2-Trichloroethane | -,-,-,? | Gavage | N | N | (P) | (P) | Yes | ||||
| TR-002 | Trichloroethylene | -,- | Gavage | N | N | (P) | (P) | No | ||||
| TR-243 | Trichloroethylene | -,- | Gavage | IS | N | (P) | (P) | No | ||||
| TR-155 | 2,4,6-Trichlorophenol | - | Dosed-Feed | P | N | (P) | (P) | Yes | ||||
| TR-384 | 1,2,3-Trichloropropane | +,+ | Gavage | CE | CE | (CE) | (CE) | Yes | ||||
| TR-518 | Triethanolamine | - | Topical Application | EE | (SE) | (MM) | No | |||||
| TR-034 | Trifluralin | + | Dosed-Feed | N | N | N | (P) | Yes | ||||
| TR-160 | 2,4,5-Trimethylaniline | + | Dosed-Feed | (P) | (P) | (E) | (P) | Yes | ||||
| TR-076 | tris(2,3-Dibromopropyl) phosphate | Dosed-Feed | P | P | P | (P) | Yes | |||||
| TR-274 | tris(2-Ethylhexyl)phosphate | - | Gavage | EE | NE | NE | (SE) | Yes | ||||
| TR-427 | Turmeric, oleoresin (curcumin) | - | Dosed-Feed | NE | EE | (EE) | (EE) | Yes | ||||
| TR-510 | Urethane | ?,+ | Dosed-Water | (CE) | (CE) | Yes | ||||||
| TR-510 | Urethane + ethanol (combination) | Dosed-Water | ||||||||||
| TR-537 | Water disinfection byproducts (Dibromoacetic acid) | Dosed-Water | SE | SE | (CE) | (CE) | Yes | |||||
| TR-278 | 2,6-Xylidine | +W,+W,- | Dosed-Feed | P | P | (FR) | Yes | |||||
| TR-235 | Zearalenone | - | Dosed-Feed | N | N | P | (P) | Yes | ||||
| Totals | 57 | 57 | 113 | 131 | ||||||||
| The number of chemicals causing tumors in Liver is 180. | ||||||||||||
Levels of Evidence of Carcinogenicity: CE or P = Clear Evidence, SE = Some Evidence, EE or E = Equivocal Evidence, NE or N = No Evidence, IS = Inadequate Experiment Salmonella Results: + = Positive, +W = Weakly Positive, ? = Inconclusive, - = Negative Parentheses indicate the animal group in which a tumor occurred in the organ specified. Sex/Species: MR = Male Rats, FR = Female Rats, MM = Male Mice, FM = Female Mice Totals include positive, equivocal and may-have-been-related responses where a tumor occurred in the organ specified. NOTE: Blank space under the animal groups indicates no experiments were done. | ||||||||||||
Web page last updated on May 14, 2008
