Chemicals Associated with Site-Specific Tumor Induction in Ovary

http://ntp.niehs.nih.gov/go/SA-52

Chemicals Associated with Site-Specific Tumor Induction in Ovary
				Levels of Evidence of Carcinogenicity				May Have Been Related
TR	Chemical	Salmonella Results	Route	Male Rats	Female Rats	Male Mice	Female Mice	Sex/Species		Multiple Tumor Sites
TR-506	Acrylonitrile	+	Gavage			CE	CE		(FM)	Yes
TR-289	Benzene	-	Gavage	CE	CE	CE	(CE)			Yes
TR-288	1,3-Butadiene	+	Inhalation			CE	(CE)			Yes
TR-434	1,3-Butadiene	+	Inhalation			CE	(CE)			Yes
TR-352	N-Methylolacrylamide	-	Gavage	NE	NE	CE	(CE)			Yes
TR-118	5-Nitroacenaphthene	+	Dosed-Feed	P	P	N	(P)			Yes
TR-341	Nitrofurantoin	+,+,+,+,+,+,+	Dosed-Feed	SE	NE	NE	(CE)			Yes
TR-337	Nitrofurazone	+	Dosed-Feed	EE	CE	NE	(CE)			Yes
TR-465	Phenolphthalein	-,-,-,?	Dosed-Feed	CE	SE	CE	(CE)			Yes
TR-510	Urethane	?,+	Dosed-Water			CE	(CE)			Yes
TR-510	Urethane + ethanol (combination)		Dosed-Water
TR-303	4-Vinylcyclohexene	-,-	Gavage	IS	IS	IS	(CE)			Yes
TR-362	4-Vinyl-1-cyclohexene diepoxide	+	Topical Application	CE	CE	CE	(CE)			Yes
			Totals	0	0	0	12
The number of chemicals causing tumors in Ovary is 12.
Levels of Evidence of Carcinogenicity: CE or P = Clear Evidence, SE = Some Evidence, EE or E = Equivocal Evidence, NE or N = No Evidence, IS = Inadequate Experiment Salmonella Results: + = Positive, +W = Weakly Positive, ? = Inconclusive, - = Negative Parentheses indicate the animal group in which a tumor occurred in the organ specified. Sex/Species: MR = Male Rats, FR = Female Rats, MM = Male Mice, FM = Female Mice Totals include positive, equivocal and may-have-been-related responses where a tumor occurred in the organ specified. NOTE: Blank space under the animal groups indicates no experiments were done.

Web page last updated on May 14, 2008

National Toxicology Program