Summaries & Associations of Study Results
| Levels of Evidence of Carcinogenicity | May Have Been Related | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TR | Chemical | Salmonella Results | Route | Male Rats | Female Rats | Male Mice | Female Mice | Sex/Species | Multiple Tumor Sites | |||
| TR-093 | 3-Amino-9-ethylcarbazole HCl | + | Dosed-Feed | (P) | (P) | P | P | Yes | ||||
| TR-289 | Benzene | - | Gavage | (CE) | (CE) | (CE) | (CE) | Yes | ||||
| TR-452 | 2,2-bis(Bromomethyl)-1,3-propanediol | +,+,- | Dosed-Feed | (CE) | CE | CE | CE | Yes | ||||
| TR-288 | 1,3-Butadiene | + | Inhalation | CE | CE | (MM) | Yes | |||||
| TR-434 | 1,3-Butadiene | + | Inhalation | CE | CE | (MM) | (FM) | Yes | ||||
| TR-467 | Chloroprene | - | Inhalation | CE | CE | CE | (CE) | Yes | ||||
| TR-405 | C.I. Acid red 114 | + | Dosed-Water | (CE) | (CE) | Yes | ||||||
| TR-397 | C.I. Direct blue 15 | - | Dosed-Water | (CE) | (CE) | Yes | ||||||
| TR-407 | C.I. Pigment red 3 | + | Dosed-Feed | SE | SE | SE | NE | (MR) | Yes | |||
| TR-285 | C.I. Basic red 9 monohydrochloride | + | Dosed-Feed | (CE) | (CE) | CE | CE | Yes | ||||
| TR-100 | Cupferron | + | Dosed-Feed | P | (P) | P | (P) | Yes | ||||
| TR-084 | 2,4-Diaminoanisole sulfate | + | Dosed-Feed | (P) | (P) | P | P | Yes | ||||
| TR-400 | 2,3-Dibromo-1-propanol | + | Topical Application | (CE) | (CE) | CE | CE | Yes | ||||
| TR-372 | 3,3'-Dimethoxybenzidine dihydrochloride | Dosed-Water | (CE) | (CE) | Yes | |||||||
| TR-128 | 3,3'-Dimethoxybenzidine-4,4'-diisocyanate | + | Dosed-Feed | (P) | (P) | N | N | Yes | ||||
| TR-390 | 3,3'-Dimethylbenzidine dihydrochloride | + | Dosed-Water | (CE) | (CE) | Yes | ||||||
| TR-493 | Emodin | +W,+ | Dosed-Feed | NE | EE | EE | NE | (FR) | Yes | |||
| TR-374 | Glycidol | +,+ | Gavage | (CE) | CE | CE | CE | Yes | ||||
| TR-092 | Hydrazobenzene | + | Dosed-Feed | (P) | P | N | P | Yes | ||||
| TR-359 | 8-Methoxypsoralen | + | Gavage | (CE) | NE | Yes | ||||||
| TR-118 | 5-Nitroacenaphthene | + | Dosed-Feed | (P) | (P) | N | P | Yes | ||||
| TR-127 | 5-Nitro-o-anisidine | + | Dosed-Feed | (P) | (P) | E | P | Yes | ||||
| TR-365 | Pentaerythritol tetranitrate | - | Dosed-Feed | (EE) | (EE) | NE | NE | No | ||||
| TR-047 | 4,4'-Thiodianiline | + | Dosed-Feed | (P) | (P) | P | P | Yes | ||||
| TR-057 | beta-Thioguanidine deoxyriboside | Intraperitoneal Injection | (E) | (P) | IS | IS | No | |||||
| TR-384 | 1,2,3-Trichloropropane | +,+ | Gavage | (CE) | (CE) | CE | CE | Yes | ||||
| TR-058 | tris(Aziridinyl)-phosphine sulfide (thio-tepa) | + | Intraperitoneal Injection | (P) | (P) | P | P | Yes | ||||
| Totals | 22 | 19 | 3 | 4 | ||||||||
| The number of chemicals causing tumors in Zymbal Gland is 26. | ||||||||||||
Levels of Evidence of Carcinogenicity: CE or P = Clear Evidence, SE = Some Evidence, EE or E = Equivocal Evidence, NE or N = No Evidence, IS = Inadequate Experiment Salmonella Results: + = Positive, +W = Weakly Positive, ? = Inconclusive, - = Negative Parentheses indicate the animal group in which a tumor occurred in the organ specified. Sex/Species: MR = Male Rats, FR = Female Rats, MM = Male Mice, FM = Female Mice Totals include positive, equivocal and may-have-been-related responses where a tumor occurred in the organ specified. NOTE: Blank space under the animal groups indicates no experiments were done. | ||||||||||||
Web page last updated on May 14, 2008
