Summaries & Associations of Study Results
| Levels of Evidence of Carcinogenicity | May Have Been Related | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TR | Chemical | Salmonella Results | Route | Male Rats | Female Rats | Male Mice | Female Mice | Sex/Species | Multiple Tumor Sites | |||
| TR-506 | Acrylonitrile | + | Gavage | CE | CE | (FM) | Yes | |||||
| TR-383 | 1-Amino-2,4-dibromoanthraquinone | + | Dosed-Feed | CE | CE | (CE) | (CE) | Yes | ||||
| TR-522 | AZT transplacental carcinogenesis study | In Utero | (CE) | NE | No | |||||||
| TR-289 | Benzene | - | Gavage | CE | CE | (CE) | (CE) | Yes | ||||
| TR-370 | Benzofuran | - | Gavage | NE | SE | (CE) | (CE) | Yes | ||||
| TR-088 | 1,2,3-Benzotriazole | +W | Dosed-Feed | E | E | N | (E) | Yes | ||||
| TR-452 | 2,2-bis(Bromomethyl)-1,3-propanediol | +,+,- | Dosed-Feed | (CE) | CE | (CE) | (CE) | Yes | ||||
| TR-239 | bis(2-Chloro-1-methylethyl) ether | +W,+,+,+,+,+ | Gavage | (P) | (P) | Yes | ||||||
| TR-363 | Bromoethane (ethyl bromide) | -,+ | Inhalation | SE | (EE) | (EE) | CE | (MR) | Yes | |||
| TR-288 | 1,3-Butadiene | + | Inhalation | (CE) | (CE) | Yes | ||||||
| TR-434 | 1,3-Butadiene | + | Inhalation | (CE) | (CE) | Yes | ||||||
| TR-304 | Chlorendic acid | - | Dosed-Feed | CE | CE | CE | NE | (MR) | Yes | |||
| TR-467 | Chloroprene | - | Inhalation | (CE) | CE | (CE) | (CE) | (FR) | Yes | |||
| TR-405 | C.I. Acid red 114 | + | Dosed-Water | CE | (CE) | (MR) | Yes | |||||
| TR-299 | C.I. Disperse blue 1 | + | Dosed-Feed | CE | CE | (EE) | NE | Yes | ||||
| TR-471 | Cobalt sulfate heptahydrate | +W | Inhalation | (SE) | (CE) | (CE) | (CE) | Yes | ||||
| TR-422 | Coumarin | + | Gavage | SE | EE | (SE) | (CE) | Yes | ||||
| TR-542 | Cumene | - | Inhalation | CE | SE | (CE) | (CE) | Yes | ||||
| TR-206 | 1,2-Dibromo-3-chloropropane | + | Inhalation | P | P | (P) | (P) | Yes | ||||
| TR-086 | 1,2-Dibromoethane | + | Gavage | P | P | (P) | (P) | Yes | ||||
| TR-210 | 1,2-Dibromoethane | + | Inhalation | P | (P) | (P) | (P) | Yes | ||||
| TR-400 | 2,3-Dibromo-1-propanol | + | Topical Application | CE | CE | (CE) | CE | (FM) | Yes | |||
| TR-055 | 1,2-Dichloroethane | + | Gavage | P | P | (P) | (P) | Yes | ||||
| TR-269 | 1,3-Dichloropropene (Telone II) | + | Gavage | CE | SE | IS | (CE) | Yes | ||||
| TR-390 | 3,3'-Dimethylbenzidine dihydrochloride | + | Dosed-Water | (CE) | (CE) | Yes | ||||||
| TR-287 | Dimethyl hydrogen phosphite | ?,+W | Gavage | (CE) | (EE) | NE | NE | Yes | ||||
| TR-121 | Dimethyl terephthalate | - | Dosed-Feed | N | N | (E) | N | No | ||||
| TR-355 | Diphenhydramine hydrochloride | - | Dosed-Feed | (EE) | EE | NE | NE | Yes | ||||
| TR-534 | Divinylbenzene | -,-,- | Inhalation | EE | NE | NE | (EE) | Yes | ||||
| TR-329 | 1,2-Epoxybutane | + | Inhalation | (CE) | EE | NE | NE | Yes | ||||
| TR-059 | Estradiol mustard | Gavage | N | N | (P) | (P) | Yes | |||||
| TR-466 | Ethylbenzene | - | Inhalation | CE | SE | (SE) | SE | Yes | ||||
| TR-326 | Ethylene oxide | Inhalation | (CE) | (CE) | Yes | |||||||
| TR-492 | Gallium arsenide | - | Inhalation | NE | (CE) | NE | NE | Yes | ||||
| TR-374 | Glycidol | +,+ | Gavage | CE | CE | (CE) | CE | Yes | ||||
| TR-271 | HC blue 1 | + | Dosed-Feed | EE | (SE) | CE | CE | Yes | ||||
| TR-499 | Indium phosphide | Inhalation | (CE) | (CE) | (CE) | (CE) | Yes | |||||
| TR-448 | Isobutyl nitrite | +,+,+ | Inhalation | (CE) | (CE) | (SE) | (SE) | Yes | ||||
| TR-359 | 8-Methoxypsoralen | + | Gavage | CE | NE | (MR) | Yes | |||||
| TR-306 | Methylene chloride | +,+,- | Inhalation | SE | CE | (CE) | (CE) | Yes | ||||
| TR-535 | 4-Methylimidazole | -,- | Dosed-Feed | NE | EE | (CE) | (CE) | Yes | ||||
| TR-352 | N-Methylolacrylamide | - | Gavage | NE | NE | (CE) | (CE) | Yes | ||||
| TR-462 | Molybdenum trioxide | - | Inhalation | (EE) | NE | (SE) | (SE) | No | ||||
| TR-410 | Naphthalene | - | Inhalation | NE | (SE) | No | ||||||
| TR-143 | 1,5-Naphthalenediamine | + | Dosed-Feed | N | P | P | (P) | Yes | ||||
| TR-451 | Nickel (II) oxide | - | Inhalation | (SE) | (SE) | NE | (EE) | Yes | ||||
| TR-453 | Nickel subsulfide | ? | Inhalation | (CE) | (CE) | NE | NE | Yes | ||||
| TR-118 | 5-Nitroacenaphthene | + | Dosed-Feed | (P) | (P) | N | P | Yes | ||||
| TR-461 | Nitromethane | - | Inhalation | NE | CE | (CE) | (CE) | Yes | ||||
| TR-504 | o-Nitrotoluene | -,- | Dosed-Feed | (CE) | CE | CE | CE | Yes | ||||
| TR-498 | p-Nitrotoluene | - | Dosed-Feed | EE | SE | (EE) | NE | Yes | ||||
| TR-485 | Oxymetholone | - | Gavage | EE | (CE) | Yes | ||||||
| TR-440 | Ozone | + | Inhalation | NE | NE | (EE) | (SE) | No | ||||
| TR-060 | Phenesterin | -,- | Gavage | N | P | (P) | (P) | Yes | ||||
| TR-019 | Procarbazine hydrochloride | - | Intraperitoneal Injection | P | P | (P) | (P) | Yes | ||||
| TR-508 | Riddelliine | + | Gavage | CE | CE | CE | (CE) | Yes | ||||
| TR-194 | Selenium sulfide | + | Gavage | P | P | N | (P) | Yes | ||||
| TR-185 | Styrene | - | Gavage | N | N | (E) | N | No | ||||
| TR-115 | Sulfallate | + | Dosed-Feed | P | P | (P) | P | Yes | ||||
| TR-421 | Talc | Inhalation | SE | (CE) | NE | NE | Yes | |||||
| TR-530 | TEF evaluation (Binary mixture; PCB 126/PCB 153) | Gavage | (CE) | Yes | ||||||||
| TR-525 | TEF evaluation (PECDF (Pentachlorodibenzofuran)) | Gavage | SE | (FR) | Yes | |||||||
| TR-531 | Tef Evaluation (Pcb Mixture; Pcb 126/Pcb 118) | Gavage | (CE) | Yes | ||||||||
| TR-521 | TEF evaluation (TCDD) | Gavage | (CE) | Yes | ||||||||
| TR-386 | Tetranitromethane | + | Inhalation | (CE) | (CE) | (CE) | (CE) | No | ||||
| TR-526 | TEF evaluation (Dioxin mixture) | Gavage | (CE) | Yes | ||||||||
| TR-520 | Toxic equivalency factor evaluation ((PCB 126) 3,3',4,4',5-pentachlorobiphenyl) | Gavage | (CE) | Yes | ||||||||
| TR-034 | Trifluralin | + | Dosed-Feed | N | N | N | (P) | Yes | ||||
| TR-160 | 2,4,5-Trimethylaniline | + | Dosed-Feed | P | (P) | E | P | Yes | ||||
| TR-076 | tris(2,3-Dibromopropyl) phosphate | Dosed-Feed | P | P | (P) | (P) | Yes | |||||
| TR-510 | Urethane | ?,+ | Dosed-Water | (CE) | (CE) | Yes | ||||||
| TR-510 | Urethane + ethanol (combination) | Dosed-Water | ||||||||||
| TR-507 | Vanadium pentoxide | - | Inhalation | (SE) | EE | (CE) | (CE) | (FR) | No | |||
| TR-362 | 4-Vinyl-1-cyclohexene diepoxide | + | Topical Application | CE | CE | CE | CE | (FM) | Yes | |||
| TR-537 | Water disinfection byproducts (Dibromoacetic acid) | Dosed-Water | SE | SE | (CE) | CE | (FM) | Yes | ||||
| TR-238 | Ziram | + | Dosed-Feed | P | N | N | (E) | Yes | ||||
| Totals | 20 | 25 | 42 | 45 | ||||||||
| The number of chemicals causing tumors in Lung is 74. | ||||||||||||
Levels of Evidence of Carcinogenicity: CE or P = Clear Evidence, SE = Some Evidence, EE or E = Equivocal Evidence, NE or N = No Evidence, IS = Inadequate Experiment Salmonella Results: + = Positive, +W = Weakly Positive, ? = Inconclusive, - = Negative Parentheses indicate the animal group in which a tumor occurred in the organ specified. Sex/Species: MR = Male Rats, FR = Female Rats, MM = Male Mice, FM = Female Mice Totals include positive, equivocal and may-have-been-related responses where a tumor occurred in the organ specified. NOTE: Blank space under the animal groups indicates no experiments were done. | ||||||||||||
Web page last updated on May 14, 2008
