Chemical Mixtures Research: Significance and Future Perspectives
William A. Suk, Kenneth Olden, and Raymond S.H. Yang Third
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International Issues on Human Health Effects of Exposure to Chemical Mixtures
Victor J. Feron, Flemming R. Cassee, John P. Groten, Petronella W. van Vliet, and Job A. van Zorge
p.893 [HTML] [ Download PDF]

Overview of Human Health and Chemical Mixtures: Problems Facing Developing Countries
Leticia Yáñez, Deogracias Ortiz, Jaqueline Calderón, Lilia Batres, Leticia Carrizales, Jesús Mejía, Lourdes Martínez, Edelmira García-Nieto, and Fernando Díaz-Barriga
p.901 [HTML] [ Download PDF]

Application of Cell and Molecular Technology to Chemical Mixtures

The Midgut Epithelium of Aquatic Arthropods: A Critical Target Organ in Environmental Toxicology
Barry J. Beaty, Ryan S. Mackie, Kimberly S. Mattingly, Jonathan O. Carlson, and Alfredo Rayms-Keller
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Deviation from Additivity in Mixture Toxicity: Relevance of Nonlinear Dose–Response Relationships and Cell Line Differences in Genotoxicity Assays with Combinations of Chemical Mutagens and g-Radiation
Werner K. Lutz, Spyros Vamvakas, Annette Kopp-Schneider, Josef Schlatter, and Helga Stopper
p.915 [HTML] [ Download PDF]

Application of Genomics to Toxicology Research
Russell S. Thomas, David R. Rank, Sharron G. Penn, Gina M. Zastrow, Kevin R. Hayes, Tianhua Hu, Kalyan Pande, Mark Lewis, Stevan B. Jovanovich, and Christopher A. Bradfield
p.919 [HTML] [ Download PDF]

Problems for Risk Assessment of Endocrine-Active Estrogenic Compounds
Stephen H. Safe, Lea Pallaroni, Kyungsil Yoon, Kevin Gaido, Susan Ross, and Donald McDonnell
p.925 [HTML] [ Download PDF]

Characterization of Gene Expression Changes Associated with MNNG, Arsenic, or Metal Mixture Treatment in Human Keratinocytes: Application of cDNA Microarray Technology
Dong-Soon Bae, William H. Hanneman, Raymond S.H. Yang, and Julie A. Campain
p.931 [HTML] [ Download PDF]

The Role of Cell Bioaugmentation and Gene Bioaugmentation in the Remediation of Co-contaminated Soils
Ian L. Pepper, Terry J. Gentry, Deborah T. Newby, Timberley M. Roane, and Karen L. Josephson
p.943 [HTML] [ Download PDF]

Gene Induction Studies and Toxicity of Chemical Mixtures
M.M. Mumtaz, D.B. Tully, H.A. El-Masri, and C.T. De Rosa
p.947 [HTML] [ Download PDF]

Application of Computer and Statistical Modeling to Chemical Mixtures

Application of Biologically Based Computer Modeling to Simple or Complex Mixtures
Kai H. Liao, Ivan D. Dobrev, James E. Dennison Jr., Melvin E. Andersen, Brad Reisfeld, Kenneth F. Reardon, Julie A. Campain, Wei Wei, Michael T. Klein, Richard J. Quann, and Raymond S. H. Yang
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Evaluating Quantitative Formulas for Dose–Response Assessment of Chemical Mixtures
Richard C. Hertzberg and Linda K. Teuschler
p.965 [HTML] [ Download PDF]

Molecular Circuits, Biological Switches, and Nonlinear Dose–Response Relationships
Melvin E. Andersen, Raymond S.H. Yang, C. Tenley French, Laura S. Chubb, and James E. Dennison
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Experimental Designs for Mixtures of Chemicals along Fixed Ratio Rays
Stephanie L. Meadows, Chris Gennings, W. Hans Carter Jr., and Dong-Soon Bae
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Toxicological Evaluation of Complex Mixtures by Pattern Recognition: Correlating Chemical Fingerprints to Mutagenicity
Ingvar Eide, Gunhild Neverdal, Bodil Thorvaldsen, Bjørn Grung, and Olav M. Kvalheim
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Physiological Modeling and Extrapolation of Pharmacokinetic Interactions from Binary to More Complex Chemical Mixtures
Kannan Krishnan, Sami Haddad, Martin Béliveau, and Robert Tardif
p.989 [HTML] [ Download PDF]

Application of Engineering and Chemical Technology to Chemical Mixtures

Molecular Identification of Organic Compounds in Atmospheric Complex Mixtures and Relationship to Atmospheric Chemistry and Sources
Monica A. Mazurek
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Biodegradation Kinetics of Aromatic Hydrocarbon Mixtures by Pure and Mixed Bacterial Cultures
Kenneth F. Reardon, Douglas C. Mosteller, Julia Bull Rogers, Nancy M. DuTeau, and Kee-Hong Kim
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Development of a Research Strategy for Integrated Technology-Based Toxicological and Chemical Evaluation of Complex Mixtures of Drinking Water Disinfection Byproducts
Jane Ellen Simmons, Susan D. Richardson, Thomas F. Speth, Richard J. Miltner, Glenn Rice, Kathleen M. Schenck, E. Sidney Hunter III, and Linda K. Teuschler
p.1013 [HTML] [ Download PDF]

BioMOL: A Computer-Assisted Biological Modeling Tool for Complex Chemical Mixtures and Biological Processes at the Molecular Level
Michael T. Klein, Gang Hou, Richard J. Quann, Wei Weil, Kai H. Liao, Raymond S. H. Yang, Julie A. Campain, Monica A. Mazurek, and Linda J. Broadbelt
p.1025 [HTML] [ Download PDF]

Protein Binding of Isofluorophate in Vivo after Coexposure to Multiple Chemicals
John S. Vogel, Garrett A. Keating II, and Bruce A. Buchholz
p.1031 [HTML] [ Download PDF]

The Methyl Parathion Story: A Chronicle of Misuse and Preventable Human Exposure

Introduction-The Methyl Parathion Story: A Chronicle of Misuse and Preventable Human Exposure
Carol Rubin, Emilio Esteban, Robert H. Hill Jr., and Ken Pearce
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Urinary p-Nitrophenol As a Biomarker of Household Exposure to Methyl Parathion
Daniel O. Hryhorczuk, Mike Moomey, Ann Burton, Ken Runkle, Edwin Chen, Tiffanie Saxer, Jennifer Slightom, John Dimos, Ken McCann, and Dana Barr
p.1041 [HTML] [ Download PDF]

Assessment of Human Exposure and Human Health Effects After Indoor Application of Methyl Parathion in Lorain County, Ohio, 1995–1996
Carol Rubin, Emilio Esteban, Stephanie Kieszak, Robert H. Hill Jr., Boadie Dunlop, Rebecca Yacovac, Janine Trottier, Kathy Boylan, Terri Tomasewski, and Ken Pearce
p.1047 [HTML] [ Download PDF]

An Investigation of Unexplained Infant Deaths in Houses Contaminated with Methyl Parathion
Annemarie Wasley, Lisa A. Lepine, Roland Jenkins, and Carol Rubin
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Public Health Decisions: The Laboratory’s Role in the Lorain County, Ohio, Investigation
Robert H. Hill Jr., Susan Head, Dana B. Barr, Carol Rubin, Emilio Esteban, Samuel E. Baker, Sandra Bailey, and Larry L. Needham
p.1057 [HTML] [ Download PDF]

Methyl Parathion in Residential Properties: Relocation and Decontamination Methodology
J. Milton Clark, John Bing-Canar, Steve Renninger, Ralph Dollhopf, Jason El-Zein, Dave Star, Dea Zimmerman, Abul Anisuzzaman, Kathline Boylan, Terrence Tomaszewski, Ken Pearce, Rebecca Yacovac, Bobby Erlwein, and John Ward
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Analysis of Environmental and Biologic Methyl Parathion Data to Improve Future Data Collection
Rubina Imtiaz and Gilbert Haugh
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Chicago Area Methyl Parathion Response
Kenneth G. McCann, C. Michael Moomey, Kenny D. Runkle, Daniel O. Hryhorczuk, J. Milton Clark, and Dana B. Barr
p.1075 [HTML] [ Download PDF]

Methods of Assessing Neurobehavioral Development in Children Exposed to Methyl Parathion in Mississippi and Ohio
Perri Zeitz, Kirsten Kakolewski, Rubina Imtiaz, and Wendy Kaye
p.1079 [HTML] [ Download PDF]

Measurement of p-Nitrophenol in the Urine of Residents Whose Homes Were Contaminated with Methyl Parathion
Dana B. Barr, Wayman E. Turner, Emily DiPietro, P. Cheryl McClure, Samuel E. Baker, John R. Barr, Kimberly Gehle, Raymond E. Grissom Jr., Roberto Bravo, W. Jack Driskell, Donald G. Patterson Jr., Robert H. Hill Jr., Larry L. Needham, James L. Pirkle, and Eric J. Sampson
p.1085 [HTML] [ Download PDF]