Genome Project 
U.S. HGP on Fast Track 
DOE Joint Genome Institute Exceeds Goal 
New 5-Year Goals 
Faster Sequencing with BACs 
Mapping with STCs and STSs 
Availability of BAC Clones and STC Data 
BAC Related Websites 
BAC Resource Success Story 
Scientists Hunt SNPs for Variation, Disease 
Who's Sequencing the Human Genome? 
Genomics Progress in Science 
EMSL Promotes Remote Access to Instrumentation 
Second Private-Sector Sequencing Project 
GeneMap'98 

In the News 
Team Delivers C. elegans Sequence 
Why Sequence Entire Genomes? Worm's Eye View 
Embnet.news on Web 
European Biotech Program 
DOE BER Research Update 
Hollaender Fellows Named 
SBIR 1998 Human Genome Awards Announced 
Mouse Resources 
Mouse Consortium for Functional Genomics 
Chlamydia Genome Analysis 
HUGO Merges Offices, Web Sites 

Microbial Genomics 
Superbug Deinococcus radiodurans 
Unfinished Microbial Genomes Searchable 
TIGR Releases Chlorobium tepidum Sequence 
DOE MGP Abstracts Online 
Microbial TV Series 
 
Ethical, Legal, and Social Issues and Educational Resources 
Cambridge ELSI Symposium 
Eric Lander, Genetics in the 21st Century 
Mark Rothstein, Genetic Privacy 
James Wilson, Gene Therapy Present & Future 
LeRoy Walters, Ethical Issues in Gene Therapy 
DNA Files on NPR, Internet 
Innovative Biotechnology Curriculum 
Short Course for Biology Teachers 
Microbial TV Series 

Proteomics 
Looking at Proteins to Understand Expression 
2-DGE:  Protein Visualization, Modification 
Tool for Protein Analysis 
TREMBL Release 6 
R&D 100 Award Goes to LANL's SOLVE 
NIH Awards Proteomics Grant to Axys 
E. coli Proteome Database 

Genetics in Medicine 
National Organization for Rare Disorders 
Translation of Genetics to Medicine: New Website 
Cancer Genetics Web Site 
HuGem Website Offers Education in New Genetics 
Calculation of Genetic Risks 2nd Edition 
New Genetics Manual Offered 
Mutation Research Genomics Online 
 
Informatics 
GDB Database Operations Restored 
In Silico Biology: Bioinformatics Journal 
Computational Methods Book Available 
Bioinformatics Guide
BioToolKit
Gene-Finding Programs at Sanger
New Sequin Version
Tandem Repeat Tool
Sequence Viewer
SmithKline Licenses Gene Logic Software 
Influenza Database at LANL 
TRANSFAC Database 
p53 Mutation Database 
TBASE at Jackson Laboratory 
Intein Database on Web 
System Identifies Polymorphisms 

Web, Other Resources, Publications 
1999 Oakland Workshop Website 
Launchpad to Human Chromosomes 
Nature Genetics Supplement 

Funding 
DOE Office of Science Grants and Contracts 
NHGRI National Service Award Fellowships 
NCI Technologies for Molecular Analysis 
NIH: Netork for Large-Scale Mouse Sequencing 
NHGRI: Genomic Technology Development 
US Genome Research Funding 

Meeting Calendars & Acronyms 
Genome and Biotechnology Meetings 
Training Courses and Workshops 
Acronyms 

HGN archives and subscriptions 
HGP Information home

The Human Genome Project: Science, Law, and Social Change in the 21st Century

Reports from Cambridge Symposium

The highly successful symposium, "The Human Genome Project: Science, Law, and Social Change in the 21st Century," was held in Cambridge, Massachusetts, on April 23-24, 1998. It was sponsored by the Whitehead Institute of Biomedical Research and the American Society of Law, Medicine, and Ethics and supported in part by the Ethical, Legal, and Social Issues component of the DOE Human Genome Program. This largest ELSI meeting ever was attended by more than 840 lawyers, judges, physicians, state legislators, journalists, educators, students, consumer advocates, and religious leaders. Topics at plenary sessions and breakout groups included genetic privacy, DNA databanks, genetic discrimination, doctor-patient relationships, gene therapy, newborn screening, and gene alteration.

Highlights of several selected plenary talks are given below. Eric Lander set the stage, describing the science behind the Human Genome Project. Mark Rothstein spoke on protecting genetic privacy, which is increasingly important as genetic tests become available. The final two speakers, James Wilson and LeRoy Walters, discussed gene therapy, a class of disease prevention or treatment expected to become more available as technologies unravel the genetic factors involved in disease.

Articles about the talks are listed below:

• Genetics in the 21st Century
  Eric Lander, Whitehead Institute
• Protecting Genetic Privacy: Why It is So Hard to Do
  Mark A. Rothstein, Health Law and Policy Institute, University of Houston Law Center
• Human Gene Therapy: Present and Future
  James M. Wilson, Institute for Human Gene Therapy, University of Pennsylvania
• Ethical Issues in Human Gene Therapy
  LeRoy Walters, Kennedy Institute of Ethics, Georgetown University

A Free CD-ROM is also available. It includes meeting syllabus, plenary talk transcripts, and Web site links. Contact Gus Cervini.

The electronic form of the newsletter may be cited in the following style:
Human Genome Program, U.S. Department of Energy, Human Genome News (v10n1-2).