Genome Project 
U.S. HGP on Fast Track 
DOE Joint Genome Institute Exceeds Goal 
New 5-Year Goals 
Faster Sequencing with BACs 
Mapping with STCs and STSs 
Availability of BAC Clones and STC Data 
BAC Related Websites 
BAC Resource Success Story 
Scientists Hunt SNPs for Variation, Disease 
Who's Sequencing the Human Genome? 
Genomics Progress in Science 
EMSL Promotes Remote Access to Instrumentation 
Second Private-Sector Sequencing Project 
GeneMap'98 

In the News 
Team Delivers C. elegans Sequence 
Why Sequence Entire Genomes? Worm's Eye View 
Embnet.news on Web 
European Biotech Program 
DOE BER Research Update 
Hollaender Fellows Named 
SBIR 1998 Human Genome Awards Announced 
Mouse Resources 
Mouse Consortium for Functional Genomics 
Chlamydia Genome Analysis 
HUGO Merges Offices, Web Sites 

Microbial Genomics 
Superbug Deinococcus radiodurans 
Unfinished Microbial Genomes Searchable 
TIGR Releases Chlorobium tepidum Sequence 
DOE MGP Abstracts Online 
Microbial TV Series 
 
Ethical, Legal, and Social Issues and Educational Resources 
Cambridge ELSI Symposium 
Eric Lander, Genetics in the 21st Century 
Mark Rothstein, Genetic Privacy 
James Wilson, Gene Therapy Present & Future 
LeRoy Walters, Ethical Issues in Gene Therapy 
DNA Files on NPR, Internet 
Innovative Biotechnology Curriculum 
Short Course for Biology Teachers 
Microbial TV Series 

Proteomics 
Looking at Proteins to Understand Expression 
2-DGE:  Protein Visualization, Modification 
Tool for Protein Analysis 
TREMBL Release 6 
R&D 100 Award Goes to LANL's SOLVE 
NIH Awards Proteomics Grant to Axys 
E. coli Proteome Database 

Genetics in Medicine 
National Organization for Rare Disorders 
Translation of Genetics to Medicine: New Website 
Cancer Genetics Web Site 
HuGem Website Offers Education in New Genetics 
Calculation of Genetic Risks 2nd Edition 
New Genetics Manual Offered 
Mutation Research Genomics Online 
 
Informatics 
GDB Database Operations Restored 
In Silico Biology: Bioinformatics Journal 
Computational Methods Book Available 
Bioinformatics Guide
BioToolKit
Gene-Finding Programs at Sanger
New Sequin Version
Tandem Repeat Tool
Sequence Viewer
SmithKline Licenses Gene Logic Software 
Influenza Database at LANL 
TRANSFAC Database 
p53 Mutation Database 
TBASE at Jackson Laboratory 
Intein Database on Web 
System Identifies Polymorphisms 

Web, Other Resources, Publications 
1999 Oakland Workshop Website 
Launchpad to Human Chromosomes 
Nature Genetics Supplement 

Funding 
DOE Office of Science Grants and Contracts 
NHGRI National Service Award Fellowships 
NCI Technologies for Molecular Analysis 
NIH: Netork for Large-Scale Mouse Sequencing 
NHGRI: Genomic Technology Development 
US Genome Research Funding 

Meeting Calendars & Acronyms 
Genome and Biotechnology Meetings 
Training Courses and Workshops 
Acronyms 

HGN archives and subscriptions 
HGP Information home

DOE Biological and Environmental Research Helps Fuel "Biology Century"

Taking advantage of the wealth of information generated by the "new biology" of the Human Genome Project, DOE's Life Sciences Division is funding $16 million in projects that focus on high-throughput approaches to solving complex biological problems related to DOE's diverse missions. The research, which is taking place at 5 DOE national laboratories and 13 universities and research institutions, will address unresolved issues in the following 4 major areas.

Biochemical Potential of Microbes
($2 million). Researchers seek to develop methods to decode the complete genomes of microbes more rapidly, identify potentially useful microbes, and explore their potential for energy production and use and for environmental cleanup.

Health Risks from Low-Level Exposures to Radiation and Other Energy-Related By-Products
($6 million). New information will be useful in the ongoing development of federal health-risk policies that protect workers and the public from radiation and environmental pollutants, including those at DOE sites.

"Engineered" Biomolecules for Use in Energy Production, Environmental Cleanup, Drug Design, and Industry
($2 million). Developing methods to rapidly determine the structure of large numbers of proteins will contribute to capabilities for designing biomolecules such as enzymes, antibodies, and other proteins for these applications.

New Genetic Information from Mice, Yeast, and Fruit Flies for Understanding Human Gene Functions More Quickly
($6 million). This research will contribute to more accurate disease prediction and diagnosis and the design of drug therapies tailored to an individual's genetic makeup.

DOE's life sciences research program began more than 50 years ago to study the health effects of radiation, initially focusing on epidemiological studies of exposed people and genetic studies in animals. Nearly 15 years ago, DOE started planning its Human Genome Program to obtain DNA sequencing and analysis technologies and information at the genetic level regarding the effects of radiation and energy production on biological systems. In seeking to translate genomics for applications in diverse fields, DOE is helping to usher in what has been called the "biology century."

The research projects were funded following extensive peer review of proposals.
List of principal investigators and projects;
OBER

The electronic form of the newsletter may be cited in the following style:
Human Genome Program, U.S. Department of Energy, Human Genome News (v10n1-2).