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  (Contains links to test method evaluation areas and projects)


• About ICCVAM
  • Awards
  • Annual and Biennial Reports
  • ICCVAM Five-Year Plan
  • Frequently Asked Questions (FAQs) about NICEATM and ICCVAM
  • ICCVAM Agencies
    • Agency Representatives (ICCVAM roster)
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  • ICCVAM Test Method Evaluation Process
    • Development, Evaluation, and Acceptance of Test Methods
  • International Cooperation
  • Mission and Vision Statement
  • Regulatory Acceptance of Alternative Methods
  • ICCVAM Brochure (PDF)
  • NIH Revitalization Act of 1993 (PDF)
  • ICCVAM Authorization Act (PDF)
  • Validation and Regulatory Acceptance of Toxicological Test Methods (final report of ad hoc ICCVAM - 1997) [PDF]


• Advisory Commitee (SACATM) (Page on National Toxicology Program website)


• International Cooperation (ICATM)
  • ICATM Framework (Page on U.S. FDA website)
  • ICATM Memorandum of Cooperation


• Frequently Asked Questions (FAQs) about NICEATM and ICCVAM


• Meetings and Workshop Schedule


• Alternative Test Method Evaluations
  
  
  • Summary of Test Methods Evaluated by ICCVAM
  
  
  • Project Milestones
  
  
  • ICCVAM-recommended Test Method Protocols
  
  
  • Acute Oral Toxicity
    
    
    • Evaluation of In Vitro Cytotoxicity Test Methods
      • Background Materials for Workshop Participants
        • List of Participants
        • Background Materials
        • List of References
      • Guidance Document
      • Overview and Agency Responses
      • References
      • Workshop Report and Test Method Recommendations
    
    
    • Validation Study of In Vitro Cytotoxicity Test Methods
      • Background Review Document
      • Overview
        • Planned Future Studies/Activities
      • Other Validation Study Documents
        • Validation Study Protocols
        • Validation Study Management
        • Photographs
        • List of Test Chemicals
      • Peer Review Documents
        • Peer Review Panel Report
        • Materials for Peer Panel Meeting
      • Presentations
      • Recommendations and Agency Responses
      • Test Method Evaluation Report
    
    
    • ICCVAM Participation in Development of OECD Test Guidelines for the Evaluation of Acute Systemic Toxicity
    
    
    • Scientific Workshop on Acute Chemical Safety Testing
      • Overview of the Workshop
      • References
      • Workshop Documents
      • Workshop Presentations
      • Workshop Report
    
    
    • Up-and-Down Procedure
      • Overview and Recommendations
      • Presentations and References
      • Report Documents
    
    
  • Biologics and Vaccines
    
    
    • Alternative Methods for Vaccine Testing
    • Workshop on Alternative Methods for Human and Veterinary Rabies Vaccine Testing
    
    
    • Workshop on Alternative Methods for Vaccine Potency and Safety Testing
      • Workshop Materials
      • Suggested Reading
      • Workshop Presentations
    
    
    • Workshop on Alternatives to the Mouse LD₅₀ Assay for Botulinum Toxin Testing
      • Overview
        • HSUS Nomination
        • Workshop Report [PDF]
      • Presentations
      • References
      • Workshop Documents
        • Agenda and Additional Meeting Materials
          • Panel Questions
          • Reference List
          • Workshop Attendees
          • Testing Guidelines and Regulations
          • Poster Session Abstracts
        • Workshop Presentations
        • Regulatory Information
    
    
  • Dermal Corrosivity
    and Irritation
    • ICCVAM Participation in Development of OECD Test Guidelines for the Detection of Dermal Irritants
    • Performance Standards for In Vitro Test Methods for Skin Corrosion
    • EPISKIN, EpiDerm (EPI-200) and the Rat Skin Transcutaneous Electrical Resistance (TER) Assay
      • Overview and Test Method Evaluation
        • Test Method Evaluation Report
        • Background Review Documents
      • Presentations and References
    • Corrositex Assay
      • Peer Panel Report
      • OECD Test Guideline 435
      • Sample Protocol
    
    
  
  
  • Developmental Toxicity: FETAX
    • Expert Panel Meeting Minutes (PDF)
    • Background Review Document
    • Related Regulations and Guidelines
  
  
  • Endocrine Disruptor
    • Review of In Vitro Endocrine Disruptor Screening Assays
      • Background Review Documents
      • Expert Panel Report
        • Expert Panel Report
        • Expert Panel Meeting Materials
      • Overview and Related Links
      • Presentations
      • Test Method Evaluation Report
    • Validation Studies of Nominated Endocrine Disruptor Screening Assays
      • Information on submitting data to be considered by the peer review panel
      • Xenobiotic Detection Systems, Inc. LUMI-CELL® Assay of Estrogenic Activity
      • CertiChem Inc. MCF-7 Cell Proliferation Assay of Estrogenic Activity
    • ICCVAM Participation in OECD Test Guidelines for the Detection of Endocrine-Disrupting Substances
  
  
  • Genetic Toxicity
  
  
  • Immunotoxicity: Allergic Contact Dermatitis
    • Summary of June 2010 ICCVAM Recommendations to Federal Agencies on New Versions and Applications of the Murine Local Lymph Node Assay
    • Publications and Presentations on ICCVAM Evaluations of the Murine Local Lymph Node Assay for Identification and Classification of Sensitizers
    • Nonradioactive Version of the Murine Local Lymph Node Assay
      • Overview
      • Peer Review Panel
      • Test Method Evaluation Report - LLNA: BrdU-ELISA
      • Test Method Evaluation Report - LLNA: DA
    • Applicability Domain for the Murine Local Lymph Node Assay
      • Overview
      • Peer Review Panel
      • Test Method Evaluation Report
    • ICCVAM Evaluation of In Vitro Assays to Identify Potential Sensitizers
    • Performance Standards for the Murine Local Lymph Node Assay
      • Overview and Recommendations
      • 2008 Peer Review Panel
    • Reduced Murine Local Lymph Node Assay
      • Overview and Recommendations
      • 2008 Peer Review Panel
      • Test Method Evaluation Report
    • ICCVAM Evaluation of the Validation Status of the LLNA
      • 1998 Peer Review Panel
      • ICCVAM Peer Review Report
      • Implementation Workshop
  
  
  • Ocular Toxicity
    • Summary of September 2010 ICCVAM Recommendations to Federal Agencies on Ocular Test Methods
    • Routine Use of Topical Anesthetics, Systemic Analgesics, and Humane Endpoints to Avoid or Minimize Pain and Distress in Ocular Safety Testing
      • Overview
      • Peer Review Panel
      • Presentations
      • Test Method Evaluation Report
      • Symposium on Minimizing Pain and Distress in Ocular Toxicity Testing
    
    
    • Current Validation Status of In Vitro Test Methods Proposed for Identifying Eye Injury Hazard Potential of Chemicals and Products
      • Overview
      • Peer Review Panel
      • Test Method Evaluation Report
    
    
    • In Vitro Testing Strategy for Ocular Hazard Classification and Labeling of Antimicrobial Cleaning Products
      • Overview
      • Peer Review Panel
      • Test Method Evaluation Report: AMCP Strategy
      • Test Method Evaluation Report: Low Volume Eye Test
    
    
    • In Vitro Test Methods for Detecting Ocular Corrosives and Severe Irritants
      • Background Review Documents
      • Expert Panel Report
        • Expert Panel Report (PDF)
        • Addendum to Expert Panel Report
        • Presentations: Expert Panel Meeting
        • Supplemental Information for Expert Panel Meeting (PDFs)
        • Materials for the September 2005 Expert Panel Teleconference
        • Draft Report: Analysis of the Estimated Underclassification and Overclassification Likelihoods of the Current In Vivo Rabbit Eye test for Hazard Classification (PDF)
      • OECD Test Guideline Proposals
      • Overview
      • Presentations
      • Recommendations and Agency Responses
      • Recommendations for Future Studies
      • Test Method Evaluation Report
    
    
    • Scientific Symposia on Ocular Toxicity
    
    
  • Pyrogenicity
    • Background Review Document
    • Overview and Recommendations
    • Peer Review Panel
      • Peer Panel Report
      • Peer Panel Meeting Materials
    • Presentations and References
    • Test Method Evaluation Report


• NICEATM Support of the Tox21 Initiative
• Nominations and Submissions
  • NTP Online Nomination Form
  • Contact ICCVAM
  • ICCVAM Nomination and Submissions Guidelines
  • Lists of nominations and submissions with appropriate links
  
  


• Testing Regulations and Guidelines
  
  • Links to General U.S. Federal Regulations and Rules
  
  
  • Links to International Guidances and Documents
    • OECD Health Effects Test Guidelines and Guidance Documents
    • ICCVAM Comments on OECD Health Effects Test Guidelines and Guidance Documents
  
  
  • Method-Specific Guidelines, Regulations and Laws
    • Acute Oral Toxicity
    • Dermal Corrosivity and Irritation
    • Developmental Toxicity
    • Endocrine Disruptor
    • Ocular Toxicity
    • Phototoxicity
    • Pyrogenicity
  
  
  • ICCVAM Guidelines and Processes
    • Guidelines for the Nomination and Submission of New, Revised, and Alternative Test Methods
    • Test Method Review Process
    • Validation and Acceptance Criteria
  
  
• Search ICCVAM Documents


• Search Federal Register Notices


• Search Agency Guidelines/Regulations


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• Manuscripts and News Articles
  • Publications by ICCVAM in Scientific Journals
  • Articles About ICCVAM Activities in the NIEHS Environmental Factor Newsletter
  • Press Releases and News Articles


• Related Links
  • Alternative Methods Centers
  • Alternative Methods Sites
  • Brochures, Pamphlets and Fact Sheets
  • Good Laboratory Practices
  • Humane Care and Use of Laboratory Animals
  • Miscellaneous Sites


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• Quick Links
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  • ICCVAM-recommended Test Method Protocols
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  • ICCVAM Five-Year Plan
  • Summary of Test Methods Evaluated by ICCVAM
  • Regulatory Acceptance of Alternative Methods
  • Upcoming Meetings and Workshops - links to Meetings and Workshop Schedule
  • Federal Register Notices - links to FR notice search page
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