| No. |
Title |
Publication Date
Notice Number |
|
| Consumer Product Safety Commission (CPSC) |
| 1 |
77 FR 73289 - Hazardous Substances and Articles; Administration and Enforcement Regulations: Revisions to Animal Testing Regulations |
12-10-2012 2012-29258 |
PDF |
| 2 |
77 FR 73286 - Codification of Animal Testing Policy |
12-10-2012 2012-29260 |
PDF |
| 3 |
16 CFR 1500.3: CPSC - Hazardous Substances - Definitions |
01-01-2010 16 CFR 1500.3 |
PDF |
| 4 |
16 CFR 1500.4: CPSC - Human Experience with Hazardous Substances |
01-01-2000 16 CFR 1500.4 |
PDF |
| 5 |
16 CFR 1500.41: CPSC - Method of Testing Primary Irritant Substances |
01-01-2000 16 CFR 1500.41 |
PDF |
| 6 |
16 CFR 1500.42: CPSC - Test for Eye Irritants |
01-01-2000 16 CFR 1500.42 |
PDF |
| Department of Transportation (DOT) |
| 1 |
49 CFR 173.132: DOT Class 6 - Definitions |
10-01-1998 49 CFR 173.132 |
PDF |
| 2 |
49 CFR 172.442: DOT - Corrosive Label (appearance and placement) |
10-01-2000 49 CFR 172.442 |
PDF |
| 3 |
49 CFR 172.558: DOT - Corrosive Placard (appearance) |
10-01-2000 49 CFR 172.558 |
PDF |
| 4 |
DOT Research and Special Programs Administration: Shippers - General Requirements for Shipments and Packaging |
10-01-1998 DOT 49.173 |
PDF |
| 5 |
49 CFR 173.133: DOT Assignment of packing group and hazard zones for Division 6.1 materials |
10-01-1999 49 CFR 173.133 |
PDF |
| 6 |
49 CFR 173.136: DOT Class 8 Definitions |
10-01-2000 49 CFR 173.136 |
PDF |
| 7 |
49 CFR 173.137: DOT Class 8 - Assignment of Packing Group |
10-01-2000 49 CFR 173.137 |
PDF |
| 8 |
DOT Pipeline and Hazardous Materials Safety Administration: Special permit authorizing the use of alternative test method for corrosivity testing |
05-03-2006 DOT-SP 10904 |
PDF |
| Environmental Protection Agency (EPA) |
| 1 |
EPA Health Effects Test Guidelines: Acute Dermal Toxicity |
06-01-1996 OPPTS 870.1200 |
PDF |
| 2 |
EPA Health Effects Test Guidelines: Acute Inhalation Toxicity |
08-01-1998 OPPTS 870.1300 |
PDF |
| 3 |
EPA Health Effects Test Guidelines: 21/28-Day Dermal Toxicity |
08-01-1998 OPPTS 870.3200 |
PDF |
| 4 |
EPA Health Effects Test Guidelines: Estrogen Receptor Transcriptional Activation (Human Cell Line (HeLa- 9903)) |
10-01-2009 OPPTS 890.1300 |
PDF |
| 5 |
EPA Guidelines for Developmental Toxicity Risk Assessment |
12-05-1991 EPA 56FR63798 |
PDF |
| 6 |
EPA Update on the Use of the Local Lymph Node Assay for End Use Pesticide Products and Adoption of the Reduced Dose Protocol for LLNA |
04-01-2011 |
PDF |
| 7 |
Environmental Protection Agency: Revised Final Health Effects Test Guideline; Skin Sensitization; Notice of Availability |
03-25-2003 EPA FR 03-7057 |
PDF |
| 8 |
EPA Method 1120 - Dermal Corrosion |
12-01-1996 EPA 1120 |
PDF |
| 9 |
40 CFR 152: EPA Pesticide Registration and Classification Procedures |
07-01-1999 40 CFR 152 |
PDF |
| 10 |
40 CFR 152.170 EPA Criteria for Restriction to use by Certified Applicators |
07-01-2000 40 CFR 152.170 |
PDF |
| 11 |
40 CFR 156: EPA Labeling Requirements for Pesticides and Devices |
07-01-1999 40 CFR 156 |
PDF |
| 12 |
40 CFR 157.22: EPA - Child-Resistant Packaging; When Required |
07-01-2000 40 CFR 157.22 |
PDF |
| 13 |
40 CFR 158: EPA Data Requirements for Registration |
07-01-1999 40 CFR 158 |
PDF |
| 14 |
40 CFR 158.70: EPA Acceptable Protocols |
07-01-2000 EPA 40.158.70 |
PDF |
| 15 |
40 CFR 721: EPA Significant New Uses of Chemical Substances |
07-01-1999 40 CFR 721 |
PDF |
| 16 |
EPA Health Effects Test Guidelines: Acute Eye Irritation |
08-01-1998 OPPTS 870.2400 |
PDF |
| 17 |
EPA Health Effects Test Guidelines; Acute Dermal Irritation |
08-01-1998 OPPTS 870.2500 |
PDF |
| 18 |
EPA Health Effects Test Guidelines: Repeated Dose 28-Day Oral Toxicity Study in Rodents |
07-01-2000 OPPTS 870.3050 |
PDF |
| 19 |
EPA Health Effects Test Guidelines: Reproduction/Developmental Toxicity Screening Test |
07-01-2000 OPPTS 870.3550 |
PDF |
| 20 |
EPA Health Effects Test Guideline: Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Screening Test |
07-01-2000 OPPTS 870.3650 |
PDF |
| 21 |
EPA Health Effects Test Guidelines: Prenatal Developmental Toxicity Study |
08-01-1998 OPPTS 870.3700 |
PDF |
| 22 |
EPA Health Effects Test Guidelines: Reproduction and Fertility Effects |
08-01-1998 OPPTS 870.3800 |
PDF |
| 23 |
EPA Health Effects Test Guidelines: Acute Toxicity Testing - Background |
12-01-2002 OPPTS 870.1000 |
PDF |
| 24 |
EPA Health Effect Test Guidelines: Acute Oral Toxicity |
12-01-2002 OPPTS 870.1100 |
PDF |
| 25 |
EPA Health Effects Test Guidelines: Skin Sensitization |
03-01-2003 OPPTS 870.2600 |
PDF |
| 26 |
EPA Method 9040B - pH Electrometric Measurement |
01-01-1995 EPA 9040B |
PDF |
| 27 |
EPA Report of the FIFRA Scientific Advisory Panel Meeting (Dec. 2001) |
02-25-2002 |
PDF |
| 28 |
EPA Federal Register Notice: 40 CFR Part 136 - Guidelines Establishing Test Procedures for the Analysis of Pollutants; Whole Effluent Toxicity Test Methods; Final Rule |
11-19-2002 EPA FR 02-29072 |
PDF |
| 29 |
40 CFR 160: EPA Good Laboratory Practice Standards |
07-01-1997 40 CFR 160 |
PDF |
| 30 |
Environmental Protection Agency: Food Quality Protection Act of 1996 |
08-03-1996 PL 104-170 |
PDF |
| 31 |
Environmental Protection Agency: Safe Drinking Water Act Amendments of 1996 |
08-06-1996 PL 104-182 |
PDF |
| European Pharmacopeia (EUR) |
| 1 |
European Pharmacopoeia: Botulinum Toxin Type A for Injection |
01-01-2005 |
PDF |
| 2 |
European Pharmacopoeia: Botulinum Antitoxin |
01-01-2005 |
PDF |
| Food and Drug Administration (FDA) |
| 1 |
21 CFR 58: FDA Good Laboratory Practice for Nonclinical Laboratory Studies |
04-01-2002 21 CFR 58 |
PDF |
| 2 |
21 CFR 211.167: FDA Good Manufacturing Practice for Finished Pharmaceuticals: Special Testing Requirements |
04-01-2005 21 CFR 211.167 |
PDF |
| 3 |
21 CFR 610.13: FDA General Biological Products Standards: Purity |
04-01-2005 21 CFR 610.13 |
PDF |
| 4 |
21 CFR 610.9: FDA General Provisions: Equivalent methods and processes |
04-01-2005 21 CFR 610.9 |
PDF |
| 5 |
21 CFR 600.3: FDA Definitions |
04-01-2005 21 CFR 600.3 |
PDF |
| 6 |
21 CFR 610.10: FDA Potency |
04-01-2005 21 CFR 610.10 |
PDF |
| 7 |
FDA Guidance: Photosafety Testing |
01-01-2000 3281Draft |
PDF |
| 8 |
FDA Guidance: Instructions and Template for Chemistry, Manufacturing, and Control (CMC) Reviewers of Human Somatic Cell Therapy Investigational New Drug Applications (INDs) |
08-01-2003 |
PDF |
| 9 |
FDA Guidance: Content and Review of Chemistry, Manufacturing, and Control (CMC) Information for Human Gene Therapy Investigational New Drug Applications (INDs) |
11-01-2004 |
PDF |
| 10 |
FDA Guidance: Considerations for Plasmid DNA Vaccines for Infectious Disease Indications |
02-01-2005 |
PDF |
| 11 |
FDA Guidance: Preparation of a Premarket Notification Application for a Surgical Mesh |
03-01-1999 |
PDF |
| Organisation for Economic Co-operation and Development (OECD) |
| 1 |
OECD Guidance Document 125: Histopathology for Subacute and Subchronic Inhalation Toxicity Studies |
06-01-2010 OECD GD 125 |
PDF |
| 2 |
OECD Guidance Document 160: The BCOP and ICE Test Methods: Collection of Tissues for Histological Evaluation and Collection of Data on Non-severe Irritants |
10-25-2011 OECD GD 160 |
PDF |
| 3 |
OECD Guidance Document 24: Acute Oral Toxicity Testing |
07-23-2001 OECD GD 24 |
PDF |
| 4 |
OECD Guidance Document 34: Validation and International Acceptance of New or Updated Internationally Acceptable Test Methods for Hazard Assessment |
08-18-2005 OECD GD 34 |
PDF |
| 5 |
OECD Guidance Document 39: Acute Inhalation Toxicity Testing |
07-21-2009 OECD GD 39 |
PDF |
| 6 |
OECD Series on Principles of Good Laboratory Practice and Compliance Monitoring Number 14 - The Application of the Principles of GLP to in vitro Studies |
11-30-2004 OECD GLP14 |
PDF |
| 7 |
OECD Test Guideline 223: Avian Acute Oral Toxicity Test |
07-22-2010 OECD TG 223 |
PDF |
| 8 |
OECD Test Guideline 403: Acute Inhalation Toxicity |
09-07-2009 OECD TG 403 |
PDF |
| 9 |
OECD Test Guideline 405: Acute Eye Irritation/Corrosion (updated 2012) |
04-24-2002 OECD TG 405 |
PDF |
| 10 |
OECD Test Guideline 412: Subacute Inhalation Toxicity: 28-day Study |
09-07-2009 OECD TG 412 |
PDF |
| 11 |
OECD Test Guideline 413: Subchronic Inhalation Toxicity: 90-day Study |
09-07-2009 OECD TG 413 |
PDF |
| 12 |
OECD Test Guideline 429: Skin Sensitisation: Local Lymph Node Assay |
07-22-2010 OECD TG 429 |
PDF |
| 13 |
OECD Test Guideline 436: Acute Inhalation Toxicity - Acute Toxic Class Method |
09-07-2009 OECD TG 436 |
PDF |
| 14 |
OECD Test Guideline 437: Bovine Corneal Opacity and Permeability Test Method for Identifying Ocular Corrosives and
Severe Irritants |
09-07-2009 OECD TG 437 |
PDF |
| 15 |
OECD Test Guideline 438: Isolated Chicken Eye Test Method for Identifying Ocular Corrosives and Severe Irritants |
09-07-2009 OECD TG 438 |
PDF |
| 16 |
OECD Test Guideline 439: In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method |
07-22-2010 OECD TG 439 |
PDF |
| 17 |
OECD Test Guideline 441: Hershberger Bioassay in Rats: A Short-term Screening Assay for (Anti)Androgenic Properties |
09-07-2009 OECD TG 441 |
PDF |
| 18 |
OECD Test Guideline 442A: Skin Sensitization: Local Lymph Node Assay: DA |
07-22-2010 OECD TG 442A |
PDF |
| 19 |
OECD Test Guideline 442B: Skin Sensitization: Local Lymph Node Assay: BrdU-ELISA |
07-22-2010 OECD TG 442B |
PDF |
| 20 |
OECD Test Guideline 443: Extended One-Generation Reproductive Toxicity Study |
10-02-2012 OECD TG 443 |
PDF |
| 21 |
OECD Test Guideline 455: Performance-Based Test Guideline for Stably Transfected Transactivation In Vitro Assays to Detect Estrogen Receptor Agonists (updated 2012) |
09-07-2009 OECD TG 455 |
PDF |
| 22 |
OECD Test Guideline 457: BG1Luc Estrogen Receptor Transactivation Test Method for Identifying Estrogen Receptor Agonists and Antagonists |
10-02-2012 OECD TG 457 |
PDF |
| 23 |
OECD Test Guideline 460: Fluorescein Leakage Test Method for Identifying Ocular Corrosives and Severe Irritants |
10-02-2012 OECD TG 460 |
PDF |
| 24 |
OECD Test Guideline 487: In Vitro Mammalian Cell Micronucleus Test |
07-22-2010 OECD TG 487 |
PDF |
| 25 |
OECD Guidance Document 19: Recognition, Assessment and Use of Clinical Signs as Humane Endpoints for Experimental Animals Used in Safety Evaluation |
11-01-2000 OECD GD 19 |
PDF |
| 26 |
OECD Test Guideline 414: Prenatal Development Toxicity Study |
01-22-2001 OECD TG 414 |
PDF |
| 27 |
OECD Test Guideline 420: Acute Oral Toxicity - Fixed Dose Procedure |
12-17-2001 OECD TG 420 |
PDF |
| 28 |
OECD Test Guideline 421: Reproduction/Developmental Toxicity Screening Test |
07-27-1995 OECD TG 421 |
PDF |
| 29 |
OECD Test Guideline 422: Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Screening Test |
03-22-1996 OECD TG 422 |
PDF |
| 30 |
OECD Test Guideline 423: Acute Oral toxicity - Acute Toxic Class Method |
12-17-2001 OECD TG 423 |
PDF |
| 31 |
Final Report of the OECD Workshop on Harmonisation of Validation and Acceptance Criteria for Alternative to Toxicological Test Methods |
10-01-1994 |
PDF |
| 32 |
OECD Guidance Document 33: Harmonised Integrated Classification System for Human Health and Environmental Hazards of Chemical Substances and Mixtures |
08-14-2001 OECD GD 33 |
PDF |
| 33 |
OECD Test Guideline 404: Acute Dermal Irritation/Corrosion |
04-24-2002 OECD TG 404 |
PDF |
| 34 |
OECD Test Guideline 406: Skin Sensitization |
07-17-1992 OECD TG 406 |
PDF |
| 35 |
OECD Test Guideline 407: Repeated 28-day Oral Toxicity Study in Rodents |
10-03-2008 OECD TG 407 |
PDF |
| 36 |
OECD Test Guideline 425: Acute Oral Toxicity - Up-and-Down Procedure (UDP) |
03-23-2006 OECD TG 425 |
PDF |
| 37 |
OECD Test Guideline 428: Skin Absorption In Vitro Method |
04-13-2004 OECD TG 428 |
PDF |
| 38 |
OECD Test Guideline 430: In Vitro Skin Corrosion: Transcutaneous Electrical Resistance Test (TER) |
04-13-2004 OECD TG 430 |
PDF |
| 39 |
OECD Test Guideline 431: In Vitro Skin Corrosion: Human Skin Model Test
|
04-13-2004 OECD TG 431 |
PDF |
| 40 |
OECD Test Guideline 432: In Vitro 3T3 NRU Phototoxicity Test |
04-13-2004 OECD TG 432 |
PDF |
| 41 |
OECD Test Guideline 435: In Vitro Membrane Barrier Test Method for Skin Corrosion |
07-19-2006 OECD TG 435 |
PDF |
| 42 |
OECD Test Guideline 440: Uterotrophic Bioassay in Rodents: A short-term screening test for oestrogenic properties |
10-16-2007 OECD TG 440 |
PDF |
| US Department of Agriculture (USDA) |
| 1 |
USDA, Center for Veterinary Biologics Notice: Use of Humane Endpoints in Animal Testing of Biological Products |
04-01-2004 USDA CVB 04-09 |
PDF |
| 2 |
9 CFR 113.110: Animal and Plant Health Inspection Service, USDA: Clostridium Botulinum Type C Bacterin-Toxoid |
01-01-2003 9 CFR 113.110 |
PDF |
