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Up-and-Down Procedure for Acute Oral Toxicity

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Peer Review Evaluation Report

An Independent Scientific Peer Review meeting was held on July 25, 2000, at the Sheraton-Crystal City, in Arlington, VA, to evaluate the usefulness and validation status of the revised UDP. NICEATM assembled available data on the revised up-and-down procedure (UDP) into a Background Review Document, which was used by the Peer Review Panel to assess the method. A UDP Peer Review Panel Teleconference meeting was held on August 21, 2001, at NIEHS, RTP, NC.

Up-and-Down Procedure Report

(NIH Publication No. 02-4501 - November 2001)

Volume 1 [PDF - 1.5 MB] and
Volume 2 [PDF - 2.2 MB]

View Table of Contents in HTML format

UDP Report Cover

Federal Register Notice:
Notice of Peer Review Meeting on the Revised Up-and-Down Procedure (UDP) as an Alternative Test Method for Assessing Acute Oral Toxicity; Request for Comments (65 FR 35109, May 31, 2000)
View Federal Register notice [PDF]

Federal Register Notice:
66FR36294 - Peer Review Panel for the Up-and-Down Procedure (UDP): Notice of Meeting (66 FR 36294, July 11, 2001)
View Federal Register notice [PDF]
View comments submitted on Federal Register notice

Materials from the UDP Evaluation

  • Agenda View PDF

  • Minutes of the public Independent Peer Review Panel meeting, on July 25, 2000, Sheraton Imperial-Crystal City in Arlington, VA [PDF]

  • Minutes of the UDP Peer Review Panel Teleconference Meeting, on August 21, 2000, NIEHS, RTP, NC. [PDF]

  • Confidence Interval Procedure Review

  • Draft Up-and-Down Procedure Background Review Document (April 14, 2000 - version reviewed by peer panel) [PDF]





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