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| In the emerging field
of systems biology, scientists are using “omics” technologies and
advanced computational tools, coupled with other disciplines, to begin piecing
together the big picture of organism function and health.
image credit: Photodisc, Matt Ray/EHP, Joseph Tart/EHPPurchase This Issue |
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Systems Biology
More than the Sum of All Parts
A 938
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Mechanisms of Toxicity
Gene Expression Signatures Offer Insight
A 944
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Estrogen’s Effects on the Uterus
Anchoring Expression to Phenotype
A 944 |
Perspectives
Editorial
p. A 926
- Systems Biology, the Second Time Around
Charles DeLisi
[Full] [PDF]
Environews
Forum
p. A 930
- The Year of the Rat
- Getting to the Core of Antimicrobials
- Tackling Innate Immunity
- Cellular Jigsaw Puzzles
- TXGnet:
Y.F. Leung’s Functional Genomics
[Full] [PDF]
NCT Update
p. A 936
- Mass Spectrometry Group Has Mass Appeal
[Full] [PDF]
Focus
p. A 938
Science Selections
p. A 944
- Template for Toxicants
- How E2 Induces Uterine Effects
[Full] [PDF]
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Toxicogenomics
Articles
Phenotypic Anchoring of Gene Expression Changes
during Estrogen-Induced Uterine Growth
Jonathan G. Moggs, Helen
Tinwell, Tracey Spurway, Hur-Song Chang, Ian Pate, Fei Ling Lim,
David J. Moore, Anthony Soames, Ruth Stuckey, Richard Currie, Tong
Zhu, Ian Kimber, John Ashby, and George Orphanides
p. 1589
[Abstract] [Full] [PDF]
[Supplemental
PDF]
Prediction of Toxicant-Specific Gene Expression
Signatures after Chemotherapeutic Treatment of Breast Cell Lines
Melissa
A. Troester, Katherine A. Hoadley, Joel S. Parker, and Charles M.
Perou
p. 1607
[Abstract] [Full]
[PDF] [Supplemental
PDF]
The TAO-Gen Algorithm for Identifying Gene Interaction
Networks with Application to SOS Repair in E. coli
Takeharu
Yamanaka, Hiroyoshi Toyoshiba, Hideko Sone, Frederick M. Parham,
and Christopher J. Portier
p. 1614
[Abstract][Full] [PDF]
Using Decision Forest to Classify Prostate Cancer
Samples on the Basis of SELDI-TOF MS Data: Assessing Chance Correlation
and Prediction Confidence
Weida Tong, Qian Xie, Huixiao Hong,
Hong Fang, Leming Shi, Roger Perkins, and Emanuel F. Petricoin
p. 1622
[Abstract] [Full] [PDF]
Renal Toxicogenomic Response to Chronic Uranyl
Nitrate Insult in Mice
Magali Taulan, François Paquet,
Christophe Maubert, Olivia Delissen, Jacques Demaille, and Marie-Catherine
Romey
p. 1628
[Abstract] [Full] [PDF]
Subchronic Exposure to TCDD, PeCDF, PCB126,
and PCB153: Effect on Hepatic Gene Expression
Chad M. Vezina,
Nigel J. Walker, and James R. Olson
p. 1636
[Abstract] [Full] [PDF]
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