ATSDR - Expert Panel Report Appendix D

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Asbestos Expert Panel Report

Appendix D: Agenda For The Expert Panel Meeting

Expert Panel on Health Effects of Asbestos
and Synthetic Vitreous Fibers (SVF):
The Influence of Fiber Length

Agenda

Day #1, Tuesday, October 29, 2002 (afternoon only)
1:00 PM	Registration
1:30 PM	Welcome and Introductory Remarks	Dr. Henry Falk Assistant Administrator, ATSDR
1:45 PM	Purpose of Meeting	RADM Robert C. Williams Director, Division of Health Assessment and Consultation, ATSDR
2:00 PM	Review of meeting charge and agenda	Moton Lippman, Ph. D Panel Chair
2:15 PM	Introduction of panelists	Panelists
2:25 PM	Meeting Logistics	ERG
Topic #1: Physiological Fate of Asbestos and SVF less than 5 Microns in Length
2:30 PM	What happens to small fibers when inhaled? Discussion Leaders: Dr. Lippman and Dr. Oberdorster Depostional Patterns in The Lung Clearance Biopersistence Migration from the lung Fiber-like vs. particle-like activity patterns Asbestos vs. MMV
3:30 PM	Break
3:45 PM	Topic #1 (continued)
5:30 PM	Observer comments/questions
6:00 PM	Adjourn
Day #2, Wednesday, October 30, 2002
8:00 AM	Review of Day #1 issues	Morton Lippmann, Ph. D Panel Chair
Topic #2: Health Effects of Asbestos and SVF less than 5 Microns in Length
8:15 AM	What do human/epidemiological data tell us about small fibers? Discussion Leaders: Dr. Lockey and Dr. Case Cancer effects Non-cancer effects Irritant effects Association between fiber length and fiber-like toxicity Thresholds of toxic action Asbestos vs. MMVF
9:45 AM		Break
10:00 AM		How do animal/experimental data augment our understanding of human health effects? Discussion Leaders: Dr. McConnell and Dr. Case Cancer effects Non-cancer effects Irritant effects Association between fiber length and fiber-like toxicity Thresholds of toxic action Asbestos vs. MMVF
12:00 PM		Lunch
1:00 PM		What are the mechanisms of action of small fibers? Can the more robust knowledge base about other fiber or particle materials supplement this understanding? Discussion Leaders: Dr. Mossman and Dr. Wallace Immune system responses Cell signaling Role of reactive oxygen/nitrogen species Function of growth factors Other mechanisms Asbestos vs. MMVF
3:30 PM	Break
*Topic #3: Data Gaps*
3:45 PM	Data gaps and research needs	Panelists
4:30 PM	Observer comments/questions
5:00 PM	Conclusions/recomendations	Panelists
5:30 PM	Adjourn

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