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| On the Cover. The National Children's Study (NCS) is one of the most ambitious research endeavors ever attempted, with plans to follow 100,000 people from birth to adulthood. The mini-monograph in this issue (p. 1414) details the experiences of the NIEHS/EPA children's environmental health centers in areas including general methodological issues for conducting longitudinal birth cohort studies and community-based participatory research, measuring air pollution exposures as well as, pesticide exposures, asthma, and neurobehavioral toxicity. This collection of papers focuses on lessons learned by the centers that will provide guidance to the NCS on what has and has not worked when studying diverse multiracial and multiethnic groups of children with unique urban and rural exposures.
image credit: Joseph Tart/EHP Purchase This Issue | |
Perspectives
Director's Perspective
p. A 650
Correspondence
p. A 652
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Environews
Forum
p. A 660
NIEHS News
p. A 664
Focus
p. A 670
Spheres of Influence
p. A 678
Innovations
p. A 682
Science Selections
p. A 686
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Commentaries & Reviews
RISK CHARACTERIZATION | Fundamental Flaws of Hormesis for Public Health Decisions
Kristina A. Thayer, Ronald Melnick, Kathy Burns, Devra Davis, and James Huff
p. 1271 [ Abstract ] [ Full ] [ PDF ]
Research
ENDOCRINE | Impact of Polychlorinated Biphenyls Contamination on Estrogenic Activity in Human Male Serum
Martina Plísková, Jan Vondrácek, Rocio Fernandez Canton, Jirí Nera, Anton Kocan, Ján Petrík, Tomás Trnovec, Thomas Sanderson, Martin van den Berg, and Miroslav Machala
p. 1277 [ Abstract ] [ Full ] [ PDF ]
ENDOCRINE | Cigarette Smoking and Effects on Hormone Function in Premenopausal Women
Gayle C. Windham, Patrick Mitchell, Meredith Anderson, and Bill L. Lasley
p. 1285 [ Abstract ] [ Full ] [ PDF ]
DEVELOPMENT | Developmental Exposure of Rats to Chlorpyrifos Elicits Sex-Selective Hyperlipidemia and Hyperinsulinemia in Adulthood
Theodore A. Slotkin, Kathleen K. Brown, and Frederic J. Seidler
p. 1291 [ Abstract ] [ Full ] [ PDF ]
POPULATION HEALTH | Declining Sex Ratio in a First Nation Community
Constanze A. Mackenzie, Ada Lockridge, and Margaret Keith
 Also see Science Selections, p. A686
p. 1295 [ Abstract ] [ Full ] [ PDF ]
ENDOCRINE | Assessing the Sensitivity of Different Life Stages for Sexual Disruption in Roach (Rutilus rutilus) Exposed to Effluents from Wastewater Treatment Works
Katherine E. Liney, Susan Jobling, Jan A. Shears, Peter Simpson, and Charles R. Tyler
Also see Science Selections, p. A686
p. 1299 [ Abstract ] [ Full ] [ PDF ]
EXPOSURE ASSESSMENT | History of Inuit Community Exposure to Lead, Cadmium, and Mercury in Sewage Lake Sediments
Mark H. Hermanson and James R. Brozowski
p. 1308 [ Abstract ] [ Full ] [ PDF ]
GENE POLYMORPHISM | Possible Influence of  -Aminolevulinic Acid Dehydratase Polymorphism and Susceptibility to Renal Toxicity of Lead: A Study of a Vietnamese Population
Sin Eng Chia, Huijun Zhou, Mei Theng Tham, Eric Yap, Nguyen-Viet Dong, NguyenThi Hong Tu, and Kee Seng Chia
p. 1313 [ Abstract ] [ Full ] [ PDF ]
TOXICOLOGY | Biomarker Measurements in a Coastal Fish-Eating Population Environmentally Exposed to Organochlorine
Pierre Ayotte, Éric Dewailly, George H. Lambert, Sherry L. Perkins, Raymond Poon, Mark Feeley, Christian Larochelle, and Daria Pereg
p. 1318 [ Abstract ] [ Full ] [ PDF ]
POPULATION HEALTH | Fish Consumption and Advisory Awareness in the Great Lakes Basin
Pamela Imm, Lynda Knobeloch, Henry A. Anderson, and the Great Lakes Sport Fish Consortium
p. 1325 [ Abstract ] [ Full ] [ PDF ]
CARDIOVASCULAR | Inorganic Arsenite Potentiates Vasoconstriction through Calcium Sensitization in Vascular Smooth Muscle
Moo-Yeol Lee, Young-Ho Lee, Kyung-Min Lim, Seung-Min Chung, Ok-Nam Bae, Heon Kim, Choong-Ryeol Lee, Jung-Duck Park, and Jin-Ho Chung
p. 1330 [ Abstract ] [ Full ] [ PDF ]
EXPOSURE ASSESSMENT | Tetrachloroethylene (PCE, Perc) Levels in Residential Dry Cleaner Buildings in Diverse Communities in New York City
Michael J. McDermott, Kimberly A. Mazor, Stephen J. Shost, Rajinder S. Narang, Kenneth M. Aldous, and Jan E. Storm
p. 1336 [ Abstract ] [ Full ] [ PDF ]
EXPOSURE ASSESSMENT | Lead Contamination in Cocoa and Cocoa Products: Isotopic Evidence of Global Contamination
Charley W. Rankin, Jerome O. Nriagu, Jugdeep K. Aggarwal, Toyin A. Arowolo, Kola Adebayo, and A. Russell Flegal
Also see Science Selections, p. A687
p. 1344 [ Abstract ] [ Full ] [ PDF ]
CARDIOVASCULAR | Second-Hand Smoke-Induced Cardiac Fibrosis Is Related to the Fas Death Receptor Apoptotic Pathway without Mitochondria-Dependent Pathway Involvement in Rats
Wei-Wen Kuo, Chieh-Hsi Wu, Shin-Da Lee, James A. Lin, Chia-Yih Chu, Jin-Ming Hwang, Kwo-Chang Ueng, Mu-Hsin Chang, Yu-Lan Yeh, Chau-Jong Wang, Jer-Yuh Liu, and Chih-Yang Huang
p. 1349 [ Abstract ] [ Full ] [ PDF ]
TOXICOGENOMICS | Molecular Characterization of Thyroid Toxicity: Anchoring Gene Expression Profiles to Biochemical and Pathologic End Points
Christine M. Glatt, Ming Ouyang, William Welsh, John W. Green, John O Connor, Steven R. Frame, Nancy E. Everds, Greg Poindexter, Suzanne Snajdr, and Don A. Delker
p. 1354 [ Abstract ] [ Full ] [ PDF ]
FETAL DEVELOPMENT | Risk of Congenital Anomalies after the Opening of Landfill Sites
Stephen R. Palmer, Frank D.J. Dunstan, Hilary Fielder, David L. Fone, Gary Higgs, and Martyn L. Senior
p. 1362 [ Abstract ] [ Full ] [ PDF ]
Environmental Medicine
RISK CHARACTERIZATION | Chronic Beryllium Disease and Sensitization at a Beryllium Processing Facility
Kenneth Rosenman, Vicki Hertzberg, Carol Rice, Mary Jo Reilly, Judith Aronchick, John E. Parker, Jackie Regovich, and Milton Rossman
p. 1366 [ Abstract ] [ Full ] [ PDF ]
INFECTIOUS DISEASE | Case Report: Occupationally Related Recurrent Varicella (Chickenpox) in a Hospital Nurse
Chih-Hung Ku, Yu-Tien Liu, David C. Christiani
p. 1373 [ Abstract ] [ Full ] [ PDF ]
Children's Health
FETAL DEVELOPMENT | Maternal Fish Consumption, Hair Mercury, and Infant Cognition in a U.S. Cohort
Emily Oken, Robert O. Wright, Ken P. Kleinman, David Bellinger, Chitra J. Amarasiriwardena, Howard Hu, Janet W. Rich-Edwards, and Matthew W. Gillman
Also see Science Selections, p. A688
p. 1376 [ Abstract ] [ Full ] [ PDF ]
EXPOSURE ASSESSMENT | Transport of Methylmercury and Inorganic Mercury to the Fetus and Breast-Fed Infant
Karolin Ask Björnberg, Marie Vahter, Birgitta Berglund, Boel Niklasson, Mats Blennow, and Gunilla Sandborgh-Englund
p. 1381 [ Abstract ] [ Full ] [ PDF ]
OXIDATIVE STRESS | Increased Levels of 8-Hydroxy-2´-Deoxyguanosine Attributable to Carcinogenic Metal Exposure among Schoolchildren
Ruey-Hong Wong, Chung-Yih Kuo, Ming-Lin Hsu, Tsun-Yen Wang, Pi-I Chang, Tsung-Hsun Wu, and Shuai Huang
p. 1386 [ Abstract ] [ Full ] [ PDF ]
IMMUNE | Air Pollution and Lymphocyte Phenotype Proportions in Cord Bloodn
Irva Hertz-Picciotto, Caroline E.W. Herr, Poh-Sin Yap, Miroslav Dostál, Robert H. Shumway, Paul Ashwood, Michael Lipsett, Jesse P. Joad, Kent E. Pinkerton, and Radim J. Srám
p. 1391 [ Abstract ] [ Full ] [ PDF ]
EXPOSURE ASSESSMENT | Phthalates in Indoor Dust and Their Association with Building Characteristics
Carl-Gustaf Bornehag, Björn Lundgren, Charles J. Weschler, Torben Sigsgaard, Linda Hagerhed-Engman, and Jan Sundell
p. 1399 [ Abstract ] [ Full ] [ PDF ]
RESPIRATORY DISEASE | Fungal Levels in the Home and Allergic Rhinitis by 5 Years of Age
Paul C. Stark, Juan C. Celedón, Ginger L. Chew, Louise M. Ryan, Harriet A. Burge, Michael L. Muilenberg, and Diane R. Gold
p. 1405 [ Abstract ] [ Full ] [ PDF ]
IMMUNE | Effect of Maternal Smoking on Breast Milk Interleukin-1 , β-Endorphin, and Leptin Concentrations
Vincenzo Zanardo, Silvia Nicolussi, Stefania Cavallin, Daniele Trevisanuto, Angelo Barbato, Diego Faggian, Flaviano Favaro, and Mario Plebani
p. 1410 [ Abstract ] [ Full ] [ PDF ]
Mini-Monograph
CHILDREN'S HEALTH | Lessons Learned for the National Children's Study from the National Institute of Environmental Health Sciences/U.S. Environmental Protection Agency Centers for Children's Environmental Health and Disease Prevention Research
Carole A. Kimmel, Gwen W. Collman, Nigel Fields, and Brenda Eskenazi
p. 1414 [ Abstract ] [ Full ] [ PDF ]
CHILDREN'S HEALTH | Methodologic and Logistic Issues in Conducting Longitudinal Birth Cohort Studies: Lessons Learned from the Centers for Children's Environmental Health and Disease Prevention Research
Brenda Eskenazi, Eleanor A. Gladstone, Gertrud S. Berkowitz, Christina H. Drew, Elaine M. Faustman, Nina T. Holland, Bruce Lanphear, Stefanie J. Meisel, Frederica P. Perera, Virginia A. Rauh, Anne Sweeney, Robin M. Whyatt, and Kimberly Yolton
p. 1419 [ Abstract ] [ Full ] [ PDF ]
CHILDREN'S HEALTH | Lessons Learned for the Study of Childhood Asthma from the Centers for Children's Environmental Health and Disease Prevention Research
Peyton A. Eggleston, Greg Diette, Michael Lipsett, Toby Lewis, Ira Tager, Rob McConnell, Elizabeth Chrischilles, Bruce Lanphear, Rachel Miller, and Jerry Krishnan
p. 1430 [ Abstract ] [ Full ] [ PDF ]
CHILDREN'S HEALTH | Principles and Practices of Neurodevelopmental Assessment in Children: Lessons Learned from the Centers for Children's Environmental Health and Disease Prevention Research
Kim N. Dietrich, Brenda Eskenazi, Susan Schantz, Kimberly Yolton, Virginia A. Rauh, Caroline B. Johnson, Abbey Alkon, Richard L. Canfield, Isaac N. Pessah, and Robert F. Berman
p. 1437 [ Abstract ] [ Full ] [ PDF ]
CHILDREN'S HEALTH | Air Pollution Exposure Assessment for Epidemiologic Studies of Pregnant Women and Children: Lessons Learned from the Centers for Children's Environmental Health and Disease Prevention Research
Frank Gilliland, Ed Avol, Patrick Kinney, Michael Jerrett, Timothy Dvonch, Frederick Lurmann, Timothy Buckley, Patrick Breysse, Gerald Keeler, Tracy de Villiers, and Rob McConnell
p. 1447 [ Abstract ] [ Full ] [ PDF ]
CHILDREN'S HEALTH | Lessons Learned for the Assessment of Children's Pesticide Exposure: Critical Sampling and Analytical Issues for Future Studies
Richard A. Fenske, Asa Bradman, Robin M. Whyatt, Mary S. Wolff, and Dana B. Barr
p. 1455 [ Abstract ] [ Full ] [ PDF ]
CHILDREN'S HEALTH | Community-Based Participatory Research: Lessons Learned from the Centers for Children's Environmental Health and Disease Prevention Research
Barbara A. Israel, Edith A. Parker, Zachary Rowe, Alicia Salvatore, Meredith Minkler, Jesús López, Arlene Butz, Adrian Mosley, Lucretia Coates, George Lambert, Paul A. Potito, Barbara Brenner, Maribel Rivera, Harry Romero, Beti Thompson, Gloria Coronado, and Sandy Halstead
p. 1463 [ Abstract ] [ Full ] [ PDF ]
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