Press Center
NTP Liaison Office Update - September 1997
September, 1997
We are pleased to provide the following information on the activities and programs of the NTP, and we welcome public input into all aspects of our programs.
- NTP Board Meets to Review Substances Nominated for Listing/Delisting in the Report on Carcinogens, October 30-31, 1997
- Coordination of Validation of Alternative Methods Update
- Interagency Coordinating Committee
- Center for the Evaluation of Alternative Toxicological Methods
- November 7 Meeting on Future Directions and Priorities
- NTP Board to Review Draft Technical Reports, December 9-10, 1997
- NTP Board Tentatively Scheduled to Evaluate Transgenic Mouse Models, February 5-6, 1998
- NIEHS Moves Forward in Preparation of Report to Congress on Health Effects of EMF
- Peer Review of NTP EMF Studies, March 11, 1998
- NIEHS Recruiting Epidemiologist for NTP Collaborations
- Request for Public Comment on Chemicals Under Review for Possible NTP Testing
- NTP Solicits Nominations for NTP Testing
- Workshop on Marine/Freshwater Microbes and Toxins
- NTP-EPA to Collaborate To Evaluate Chemicals in Drinking Water
- NTP Information Now Available Through the "New" Environmental Health Information Service
- "What's New" on the NTP Website
- Recently Published Technical Reports of NTP Long-Term Studies
- NTP May 14, 1997, Board Minutes Available Upon Request
NTP Board Meets in Public
Session to Review Substances Nominated for Listing/Delisting in
the Report on Carcinogens
The next meeting of the
NTP Board of Scientific Counselors' Report on Carcinogens Subcommittee
will be held on October 30 & 31, 1997, in the Conference Center,
Building 101, South Campus, National Institute of Environmental
Health Sciences (NIEHS), 111 Alexander Drive, Research Triangle
Park, North Carolina. The meeting will begin at 8:30 a.m. both
days and is open to the public. The agenda includes the peer
review of substances nominated for listing in or delisting from
the 9th Report on Carcinogens (formerly the Annual Report
on Carcinogens), and provision of an opportunity for public
input.
Background
Over the past three years,
there was an extensive public and Federal interagency review of
the process for the preparation of the Report on Carcinogens
(RC) to broaden input to its preparation, broaden the scope
of scientific review, and provide review of the criteria used
for inclusion in or removal of substances from the Report. As
a result, the criteria were revised and approved in September
1996 by the Secretary, Department of Health and Human Services.
The major change in the RC which occurred as a result of the
criteria revision was to include consideration of all relevant
information, including mechanistic data, in the decision to list
substances in or delist substances from future volumes. To broaden
the scope of scientific review, a new standing subcommittee of
the NTP Board of Scientific Counselors was established. A November
1996 meeting of the Report on Carcinogens (RC) Subcommittee was
the first where public review of nominations took place, and using
the revised criteria. Thus, the current review process for review
of petitions considered by the NTP for listing in or delisting
from the Report begins with initial scientific review by the NIEHS/NTP
Report on Carcinogens Review Committee (RG1). The RG1 makes a
formal recommendation for those petitions determined to contain
sufficient information for listing or delisting in the Report.
The second scientific review is done by the NTP Executive Committee's
Working Group for the Report on Carcinogens (RG2). RG2 is comprised
of representatives of the Federal health research and regulatory
agencies on the NTP Executive Committee. Following external scientific
peer review by the RC Subcommittee in public session and solicitation
of public comments through announcements in the Federal Register
and other media, the independent recommendations of the three
review groups and all public comments are presented to the NTP
Executive Committee for review and comment. The Director, NTP,
receives the four independent recommendations and makes the final
recommendation to the Secretary for review and approval.
Agenda
Tentatively scheduled to
be peer reviewed on October 30 & 31, are 14 agents, substances,
mixtures or exposure circumstances which are listed alphabetically,
along with supporting information, in the table shown as attachment
1 in this Update. The table lists the nominations
in the tentative order of their presentation and review, and gives
their primary uses or exposures and the category for which they
were originally nominated.
Background summary documents
on each of the substances will be provided to reviewers around
October 1, and will be available to the public at that time as
well. Background documents include 1) a summary of the background
data and information used to evaluate the nomination, and 2) the
recommendation for: listing as a "known to be a human carcinogen"
or as a "reasonably anticipated to be a human carcinogen;"
the upgrading of a current listing; or the removal from the Report.
Copies of draft background documents can be obtained, as available,
from: the Executive Secretary, Dr. Larry G. Hart, P.O. Box 12233,
Research Triangle Park, NC 27709 (Tel: 919/541-3971; FAX
919/541-0295; e-mail: hart@ niehs.nih.gov).
Public Input Encouraged
The entire meeting is open
to the public and time will be provided for public comment on
each of the substances being reviewed. In order to facilitate
planning for the meeting, persons wanting to make a formal presentation
regarding a particular nominated substance must notify the Executive
Secretary by telephone, by FAX, by mail, or by e-mail no later
than October 23, 1997, and provide a written copy in advance of
the meeting. Written statements should supplement and may expand
on the oral presentation, or may be submitted in lieu of an oral
presentation, and should be received by October 27 so copies can
be made for distribution to Subcommittee members and staff and
made available for the public. Oral presentations should be
limited to no more than five minutes. Should the requests for
time exceed the likely available time, the comment period may
have to be limited to three minutes and presenters will be contacted.
The program would welcome receiving carcinogenesis information from completed, ongoing, or planned studies by others, as well as current production data, human exposure information, and use patterns for any of the substances listed in this announcement. Please contact Dr. C. W. Jameson, Report on Carcinogens, MD: EC-14, P.O. Box 12233, Research Triangle Park, NC 27709 (Tel: 919/541-4096; FAX 919/541-2242).
Coordination of Validation of Alternative Methods
Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM)
Becomes Permanent
At the invitation of the
Director of NIEHS, 14 Federal agencies and programs have agreed
to participate in the newly formed permanent,-Interagency
Coordinating Committee on the Validation of Alternative Methods
(ICCVAM). The Committee will facilitate cross agency communication
and coordination on issues relating to validation, acceptance,
and national/international harmonization of toxicological test
methods. This will include coordinating reviews of proposed methods
of multi-agency interest and providing recommendations regarding
their usefulness to agencies. The Committee seeks to promote
sound toxicological test methods that will enhance agencies' ability
to assess risks and make decisions, and that will refine, reduce,
and replace animal use whenever possible. Final regulatory acceptance
of methods will be the purview of each agency according to its
mandates.
Additional information
on the activities and functions of the ICCVAM can be found in
the recent publication Validation and Regulatory Acceptance
of Toxicological Test Methods, a Report of the ad hoc Interagency
Coordinating Committee on the Validation of Alternative Methods
(NIH Publication 97-3981). This report was prepared in response
to the National Institutes of Health (NIH) Revitalization Act
of 1993 (P.L. 103-43), which required the National Institute of
Environmental Health Sciences (NIEHS) to develop criteria and
recommend processes for the validation and regulatory acceptance
of alternative toxicological test methods.
Center for the Evaluation
of Alternative Toxicological Methods
NIEHS is establishing a
Center for the Evaluation of Alternative Toxicological Methods
that will provide operational support for the ICCVAM, and function
to carry out committee related activities, including peer review
panels and workshops. The Center will provide an opportunity
for partnerships with other agencies and organizations to facilitate
the development, validation, and review of alternative testing
methods.
A Federal Advisory Committee
on Alternative Toxicological Methods is being established to provide
advice on the activities and priorities of the Center and ICCVAM,
and to provide advice on ways to foster partnership activities
and productive interactions among all stakeholders. The Advisory
Committee will be composed of knowledgeable representatives drawn
from academia, industry, public interest/animal welfare organizations,
other agencies, and the international community.
Public Meeting Scheduled
to Obtain Input on the Directions and Priorities of ICCVAM and
the Center
A meeting is scheduled
for November 7, 1997, at NIEHS in Research Triangle Park, where
the proposed procedures and activities of ICCVAM and the Center
will be presented, and opportunities for partnerships with stakeholders
will be discussed. There will be an opportunity for public comment.
The recent publication
Validation and Regulatory Acceptance of Toxicological Test
Methods, a Report of the ad hoc Interagency Coordinating Committee
on the Validation of Alternative Methods (NIH Publication
97-3981) can be located on the internet at:Alternative Methods
To receive a copy of the
report, or to obtain additional information about the November
7 meeting, please contact the NTP Liaison Office [P.O. Box 12233,
MD: A3-01, Research Triangle Park, NC 27709, Fax: (919) 541-0295)
e-mail: britton@niehs.nih.gov
For further information about ICCVAM and the Center, contact one of the ICCVAM co-chairs:
Dr. William Stokes
NIEHS
P.O. Box 12233 MD: EC-14
Research Triangle Park, NC 27709
(919) 541-7997
e-mail: stokes@niehs.nih.gov
Dr. Richard Hill
US EPA
Mail Code: 7101
401 M Street, SW
Washington, DC 20460
Fax: (202) 260-1847
e-mail: hill.richard@epamail.epa.gov
NTP Board to Review Draft Technical Reports on December 9-10
The NTP Board of Scientific
Counselors' Technical Reports Subcommittee will tentatively review
the following Reports at a December 9-10 meeting at the NIEHS
Conference Center in Research Triangle Park, NC
1-Chloro-2-propanol, Coconut Oil Diethanolamine, Diethanolamine, Furfuryl Alcohol, Isoprene, Isobutene, Lauric Acid Diethanolamine, Oleic Acid Diethanolamine, Oxymetholone, Pentachlorophenol, and Pyridine.
Copies of the draft reports will be forwarded to the reviewers approximately one month ahead of the meeting and will be available to the public at that time. To receive copies, please contact: Central Data Management, NIEHS, P.O. Box 12233, Research Triangle Park, NC 27709 (Tel: 919/541-3419 or Fax: 919/541-3687) e-mail: CDM@niehs.nih.gov
NTP Board Tentatively Scheduled to Evaluate Transgenic Mouse Models
The NTP Board of Scientific Counselors' is tentatively scheduled to meet February 5-6, 1998, with the primary agenda topic to be a comprehensive evaluation of the sensitivity and specificity of several transgenic mouse models for detecting carcinogens, and their possible utility as adjuncts or replacements for conventional mice in carcinogenesis testing. Additional information regarding the meeting will be available late December-January from NTP Board Executive Secretary, Dr. Larry G. Hart, P.O. Box 12233, MD: A3-07, Research Triangle Park, NC 27709 (Tel: 919/541-3971; FAX 919/541-0295; e-mail: hart@niehs.nih.gov)
NIEHS Moves Forward in Preparation of Report to Congress on the Health Effects of
Electric and Magnetic Fields
Background
The National Institute of Environmental Health Sciences (NIEHS) and the Department of Energy are partners in the Congressionally mandated Electric and Magnetic Fields (EMF) Research and Public Information (RAPID) Program. The EMFRAPID Program was established to address the question of whether extremely low frequency EMF produced by the generation, transmission, and use of electric energy pose a risk to human health, and if so, to determine the significance of the risk and to develop mitigation technologies. As part of its mandate, the NIEHS Director must provide a report to Congress on the extent to which exposure to EMF affects human health. This report will be an objective scientific judgment that results from a critical evaluation of the scientific literature as well as an assessment of the weight and strength of the evidence concerning human health effects associated with EMF exposures.
Science Review Symposia
In preparation for its
report, the NIEHS is convening a series of science review symposia
and a working group meeting. These symposia are to be open forums
for debate and communication about research findings related to
EMF exposures for three areas: theoretical mechanisms/in vitro
findings, epidemiological studies, and in vivo/clinical
findings.
The NIEHS held its first
science review symposium, which covered the area of theoretical
mechanisms and in vitro research studies, on March 24-27, 1997
in Durham, NC. This event brought together over 100 experts including
physicists, biologists, engineers, mathematicians, and epidemiologists
to evaluate the quality and reproducibility of the scientific
findings and to discuss their relationships to any potential health
effects from EMF exposures. The NIEHS was pleased with attendance
at the symposium and found it promoted an atmosphere of collegial
exchange among the participants. Plenary lectures were given
as overviews of the research for particular topics while in-depth
discussions of the experimental findings were held during breakout
group sessions. As part of the proceedings from this symposium,
a report is being generated for each breakout group to capture
the discussions held in that session. Upon completion of the
draft report for a particular breakout session, it is circulated
among the group's attendees for review and comment. After all
reports are finalized, they will be collectively bound and made
publicly available both in hard copy (First SRS Report, EMFRAPID
Program, NIEHS, PO Box 12233, MD: EC-16, Research Triangle Park,
NC 27709) and on the world wide web (http://www.niehs.nih.gov/emfrapid/home.htm).
The anticipated availability date is September 30, 1997.
Two additional symposia
are planned. The second science review symposium will focus on
epidemiological studies and is scheduled for January 12-14, 1998,
in San Antonio, TX. Planning for the third symposium, which will
cover in vivo and clinical research findings, is underway
and is targeted for April 1998. All symposia are public, open
meetings for which interested public, scientists, and stakeholders
are encouraged to attend. For additional information regarding
symposia agenda and/or registration please contact Dr. Mary Wolfe,
P.O. Box 12233, MD: EC-16, Research Triangle Park, NC 27709 (Tel:
919/541-7534 FAX: 919/541-0144).
Working Group Meeting
A working group meeting
will follow the symposium. The working group will be composed
of scientists who will produce a report for the NIEHS that draws
conclusions on the strength and robustness of the scientific data
and its implications for human health and disease etiology. In
preparation of this document, the working group will have available
the symposia's discussion reports but will also perform its own
overall critical review of the literature. The NIEHS will use
the symposia's breakout group reports, the working group document,
and any other relevant information to prepare its report to Congress.
The working group meeting is planned tentatively for June 1998.
NTP EMF Studies to be Peer Reviewed in Public Session March 11, 1998
In 1979, an epidemiology
study reported that children living in homes predicted to have
higher than 60 Hz electric or magnetic fields were at increased
risk for developing cancer. Fifteen years and more than 40 additional
epidemiology studies later, a conclusive answer to this question
of potential human risk does not exist. Approximately five years
ago, the National Toxicology Program was asked to help resolve
this question through a series of animal studies. The results
of the effects of the first 2- year study, exposure of rats to
60 Hz magnetic fields, just arrived at NTP. The results of a
2-year mouse study will arrive mid-September. In addition, as
part of a Congressional Mandate, NIEHS also studied promotion
of breast cancer in rats by 50 Hz (European frequency) and 60
Hz magnetic fields. The results of these initiation/promotion
studies are due at the end of September. NTP is now beginning
the large task of reviewing all of the pathology specimens, other
laboratory results and the pathology diagnoses from these studies
involving over 3,000 animals. The five animal studies (two year
rat and mouse studies; three breast cancer promotion studies)
will be peer reviewed March 11, 1998, by the NTP Board of Scientific
Counselors' Technical Reports Review Subcommittee in an open public
meeting. It is anticipated that these NTP studies will contribute
significantly to assessing the potential human health effects
of exposure to electric and magnetic fields associated with the
generation, transport and use of electricity.
Quality assurance reviews will be conducted, and study reports will be available in February 1998. Copies of the study reports, the agenda and roster of Board Subcommittee members, as well as any other background for the March 11, Board Subcommittee meeting can be obtained during February 1998 by contacting the NTP Executive Secretary, Dr. Larry G. Hart, P.O. Box 12233, MD: A3-97, Research Triangle Park, NC 27709 (Tel: 919/541-3971; FAX 919/541-0295; e-mail: hart@ niehs.nih.gov)
Epidemiologist Recruitment Underway
The NIEHS Division of Intramural
Research is in the process of recruiting a staff epidemiologist
whose role will be to foster effective interactions between epidemiologists
and toxicologists. There are many occasions where an intriguing
or controversial finding in an epidemiology study will be the
main driving force to conduct a toxicology study designed to answer
specific questions regarding human risk. On the other hand, toxicology
data (i.e. reproductive or cancer effects in animals) will provide
the stimulus for human studies to provide a more complete evaluation
of human hazards. A search committee has been formed to recruit
a tenure track staff scientist for NIEHS' Epidemiology Branch
to work in collaboration with the Environmental Toxicology Program.
We are searching for a scientist with expertise in the area of
environmental epidemiology and exposure assessment. The individual
selected will focus on activities to develop strategies for incorporating
human studies into the National Toxicology Program. Questions
should be referred to Ayn Clayborne, NIEHS, Human Resource
Management Branch, P.O. Box 12233, MD: EC-11, Research Triangle
Park, NC 27709 (919) 541-2807
The ICCEC Recommends Actions on Chemicals Nominated for NTP Studies: Public Input Solicited
Background
As part of an effort to
earlier inform and obtain public input into the selection of chemicals
for evaluation, the National Toxicology Program (NTP) routinely
seeks public input on (1) chemicals nominated to the Program for
toxicological studies, and (2) the testing recommendations made
by the Interagency Committee for Chemical Evaluation and Coordination
(ICCEC). Summaries of the ICCEC's recommendations and public
comments received on the nominated chemicals are next presented
to the NTP Board of Scientific Counselors for their review and
comment in an open, public session. ICCEC recommendations, Board
recommendations, and public comments are incorporated into recommendations
that are then submitted to the NTP Executive Committee. The Executive
Committee reviews and approves action to move forward to test,
defer, or delete each of the nominated chemicals for the various
types of study, and recommends priorities.
Request for Comment
Interested parties are
encouraged to comment and provide information on the chemicals
listed in the table shown in attachment 2 of this Update.
The Program would welcome receiving toxicology and carcinogenesis
information from completed or ongoing studies, and information
on planned studies, as well as current production data, human
exposure information, use patterns, and environmental occurrence
for any of the chemicals listed in this announcement. To provide
comments or information, please contact Dr. William Eastin at
the address given below within the next 45 days.
At its meeting on August
15, 1997, the ICCEC reviewed and recommended four chemicals or
substances for toxicity and/or carcinogenicity studies, recommended
that no studies be performed on five chemicals, and deferred four
chemicals pending receipt of test data from other agencies, and
additional information on production, exposure, and use patterns
Chemicals with CAS numbers, nomination source, types of studies
recommended, and other supporting information, are given in attachment
2 of this Update.
Comments may be forwarded by mail to: Dr. William Eastin, NIEHS/NTP, P. O. Box 12233, Research Triangle Park, North Carolina 27709; by telephone at (919) 541-7941; by FAX at (919) 541-4714; or by email at Eastin@niehs.nih.gov.
NTP Solicits Nominations for Chemicals
The NTP continues to solicit chemicals and chemical classes to be tested for toxicity. This program was established by the U.S. Department of Health and Human Services to characterize the toxicity of chemicals and coordinate chemical toxicity testing within the Department. The NTP is made up of research and testing activities of the National Institute of Environmental Health Sciences (NIEHS), the National Institute for Occupational Safety and Health (NIOSH), and the Food and Drug Administration (FDA). The NTP supports research and testing to increase the toxicologic information on selected chemicals, and to develop and validate toxicology tests. Chemicals are selected for testing on the basis of the data and information needs of NTP member agencies and other Government agencies, and in response to public concerns regarding the safety and health effects of specific chemicals or chemical classes.
Chemicals are tested for any or all of the following health-related effects, including reproductive and developmental toxicity, carcinogenicity, genetic toxicity, immunotoxicity, neurotoxicity, general toxicity, and chemical metabolism and disposition, as well as other effects that may be considered relevant to human health concerns. The results of the NTP testing are used by other Federal and State agencies and private sector organizations. The results also are available to the public, and are published in the open scientific literature.
There is no time limit
for nominating chemicals and health effects to be tested. The
NTP will consider each nomination as it is received, but the available
resources will limit the numbers of chemicals that can be tested,
or the types of tests that can be performed. Please send all
chemical nominations and relevant information about the nominated
chemicals to: Errol Zeiger, Ph.D., J.D., Chemical Selection
Office (EC-14), National Institute of Environmental Health Sciences,
P.O. Box 12233, Research Triangle Park, NC 27709
Workshop on Marine/Freshwater Microbes and Toxins
On August 26 and 27, NIEHS hosted an International Workshop on "Hazardous Marine/Freshwater Microbes and Toxins". Attending were researchers, health and environmental officials from several states, and representatives from the Federal Centers for Disease Control and Prevention (CDC), Environmental Protection Agency (EPA), Food and Drug Administration (FDA), the National Oceanic and Atmospheric Administration (NOAA), and the NIEHS. The meeting focus was to discuss current understanding of hazardous toxins arising from aquatic microorganisms. Agents discussed were the brevetoxins, ciguatera, microcystins, demoic acid, and the as yet uncharacterized toxin of the dinoflagellate, Pfisteria. Abstracts of the presentations will be available on the NIEHS external homepage. In addition, an issue of Environmental Health Perspectives will be devoted to this topic.
EPA-NTP Collaborate to Evaluate Chemicals in Drinking Water
The National Toxicology Program is collaborating with the US Environmental Protection Agency (EPA) in a Safe Drinking Water Program to evaluate the chemicals that occur in drinking water.
There is widespread potential for human exposure to disinfection byproducts (DBPs) in finished drinking water. Since everyone drinks, bathes, cooks and cleans with water, the potential for exposure to the disinfectants and their by-products is large. In 1979, chloroform, a principal disinfection by-product (DBP) was shown to be carcinogenic in rodents. It has since been shown that many other DBPs occur in drinking water with trihalomethanes and haloacetic acids as the most important families of chemicals. Some trihalomethanes and haloacetic acids cause an increased incidence of cancer in rodents when given for prolonged periods. Epidemiology studies also suggest a possible association between the consumption of treated drinking water and the occurrence of bladder cancer and colon/rectal cancer.
The 1996 Amendments to the Safe Drinking Water Act called for regulatory action on specific DBPs. For many of these, insufficient toxicological data exists. Disinfection of drinking water has a major positive public health impact reducing morbidity and mortality from infectious diseases. Thus, changes in the disinfection process to limit DBPs must not increase microbial risks. Further, since there is limited toxicology information about the DBPs, switching to an alternate disinfection process may in fact increase different DBPs with a greater potential for human health hazard.
The US EPA is working with the National Institute of Environmental Health Sciences to initiate a systematic approach to create a biological and mechanistic data base on DBPs so that policy decisions can be based on sound science. In addition, the US Army (DOD), with expertise in alternate species in water safety assessment has joined the effort and will coordinate DBP testing in the Medaka, a small fish model. Agencies will be sharing costs, animals and tissues to enhance opportunities for increasing the knowledge gained from each study. The NTP will be initiating six long-term rodent studies on DBPs and three DBPs will be evaluated in two transgenic mouse models. In collaboration with DOD, four DBPs will be evaluated in small fish models.
The transgenic mouse models and small fish models will be used to compare toxicity of DBPs with the results in long-term rodent studies. Information from the new short-term models will provide an opportunity for testing a large number of chemicals and for setting priorities in the testing program. This coordinated and systematic approach by multiple agencies with varying expertise can address the DBP issue in a timely manner. Furthermore, a hypothesis driven approach will be implemented that offers the best chance to provide answers to policy makers.
NTP Information Now Available Through the EHIS
Please note the information accompanying this update on the newly established Environmental Health Information Service and particularly the reminder that the "free trial" password provided to those who received NTP information in the past expires October 1. Instructions are provided on the enclosed flyer to ensure continued receipt of the NTP information being disseminated by the EHIS. You may contact EHIS by phone at 919-541-3841, Fax 919-541-0273, or e-mail ehis@niehs.nih.gov. (EHIS Homepage address: ehis@niehs.nih.gov)
"What's New" in the NTP Website
AIDS Therapeutics Toxicity
Studies Program Homepage (http://ntp.niehs.nih.gov/ntp/
Main_Pages/AIDS/AIDSpage.html)
The National Toxicology
Program (NTP) collaborates with other programs of the NIEHS, other
NIH institutes, other government agencies, and manufacturers developing
antiretroviral drugs and drugs for opportunistic infections, to
identify and study toxicities associated with AIDS therapeutics.
The first in a series of AIDS Therapeutic Toxicity reports is
available electronically from this site. (NIEHS Technical Report
on the Reproductive, Developmental, and General Toxicity Studies
of Pyrazinamide (CAS No. 98-96-4) Administered by Gavage
to Swiss CD-1®) Mice - March 1997)
******************************
Visit the new Alternative
Models in Toxicity Testing Homepage
(
http://ntp.niehs.nih.gov/ntp/ Main_Pages/transgen/Transgen_default.html).
This site includes information on Transgenic Model Studies at
NIEHS, Partnerships to Evaluate Alternative Test Models, as well
as the Report of the Interagency Coordinating Committee on the
Validation of Alternative Methods (ICCVAM report).
******************************
The following Special
Reports extracted from the NTP studies database are available
on the world wide web from the NTP Homepage
(/index.cfm?objectid=0361326F-956A-B218-417F400A98DF860D).
Individual Study
Summary Reports:
A searchable site that gives target organs and "Levels of
Evidence" from individual two-year studies.
A List of Organ Sites
and the numbers of chemicals associated with neoplasia. Links
are provided for each site to identify the chemicals causing the
effect and the sex/species in which the effect occurred and to
the Technical Report abstract for each chemical.
Index of NTP Peer
Reviewed Technical Reports:
List of NTP
Peer Reviewed Technical Reports ordered by report number with
carcinogenicity conclusions and links to the Abstracts, Levels
of Evidence, and Results/Status Report.
Mutagenesis and Carcinogenesis:
Lists of studies
grouped by the results of in vitro (Salmonella) tests and
two-year study conclusions.
********************************
Recently Published
NTP Long Term Technical Reports:
TR-445
Toxicology and Carcinogenesis
Studies of Scopolamine Hydrobromide Trihydrate (CAS No. 6533-68-2)
in F344 Rats and B6C3F1 Mice (Gavage Studies) - March
1997
TR-450
Toxicology and Carcinogenesis
Studies of Tetrafluoroethylene (CAS No. 116-14-3) in F344 Rats
and B6C3F1 Mice (Inhalation Studies) - April 1997
TR-456
Toxicology and Carcinogenesis
Studies of 1,2-Dihydro-2,2,4-Trimethylquino- line (CAS No. 147-47-7)
in F344/N Rats and B6C3F1 Mice (Dermal Studies) and
the Dermal Initiation/ Promotion Study in Female Sencar Mice
- February 1997
TR-457
Toxicology and Carcinogenesis
Studies of Salicylazosulfapyridine (CAS No. 599-79-1) in F344
Rats and B6C3F1 Mice (Gavage Studies) - May 1997
TR-459
Toxicology and Carcinogenesis
Studies of t-Butylhydroquinone (CAS No. 1948-33-0) in F344 Rats
and B6C3F1 Mice (Feed Studies) - May 1997
TR-461
Toxicology and Carcinogenesis
Studies of Nitromethane (CAS No. 75-52-5) in F344 Rats and B6C3F1
Mice (Inhalation Studies) - February 1997
TR-462
Toxicology and Carcinogenesis
Studies of Molybdenum Trioxide (CAS No. 1313-27-5) in F344 Rats
and B6C3F1 Mice (Inhalation Studies) - April 1997
TR-463
Toxicology and Carcinogenesis
Studies of D&C Yellow No. 11 (CAS No. 8003-22-3) in F344 Rats
(Feed Studies) - April 1997
Abstracts from these and
other NTP reports for the individual studies may be viewed via
the World Wide Web from the NTP Homepage (URL: http://ntp.niehs.nih.gov/ntp/)
For NTP information, contact Central Data Management:
Central Data Management
National Institute of Environmental Health Sciences
P.O. Box 12233
MD: E1-02
Research Triangle Park, NC 27709
Telephone number: (919) 541-3419
FAX number: (919) 541-3687
mail: CDM@niehs.nih.gov
NTP Board of Scientific Counselors' Meeting, May 14, 1997
The NTP Board of Scientific Counselors met in public session at the NIEHS on May 14, 1997. The primary agenda topic was concerned with presentations and discussions of endocrine disruptor initiatives and activities at NIEHS and other Federal health agencies. Scientists from the National Center for Environmental Health (NCEH)/CDC, FDA, and EPA described their agency's endocrine disruptor research. The Board addressed three specific questions: (1) is the scope of NIEHS/NTP research in endocrine disruptors appropriate?; (2) are opportunities being missed?; and (3) taken together, are the links between fundamental knowledge, toxicology, human studies, and risk assessment being strengthened? The Board reviewed and approved a concept proposal for a molecular oncology support contract that will enable the NIEHS to rapidly perform in vivo pilot and risk characterization studies to investigate mechanisms of toxicity and carcinogenicity. Copies of the summary minutes may be obtained by contacting: Central Data Management (CDM), P.O. Box 12233, MD: E1-02, Research Triangle Park, NC 27709 (Tel): (919) 541-3419; (Fax): (919) 541-3687; Internet: CDM@niehs.nih.gov.
Web page last updated on December 17, 2007