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Chemicals Recommended for NTP Studies
| Attachment 2 |
ICCEC Recommended Actions for NTP Studies August 15, 1997
Chemicals Recommended for Testing:
| Chemical | CASRN | Nomin. By | Recommended For | Rationale; Other Info. |
| Asphalt fumes | 8052-42-4 | NIOSH;
Calif. | - 28-day toxicological assessment - pulmonary function and irritation - biomarkers of exposure | - high exposure - lack of adequate short term toxicity information - need to identify biomarkers of exposure |
| Luminol (o-Aminophthalic hydrazide) | 521-31-3 | private indiv.; NIOSH | - toxicity
- carcinogenicity - in vivo genetic toxicity | - widespread use and potential for exposure |
| Orthanilic acid | 88-21-1 | NIEHS | - short-term toxicity studies | - high production
- very little toxicology data available |
| Phenothiazine | 92-84-2 | NIEHS | - carcinogenicity | - high production and exposure
- no carcinogenicity data available |
Chemicals for Which No Testing is Recommended:
| Chemical | CASRN | Nomin. By | Nominated For | Rationale; Other Info. |
| Dicyclopentadiene | 77-73-6 | NCI | - reproductive toxicity
- carcinogenicity | - no adverse effects seen in teratology tests - not mutagenic in Salmonella - low potential for human exposure |
| C.I. Direct Black 80 | 8003-69-8 | NCI | - carcinogenicity by dermal route | - dermal absorption too low (1.3%) to support a study |
| Ethyl cyanoacrylate | 7085-85-0 | NCI | - reproductive and developmental toxicity
- neurotoxicity - carcinogenicity | - stable aerosol cannot be generated - rapidly polymerizes in presence of atmospheric moisture |
| Isoamyl acetate | 123-92-2 | NIEHS | - toxicity
- neurotoxicity - carcinogenicity | - rapidly hydrolyzed in blood to isoamyl alcohol, which has been studied, and acetic acid |
| 2,4,6-Tribromophenol | 118-79-6 | NIEHS | - carcinogenicity | - low production and exposure - little chance for bioaccumulation |
Chemicals Deferred for Additional Information:
| Chemical | CASRN | Nomin. By | Nominated For | Rationale; Other Info. |
| 3-Amino-5-mercapto- 1,2,4-triazole | 16691-43-3 | NIEHS | toxicity; carcinogenicity | - high production
- suspect chemical structure |
| Diethylamine | 109-89-7 | NIEHS | toxicity; carcinogenicity | - high production and exposure
- very little toxicology data available - not mutagenic in Salmonella |
| Isopropylamine | 75-31-0 | NIEHS | toxicity; carcinogenicity | - high production and exposure
- very little toxicology data available - not mutagenic in Salmonella |
| Triethylamine | 121-44-8 | UAW; NIEHS | carcinogenicity | - high production and exposure
- not mutagenic in Salmonella |
Web page last updated on December 17, 2007
