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Summary Data for.... Review at the Report on Carcinogens Subcommittee

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Attachment 1

Summary Data for
Agents, Substances, Mixtures or Exposure Circumstances
Tentatively Scheduled for Review at the Meeting of the
NTP Board of Scientific Counselors' Report on Carcinogens Subcommittee
October 30 & 31, 1997

SUBSTANCE OR EXPOSURE CIRCUMSTANCE/
CAS NUMBER
PRIMARY USES OR
EXPOSURES


NOMINATED FOR1
TENTATIVE REVIEW ORDER
DYES METABOLIZED TO BENZIDINE (BENZIDINE DYES
AS A CLASS) 		Benzidine-based dyes are used primarily for dyeing textiles, paper and leather products. More than 250 benzidine-based dyes have been reported by the Society of Dyers and Colorists. Listing as Known to be a Human Carcinogen in the 9th Report
14
1,3-BUTADIENE/
106-99-0 		Used primarily as a chemical intermediate and polymer component in the manufacture of synthetic rubber Upgrading current listing to Known to be a Human Carcinogen in the 9th Report
4
CADMIUM and
CADMIUM COMPOUNDS/
7440-43-9 		Used in batteries, coating and plating, plastic and synthetic products and in alloys. Upgrading current listing to Known to be a Human Carcinogen in the 9th Report
2
CHLOROPRENE/
126-99-8 		Used as a monomer for neoprene elastomers, industrial rubber products, and as a component of adhesives in food packaging. Listing as Reasonably Anticipated to be a Human Carcinogen in the 9th Report
3
PHENOLPHTHALEIN/
77-09-8 		Used as a laboratory reagent and acid-base indicator and as a cathartic drug in over-the-counter laxative preparations. Listing as Reasonably Anticipated to be a Human Carcinogen in the 9th Report
10
SACCHARIN/
218-44-9 		Used primarily as a nonnutritive sweetening agent. Removal from the Report on Carcinogens
11
SMOKELESS TOBACCO Oral use of smokeless tobacco products. Listing as Known to be a Human Carcinogen in the 9th Report
7
STRONG INORGANIC ACID MISTS CONTAINING SULFURIC ACID Used in the manufacture of fertilizers, rayon and other fibers, pigments and colors, explosives, plastics, coal-tar products such as dyes and drugs, storage batteries, synthetic detergents, natural and synthetic rubber, pulp and paper, cellophane and catalysts. It is also used in petroleum refining, pickling iron, steel and other metals and in ore concentration. Listing as Known to be a Human Carcinogen in the 9th Report
8
TAMOXIFEN/
10540-29-1 		Used as an anti-estrogen drug and in the palliative treatment of breast cancer. Listing as Known to be a Human Carcinogen in the 9th Report
9
2,3,7,8- TETRACHLORODIBENZO-P- DIOXIN (TCDD)/
1746-01-6 		Not used commercially, used only as a research chemical. Potential exposure from municipal incinerators, dump sites and contaminated soil. Upgrading current listing to Known to be a Human Carcinogen in the 9th Report
12
TETRAFLUOROETHYLENE/
116-14-3 		Used in the production of polytetrafluoroethylene (Teflon) and other polymers. Has also been used as a propellant for food product aerosols. Listing as Reasonably Anticipated to be a Human Carcinogen in the 9th Report
1
TOBACCO SMOKING Inhalation of tobacco smoke Listing as Known to be a Human Carcinogen in the 9th Report
6
TRICHLOROETHYLENE/
79-01-6 		Used as an industrial solvent for vapor degreasing and cold cleaning of fabricated metal parts. Has also been used as a carrier solvent for the active ingredients of insecticides and fungicides, as a solvent for waxes, fats, resins, and oils, as an anesthetic for medical and dental use, and as an extractant for spice oleoresins and for caffeine from coffee. Listing as Reasonably Anticipated to be a Human Carcinogen in the 9th Report
13
UV RADIATION Solar and artificial sources of ultraviolet radiation Listing as Known to be a Human Carcinogen in the 9th Report
5
1Nomination does not necessarily reflect the final recommendation of the two NTP Scientific Review Committees for the Report on Carcinogens.

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