| | This journal provides immediate access to some articles. Commentaries TLR7: A new sensor of viral infection K. Crozat and B. Beutler PMCID: PMC406426 Latest folding game results: Protein A barely frustrates computationalists Peter G. Wolynes PMCID: PMC406427 Microtubule composition: Cryptography of dynamic polymers Kerry Bloom PMCID: PMC406428 Physical Sciences Chemistry From the Cover:
Experimentally exploring the conformational space sampled by domain reorientation in calmodulin Ivano Bertini, Cristina Del Bianco, Ioannis Gelis, Nikolaus Katsaros, Claudio Luchinat, Giacomo Parigi, Massimiliano Peana, Alessandro Provenzani, and Maria Antonietta Zoroddu PMCID: PMC406429 Geology Space weathering on airless planetary bodies: Clues from the lunar mineral hapkeite Mahesh Anand, Lawrence A. Taylor, Mikhail A. Nazarov, J. Shu, H.-K. Mao, and Russell J. Hemley PMCID: PMC406430 Biological Sciences Applied Biological Sciences In planta engineering of viral RNA replicons: Efficient assembly by recombination of DNA modules delivered by Agrobacterium Sylvestre Marillonnet, Anatoli Giritch, Mario Gils, Romy Kandzia, Victor Klimyuk, and Yuri Gleba PMCID: PMC406431 Cloned transgenic farm animals produce a bispecific antibody for T cell-mediated tumor cell killing Ludger Grosse-Hovest, Sigrid Müller, Rosa Minoia, Eckhard Wolf, Valeri Zakhartchenko, Hendrik Wenigerkind, Caroline Lassnig, Urban Besenfelder, Mathias Müller, Simon D. Lytton, Gundram Jung, and Gottfried Brem PMCID: PMC406432 Biochemistry From the Cover:
Molecular recognition of the nucleosomal “supergroove” Rajeswari S. Edayathumangalam, Philipp Weyermann, Joel M. Gottesfeld, Peter B. Dervan, and Karolin Luger PMCID: PMC406433 Communication between the active sites and dimer interface of a herpesvirus protease revealed by a transition-state inhibitor Alan B. Marnett, Anson M. Nomura, Nobuhisa Shimba, Paul R. Ortiz de Montellano, and Charles S. Craik PMCID: PMC406434 Infertility with defective spermatogenesis and hypotestosteronemia in male mice lacking the androgen receptor in Sertoli cells Chawnshang Chang, Yen-Ta Chen, Shauh-Der Yeh, Qingquan Xu, Ruey-Sheng Wang, Florian Guillou, Henry Lardy, and Shuyuan Yeh PMCID: PMC406435 Turning on ribonucleotide reductase by light-initiated amino acid radical generation Michelle C. Y. Chang, Cyril S. Yee, JoAnne Stubbe, and Daniel G. Nocera PMCID: PMC406436 Crystal structure of Clostridium botulinum neurotoxin protease in a product-bound state: Evidence for noncanonical zinc protease activity Brent Segelke, Mark Knapp, Saloumeh Kadkhodayan, Rod Balhorn, and Bernhard Rupp PMCID: PMC406437 Identification of an inhibitor-binding site to HIV-1 integrase with affinity acetylation and mass spectrometry Nick Shkriabai, Sachindra S. Patil, Sonja Hess, Scott R. Budihas, Robert Craigie, Terrence R. Burke, Jr., Stuart F. J. Le Grice, and Mamuka Kvaratskhelia PMCID: PMC406438 Biologically active noncalcemic analogs of 1α,25-dihydroxyvitamin D with an abbreviated side chain containing no hydroxyl Lori A. Plum, Jean M. Prahl, Xiaohong Ma, Rafal R. Sicinski, Sumithra Gowlugari, Margaret Clagett-Dame, and Hector F. DeLuca PMCID: PMC406439 Stable down-regulation of human polynucleotide kinase enhances spontaneous mutation frequency and sensitizes cells to genotoxic agents Aghdass Rasouli-Nia, Feridoun Karimi-Busheri, and Michael Weinfeld PMCID: PMC406440 A mutant spacer sequence between -35 and -10 elements makes the Plac promoter hyperactive and cAMP receptor protein-independent Mofang Liu, Michael Tolstorukov, Victor Zhurkin, Susan Garges, and Sankar Adhya PMCID: PMC406441 Membrane protease proteomics: Isotope-coded affinity tag MS identification of undescribed MT1–matrix metalloproteinase substrates Eric M. Tam, Charlotte J. Morrison, Yi I. Wu, M. Sharon Stack, and Christopher M. Overall PMCID: PMC406442 Heterochromatin on the inactive X chromosome delays replication timing without affecting origin usage María Gómez and Neil Brockdorff PMCID: PMC406443 Structural and functional analysis of Aplysia attractins, a family of water-borne protein pheromones with interspecific attractiveness Sherry D. Painter, Scott F. Cummins, Amy E. Nichols, David-B. G. Akalal, Catherine H. Schein, Werner Braun, John S. Smith, Abraham J. Susswein, Miriam Levy, Pamela A. C. M. de Boer, Andries ter Maat, Mark W. Miller, Cory Scanlan, Richard M. Milberg, Jonathan V. Sweedler, and Gregg T. Nagle PMCID: PMC406444 Probing TBP interactions in transcription initiation and reinitiation with RNA aptamers that act in distinct modes Xiaochun Fan, Hua Shi, Karen Adelman, and John T. Lis PMCID: PMC406445 Biophysics From the Cover:
L-selectin-mediated leukocyte tethering in shear flow is controlled by multiple contacts and cytoskeletal anchorage facilitating fast rebinding events Ulrich S. Schwarz and Ronen Alon PMCID: PMC406518 Close agreement between the orientation dependence of hydrogen bonds observed in protein structures and quantum mechanical calculations Alexandre V. Morozov, Tanja Kortemme, Kiril Tsemekhman, and David Baker PMCID: PMC406446 From the Cover:
Testing protein-folding simulations by experiment: B domain of protein A Satoshi Sato, Tomasz L. Religa, Valerie Daggett, and Alan R. Fersht PMCID: PMC406447 On the use of low-frequency normal modes to enforce collective movements in refining macromolecular structural models Marc Delarue and Philippe Dumas PMCID: PMC406448 Mechanism of homophilic adhesion by the neural cell adhesion molecule: Use of multiple domains and flexibility C. P. Johnson, I. Fujimoto, C. Perrin-Tricaud, U. Rutishauser, and D. Leckband PMCID: PMC406449 Dual architectural roles of HU: Formation of flexible hinges and rigid filaments John van Noort, Sander Verbrugge, Nora Goosen, Cees Dekker, and Remus Thei Dame PMCID: PMC406450 Cell Biology Essential role of GATA-4 in cell survival and drug-induced cardiotoxicity Anne Aries, Pierre Paradis, Chantal Lefebvre, Robert J. Schwartz, and Mona Nemer PMCID: PMC406451 Modular construction of a signaling scaffold: MORG1 interacts with components of the ERK cascade and links ERK signaling to specific agonists Tomas Vomastek, Hans-Joerg Schaeffer, Adel Tarcsafalvi, Mark E. Smolkin, Eric A. Bissonette, and Michael J. Weber PMCID: PMC406452 Matefin, a Caenorhabditis elegans germ line-specific SUN-domain nuclear membrane protein, is essential for early embryonic and germ cell development Alexandra Fridkin, Erez Mills, Ayelet Margalit, Esther Neufeld, Kenneth K. Lee, Naomi Feinstein, Merav Cohen, Katherine L. Wilson, and Yosef Gruenbaum PMCID: PMC406453 PIKE-A is amplified in human cancers and prevents apoptosis by up-regulating Akt Jee-Yin Ahn, Yuanxin Hu, Todd G. Kroll, Paulette Allard, and Keqiang Ye PMCID: PMC406454 High-density lipoprotein and apolipoprotein AI increase endothelial NO synthase activity by protein association and multisite phosphorylation Brian G. Drew, Noel H. Fidge, Gabrielle Gallon-Beaumier, Bruce E. Kemp, and Bronwyn A. Kingwell PMCID: PMC406455 Developmental Biology An orderly retreat: Dedifferentiation is a regulated process Mariko Katoh, Chad Shaw, Qikai Xu, Nancy Van Driessche, Takahiro Morio, Hidekazu Kuwayama, Shinji Obara, Hideko Urushihara, Yoshimasa Tanaka, and Gad Shaulsky PMCID: PMC406456 Evolution Directed evolution of protein enzymes using nonhomologous random recombination Joshua A. Bittker, Brian V. Le, Jane M. Liu, and David R. Liu PMCID: PMC406457 The optimal rate of chromosome loss for the inactivation of tumor suppressor genes in cancer Natalia L. Komarova and Dominik Wodarz PMCID: PMC406458 Genetics The cleft lip and palate defects in Dancer mutant mice result from gain of function of the Tbx10 gene Jeffrey O. Bush, Yu Lan, and Rulang Jiang PMCID: PMC406459 Developmental stage differences in chromatin subdomains of the β-globin locus AeRi Kim and Ann Dean PMCID: PMC406460 Genome-wide transcription profile of field- and laboratory-selected dichlorodiphenyltrichloroethane (DDT)-resistant Drosophila J. H. F. Pedra, L. M. McIntyre, M. E. Scharf, and Barry R. Pittendrigh PMCID: PMC406461 Theoretical basis for genetic linkage analysis in autotetraploid species Z. W. Luo, R. M. Zhang, and M. J. Kearsey PMCID: PMC406462 Three replication origins in Sulfolobus species: Synchronous initiation of chromosome replication and asynchronous termination Magnus Lundgren, Anders Andersson, Lanming Chen, Peter Nilsson, and Rolf Bernander PMCID: PMC406463 Immunology From the Cover:
L-selectin-mediated leukocyte tethering in shear flow is controlled by multiple contacts and cytoskeletal anchorage facilitating fast rebinding events Ulrich S. Schwarz and Ronen Alon PMCID: PMC406518 Negative selection of semimature CD4+8-HSA+ thymocytes requires the BH3-only protein Bim but is independent of death receptor signaling Andreas Villunger, Vanessa S. Marsden, Yifan Zhan, Miriam Erlacher, Andrew M. Lew, Philippe Bouillet, Stuart Berzins, Dale I. Godfrey, William R. Heath, and Andreas Strasser PMCID: PMC406464 Development of innate CD4+ α-chain variable gene segment 24 (Vα24) natural killer T cells in the early human fetal thymus is regulated by IL-7 Johan K. Sandberg, Cheryl A. Stoddart, Fabienne Brilot, Kimberly A. Jordan, and Douglas F. Nixon PMCID: PMC406465 HLA-G1-expressing antigen-presenting cells induce immunosuppressive CD4+ T cells Joël LeMaoult, Irène Krawice-Radanne, Jean Dausset, and Edgardo D. Carosella PMCID: PMC406466 Medical Sciences HIV-1-mediated apoptosis of neuronal cells: Proximal molecular mechanisms of HIV-1-induced encephalopathy Yan Xu, Joseph Kulkosky, Edward Acheampong, Giuseppe Nunnari, Julie Sullivan, and Roger J. Pomerantz PMCID: PMC406467 Neutrophils alter the inflammatory milieu by signal-dependent translation of constitutive messenger RNAs Stephan W. Lindemann, Christian C. Yost, Melvin M. Denis, Thomas M. McIntyre, Andrew S. Weyrich, and Guy A. Zimmerman PMCID: PMC406468 Regulation of cardiac contractility by Rab4-modulated β2-adrenergic receptor recycling Amy Odley, Harvey S. Hahn, Roy A. Lynch, Yehia Marreez, Hanna Osinska, Jeffrey Robbins, and Gerald W. Dorn, II PMCID: PMC406469 Metabolic syndrome without obesity: Hepatic overexpression of 11β-hydroxysteroid dehydrogenase type 1 in transgenic mice Janice M. Paterson, Nicholas M. Morton, Catherine Fievet, Christopher J. Kenyon, Megan C. Holmes, Bart Staels, Jonathan R. Seckl, and John J. Mullins PMCID: PMC406470 Dietary approach to attenuate oxidative stress, hypertension, and inflammation in the cardiovascular system Lingyun Wu, M. Hossein Noyan Ashraf, Marina Facci, Rui Wang, Phyllis G. Paterson, Alison Ferrie, and Bernhard H. J. Juurlink PMCID: PMC406471 Adenoviral-mediated expression of Pcsk9 in mice results in a low-density lipoprotein receptor knockout phenotype Kara N. Maxwell and Jan L. Breslow PMCID: PMC406472 Hepatic insig-1 or -2 overexpression reduces lipogenesis in obese Zucker diabetic fatty rats and in fasted/refed normal rats Kiyosumi Takaishi, Laurence Duplomb, May-Yun Wang, Jinping Li, and Roger H. Unger PMCID: PMC406473 Secreted transforming growth factor β2 activates NF-κB, blocks apoptosis, and is essential for the survival of some tumor cells Tao Lu, Lyudmila G. Burdelya, Shannon M. Swiatkowski, Alexander D. Boiko, Philip H. Howe, George R. Stark, and Andrei V. Gudkov PMCID: PMC406474 Microbiology Gram-positive bacteria are a major reservoir of Class 1 antibiotic resistance integrons in poultry litter Sobhan Nandi, John J. Maurer, Charles Hofacre, and Anne O. Summers PMCID: PMC406475 Neuroscience Axonal growth of embryonic stem cell-derived motoneurons in vitro and in motoneuron-injured adult rats James M. Harper, Chitra Krishnan, Jessica S. Darman, Deepa M. Deshpande, Schonze Peck, Irina Shats, Stephanie Backovic, Jeffrey D. Rothstein, and Douglas A. Kerr PMCID: PMC406476 Prenatal androgens alter GABAergic drive to gonadotropin-releasing hormone neurons: Implications for a common fertility disorder Shannon D. Sullivan and Suzanne M. Moenter PMCID: PMC406477 Changes in corticothalamic modulation of receptive fields during peripheral injury-induced reorganization S. A. Chowdhury, K. A. Greek, and D. D. Rasmusson PMCID: PMC406478 Selective vulnerability of dentate granule cells prior to amyloid deposition in PDAPP mice: Digital morphometric analyses Chi-Cheng Wu, Faisal Chawla, Dora Games, Russell E. Rydel, Stephen Freedman, Dale Schenk, Warren G. Young, John H. Morrison, and Floyd E. Bloom PMCID: PMC406479 Projections from primary visual cortex to cytochrome oxidase thin stripes and interstripes of macaque visual area 2 Youping Xiao and Daniel J. Felleman PMCID: PMC406480 A role for fast rhythmic bursting neurons in cortical gamma oscillations in vitro Mark O. Cunningham, Miles A. Whittington, Andrea Bibbig, Anita Roopun, Fiona E. N. LeBeau, Angelika Vogt, Hannah Monyer, Eberhard H. Buhl, and Roger D. Traub PMCID: PMC406481 An essential role for vesicular glutamate transporter 1 (VGLUT1) in postnatal development and control of quantal size S. M. Wojcik, J. S. Rhee, E. Herzog, A. Sigler, R. Jahn, S. Takamori, N. Brose, and C. Rosenmund PMCID: PMC406482 Fundamental role of inferior olive connexin 36 in muscle coherence during tremor Dimitris G. Placantonakis, Anatoly A. Bukovsky, Xiao-Hui Zeng, Hans-Peter Kiem, and John P. Welsh PMCID: PMC406483 Specialization of primary auditory cortex processing by sound exposure in the “critical period” Haruka Nakahara, Li I. Zhang, and Michael M. Merzenich PMCID: PMC406484 Sensory neuron-specific receptor activation elicits central and peripheral nociceptive effects in rats Eric Grazzini, Carole Puma, Marie-Odile Roy, Xiao Hong Yu, Dajan O'Donnell, Ralf Schmidt, Sophie Dautrey, Julie Ducharme, Martin Perkins, Rosemarie Panetta, Jennifer M. A. Laird, Sultan Ahmad, and Paola M. C. Lembo PMCID: PMC406485 From the Cover:
Imaging correlates of brain function in monkeys and rats isolates a hippocampal subregion differentially vulnerable to aging Scott A. Small, Monica K. Chawla, Michael Buonocore, Peter R. Rapp, and Carol A. Barnes PMCID: PMC406486 Phactrs 1–4: A family of protein phosphatase 1 and actin regulatory proteins Patrick B. Allen, Audrey T. Greenfield, Per Svenningsson, Derek C. Haspeslagh, and Paul Greengard PMCID: PMC406487 Membrane-associated guanylate kinase-like properties of β-subunits required for modulation of voltage-dependent Ca2+ channels Shoji X. Takahashi, Jayalakshmi Miriyala, and Henry M. Colecraft PMCID: PMC406488 Pharmacology Short-chain fatty acids enhance nuclear receptor activity through mitogen-activated protein kinase activation and histone deacetylase inhibition Michelle S. Jansen, Susan C. Nagel, Phillippa J. Miranda, Edward K. Lobenhofer, Cynthia A. Afshari, and Donald P. McDonnell PMCID: PMC406489 Correction Proc Natl Acad Sci U S A. 2004 May 4; 101(18): 7205. Published online 2004 April 15. doi: 10.1073/pnas.0401411101.PMCID: PMC406490 Corrects: Bettina Malnic, et al. The human olfactory receptor gene family. Proc Natl Acad Sci U S A. 2004 February 24; 101(8): 2584–2589. |
