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Volume 101(17);  April 27, 2004
Commentaries
Is 11β-hydroxysteroid dehydrogenase type 1 a good therapeutic target for blockade of glucocorticoid actions?
George P. Chrousos
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6329–6330. Published online 2004 April 19. doi: 10.1073/pnas.0401671101.
PMCID: PMC404042
Behavior of fluids in nanoscopic space
Sandip Niyogi and Robert C. Haddon
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6331–6332. Published online 2004 April 19. doi: 10.1073/pnas.0401508101.
PMCID: PMC404043
The human cortex responds to an interoceptive challenge
Hugo D. Critchley
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6333–6334. Published online 2004 April 19. doi: 10.1073/pnas.0401510101.
PMCID: PMC404044
Physical Sciences
Engineering
Deformation mechanisms in free-standing nanoscale thin films: A quantitative in situ transmission electron microscope study
M. A. Haque and M. T. A. Saif
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6335–6340. Published online 2004 April 14. doi: 10.1073/pnas.0400066101.
PMCID: PMC404045
Geophysics
Bipolar correlation of volcanism with millennial climate change
Ryan C. Bay, Nathan Bramall, and P. Buford Price
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6341–6345. Published online 2004 April 19. doi: 10.1073/pnas.0400323101.
PMCID: PMC404046
Industrial emissions cause extreme urban ozone diurnal variability
Renyi Zhang, Wenfang Lei, Xuexi Tie, and Peter Hess
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6346–6350. Published online 2004 April 14. doi: 10.1073/pnas.0401484101.
PMCID: PMC404047
Biological Sciences
Agricultural Sciences
Nitrogen-bonded aromatics in soil organic matter and their implications for a yield decline in intensive rice cropping
K. Schmidt-Rohr, J.-D. Mao, and D. C. Olk
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6351–6354. Published online 2004 April 19. doi: 10.1073/pnas.0401349101.
PMCID: PMC404048
Applied Biological Sciences
Spatiotemporal control of gene expression with pulse-generating networks
Subhayu Basu, Rishabh Mehreja, Stephan Thiberge, Ming-Tang Chen, and Ron Weiss
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6355–6360. Published online 2004 April 19. doi: 10.1073/pnas.0307571101.
PMCID: PMC404049
From the Cover:
Functional expression of a Δ12 fatty acid desaturase gene from spinach in transgenic pigs
Kazuhiro Saeki, Kazuya Matsumoto, Mikio Kinoshita, Iwane Suzuki, Yasushi Tasaka, Koichiro Kano, Yoshitomo Taguchi, Koji Mikami, Masumi Hirabayashi, Naomi Kashiwazaki, Yoshihiko Hosoi, Norio Murata, and Akira Iritani
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6361–6366. Published online 2004 April 5. doi: 10.1073/pnas.0308111101.
PMCID: PMC404050
Biochemistry
Crystal structure of the von Willebrand factor A domain of human capillary morphogenesis protein 2: An anthrax toxin receptor
D. Borden Lacy, Darran J. Wigelsworth, Heather M. Scobie, John A. T. Young, and R. John Collier
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6367–6372. Published online 2004 April 12. doi: 10.1073/pnas.0401506101.
PMCID: PMC404051
Gonadotropin-regulated testicular RNA helicase (GRTH/Ddx25) is essential for spermatid development and completion of spermatogenesis
Chon-Hwa Tsai-Morris, Yi Sheng, Eric Lee, Ke-Jian Lei, and Maria L. Dufau
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6373–6378. Published online 2004 April 19. doi: 10.1073/pnas.0401855101.
PMCID: PMC404052
Small Maf proteins serve as transcriptional cofactors for keratinocyte differentiation in the Keap1–Nrf2 regulatory pathway
Hozumi Motohashi, Fumiki Katsuoka, James Douglas Engel, and Masayuki Yamamoto
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6379–6384. Published online 2004 April 15. doi: 10.1073/pnas.0305902101.
PMCID: PMC404053
BofA protein inhibits intramembrane proteolysis of pro-σK in an intercompartmental signaling pathway during Bacillus subtilis sporulation
Ruanbao Zhou and Lee Kroos
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6385–6390. Published online 2004 April 15. doi: 10.1073/pnas.0307709101.
PMCID: PMC404054
Escherichia coli nucleoside diphosphate kinase does not act as a uracil-processing DNA repair nuclease
Samuel E. Bennett, Cheng-Yao Chen, and Dale W. Mosbaugh
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6391–6396. Published online 2004 April 19. doi: 10.1073/pnas.0401031101.
PMCID: PMC404055
Semisynthesis of a segmental isotopically labeled protein splicing precursor: NMR evidence for an unusual peptide bond at the N-extein–intein junction
Alessandra Romanelli, Alexander Shekhtman, David Cowburn, and Tom W. Muir
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6397–6402. Published online 2004 April 15. doi: 10.1073/pnas.0306616101.
PMCID: PMC404056
From the Cover:
Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation
Ellen A. A. Nollen, Susana M. Garcia, Gijs van Haaften, Soojin Kim, Alejandro Chavez, Richard I. Morimoto, and Ronald H. A. Plasterk
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6403–6408. Published online 2004 April 14. doi: 10.1073/pnas.0307697101.
PMCID: PMC404057
Stearoyl-CoA desaturase 1 deficiency increases fatty acid oxidation by activating AMP-activated protein kinase in liver
Pawel Dobrzyn, Agnieszka Dobrzyn, Makoto Miyazaki, Paul Cohen, Esra Asilmaz, D. Grahame Hardie, Jeffrey M. Friedman, and James M. Ntambi
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6409–6414. Published online 2004 April 19. doi: 10.1073/pnas.0401627101.
PMCID: PMC404058
A signal-arrest-release sequence mediates export and control of the phage P1 endolysin
Min Xu, Douglas K. Struck, John Deaton, Ing-Nang Wang, and Ry Young
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6415–6420. Published online 2004 April 16. doi: 10.1073/pnas.0400957101.
PMCID: PMC404059
New RNA motifs suggest an expanded scope for riboswitches in bacterial genetic control
Jeffrey E. Barrick, Keith A. Corbino, Wade C. Winkler, Ali Nahvi, Maumita Mandal, Jennifer Collins, Mark Lee, Adam Roth, Narasimhan Sudarsan, Inbal Jona, J. Kenneth Wickiser, and Ronald R. Breaker
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6421–6426. Published online 2004 April 19. doi: 10.1073/pnas.0308014101.
PMCID: PMC404060
Modulation of mammalian cell growth and death by prokaryotic and eukaryotic cytochrome c
Yoshinori Hiraoka, Tohru Yamada, Masatoshi Goto, Tapas K. Das Gupta, and Ananda M. Chakrabarty
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6427–6432. Published online 2004 April 13. doi: 10.1073/pnas.0401631101.
PMCID: PMC404061
Biophysics
Counteraction of urea-induced protein denaturation by trimethylamine N-oxide: A chemical chaperone at atomic resolution
Brian J. Bennion and Valerie Daggett
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6433–6438. Published online 2004 April 19. doi: 10.1073/pnas.0308633101.
PMCID: PMC404062
Single-molecule assay reveals strand switching and enhanced processivity of UvrD
Marie-Noëlle Dessinges, Timothée Lionnet, Xu Guang Xi, David Bensimon, and Vincent Croquette
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6439–6444. Published online 2004 April 12. doi: 10.1073/pnas.0306713101.
PMCID: PMC404063
Stochastic model of protein–protein interaction: Why signaling proteins need to be colocalized
Nizar N. Batada, Larry A. Shepp, and David O. Siegmund
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6445–6449. Published online 2004 April 19. doi: 10.1073/pnas.0401314101.
PMCID: PMC404064
Demonstration of a low-energy on-pathway intermediate in a fast-folding protein by kinetics, protein engineering, and simulation
Per Jemth, Stefano Gianni, Ryan Day, Bin Li, Christopher M. Johnson, Valerie Daggett, and Alan R. Fersht
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6450–6455. Published online 2004 April 19. doi: 10.1073/pnas.0401732101.
PMCID: PMC404065
Simulations of the role of water in the protein-folding mechanism
Young Min Rhee, Eric J. Sorin, Guha Jayachandran, Erik Lindahl, and Vijay S. Pande
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6456–6461. Published online 2004 April 16. doi: 10.1073/pnas.0307898101.
PMCID: PMC404066
Single-molecule high-resolution imaging with photobleaching
Matthew P. Gordon, Taekjip Ha, and Paul R. Selvin
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6462–6465. Published online 2004 April 19. doi: 10.1073/pnas.0401638101.
PMCID: PMC404067
Freezing immunoglobulins to see them move
L. Bongini, D. Fanelli, F. Piazza, P. De Los Rios, S. Sandin, and U. Skoglund
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6466–6471. Published online 2004 April 13. doi: 10.1073/pnas.0400119101.
PMCID: PMC404068
Cell Biology
The estrogen-related receptor α (ERRα) functions in PPARγ coactivator 1α (PGC-1α)-induced mitochondrial biogenesis
Sylvia N. Schreiber, Roger Emter, M. Benjamin Hock, Darko Knutti, Jessica Cardenas, Michael Podvinec, Edward J. Oakeley, and Anastasia Kralli
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6472–6477. Published online 2004 April 15. doi: 10.1073/pnas.0308686101.
PMCID: PMC404069
The Six1 homeoprotein stimulates tumorigenesis by reactivation of cyclin A1
Ricardo D. Coletta, Kimberly Christensen, Kelly J. Reichenberger, Justin Lamb, Damian Micomonaco, Lili Huang, Douglas M. Wolf, Carsten Müller-Tidow, Todd R. Golub, Kiyoshi Kawakami, and Heide L. Ford
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6478–6483. Published online 2004 April 26. doi: 10.1073/pnas.0401139101.
PMCID: PMC404070
Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation
Shiaw-Yih Lin, Kaiyi Li, Grant S. Stewart, and Stephen J. Elledge
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6484–6489. Published online 2004 April 19. doi: 10.1073/pnas.0401847101.
PMCID: PMC404071
Lactosylceramide recruits PKCα/ε and phospholipase A2 to stimulate PECAM-1 expression in human monocytes and adhesion to endothelial cells
NanLing Gong, Heming Wei, Sanaul Haq Chowdhury, and Subroto Chatterjee
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6490–6495. Published online 2004 April 14. doi: 10.1073/pnas.0308684101.
PMCID: PMC404072
Developmental Biology
Irregular telomeres impair meiotic synapsis and recombination in mice
Lin Liu, Sonia Franco, Barbara Spyropoulos, Peter B. Moens, Maria A. Blasco, and David L. Keefe
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6496–6501. Published online 2004 April 14. doi: 10.1073/pnas.0400755101.
PMCID: PMC404073
Essential role of Sox9 in the pathway that controls formation of cardiac valves and septa
Haruhiko Akiyama, Marie-Christine Chaboissier, Richard R. Behringer, David H. Rowitch, Andreas Schedl, Jonathan A. Epstein, and Benoit de Crombrugghe
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6502–6507. Published online 2004 April 19. doi: 10.1073/pnas.0401711101.
PMCID: PMC404074
Lineage specificity of gene expression patterns
Yuval Kluger, David P. Tuck, Joseph T. Chang, Yasuhiro Nakayama, Ranjana Poddar, Naohiko Kohya, Zheng Lian, Abdelhakim Ben Nasr, H. Ruth Halaban, Diane S. Krause, Xueqing Zhang, Peter E. Newburger, and Sherman M. Weissman
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6508–6513. Published online 2004 April 19. doi: 10.1073/pnas.0401136101.
PMCID: PMC404075
Evolution
Giant tortoises are not so slow: Rapid diversification and biogeographic consensus in the Galápagos
Luciano B. Beheregaray, James P. Gibbs, Nathan Havill, Thomas H. Fritts, Jeffrey R. Powell, and Adalgisa Caccone
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6514–6519. Published online 2004 April 14. doi: 10.1073/pnas.0400393101.
PMCID: PMC404076
Persistence of an extreme sex-ratio bias in a natural population
Emily A. Dyson and Gregory D. D. Hurst
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6520–6523. Published online 2004 April 15. doi: 10.1073/pnas.0304068101.
PMCID: PMC404077
Transgenic study of parallelism in plant morphological evolution
Ho-Sung Yoon and David A. Baum
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6524–6529. Published online 2004 April 19. doi: 10.1073/pnas.0401824101.
PMCID: PMC404078
Polyandry in a marine turtle: Females make the best of a bad job
Patricia L. M. Lee and Graeme C. Hays
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6530–6535. Published online 2004 April 19. doi: 10.1073/pnas.0307982101.
PMCID: PMC404079
Estimating metazoan divergence times with a molecular clock
Kevin J. Peterson, Jessica B. Lyons, Kristin S. Nowak, Carter M. Takacs, Matthew J. Wargo, and Mark A. McPeek
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6536–6541. Published online 2004 April 14. doi: 10.1073/pnas.0401670101.
PMCID: PMC404080
Human centromere repositioning “in progress”
David J. Amor, Karen Bentley, Jacinta Ryan, Jo Perry, Lee Wong, Howard Slater, and K. H. Andy Choo
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6542–6547. Published online 2004 April 14. doi: 10.1073/pnas.0308637101.
PMCID: PMC404081
Genetics
RNA interference microarrays: High-throughput loss-of-function genetics in mammalian cells
Jose M. Silva, Hana Mizuno, Amy Brady, Robert Lucito, and Gregory J. Hannon
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6548–6552. Published online 2004 April 14. doi: 10.1073/pnas.0400165101.
PMCID: PMC404082
From the Cover:
Suppressor screen in Mpl-/- mice: c-Myb mutation causes supraphysiological production of platelets in the absence of thrombopoietin signaling
Marina R. Carpinelli, Douglas J. Hilton, Donald Metcalf, Jennifer L. Antonchuk, Craig D. Hyland, Sandra L. Mifsud, Ladina Di Rago, Adrienne A. Hilton, Tracy A. Willson, Andrew W. Roberts, Robert G. Ramsay, Nicos A. Nicola, and Warren S. Alexander
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6553–6558. Published online 2004 April 7. doi: 10.1073/pnas.0401496101.
PMCID: PMC404083
Protein ranking: From local to global structure in the protein similarity network
Jason Weston, Andre Elisseeff, Dengyong Zhou, Christina S. Leslie, and William Stafford Noble
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6559–6563. Published online 2004 April 15. doi: 10.1073/pnas.0308067101.
PMCID: PMC404084
Cells have distinct mechanisms to maintain protection against different reactive oxygen species: Oxidative-stress-response genes
Geoffrey W. Thorpe, Chii S. Fong, Nazif Alic, Vincent J. Higgins, and Ian W. Dawes
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6564–6569. Published online 2004 April 15. doi: 10.1073/pnas.0305888101.
PMCID: PMC404085
Errα and Gabpa/b specify PGC-1α-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle
Vamsi K. Mootha, Christoph Handschin, Dan Arlow, Xiaohui Xie, Julie St. Pierre, Smita Sihag, Wenli Yang, David Altshuler, Pere Puigserver, Nick Patterson, Patricia J. Willy, Ira G. Schulman, Richard A. Heyman, Eric S. Lander, and Bruce M. Spiegelman
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6570–6575. Published online 2004 April 20. doi: 10.1073/pnas.0401401101.
PMCID: PMC404086
Functional classification of proteins and protein variants
Albert Y. Lau and Daniel I. Chasman
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6576–6581. Published online 2004 April 15. doi: 10.1073/pnas.0305043101.
PMCID: PMC404087
Regulation of ultraviolet light-induced gene expression by gene size
Bruce C. McKay, Lawton J. Stubbert, Casey C. Fowler, Jennifer M. Smith, Robin A. Cardamore, and Jennifer C. Spronck
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6582–6586. Published online 2004 April 15. doi: 10.1073/pnas.0308181101.
PMCID: PMC404088
Immunology
The membrane organization of leukotriene synthesis
Asim K. Mandal, Jesse Skoch, Brian J. Bacskai, Bradley T. Hyman, Peter Christmas, Douglas Miller, Ting-ting D. Yamin, Shihua Xu, Douglas Wisniewski, Jilly F. Evans, and Roy J. Soberman
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6587–6592. Published online 2004 April 14. doi: 10.1073/pnas.0308523101.
PMCID: PMC404089
Requirement for a conserved Toll/interleukin-1 resistance domain protein in the Caenorhabditis elegans immune response
Nicole T. Liberati, Katherine A. Fitzgerald, Dennis H. Kim, Rhonda Feinbaum, Douglas T. Golenbock, and Frederick M. Ausubel
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6593–6598. doi: 10.1073/pnas.0308625101.
PMCID: PMC404090
Fas-disabling small exocyclic peptide mimetics limit apoptosis by an unexpected mechanism
Akihiro Hasegawa, Xin Cheng, Kiichi Kajino, Alan Berezov, Kaoru Murata, Toshinori Nakayama, Hideo Yagita, Ramachandran Murali, and Mark I. Greene
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6599–6604. Published online 2004 April 14. doi: 10.1073/pnas.0401597101.
PMCID: PMC404091
Medical Sciences
Identification of the antivasopermeability effect of pigment epithelium-derived factor and its active site
Hua Liu, Jian-Guo Ren, William L. Cooper, Charles E. Hawkins, Mitra R. Cowan, and Patrick Y. Tong
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6605–6610. Published online 2004 April 19. doi: 10.1073/pnas.0308342101.
PMCID: PMC404092
Expression of the cellular FLICE-inhibitory protein (c-FLIP) protects Hodgkin's lymphoma cells from autonomous Fas-mediated death
A. Dutton, J. D. O'Neil, A. E. Milner, G. M. Reynolds, J. Starczynski, J. Crocker, L. S. Young, and P. G. Murray
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6611–6616. Published online 2004 April 19. doi: 10.1073/pnas.0400765101.
PMCID: PMC404093
Apoptosis-inducing signal sequence mutation in carbonic anhydrase IV identified in patients with the RP17 form of retinitis pigmentosa
George Rebello, Rajkumar Ramesar, Alvera Vorster, Lisa Roberts, Liezle Ehrenreich, Ekow Oppon, Dumisani Gama, Soraya Bardien, Jacquie Greenberg, Giuseppe Bonapace, Abdul Waheed, Gul N. Shah, and William S. Sly
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6617–6622. Published online 2004 April 16. doi: 10.1073/pnas.0401529101.
PMCID: PMC404094
Dissecting the pathological effects of human Aβ40 and Aβ42 in Drosophila: A potential model for Alzheimer's disease
Koichi Iijima, Hsin-Ping Liu, Ann-Shyn Chiang, Stephen A. Hearn, Mary Konsolaki, and Yi Zhong
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6623–6628. Published online 2004 April 6. doi: 10.1073/pnas.0400895101.
PMCID: PMC404095
Suppression of tumor growth and cell proliferation by p13II, a mitochondrial protein of human T cell leukemia virus type 1
Micol Silic-Benussi, Ilaria Cavallari, Tatiana Zorzan, Elisabetta Rossi, Hajime Hiraragi, Antonio Rosato, Kyoji Horie, Daniela Saggioro, Michael D. Lairmore, Luc Willems, Luigi Chieco-Bianchi, Donna M. D'Agostino, and Vincenzo Ciminale
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6629–6634. Published online 2004 April 20. doi: 10.1073/pnas.0305502101.
PMCID: PMC404096
Toxicity from radiation therapy associated with abnormal transcriptional responses to DNA damage
Kerri E. Rieger, Wan-Jen Hong, Virginia Goss Tusher, Jean Tang, Robert Tibshirani, and Gilbert Chu
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6635–6640. Published online 2004 April 19. doi: 10.1073/pnas.0307761101.
PMCID: PMC404097
Severe acute respiratory syndrome coronavirus spike protein expressed by attenuated vaccinia virus protectively immunizes mice
Himani Bisht, Anjeanette Roberts, Leatrice Vogel, Alexander Bukreyev, Peter L. Collins, Brian R. Murphy, Kanta Subbarao, and Bernard Moss
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6641–6646. Published online 2004 April 19. doi: 10.1073/pnas.0401939101.
PMCID: PMC404098
Requirement for Arf6 in breast cancer invasive activities
Shigeru Hashimoto, Yasuhito Onodera, Ari Hashimoto, Miwa Tanaka, Michinari Hamaguchi, Atsuko Yamada, and Hisataka Sabe
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6647–6652. Published online 2004 April 15. doi: 10.1073/pnas.0401753101.
PMCID: PMC404099
Tob deficiency superenhances osteoblastic activity after ovariectomy to block estrogen deficiency-induced osteoporosis
Michihiko Usui, Yutaka Yoshida, Kunikazu Tsuji, Kaoru Oikawa, Kohei Miyazono, Isao Ishikawa, Tadashi Yamamoto, Akira Nifuji, and Masaki Noda
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6653–6658. Published online 2004 April 20. doi: 10.1073/pnas.0303093101.
PMCID: PMC404100
Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans
Luigi Fontana, Timothy E. Meyer, Samuel Klein, and John O. Holloszy
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6659–6663. Published online 2004 April 19. doi: 10.1073/pnas.0308291101.
PMCID: PMC404101
Microbiology
Pseudomonas aeruginosa regulates flagellin expression as part of a global response to airway fluid from cystic fibrosis patients
Matthew C. Wolfgang, Jeevan Jyot, Andrew L. Goodman, Reuben Ramphal, and Stephen Lory
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6664–6668. Published online 2004 April 14. doi: 10.1073/pnas.0307553101.
PMCID: PMC404102
Genomic analysis of the host response to hepatitis B virus infection
Stefan Wieland, Robert Thimme, Robert H. Purcell, and Francis V. Chisari
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6669–6674. Published online 2004 April 20. doi: 10.1073/pnas.0401771101.
PMCID: PMC404103
Ancestral hemoglobins in Archaea
Tracey Allen K. Freitas, Shaobin Hou, Elhadji M. Dioum, Jennifer A. Saito, James Newhouse, Gonzalo Gonzalez, Marie-Alda Gilles-Gonzalez, and Maqsudul Alam
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6675–6680. Published online 2004 April 19. doi: 10.1073/pnas.0308657101.
PMCID: PMC404104
A modular minimal cell model: Purine and pyrimidine transport and metabolism
M. Castellanos, D. B. Wilson, and M. L. Shuler
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6681–6686. Published online 2004 April 16. doi: 10.1073/pnas.0400962101.
PMCID: PMC404105
Neuroscience
Bistable UV pigment in the lamprey pineal
Mitsumasa Koyanagi, Emi Kawano, Yoshimi Kinugawa, Tadashi Oishi, Yoshinori Shichida, Satoshi Tamotsu, and Akihisa Terakita
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6687–6691. Published online 2004 April 19. doi: 10.1073/pnas.0400819101.
PMCID: PMC404106
Improving vision in adult amblyopia by perceptual learning
Uri Polat, Tova Ma-Naim, Michael Belkin, and Dov Sagi
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6692–6697. Published online 2004 April 19. doi: 10.1073/pnas.0401200101.
PMCID: PMC404107
Fibrin depletion decreases inflammation and delays the onset of demyelination in a tumor necrosis factor transgenic mouse model for multiple sclerosis
Katerina Akassoglou, Ryan A. Adams, Jan Bauer, Peter Mercado, Vivian Tseveleki, Hans Lassmann, Lesley Probert, and Sidney Strickland
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6698–6703. Published online 2004 April 19. doi: 10.1073/pnas.0303859101.
PMCID: PMC404108
Corazonin receptor signaling in ecdysis initiation
Young-Joon Kim, Ivana Spalovská-Valachová, Kook-Ho Cho, Inka Zitnanova, Yoonseong Park, Michael E. Adams, and Dušan Žitňan
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6704–6709. Published online 2004 April 19. doi: 10.1073/pnas.0305291101.
PMCID: PMC404109
The anatomy of semantic knowledge: Medial vs. lateral temporal lobe
D. A. Levy, P. J. Bayley, and L. R. Squire
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6710–6715. Published online 2004 April 16. doi: 10.1073/pnas.0401679101.
PMCID: PMC404110
Histamine modulates thalamocortical activity by activating a chloride conductance in ferret perigeniculate neurons
Kendall H. Lee, Christian Broberger, Uhnoh Kim, and David A. McCormick
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6716–6721. Published online 2004 April 19. doi: 10.1073/pnas.0400817101.
PMCID: PMC404111
Cooperative synchronized assemblies enhance orientation discrimination
Jason M. Samonds, John D. Allison, Heather A. Brown, and A. B. Bonds
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6722–6727. Published online 2004 April 19. doi: 10.1073/pnas.0401661101.
PMCID: PMC404112
Cyclin-dependent kinase 5 phosphorylates signal transducer and activator of transcription 3 and regulates its transcriptional activity
Amy K. Y. Fu, Wing-Yu Fu, Alberto K. Y. Ng, Winnie W. Y. Chien, Yu-Pong Ng, Jerry H. Wang, and Nancy Y. Ip
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6728–6733. Published online 2004 April 19. doi: 10.1073/pnas.0307606100.
PMCID: PMC404113
From the Cover:
11β-Hydroxysteroid dehydrogenase inhibition improves cognitive function in healthy elderly men and type 2 diabetics
Thekkepat C. Sandeep, Joyce L. W. Yau, Alasdair M. J. MacLullich, June Noble, Ian J. Deary, Brian R. Walker, and Jonathan R. Seckl
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6734–6739. Published online 2004 April 7. doi: 10.1073/pnas.0306996101.
PMCID: PMC404114
Reconstruction of in vivo time-evolving neuroendocrine dose–response properties unveils admixed deterministic and stochastic elements
Daniel M. Keenan, Susan Alexander, Clifford H. G. Irvine, Iain Clarke, Chris Scott, Anne Turner, A. J. Tilbrook, B. J. Canny, and Johannes D. Veldhuis
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6740–6745. Published online 2004 April 16. doi: 10.1073/pnas.0300619101.
PMCID: PMC404115
Evidence for two distinct binding sites for tau on microtubules
Victoria Makrides, Michelle R. Massie, Stuart C. Feinstein, and John Lew
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6746–6751. Published online 2004 April 19. doi: 10.1073/pnas.0400992101.
PMCID: PMC404116
Extracellular acidosis increases neuronal cell calcium by activating acid-sensing ion channel 1a
Olena Yermolaieva, A. Soren Leonard, Mikael K. Schnizler, Francois M. Abboud, and Michael J. Welsh
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6752–6757. Published online 2004 April 13. doi: 10.1073/pnas.0308636100.
PMCID: PMC404117
Human posterior auditory cortex gates novel sounds to consciousness
Iiro P. Jääskeläinen, Jyrki Ahveninen, Giorgio Bonmassar, Anders M. Dale, Risto J. Ilmoniemi, Sari Levänen, Fa-Hsuan Lin, Patrick May, Jennifer Melcher, Steven Stufflebeam, Hannu Tiitinen, and John W. Belliveau
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6809–6814. Published online 2004 April 19. doi: 10.1073/pnas.0303760101.
PMCID: PMC404127
Pharmacology
Activation of dopamine D4 receptors by ABT-724 induces penile erection in rats
Jorge D. Brioni, Robert B. Moreland, Marlon Cowart, Gin C. Hsieh, Andrew O. Stewart, Petter Hedlund, Diana L. Donnelly-Roberts, Masaki Nakane, James J. Lynch, III, Teodozyi Kolasa, James S. Polakowski, Mark A. Osinski, Kennan Marsh, Karl-Erik Andersson, and James P. Sullivan
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6758–6763. Published online 2004 April 15. doi: 10.1073/pnas.0308292101.
PMCID: PMC404118
Physiology
Isotopolog perturbation techniques for metabolic networks: Metabolic recycling of nutritional glucose in Drosophila melanogaster
Wolfgang Eisenreich, Christian Ettenhuber, Ralf Laupitz, Cornelia Theus, and Adelbert Bacher
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6764–6769. Published online 2004 April 19. doi: 10.1073/pnas.0400916101.
PMCID: PMC404119
A role of reactive oxygen species in apoptotic activation of volume-sensitive Cl- channel
Takahiro Shimizu, Tomohiro Numata, and Yasunobu Okada
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6770–6773. Published online 2004 April 19. doi: 10.1073/pnas.0401604101.
PMCID: PMC404120
Zymogen granule exocytosis is characterized by long fusion pore openings and preservation of vesicle lipid identity
Peter Thorn, Kevin E. Fogarty, and Ian Parker
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6774–6779. Published online 2004 April 16. doi: 10.1073/pnas.0400336101.
PMCID: PMC404121
Dominant inhibitory adipocyte-specific secretory factor (ADSF)/resistin enhances adipogenesis and improves insulin sensitivity
Kee-Hong Kim, Ling Zhao, Yangsoo Moon, Chulho Kang, and Hei Sook Sul
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6780–6785. Published online 2004 April 16. doi: 10.1073/pnas.0305905101.
PMCID: PMC404122
Plant Biology
Engineering tropane biosynthetic pathway in Hyoscyamus niger hairy root cultures
Lei Zhang, Ruxian Ding, Yourong Chai, Mercedes Bonfill, Elisabet Moyano, Kirsi-Marja Oksman-Caldentey, Tiefeng Xu, Yan Pi, Zinan Wang, Hanming Zhang, Guoyin Kai, Zhihua Liao, Xiaofen Sun, and Kexuan Tang
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6786–6791. Published online 2004 April 14. doi: 10.1073/pnas.0401391101.
PMCID: PMC404123
Arabidopsis thaliana has the enzymatic machinery for replicating representative viroid species of the family Pospiviroidae
José-Antonio Daròs and Ricardo Flores
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6792–6797. Published online 2004 April 19. doi: 10.1073/pnas.0401090101.
PMCID: PMC404124
The Arabidopsis repressor of light signaling, COP1, is regulated by nuclear exclusion: Mutational analysis by bioluminescence resonance energy transfer
Chitra Subramanian, Byung-Hoon Kim, Nicholas N. Lyssenko, Xiaodong Xu, Carl Hirschie Johnson, and Albrecht G. von Arnim
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6798–6802. Published online 2004 April 14. doi: 10.1073/pnas.0307964101.
PMCID: PMC404125
Arabidopsis EIN3-binding F-box 1 and 2 form ubiquitin-protein ligases that repress ethylene action and promote growth by directing EIN3 degradation
Jennifer M. Gagne, Jan Smalle, Derek J. Gingerich, Joseph M. Walker, Sang-Dong Yoo, Shuichi Yanagisawa, and Richard D. Vierstra
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6803–6808. Published online 2004 April 16. doi: 10.1073/pnas.0401698101.
PMCID: PMC404126
Psychology
Human posterior auditory cortex gates novel sounds to consciousness
Iiro P. Jääskeläinen, Jyrki Ahveninen, Giorgio Bonmassar, Anders M. Dale, Risto J. Ilmoniemi, Sari Levänen, Fa-Hsuan Lin, Patrick May, Jennifer Melcher, Steven Stufflebeam, Hannu Tiitinen, and John W. Belliveau
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6809–6814. Published online 2004 April 19. doi: 10.1073/pnas.0303760101.
PMCID: PMC404127
Brain networks underlying human timing behavior are influenced by prior context
Kelly J. Jantzen, Fred L. Steinberg, and J. A. Scott Kelso
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6815–6820. Published online 2004 April 12. doi: 10.1073/pnas.0401300101.
PMCID: PMC404128
Social Sciences
Anthropology
From the Cover:
Stone Age hut in Israel yields world's oldest evidence of bedding
Dani Nadel, Ehud Weiss, Orit Simchoni, Alexander Tsatskin, Avinoam Danin, and Mordechai Kislev
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6821–6826. Published online 2004 April 16. doi: 10.1073/pnas.0308557101.
PMCID: PMC404215
Psychology
Parietal cortex and representation of the mental Self
Hans C. Lou, Bruce Luber, Michael Crupain, Julian P. Keenan, Markus Nowak, Troels W. Kjaer, Harold A. Sackeim, and Sarah H. Lisanby
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6827–6832. Published online 2004 April 19. doi: 10.1073/pnas.0400049101.
PMCID: PMC404216
Corrections
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6833. doi: 10.1073/pnas.0402075101.
PMCID: PMC404131
Corrects: Jacob B. Hansen, et al. Retinoblastoma protein functions as a molecular switch determining white versus brown adipocyte differentiation. Proc Natl Acad Sci U S A. 2004 March 23; 101(12): 4112–4117.
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6833. doi: 10.1073/pnas.0401856101.
PMCID: PMC404132
Corrects: Patricia V. Burgos, et al. Cholesterol depletion induces PKA-mediated basolateral-to-apical transcytosis of the scavenger receptor class B type I in MDCK cells. Proc Natl Acad Sci U S A. 2004 March 16; 101(11): 3845–3850.
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6834. doi: 10.1073/pnas.0401763101.
PMCID: PMC404133
Corrects: Sharon Cantor, et al. The BRCA1-associated protein BACH1 is a DNA helicase targeted by clinically relevant inactivating mutations. Proc Natl Acad Sci U S A. 2004 February 24; 101(8): 2357–2362.
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6834. doi: 10.1073/pnas.0401899101.
PMCID: PMC404134
Corrects: Frederik W. van Ginkel, et al. Pneumococcal carriage results in ganglioside-mediated olfactory tissue infection. Proc Natl Acad Sci U S A. 2003 November 25; 100(24): 14363–14367.
Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6834. doi: 10.1073/pnas.0402005101.
PMCID: PMC404135
Corrects: Kenolisa C. Onwueme, et al. Mycobacterial polyketide-associated proteins are acyltransferases: Proof of principle with Mycobacterium tuberculosis PapA5. Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4608–4613.
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