| | This journal provides immediate access to some articles. Anthropology INAUGURAL ARTICLE by a Recently Elected Academy Member: Biography of Richard G. Klein Erica Klarreich PMCID: PMC395972 Commentaries Return of calcium: Manipulating intracellular calcium to prevent cardiac pathologies Yibin Wang and Joshua I. Goldhaber PMCID: PMC395854 Circadian lessons from peripheral clocks: Is the time of the mammalian pacemaker up? Roland Brandstaetter PMCID: PMC395855 A possible therapeutic target for Lou Gehrig's disease Soumya S. Ray and Peter T. Lansbury, Jr. PMCID: PMC395856 Death of injured neurons caused by the precursor of nerve growth factor Y.-A. Barde PMCID: PMC395857 Asymmetric Catalysis Special Feature Part II Research Articles Zr[bis(salicylidene)ethylenediaminato]-mediated Baeyer–Villiger oxidation: Stereospecific synthesis of abnormal and normal lactones Akira Watanabe, Tatsuya Uchida, Ryo Irie, and Tsutomu Katsuki PMCID: PMC395977 Epoxidation of unfunctionalized olefins by Mn(salen) catalyst using organic peracids as oxygen source: A theoretical study Ilja V. Khavrutskii, Djamaladdin G. Musaev, and Keiji Morokuma PMCID: PMC395978 Cu(I)-catalyzed direct addition and asymmetric addition of terminal alkynes to imines Chunmei Wei, Joel T. Mague, and Chao-Jun Li PMCID: PMC395979 Enantioselective direct aldol reactions catalyzed by l-prolinamide derivatives Zhuo Tang, Fan Jiang, Xin Cui, Liu-Zhu Gong, Ai-Qiao Mi, Yao-Zhong Jiang, and Yun-Dong Wu PMCID: PMC395980 One-pot synthesis of enantiopure syn-1,3-diacetates from racemic syn/anti mixtures of 1,3-diols by dynamic kinetic asymmetric transformation Michaela Edin, Johannes Steinreiber, and Jan-E. Bäckvall PMCID: PMC395981 Palladium-catalyzed carbocyclization of 1,6-enynes leading to six-membered rings or oxidized five-membered trifluoroacetates Koichi Mikami and Manabu Hatano PMCID: PMC395982 Computational predictions of stereochemistry in asymmetric thiazolium- and triazolium-catalyzed benzoin condensations Travis Dudding and Kendall N. Houk PMCID: PMC395983 An efficient asymmetric synthesis of an estrogen receptor modulator by sulfoxide-directed borane reduction Zhiguo J. Song, Anthony O. King, Marjorie S. Waters, Fengrui Lang, Daniel Zewge, Matthew Bio, Johnnie L. Leazer, Jr., Gary Javadi, Amude Kassim, David M. Tschaen, Robert A. Reamer, Thorsten Rosner, Jennifer R. Chilenski, David J. Mathre, R. P. Volante, and Richard Tillyer PMCID: PMC395984 An efficient and general route to reduced polypropionates via Zr-catalyzed asymmetric C—C bond formation Ei-ichi Negishi, Ze Tan, Bo Liang, and Tibor Novak PMCID: PMC395985 Development of an efficient, scalable, aldolase-catalyzed process for enantioselective synthesis of statin intermediates William A. Greenberg, Alexander Varvak, Sarah R. Hanson, Kelvin Wong, Hongjun Huang, Pei Chen, and Mark J. Burk PMCID: PMC395986 Highly enantioselective epoxidation of styrenes: Implication of an electronic effect on the competition between spiro and planar transition states Matthew Hickey, David Goeddel, Zackary Crane, and Yian Shi PMCID: PMC395987 Chiral biphenyl diphosphines for asymmetric catalysis: Stereoelectronic design and industrial perspectives Séverine Jeulin, Sébastien Duprat de Paule, Virginie Ratovelomanana-Vidal, Jean-Pierre Genêt, Nicolas Champion, and Philippe Dellis PMCID: PMC395988 Mo-catalyzed asymmetric olefin metathesis in target-oriented synthesis: Enantioselective synthesis of (+)-africanol Gabriel S. Weatherhead, G. A. Cortez, Richard R. Schrock, and Amir H. Hoveyda PMCID: PMC395989 Expanding the scope of asymmetric electrophilic atom-transfer reactions: Titanium- and ruthenium-catalyzed hydroxylation of β-ketoesters Patrick Y. Toullec, Cristina Bonaccorsi, Antonio Mezzetti, and Antonio Togni PMCID: PMC395990 Remarkably diastereoselective synthesis of a chiral biphenyl diphosphine ligand and its application in asymmetric hydrogenation Liqin Qiu, Jing Wu, Shusun Chan, Terry T.-L. Au-Yeung, Jian-Xin Ji, Rongwei Guo, Cheng-Chao Pai, Zhongyuan Zhou, Xingshu Li, Qing-Hua Fan, and Albert S. C. Chan PMCID: PMC395991 Copper-catalyzed asymmetric conjugate reduction as a route to novel β-azaheterocyclic acid derivatives Matthew P. Rainka, Yimon Aye, and Stephen L. Buchwald PMCID: PMC395992 Stereoselective terminal functionalization of small peptides for catalytic asymmetric synthesis of unnatural peptides Keiji Maruoka, Eiji Tayama, and Takashi Ooi PMCID: PMC395993 Editing the stereochemical elements in an iridium catalyst for enantioselective allylic amination Andreas Leitner, Chutian Shu, and John F. Hartwig PMCID: PMC395994 Copper-catalyzed asymmetric conjugate addition of Grignard reagents to cyclic enones Ben L. Feringa, Ramón Badorrey, Diego Peña, Syuzanna R. Harutyunyan, and Adriaan J. Minnaard PMCID: PMC395995 New mechanistic studies on the proline-catalyzed aldol reaction Benjamin List, Linh Hoang, and Harry J. Martin PMCID: PMC395996 Infrared spectroscopic investigations on the metallation of terminal alkynes by Zn(OTf)2 Roger Fässler, Craig S. Tomooka, Doug E. Frantz, and Erick M. Carreira PMCID: PMC395997 Enantioselective Diels–Alder reactions catalyzed by hydrogen bonding Avinash N. Thadani, Ana R. Stankovic, and Viresh H. Rawal PMCID: PMC395998 Perspective Controlling the enantioselectivity of enzymes by directed evolution: Practical and theoretical ramifications Manfred T. Reetz PMCID: PMC395973 Design of chiral ligands for asymmetric catalysis: From C2-symmetric P,P- and N,N-ligands to sterically and electronically nonsymmetrical P,N-ligands Andreas Pfaltz and William J. Drury, III PMCID: PMC395974 Asymmetric autocatalysis: Novel structures, novel mechanism? Ilya D. Gridnev and John M. Brown PMCID: PMC395975 Asymmetric autocatalysis and its implications for the origin of homochirality Donna G. Blackmond PMCID: PMC395976 Physical Sciences Applied Physical Sciences Nanohydrodynamics simulations: An atomistic view of the Rayleigh–Taylor instability Kai Kadau, Timothy C. Germann, Nicolas G. Hadjiconstantinou, Peter S. Lomdahl, Guy Dimonte, Brad Lee Holian, and Berni J. Alder PMCID: PMC395886 Optics at critical intensity: Applications to nanomorphing Ajit P. Joglekar, Hsiao-hua Liu, Edgar Meyhöfer, Gerard Mourou, and Alan J. Hunt PMCID: PMC395887 Chemistry Zr[bis(salicylidene)ethylenediaminato]-mediated Baeyer–Villiger oxidation: Stereospecific synthesis of abnormal and normal lactones Akira Watanabe, Tatsuya Uchida, Ryo Irie, and Tsutomu Katsuki PMCID: PMC395977 Epoxidation of unfunctionalized olefins by Mn(salen) catalyst using organic peracids as oxygen source: A theoretical study Ilja V. Khavrutskii, Djamaladdin G. Musaev, and Keiji Morokuma PMCID: PMC395978 Cu(I)-catalyzed direct addition and asymmetric addition of terminal alkynes to imines Chunmei Wei, Joel T. Mague, and Chao-Jun Li PMCID: PMC395979 Enantioselective direct aldol reactions catalyzed by l-prolinamide derivatives Zhuo Tang, Fan Jiang, Xin Cui, Liu-Zhu Gong, Ai-Qiao Mi, Yao-Zhong Jiang, and Yun-Dong Wu PMCID: PMC395980 One-pot synthesis of enantiopure syn-1,3-diacetates from racemic syn/anti mixtures of 1,3-diols by dynamic kinetic asymmetric transformation Michaela Edin, Johannes Steinreiber, and Jan-E. Bäckvall PMCID: PMC395981 Palladium-catalyzed carbocyclization of 1,6-enynes leading to six-membered rings or oxidized five-membered trifluoroacetates Koichi Mikami and Manabu Hatano PMCID: PMC395982 Computational predictions of stereochemistry in asymmetric thiazolium- and triazolium-catalyzed benzoin condensations Travis Dudding and Kendall N. Houk PMCID: PMC395983 An efficient asymmetric synthesis of an estrogen receptor modulator by sulfoxide-directed borane reduction Zhiguo J. Song, Anthony O. King, Marjorie S. Waters, Fengrui Lang, Daniel Zewge, Matthew Bio, Johnnie L. Leazer, Jr., Gary Javadi, Amude Kassim, David M. Tschaen, Robert A. Reamer, Thorsten Rosner, Jennifer R. Chilenski, David J. Mathre, R. P. Volante, and Richard Tillyer PMCID: PMC395984 An efficient and general route to reduced polypropionates via Zr-catalyzed asymmetric C—C bond formation Ei-ichi Negishi, Ze Tan, Bo Liang, and Tibor Novak PMCID: PMC395985 Development of an efficient, scalable, aldolase-catalyzed process for enantioselective synthesis of statin intermediates William A. Greenberg, Alexander Varvak, Sarah R. Hanson, Kelvin Wong, Hongjun Huang, Pei Chen, and Mark J. Burk PMCID: PMC395986 Highly enantioselective epoxidation of styrenes: Implication of an electronic effect on the competition between spiro and planar transition states Matthew Hickey, David Goeddel, Zackary Crane, and Yian Shi PMCID: PMC395987 Chiral biphenyl diphosphines for asymmetric catalysis: Stereoelectronic design and industrial perspectives Séverine Jeulin, Sébastien Duprat de Paule, Virginie Ratovelomanana-Vidal, Jean-Pierre Genêt, Nicolas Champion, and Philippe Dellis PMCID: PMC395988 Mo-catalyzed asymmetric olefin metathesis in target-oriented synthesis: Enantioselective synthesis of (+)-africanol Gabriel S. Weatherhead, G. A. Cortez, Richard R. Schrock, and Amir H. Hoveyda PMCID: PMC395989 Expanding the scope of asymmetric electrophilic atom-transfer reactions: Titanium- and ruthenium-catalyzed hydroxylation of β-ketoesters Patrick Y. Toullec, Cristina Bonaccorsi, Antonio Mezzetti, and Antonio Togni PMCID: PMC395990 Remarkably diastereoselective synthesis of a chiral biphenyl diphosphine ligand and its application in asymmetric hydrogenation Liqin Qiu, Jing Wu, Shusun Chan, Terry T.-L. Au-Yeung, Jian-Xin Ji, Rongwei Guo, Cheng-Chao Pai, Zhongyuan Zhou, Xingshu Li, Qing-Hua Fan, and Albert S. C. Chan PMCID: PMC395991 Copper-catalyzed asymmetric conjugate reduction as a route to novel β-azaheterocyclic acid derivatives Matthew P. Rainka, Yimon Aye, and Stephen L. Buchwald PMCID: PMC395992 Stereoselective terminal functionalization of small peptides for catalytic asymmetric synthesis of unnatural peptides Keiji Maruoka, Eiji Tayama, and Takashi Ooi PMCID: PMC395993 Editing the stereochemical elements in an iridium catalyst for enantioselective allylic amination Andreas Leitner, Chutian Shu, and John F. Hartwig PMCID: PMC395994 Copper-catalyzed asymmetric conjugate addition of Grignard reagents to cyclic enones Ben L. Feringa, Ramón Badorrey, Diego Peña, Syuzanna R. Harutyunyan, and Adriaan J. Minnaard PMCID: PMC395995 New mechanistic studies on the proline-catalyzed aldol reaction Benjamin List, Linh Hoang, and Harry J. Martin PMCID: PMC395996 Infrared spectroscopic investigations on the metallation of terminal alkynes by Zn(OTf)2 Roger Fässler, Craig S. Tomooka, Doug E. Frantz, and Erick M. Carreira PMCID: PMC395997 Enantioselective Diels–Alder reactions catalyzed by hydrogen bonding Avinash N. Thadani, Ana R. Stankovic, and Viresh H. Rawal PMCID: PMC395998 Identification of GAPDH as a protein target of the saframycin antiproliferative agents Chengguo Xing, Jacob R. LaPorte, Joseph K. Barbay, and Andrew G. Myers PMCID: PMC395888 Geophysics Shear waves in the diamond-anvil cell reveal pressure-induced instability in (Mg,Fe)O Steven D. Jacobsen, Hartmut Spetzler, Hans J. Reichmann, and Joseph R. Smyth PMCID: PMC395889 Mathematics From the Cover:
Oscillation of functions with a spectral gap A. Eremenko and D. Novikov PMCID: PMC395890 Biological Sciences Agricultural Sciences Two feeding-induced proteins from the male gonad trigger engorgement of the female tick Amblyomma hebraeum Brian L. Weiss and W. Reuben Kaufman PMCID: PMC395891 Long-term effect of in vitro culture of mouse embryos with serum on mRNA expression of imprinting genes, development, and behavior Raúl Fernández-Gonzalez, Pedro Moreira, Ainhoa Bilbao, Adela Jiménez, Miriam Pérez-Crespo, Miguel Angel Ramírez, Fernando Rodríguez De Fonseca, Belén Pintado, and Alfonso Gutiérrez-Adán PMCID: PMC395892 Biochemistry Genetic evidence for nonredundant functional cooperativity between NPC1 and NPC2 in lipid transport David E. Sleat, Jennifer A. Wiseman, Mukarram El-Banna, Sandy M. Price, Lucie Verot, Michael M. Shen, G. Stephen Tint, Marie T. Vanier, Steven U. Walkley, and Peter Lobel PMCID: PMC395893 Structures of nitric oxide synthase isoforms complexed with the inhibitor AR-R17477 suggest a rational basis for specificity and inhibitor design Roman Fedorov, Ryan Vasan, Dipak K. Ghosh, and Ilme Schlichting PMCID: PMC395894 Direct regulation of CREB transcriptional activity by ATM in response to genotoxic stress Yuling Shi, Sujatha L. Venkataraman, Gerald E. Dodson, Angela M. Mabb, Scott LeBlanc, and Randal S. Tibbetts PMCID: PMC395895 Physical and functional association of RNA polymerase II and the proteasome Thomas G. Gillette, Fernando Gonzalez, Agnes Delahodde, Stephen Albert Johnston, and Thomas Kodadek PMCID: PMC395896 Molecular basis for the inhibition of the carboxyltransferase domain of acetyl-coenzyme-A carboxylase by haloxyfop and diclofop Hailong Zhang, Benjamin Tweel, and Liang Tong PMCID: PMC395897 Structural elements responsible for conversion of streptavidin to a pseudoenzyme Yael Eisenberg-Domovich, Yael Pazy, Orit Nir, Bilha Raboy, Edward A. Bayer, Meir Wilchek, and Oded Livnah PMCID: PMC395898 A duplicated motif controls assembly of zona pellucida domain proteins Luca Jovine, Huayu Qi, Zev Williams, Eveline S. Litscher, and Paul M. Wassarman PMCID: PMC395899 Light exposure stimulates formation of A2E oxiranes in a mouse model of Stargardt's macular degeneration Roxana A. Radu, Nathan L. Mata, Aarti Bagla, and Gabriel H. Travis PMCID: PMC395900 Network motifs in integrated cellular networks of transcription–regulation and protein–protein interaction Esti Yeger-Lotem, Shmuel Sattath, Nadav Kashtan, Shalev Itzkovitz, Ron Milo, Ron Y. Pinter, Uri Alon, and Hanah Margalit PMCID: PMC395901 Crystal structure and characterization of a cytochrome c peroxidase–cytochrome c site-specific cross-link Maolin Guo, B. Bhaskar, Huiying Li, Tiffany P. Barrows, and Thomas L. Poulos PMCID: PMC395902 Evidence for the physiological role of a rhodanese-like protein for the biosynthesis of the molybdenum cofactor in humans Andreas Matthies, K. V. Rajagopalan, Ralf R. Mendel, and Silke Leimkühler PMCID: PMC395903 Two RNA polymerase complexes from vesicular stomatitis virus-infected cells that carry out transcription and replication of genome RNA Kaustubha R. Qanungo, Daniel Shaji, Manjula Mathur, and Amiya K. Banerjee PMCID: PMC395904 A domain for editing by an archaebacterial tRNA synthetase Kirk Beebe, Eve Merriman, Lluis Ribas de Pouplana, and Paul Schimmel PMCID: PMC395905 Mechanisms for activating Cu- and Zn-containing superoxide dismutase in the absence of the CCS Cu chaperone Mark C. Carroll, Jody B. Girouard, Janella L. Ulloa, Jamuna R. Subramaniam, Phillip C. Wong, Joan Selverstone Valentine, and Valeria Cizewski Culotta PMCID: PMC395906 Biophysics Orchestration of cooperative events in DNA synthesis and repair mechanism unraveled by transition path sampling of DNA polymerase β's closing Ravi Radhakrishnan and Tamar Schlick PMCID: PMC395907 From the Cover:
Dimer destabilization in superoxide dismutase may result in disease-causing properties: Structures of motor neuron disease mutants Michael A. Hough, J. Günter Grossmann, Svetlana V. Antonyuk, Richard W. Strange, Peter A. Doucette, Jorge A. Rodriguez, Lisa J. Whitson, P. John Hart, Lawrence J. Hayward, Joan Selverstone Valentine, and S. Samar Hasnain PMCID: PMC395908 Time-resolved crystallographic studies of light-induced structural changes in the photosynthetic reaction center Richard H. G. Baxter, Nina Ponomarenko, Vukica Šrajer, Reinhard Pahl, Keith Moffat, and James R. Norris PMCID: PMC395909 Membrane channel structure of Helicobacter pylori vacuolating toxin: Role of multiple GXXXG motifs in cylindrical channels Sanguk Kim, Aaron K. Chamberlain, and James U. Bowie PMCID: PMC395910 Forces generated during actin-based propulsion: A direct measurement by micromanipulation Yann Marcy, Jacques Prost, Marie-France Carlier, and Cécile Sykes PMCID: PMC395911 CO migration in native and mutant myoglobin: Atomistic simulations for the understanding of protein function David R. Nutt and Markus Meuwly PMCID: PMC395912 Molecular architecture of the prolate head of bacteriophage T4 Andrei Fokine, Paul R. Chipman, Petr G. Leiman, Vadim V. Mesyanzhinov, Venigalla B. Rao, and Michael G. Rossmann PMCID: PMC395913 Cell Biology Receptor-mediated regulation of the TRPM7 channel through its endogenous protein kinase domain Ryuichi Takezawa, Carsten Schmitz, Philippe Demeuse, Andrew M. Scharenberg, Reinhold Penner, and Andrea Fleig PMCID: PMC395914 Developmental Biology Targeted mutations of the juxtamembrane tyrosines in the Kit receptor tyrosine kinase selectively affect multiple cell lineages Yuki Kimura, Nina Jones, Michael Klüppel, Masanori Hirashima, Kazunobu Tachibana, Jason B. Cohn, Jeffrey L. Wrana, Tony Pawson, and Alan Bernstein PMCID: PMC395915 Regulation of spalt expression in the Drosophila wing blade in response to the Decapentaplegic signaling pathway Rosa Barrio and Jose F. de Celis PMCID: PMC395916 BMP4 supports self-renewal of embryonic stem cells by inhibiting mitogen-activated protein kinase pathways Xiaoxia Qi, Teng-Guo Li, Jing Hao, Jie Hu, Jing Wang, Holly Simmons, Shigeto Miura, Yuji Mishina, and Guang-Quan Zhao PMCID: PMC395917 Expression of MeCP2 in postmitotic neurons rescues Rett syndrome in mice Sandra Luikenhuis, Emanuela Giacometti, Caroline F. Beard, and Rudolf Jaenisch PMCID: PMC395918 Ecology From the Cover:
Drought stress and carbon uptake in an Amazon forest measured with spaceborne imaging spectroscopy Gregory P. Asner, Daniel Nepstad, Gina Cardinot, and David Ray PMCID: PMC395919 Long-term impacts of logging on forest diversity in Madagascar Kerry A. Brown and Jessica Gurevitch PMCID: PMC395920 Evolution Parallel genetic basis for repeated evolution of armor loss in Alaskan threespine stickleback populations William A. Cresko, Angel Amores, Catherine Wilson, Joy Murphy, Mark Currey, Patrick Phillips, Michael A. Bell, Charles B. Kimmel, and John H. Postlethwait PMCID: PMC395921 From the Cover:
The effect of climatic forcing on population synchrony and genetic structuring of the Canadian lynx Nils Chr. Stenseth, Dorothee Ehrich, Eli Knispel Rueness, Ole Chr. Lingjærde, Kung-Sik Chan, Stan Boutin, Mark O'Donoghue, David A. Robinson, Hildegunn Viljugrein, and Kjetill S. Jakobsen PMCID: PMC395922 Genetics A gene atlas of the mouse and human protein-encoding transcriptomes Andrew I. Su, Tim Wiltshire, Serge Batalov, Hilmar Lapp, Keith A. Ching, David Block, Jie Zhang, Richard Soden, Mimi Hayakawa, Gabriel Kreiman, Michael P. Cooke, John R. Walker, and John B. Hogenesch PMCID: PMC395923 Transcriptional termination by RNA polymerase I requires the small subunit Rpa12p Elizabeth M. Prescott, Yvonne N. Osheim, Hannah S. Jones, Claudia M. Alen, Judith G. Roan, Ronald H. Reeder, Ann L. Beyer, and Nick J. Proudfoot PMCID: PMC395924 A DNA polymerase β mutant from colon cancer cells induces mutations Tieming Lang, Mausumi Maitra, Daniela Starcevic, Shu-Xia Li, and Joann B. Sweasy PMCID: PMC395925 Distinct dosage requirements for the maintenance of long and short telomeres in mTert heterozygous mice Natalie Erdmann, Yie Liu, and Lea Harrington PMCID: PMC395926 Involvement of S-adenosylmethionine in G1 cell-cycle regulation in Saccharomyces cerevisiae Masaki Mizunuma, Kazunori Miyamura, Dai Hirata, Hiroshi Yokoyama, and Tokichi Miyakawa PMCID: PMC395927 Immunology Dendritic cells cross-present HIV antigens from live as well as apoptotic infected CD4+ T lymphocytes Concepción Marañón, Jean-François Desoutter, Guillaume Hoeffel, William Cohen, Daniel Hanau, and Anne Hosmalin PMCID: PMC395928 CD28 delivers a unique signal leading to the selective recruitment of RelA and p52 NF-κB subunits on IL-8 and Bcl-xL gene promoters Barbara Marinari, Antonio Costanzo, Valeria Marzano, Enza Piccolella, and Loretta Tuosto PMCID: PMC395929 Masking of CD22 by cis ligands does not prevent redistribution of CD22 to sites of cell contact Brian E. Collins, Ola Blixt, Alexis R. DeSieno, Nicolai Bovin, Jamey D. Marth, and James C. Paulson PMCID: PMC395930 Intestinal villous M cells: An antigen entry site in the mucosal epithelium Myoung Ho Jang, Mi-Na Kweon, Koichi Iwatani, Masafumi Yamamoto, Kazutaka Terahara, Chihiro Sasakawa, Toshihiko Suzuki, Tomonori Nochi, Yoshifumi Yokota, Paul D. Rennert, Takachika Hiroi, Hiroshi Tamagawa, Hideki Iijima, Jun Kunisawa, Yoshikazu Yuki, and Hiroshi Kiyono PMCID: PMC395931 Bystander suppression of allergic airway inflammation by lung resident memory CD8+ T cells Benjamin J. Marsland, Nicola L. Harris, Mali Camberis, Manfred Kopf, Sarah M. Hook, and Graham Le Gros PMCID: PMC395932 Illegitimate WNT signaling promotes proliferation of multiple myeloma cells Patrick W. B. Derksen, Esther Tjin, Helen P. Meijer, Melanie D. Klok, Harold D. Mac Gillavry, Marinus H. J. van Oers, Henk M. Lokhorst, Andries C. Bloem, Hans Clevers, Roel Nusse, Ronald van der Neut, Marcel Spaargaren, and Steven T. Pals PMCID: PMC395933 Essential role of CD91 in re-presentation of gp96-chaperoned peptides Robert J. Binder and Pramod K. Srivastava PMCID: PMC395934 Medical Sciences Identification of GAPDH as a protein target of the saframycin antiproliferative agents Chengguo Xing, Jacob R. LaPorte, Joseph K. Barbay, and Andrew G. Myers PMCID: PMC395888 Cell-interdependent cisplatin killing by Ku/DNA-dependent protein kinase signaling transduced through gap junctions Ryan Jensen and Peter M. Glazer PMCID: PMC395935 Mutations in the G-quadruplex silencer element and their relationship to c-MYC overexpression, NM23 repression, and therapeutic rescue Cory L. Grand, Tiffanie J. Powell, Raymond B. Nagle, David J. Bearss, Denise Tye, Mary Gleason-Guzman, and Laurence H. Hurley PMCID: PMC395936 Factors that make an infectious disease outbreak controllable Christophe Fraser, Steven Riley, Roy M. Anderson, and Neil M. Ferguson PMCID: PMC395937 Targeting and crossing of the human maternofetal barrier by Listeria monocytogenes: Role of internalin interaction with trophoblast E-cadherin Marc Lecuit, D. Michael Nelson, Steve D. Smith, Huot Khun, Michel Huerre, Marie-Cécile Vacher-Lavenu, Jeffrey I. Gordon, and Pascale Cossart PMCID: PMC395938 The immunomodulatory adapter proteins DAP12 and Fc receptor γ-chain (FcRγ) regulate development of functional osteoclasts through the Syk tyrosine kinase Attila Mócsai, Mary Beth Humphrey, Jessica A. G. Van Ziffle, Yongmei Hu, Andrew Burghardt, Steven C. Spusta, Sharmila Majumdar, Lewis L. Lanier, Clifford A. Lowell, and Mary C. Nakamura PMCID: PMC395939 Bim is a suppressor of Myc-induced mouse B cell leukemia Alexander Egle, Alan W. Harris, Philippe Bouillet, and Suzanne Cory PMCID: PMC395940 Suppression of caspase-8- and -10-associated RING proteins results in sensitization to death ligands and inhibition of tumor cell growth E. Robert McDonald, III and Wafik S. El-Deiry PMCID: PMC395941 Microbiology Methanogenic Archaea and human periodontal disease Paul W. Lepp, Mary M. Brinig, Cleber C. Ouverney, Katherine Palm, Gary C. Armitage, and David A. Relman PMCID: PMC395942 Comparative analysis of gene expression among low G+C gram-positive genomes Samuel Karlin, Julie Theriot, and Jan Mrázek PMCID: PMC395943 A chimeric adenovirus vector encoding reovirus attachment protein σ1 targets cells expressing junctional adhesion molecule 1 George T. Mercier, Jacquelyn A. Campbell, James D. Chappell, Thilo Stehle, Terence S. Dermody, and Michael A. Barry PMCID: PMC395944 The crystal structure of filamentous hemagglutinin secretion domain and its implications for the two-partner secretion pathway Bernard Clantin, Hélène Hodak, Eve Willery, Camille Locht, Françoise Jacob-Dubuisson, and Vincent Villeret PMCID: PMC395945 Adenovirus-induced maturation of dendritic cells through a PI3 kinase-mediated TNF-α induction pathway Nicola J. Philpott, Marcelo Nociari, Keith B. Elkon, and Erik Falck-Pedersen PMCID: PMC395946 A pathway for phosphatidylcholine biosynthesis in Plasmodium falciparum involving phosphoethanolamine methylation Gabriella Pessi, Guillermo Kociubinski, and Choukri Ben Mamoun PMCID: PMC395947 A previously undescribed coronavirus associated with respiratory disease in humans Ron A. M. Fouchier, Nico G. Hartwig, Theo M. Bestebroer, Berend Niemeyer, Jan C. de Jong, James H. Simon, and Albert D. M. E. Osterhaus PMCID: PMC395948 Neuroscience Activation of human medial prefrontal cortex during autonomic responses to hypoglycemia Denise Teves, Tom O. Videen, Philip E. Cryer, and William J. Powers PMCID: PMC395949 Fluoxetine and norfluoxetine stereospecifically facilitate pentobarbital sedation by increasing neurosteroids Graziano Pinna, Erminio Costa, and Alessandro Guidotti PMCID: PMC395950 From the Cover:
Secreted proNGF is a pathophysiological death-inducing ligand after adult CNS injury A. W. Harrington, B. Leiner, C. Blechschmitt, J. C. Arevalo, R. Lee, K. Mörl, M. Meyer, B. L. Hempstead, S. O. Yoon, and K. M. Giehl PMCID: PMC395951 Insight into molecular core clock mechanism of embryonic and early postnatal rat suprachiasmatic nucleus Martin Sládek, Alena Sumová, Zuzana Kováčiková, Zdenka Bendová, Kristýna Laurinová, and Helena Illnerová PMCID: PMC395952 Unique domain anchoring of Src to synaptic NMDA receptors via the mitochondrial protein NADH dehydrogenase subunit 2 Jeffrey R. Gingrich, Kenneth A. Pelkey, Sami R. Fam, Yueqiao Huang, Ronald S. Petralia, Robert J. Wenthold, and Michael W. Salter PMCID: PMC395953 Evidence of tectorial membrane radial motion in a propagating mode of a complex cochlear model Hongxue Cai, Brett Shoelson, and Richard S. Chadwick PMCID: PMC395954 Perinatal abrogation of Cdk5 expression in brain results in neuronal migration defects Motoyuki Hirasawa, Toshio Ohshima, Satoru Takahashi, Glenn Longenecker, Yasuyuki Honjo, Veeranna, Harish C. Pant, Katsuhiko Mikoshiba, Roscoe O. Brady, and Ashok B. Kulkarni PMCID: PMC395955 Encoding for computation: Recognizing brief dynamical patterns by exploiting effects of weak rhythms on action-potential timing J. J. Hopfield PMCID: PMC395956 Mating, seminal fluid components, and sperm cause changes in vesicle release in the Drosophila female reproductive tract Yael Heifetz and Mariana F. Wolfner PMCID: PMC395957 Cavβ-subunit displacement is a key step to induce the reluctant state of P/Q calcium channels by direct G protein regulation Guillaume Sandoz, Ignacio Lopez-Gonzalez, Didier Grunwald, Delphine Bichet, Xavier Altafaj, Norbert Weiss, Michel Ronjat, Alain Dupuis, and Michel De Waard PMCID: PMC395958 Isolation of glutamate transport-coupled charge flux and estimation of glutamate uptake at the climbing fiber–Purkinje cell synapse Gabor Brasnjo and Thomas S. Otis PMCID: PMC395959 Physiology Real-time evaluation of myosin light chain kinase activation in smooth muscle tissues from a transgenic calmodulin-biosensor mouse Eiji Isotani, Gang Zhi, Kim S. Lau, Jian Huang, Yusuke Mizuno, Anthony Persechini, Ramaz Geguchadze, Kristine E. Kamm, and James T. Stull PMCID: PMC395960 Plant Biology Evolutionary conservation of a phosphate transporter in the arbuscular mycorrhizal symbiosis Vladimir Karandashov, Réka Nagy, Sarah Wegmüller, Nikolaus Amrhein, and Marcel Bucher PMCID: PMC395961 Tobacco mosaic virus infection spreads cell to cell as intact replication complexes Shigeki Kawakami, Yuichiro Watanabe, and Roger N. Beachy PMCID: PMC395962 A natural variant of a host RNA-dependent RNA polymerase is associated with increased susceptibility to viruses by Nicotiana benthamiana Shu-Jun Yang, Shelly A. Carter, Anthony B. Cole, Ning-Hui Cheng, and Richard S. Nelson PMCID: PMC395963 Switch from intracellular to intercellular invasion during water stress-tolerant legume nodulation Sofie Goormachtig, Ward Capoen, Euan K. James, and Marcelle Holsters PMCID: PMC395964 Overexpression of a zinc-finger protein gene from rice confers tolerance to cold, dehydration, and salt stress in transgenic tobacco Arnab Mukhopadhyay, Shubha Vij, and Akhilesh K. Tyagi PMCID: PMC395965 Enhanced translation of a chloroplast-expressed RbcS gene restores small subunit levels and photosynthesis in nuclear RbcS antisense plants Amit Dhingra, Archie R. Portis, Jr., and Henry Daniell PMCID: PMC395966 Psychology Activation of the prefrontal cortex in the human visual aesthetic perception Camilo J. Cela-Conde, Gisèle Marty, Fernando Maestú, Tomás Ortiz, Enric Munar, Alberto Fernández, Miquel Roca, Jaume Rosselló, and Felipe Quesney PMCID: PMC395967 Social Sciences Anthropology INAUGURAL ARTICLE by a Recently Elected Academy Member: The Ysterfontein 1 Middle Stone Age site, South Africa, and early human exploitation of coastal resources Richard G. Klein, Graham Avery, Kathryn Cruz-Uribe, David Halkett, John E. Parkington, Teresa Steele, Thomas P. Volman, and Royden Yates PMCID: PMC395859 Corrections Proc Natl Acad Sci U S A. 2004 April 20; 101(16): 6326. Published online 2004 March 31. doi: 10.1073/pnas.0401524101.PMCID: PMC395968 Corrects: Xavier Daniel, et al. CK2 phosphorylation of CCA1 is necessary for its circadian oscillator function in Arabidopsis. Proc Natl Acad Sci U S A. 2004 March 2; 101(9): 3292–3297. Proc Natl Acad Sci U S A. 2004 April 20; 101(16): 6326. Published online 2004 March 30. doi: 10.1073/pnas.0401560101.PMCID: PMC395969 Corrects: Domenico Mavilio, et al. Natural killer cells in HIV-1 infection: Dichotomous effects of viremia on inhibitory and activating receptors and their functional correlates. Proc Natl Acad Sci U S A. 2003 December 9; 100(25): 15011–15016. Proc Natl Acad Sci U S A. 2004 April 20; 101(16): 6326. Published online 2004 April 2. doi: 10.1073/pnas.0400260101.PMCID: PMC395970 Corrects: S. L. Singla-Pareek, et al. Genetic engineering of the glyoxalase pathway in tobacco leads to enhanced salinity tolerance. Proc Natl Acad Sci U S A. 2003 December 9; 100(25): 14672–14677. Proc Natl Acad Sci U S A. 2004 April 20; 101(16): 6327. Published online 2004 April 2. doi: 10.1073/pnas.0401639101.PMCID: PMC395971 Corrects: E. S. Bernhardt, et al. From the Cover:
In-stream uptake dampens effects of major forest disturbance on watershed
nitrogen export. Proc Natl Acad Sci U S A. 2003 September 2; 100(18): 10304–10308. |
