| | This journal provides immediate access to some articles. Commentaries Ganglioside rafts as MAG receptors that mediate blockade of axon growth Lisa McKerracher Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7811–7813. doi: 10.1073/pnas.132280299.PMCID: PMC122973 Chasing “fear memories” to the cerebellum Almira Vazdarjanova Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7814–7815. doi: 10.1073/pnas.142288899.PMCID: PMC122974 After 130 years, the molecular mechanism of action of nitroglycerin is revealed Louis J. Ignarro Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7816–7817. doi: 10.1073/pnas.132271799.PMCID: PMC122975 Founder effects and silvereyes Peter R. Grant Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7818–7820. doi: 10.1073/pnas.132260299.PMCID: PMC122976 Physical Sciences Applied Mathematics Community structure in social and biological networks M. Girvan and M. E. J. Newman Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7821–7826. doi: 10.1073/pnas.122653799.PMCID: PMC122977 Chemistry Electrolytic actuators: Alternative, high-performance, material-based devices Colin G. Cameron and Michael S. Freund Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7827–7831. doi: 10.1073/pnas.122212299.PMCID: PMC122978 Computer Sciences Diversity and complexity of HIV-1 drug resistance: A bioinformatics approach to predicting phenotype from genotype Niko Beerenwinkel, Barbara Schmidt, Hauke Walter, Rolf Kaiser, Thomas Lengauer, Daniel Hoffmann, Klaus Korn, and Joachim Selbig Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8271–8276. doi: 10.1073/pnas.112177799.PMCID: PMC123057 Geology Documenting a significant relationship between macroevolutionary origination rates and Phanerozoic pCO2 levels James L. Cornette, Bruce S. Lieberman, and Robert H. Goldstein Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7832–7835. Published online 2002 June 4. doi: 10.1073/pnas.122225499.PMCID: PMC122979 An atmospheric pCO2 reconstruction across the Cretaceous-Tertiary boundary from leaf megafossils D. J. Beerling, B. H. Lomax, D. L. Royer, G. R. Upchurch, Jr., and L. R. Kump Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7836–7840. doi: 10.1073/pnas.122573099.PMCID: PMC122980 Latitudinal difference in biodiversity caused by higher tropical rate of increase Martin A. Buzas, Laurel S. Collins, and Stephen J. Culver Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7841–7843. doi: 10.1073/pnas.122241499.PMCID: PMC122981 Temperature profile for glacial ice at the South Pole: Implications for life in a nearby subglacial lake P. Buford Price, Oleg V. Nagornov, Ryan Bay, Dmitry Chirkin, Yudong He, Predrag Miocinovic, Austin Richards, Kurt Woschnagg, Bruce Koci, and Victor Zagorodnov Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7844–7847. doi: 10.1073/pnas.082238999.PMCID: PMC122982 Geophysics The change in oceanic O2 inventory associated with recent global warming Ralph F. Keeling and Hernan E. Garcia Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7848–7853. Published online 2002 June 4. doi: 10.1073/pnas.122154899.PMCID: PMC122983 Physics Adhesion induced by mobile binders: Dynamics F. Brochard-Wyart and P. G. de Gennes Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7854–7859. Published online 2002 June 4. doi: 10.1073/pnas.112221299.PMCID: PMC122984 Biological Sciences Agricultural Sciences A framework for sustainability science: A renovated IPAT identity P. E. Waggoner and J. H. Ausubel Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7860–7865. doi: 10.1073/pnas.122235999.PMCID: PMC122985 Applied Biological Sciences In vitro and in vivo studies of a VEGF121/rGelonin chimeric fusion toxin targeting the neovasculature of solid tumors Liesbeth M. Veenendaal, Hangqing Jin, Sophia Ran, Lawrence Cheung, Nora Navone, John W. Marks, Johannes Waltenberger, Philip Thorpe, and Michael G. Rosenblum Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7866–7871. doi: 10.1073/pnas.122157899.PMCID: PMC122986 Biochemistry In vitro formation of a c-type cytochrome Oliver Daltrop, James W. A. Allen, Anthony C. Willis, and Stuart J. Ferguson Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7872–7876. doi: 10.1073/pnas.132259099.PMCID: PMC122987 A monomeric red fluorescent protein Robert E. Campbell, Oded Tour, Amy E. Palmer, Paul A. Steinbach, Geoffrey S. Baird, David A. Zacharias, and Roger Y. Tsien Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7877–7882. doi: 10.1073/pnas.082243699.PMCID: PMC122988 Neuronal loss and brain atrophy in mice lacking cathepsins B and L Ute Felbor, Benedikt Kessler, Walther Mothes, Hans H. Goebel, Hidde L. Ploegh, Roderick T. Bronson, and Bjorn R. Olsen Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7883–7888. Published online 2002 June 4. doi: 10.1073/pnas.112632299.PMCID: PMC122989 Characterization of the novel E3 ubiquitin ligase encoded in exon 3 of herpes simplex virus-1-infected cell protein 0 Ryan Hagglund and Bernard Roizman Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7889–7894. doi: 10.1073/pnas.122246999.PMCID: PMC122990 Domain movements in human fatty acid synthase by quantized elastic deformational model Dengming Ming, Yifei Kong, Salih J. Wakil, Jacob Brink, and Jianpeng Ma Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7895–7899. doi: 10.1073/pnas.112222299.PMCID: PMC122991 Shotgun identification of protein modifications from protein complexes and lens tissue Michael J. MacCoss, W. Hayes McDonald, Anita Saraf, Rovshan Sadygov, Judy M. Clark, Joseph J. Tasto, Kathleen L. Gould, Dirk Wolters, Michael Washburn, Avery Weiss, John I. Clark, and John R. Yates, III Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7900–7905. doi: 10.1073/pnas.122231399.PMCID: PMC122992 RNA hairpins in noncoding regions of human brain and Caenorhabditis elegans mRNA are edited by adenosine deaminases that act on RNA Daniel P. Morse, P. Joseph Aruscavage, and Brenda L. Bass Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7906–7911. Published online 2002 June 4. doi: 10.1073/pnas.112704299.PMCID: PMC122993 p38 is essential for the assembly and stability of macromolecular tRNA synthetase complex: Implications for its physiological significance Jin Young Kim, Young-Sun Kang, Joong-Won Lee, Hyoung June Kim, Young Ha Ahn, Heonyong Park, Young-Gyu Ko, and Sunghoon Kim Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7912–7916. doi: 10.1073/pnas.122110199.PMCID: PMC122994 The RecA proteins of Deinococcus radiodurans and Escherichia coli promote DNA strand exchange via inverse pathways Jong-Il Kim and Michael M. Cox Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7917–7921. Published online 2002 June 4. doi: 10.1073/pnas.122218499.PMCID: PMC122995 A theoretical examination of the factors controlling the catalytic efficiency of the DNA-(adenine-N6)-methyltransferase from Thermus aquaticus Zachary E. R. Newby, Edmond Y. Lau, and Thomas C. Bruice Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7922–7927. doi: 10.1073/pnas.122231499.PMCID: PMC122996 TAR RNA loop: A scaffold for the assembly of a regulatory switch in HIV replication Sara Richter, Yueh-Hsin Ping, and Tariq M. Rana Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7928–7933. Published online 2002 June 4. doi: 10.1073/pnas.122119999.PMCID: PMC122997 Ordered recruitment of histone acetyltransferases and the TRAP/Mediator complex to thyroid hormone-responsive promoters in vivo Dipali Sharma and Joseph D. Fondell Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7934–7939. Published online 2002 May 28. doi: 10.1073/pnas.122004799.PMCID: PMC122998 Coactivator/corepressor ratios modulate PR-mediated transcription by the selective receptor modulator RU486 Zheng Liu, Didier Auboeuf, Jiemin Wong, J. Don Chen, Sophia Y. Tsai, Ming-Jer Tsai, and Bert W. O'Malley Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7940–7944. Published online 2002 June 4. doi: 10.1073/pnas.122225699.PMCID: PMC122999 MEKK1 plays a critical role in activating the transcription factor C/EBP-β-dependent gene expression in response to IFN-γ Sanjit K. Roy, Junbo Hu, Qingjun Meng, Ying Xia, Paul S. Shapiro, Sekhar P. M. Reddy, Leonidas C. Platanias, Daniel J. Lindner, Peter F. Johnson, Catrin Pritchard, Gilles Pagés, Jacques Pouyssegur, and Dhananjaya V. Kalvakolanu Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7945–7950. Published online 2002 June 4. doi: 10.1073/pnas.122075799.PMCID: PMC123000 Direct, activating interaction between glycogen synthase kinase-3β and p53 after DNA damage Piyajit Watcharasit, Gautam N. Bijur, Jaroslaw W. Zmijewski, Ling Song, Anna Zmijewska, Xinbin Chen, Gail V. W. Johnson, and Richard S. Jope Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7951–7955. Published online 2002 June 4. doi: 10.1073/pnas.122062299.PMCID: PMC123001 HIV type 1 Gag virus-like particle budding from spheroplasts of Saccharomyces cerevisiae Sayuri Sakuragi, Toshiyuki Goto, Kouichi Sano, and Yuko Morikawa Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7956–7961. doi: 10.1073/pnas.082281199.PMCID: PMC123002 Regulatory interaction of phosducin-like protein with the cytosolic chaperonin complex Joseph N. McLaughlin, Craig D. Thulin, Sarah J. Hart, Katheryn A. Resing, Natalie G. Ahn, and Barry M. Willardson Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7962–7967. doi: 10.1073/pnas.112075699.PMCID: PMC123003 The biosynthetic gene cluster of the maytansinoid antitumor agent ansamitocin from Actinosynnema pretiosum Tin-Wein Yu, Linquan Bai, Dorothee Clade, Dietmar Hoffmann, Sabine Toelzer, Khue Q. Trinh, Jun Xu, Steven J. Moss, Eckhard Leistner, and Heinz G. Floss Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7968–7973. doi: 10.1073/pnas.092697199.PMCID: PMC123004 Preferential cleavage of plasmid-based R-loops and D-loops by Drosophila topoisomerase IIIβ Tina Wilson-Sali and Tao-shih Hsieh Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7974–7979. Published online 2002 June 4. doi: 10.1073/pnas.122007999.PMCID: PMC123005 Biophysics Crystal structure of conserved hypothetical protein Aq1575 from Aquifex aeolicus Dong Hae Shin, Hisao Yokota, Rosalind Kim, and Sung-Hou Kim Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7980–7985. doi: 10.1073/pnas.132241399.PMCID: PMC123006 Obligatory heterotetramerization of three previously uncharacterized Kv channel α-subunits identified in the human genome N. Ottschytsch, A. Raes, D. Van Hoorick, and D. J. Snyders Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7986–7991. doi: 10.1073/pnas.122617999.PMCID: PMC123007 Ligand binding and protein dynamics in neuroglobin Jan M. Kriegl, Aninda J. Bhattacharyya, Karin Nienhaus, Pengchi Deng, Oleksandr Minkow, and G. Ulrich Nienhaus Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7992–7997. Published online 2002 June 4. doi: 10.1073/pnas.082244399.PMCID: PMC123008 Ultrafast spectroscopy reveals subnanosecond peptide conformational dynamics and validates molecular dynamics simulation Sebastian Spörlein, Heiko Carstens, Helmut Satzger, Christian Renner, Raymond Behrendt, Luis Moroder, Paul Tavan, Wolfgang Zinth, and Josef Wachtveitl Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7998–8002. doi: 10.1073/pnas.122238799.PMCID: PMC123009 Crystal structures of the vitamin D-binding protein and its complex with actin: Structural basis of the actin-scavenger system Ludovic R. Otterbein, Christophe Cosio, Philip Graceffa, and Roberto Dominguez Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8003–8008. Published online 2002 June 4. doi: 10.1073/pnas.122126299.PMCID: PMC123010 Reduced-dimensionality NMR spectroscopy for high-throughput protein resonance assignment Thomas Szyperski, Deok C. Yeh, Dinesh K. Sukumaran, Hunter N. B. Moseley, and Gaetano T. Montelione Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8009–8014. doi: 10.1073/pnas.122224599.PMCID: PMC123011 Minimal principle for rotor filaments Marcel Wellner, Omer Berenfeld, José Jalife, and Arkady M. Pertsov Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8015–8018. Published online 2002 June 4. doi: 10.1073/pnas.112026199.PMCID: PMC123012 Simulations of β-hairpin folding confined to spherical pores using distributed computing D. K. Klimov, D. Newfield, and D. Thirumalai Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8019–8024. doi: 10.1073/pnas.072220699.PMCID: PMC123013 Cell Biology Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Aβ42 production Tobias Moehlmann, Edith Winkler, Xuefeng Xia, Dieter Edbauer, Jill Murrell, Anja Capell, Christoph Kaether, Hui Zheng, Bernardino Ghetti, Christian Haass, and Harald Steiner Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8025–8030. Published online 2002 June 4. doi: 10.1073/pnas.112686799.PMCID: PMC123014 Cell surface expression of the HIV-1 envelope glycoproteins is directed from intracellular CTLA-4-containing regulated secretory granules Luis R. Miranda, Brian C. Schaefer, Abraham Kupfer, Zixin Hu, and Alex Franzusoff Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8031–8036. doi: 10.1073/pnas.122696599.PMCID: PMC123015 One of the two cytoplasmic actin isoforms in Drosophila is essential Cynthia R. Wagner, Anthony P. Mahowald, and Kathryn G. Miller Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8037–8042. Published online 2002 May 28. doi: 10.1073/pnas.082235499.PMCID: PMC123016 Mutational switch of an IL-6 response to an interferon-γ-like response Ana P. Costa-Pereira, Silvia Tininini, Birgit Strobl, Tonino Alonzi, Joerg F. Schlaak, Hayaatun Is'harc, Ida Gesualdo, Sally J. Newman, Ian M. Kerr, and Valeria Poli Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8043–8047. doi: 10.1073/pnas.122236099.PMCID: PMC123017 Integration of Runx and Smad regulatory signals at transcriptionally active subnuclear sites Sayyed K. Zaidi, Andrew J. Sullivan, Andre J. van Wijnen, Janet L. Stein, Gary S. Stein, and Jane B. Lian Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8048–8053. doi: 10.1073/pnas.112664499.PMCID: PMC123018 DT40 cells lacking the Ca2+-binding protein annexin 5 are resistant to Ca2+-dependent apoptosis Timothy E. Hawkins, Debipriya Das, Barry Young, and Stephen E. Moss Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8054–8059. doi: 10.1073/pnas.132598099.PMCID: PMC123019 A negative feedback system between oocyte bone morphogenetic protein 15 and granulosa cell kit ligand: Its role in regulating granulosa cell mitosis Fumio Otsuka and Shunichi Shimasaki Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8060–8065. Published online 2002 June 4. doi: 10.1073/pnas.122066899.PMCID: PMC123020 Proton-motive force stimulates the proteolytic activity of FtsH, a membrane-bound ATP- dependent protease in Escherichia coli Yoshinori Akiyama Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8066–8071. Published online 2002 May 28. doi: 10.1073/pnas.122616899.PMCID: PMC123021 Autoinhibition of the ligand-binding site of GGA1/3 VHS domains by an internal acidic cluster-dileucine motif Balraj Doray, Kerry Bruns, Pradipta Ghosh, and Stuart A. Kornfeld Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8072–8077. doi: 10.1073/pnas.082235699.PMCID: PMC123022 Developmental Biology In vitro trans-differentiation of adult hepatic stem cells into pancreatic endocrine hormone-producing cells Lijun Yang, Shiwu Li, Heather Hatch, Kim Ahrens, Janet G. Cornelius, Bryon E. Petersen, and Ammon B. Peck Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8078–8083. Published online 2002 June 4. doi: 10.1073/pnas.122210699.PMCID: PMC123023 Transient expression of the bHLH factor neurogenin-2 marks a subpopulation of neural crest cells biased for a sensory but not a neuronal fate Mariela Zirlinger, Liching Lo, Jill McMahon, Andrew P. McMahon, and David J. Anderson Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8084–8089. doi: 10.1073/pnas.122231199.PMCID: PMC123024 Hoxa 11 is upstream of Integrin α8 expression in the developing kidney M. Todd Valerius, Larry T. Patterson, Yuxin Feng, and S. Steven Potter Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8090–8095. doi: 10.1073/pnas.122229199.PMCID: PMC123025 Ecology Stable isotope signature of philopatry and dispersal in a migratory songbird Gary R. Graves, Christopher S. Romanek, and Alejandro Rodriguez Navarro Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8096–8100. Published online 2002 May 28. doi: 10.1073/pnas.082240899.PMCID: PMC123026 Bioavailability of organic matter in a highly disturbed estuary: The role of detrital and algal resources William V. Sobczak, James E. Cloern, Alan D. Jassby, and Anke B. Müller-Solger Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8101–8105. doi: 10.1073/pnas.122614399.PMCID: PMC123027 Evolution Documenting a significant relationship between macroevolutionary origination rates and Phanerozoic pCO2 levels James L. Cornette, Bruce S. Lieberman, and Robert H. Goldstein Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7832–7835. Published online 2002 June 4. doi: 10.1073/pnas.122225499.PMCID: PMC122979 Latitudinal difference in biodiversity caused by higher tropical rate of increase Martin A. Buzas, Laurel S. Collins, and Stephen J. Culver Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7841–7843. doi: 10.1073/pnas.122241499.PMCID: PMC122981 Localized expression of a dpp/BMP2/4 ortholog in a coral embryo David C. Hayward, Gabrielle Samuel, Patricia C. Pontynen, Julian Catmull, Robert Saint, David J. Miller, and Eldon E. Ball Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8106–8111. Published online 2002 June 4. doi: 10.1073/pnas.112021499.PMCID: PMC123028 A methodological bias toward overestimation of molecular evolutionary time scales Francisco Rodríguez-Trelles, Rosa Tarrío, and Francisco J. Ayala Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8112–8115. doi: 10.1073/pnas.122231299.PMCID: PMC123029 A gene network model accounting for development and evolution of mammalian teeth Isaac Salazar-Ciudad and Jukka Jernvall Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8116–8120. Published online 2002 June 4. doi: 10.1073/pnas.132069499.PMCID: PMC123030 Intron presence–absence polymorphism in Drosophila driven by positive Darwinian selection Ana Llopart, Josep M. Comeron, Frédéric G. Brunet, Daniel Lachaise, and Manyuan Long Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8121–8126. doi: 10.1073/pnas.122570299.PMCID: PMC123031 From the Cover: Genetic consequences of sequential founder events by an island-colonizing bird Sonya M. Clegg, Sandie M. Degnan, Jiro Kikkawa, Craig Moritz, Arnaud Estoup, and Ian P. F. Owens Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8127–8132. Published online 2002 May 28. doi: 10.1073/pnas.102583399.PMCID: PMC123032 Genes encoding plastid acetyl-CoA carboxylase and 3-phosphoglycerate kinase of the Triticum/Aegilops complex and the evolutionary history of polyploid wheat Shaoxing Huang, Anchalee Sirikhachornkit, Xiujuan Su, Justin Faris, Bikram Gill, Robert Haselkorn, and Piotr Gornicki Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8133–8138. doi: 10.1073/pnas.072223799.PMCID: PMC123033 Survival without recovery after mass extinctions David Jablonski Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8139–8144. doi: 10.1073/pnas.102163299.PMCID: PMC123034 Adaptive evolution of small heat shock protein/ αB-crystallin promoter activity of the blind subterranean mole rat, Spalax ehrenbergi R. B. Hough, A. Avivi, J. Davis, A. Joel, E. Nevo, and J. Piatigorsky Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8145–8150. doi: 10.1073/pnas.122231099.PMCID: PMC123035 Mammalian mitogenomic relationships and the root of the eutherian tree Ulfur Arnason, Joseph A. Adegoke, Kristina Bodin, Erik W. Born, Yuzine B. Esa, Anette Gullberg, Maria Nilsson, Roger V. Short, Xiufeng Xu, and Axel Janke Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8151–8156. Published online 2002 May 28. doi: 10.1073/pnas.102164299.PMCID: PMC123036 Genetic determination of the queen caste in an ant hybrid zone Glennis E. Julian, Jennifer H. Fewell, Jürgen Gadau, Robert A. Johnson, and Debbie Larrabee Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8157–8160. Published online 2002 May 28. doi: 10.1073/pnas.112222099.PMCID: PMC123037 Genetics Attenuated APC alleles produce functional protein from internal translation initiation Kathleen Heppner Goss, Chris Trzepacz, Thérèse M. F. Tuohy, and Joanna Groden Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8161–8166. Published online 2002 May 28. doi: 10.1073/pnas.112072199.PMCID: PMC123038 Quantitative prediction of NF-κB DNA– protein interactions Irina A. Udalova, Richard Mott, Dawn Field, and Dominic Kwiatkowski Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8167–8172. Published online 2002 June 4. doi: 10.1073/pnas.102674699.PMCID: PMC123039 Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX Craig H. Bassing, Katrin F. Chua, JoAnn Sekiguchi, Heikyung Suh, Scott R. Whitlow, James C. Fleming, Brianna C. Monroe, David N. Ciccone, Catherine Yan, Katerina Vlasakova, David M. Livingston, David O. Ferguson, Ralph Scully, and Frederick W. Alt Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8173–8178. Published online 2002 May 28. doi: 10.1073/pnas.122228699.PMCID: PMC123040 Comparative genomic analysis in the region of a major Plasmodium-refractoriness locus of Anopheles gambiae Dana Thomasová, Lucas Q. Ton, Richard R. Copley, Evgeny M. Zdobnov, Xuelan Wang, Young S. Hong, Cheolho Sim, Peer Bork, Fotis C. Kafatos, and Frank H. Collins Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8179–8184. doi: 10.1073/pnas.082235599.PMCID: PMC123041 Regulation of alternative splicing by a transcriptional enhancer through RNA pol II elongation Sebastián Kadener, Juan Pablo Fededa, Michael Rosbash, and Alberto R. Kornblihtt Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8185–8190. doi: 10.1073/pnas.122246099.PMCID: PMC123042 Constitutive telomerase expression promotes mammary carcinomas in aging mice Steven E. Artandi, Scott Alson, Maja K. Tietze, Norman E. Sharpless, Siqin Ye, Roger A. Greenberg, Diego H. Castrillon, James W. Horner, Sarah R. Weiler, Ruben D. Carrasco, and Ronald A. DePinho Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8191–8196. Published online 2002 May 28. doi: 10.1073/pnas.112515399.PMCID: PMC123043 Immunology Inhibition of glycolipid shedding rescues recognition of a CD1+ T cell lymphoma by natural killer T (NKT) cells Venkataraman Sriram, Sungyoo Cho, Ping Li, Patrick W. O'Donnell, Claire Dunn, Kyoko Hayakawa, Janice S. Blum, and Randy R. Brutkiewicz Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8197–8202. doi: 10.1073/pnas.122636199.PMCID: PMC123044 Allogeneic β-islet cells correct diabetes and resist immune rejection Marcus Pericin, Alana Althage, Stefan Freigang, Hans Hengartner, Eric Rolland, Philippe Dupraz, Bernard Thorens, Patrick Aebischer, and Rolf M. Zinkernagel Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8203–8206. doi: 10.1073/pnas.122241299.PMCID: PMC123045 Molecular characterization of antibody specificities against myelin/oligodendrocyte glycoprotein in autoimmune demyelination Hans-Christian von Büdingen, Stephen L. Hauser, Antje Fuhrmann, Cameron B. Nabavi, Joy I. Lee, and Claude P. Genain Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8207–8212. doi: 10.1073/pnas.122092499.PMCID: PMC123046 Specificity requirements for selection and effector functions of CD25+4+ regulatory T cells in anti-myelin basic protein T cell receptor transgenic mice Shohei Hori, Matthias Haury, António Coutinho, and Jocelyne Demengeot Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8213–8218. Published online 2002 May 28. doi: 10.1073/pnas.122224799.PMCID: PMC123047 Medical Sciences Orchestration of angiogenesis and arteriovenous contribution by angiopoietins and vascular endothelial growth factor (VEGF) Richard P. Visconti, Charlene D. Richardson, and Thomas N. Sato Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8219–8224. Published online 2002 June 4. doi: 10.1073/pnas.122109599.PMCID: PMC123048 From the Cover: X-linked adrenal hypoplasia congenita is caused by abnormal nuclear localization of the DAX-1 protein Sylvia G. Lehmann, Enzo Lalli, and Paolo Sassone-Corsi Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8225–8230. Published online 2002 May 28. doi: 10.1073/pnas.122044099.PMCID: PMC123049 ADP ribosylation of human neutrophil peptide-1 regulates its biological properties Gregorino Paone, Akihiro Wada, Linda A. Stevens, Abul Matin, Toshiya Hirayama, Rodney L. Levine, and Joel Moss Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8231–8235. doi: 10.1073/pnas.122238899.PMCID: PMC123050 FLIP switches Fas-mediated glucose signaling in human pancreatic β cells from apoptosis to cell replication Kathrin Maedler, Adriano Fontana, Frédéric Ris, Pavel Sergeev, Christian Toso, José Oberholzer, Roger Lehmann, Felix Bachmann, Andrea Tasinato, Giatgen A. Spinas, Philippe A. Halban, and Marc Y. Donath Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8236–8241. doi: 10.1073/pnas.122686299.PMCID: PMC123051 Chromosome translocations and covert leukemic clones are generated during normal fetal development Hiroshi Mori, Susan M. Colman, Zhijian Xiao, Anthony M. Ford, Lyn E. Healy, Craig Donaldson, Jill M. Hows, Cristina Navarrete, and Mel Greaves Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8242–8247. Published online 2002 June 4. doi: 10.1073/pnas.112218799.PMCID: PMC123052 A genetically clamped renin transgene for the induction of hypertension Kathleen M. I. Caron, Leighton R. James, Hyung-Suk Kim, Scott G. Morham, Maria Luisa S. Sequeira Lopez, R. Ariel Gomez, Timothy L. Reudelhuber, and Oliver Smithies Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8248–8252. Published online 2002 May 28. doi: 10.1073/pnas.112222199.PMCID: PMC123053 Constitutive activation of Stat5a by retrovirus integration in early pre-B lymphomas of SL/Kh strain mice Tatsuaki Tsuruyama, Takuro Nakamura, Guang Jin, Munetaka Ozeki, Yoshihiro Yamada, and Hiroshi Hiai Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8253–8258. Published online 2002 June 4. doi: 10.1073/pnas.112202899.PMCID: PMC123054 Basic FGF mediates an immediate response of articular cartilage to mechanical injury Tonia Vincent, Monika Hermansson, Mark Bolton, Robin Wait, and Jeremy Saklatvala Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8259–8264. Published online 2002 May 28. doi: 10.1073/pnas.122033199.PMCID: PMC123055 Targeted inactivation of CTNNB1 reveals unexpected effects of β-catenin mutation Timothy A. Chan, Zhenghe Wang, Long H. Dang, Bert Vogelstein, and Kenneth W. Kinzler Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8265–8270. doi: 10.1073/pnas.082240999.PMCID: PMC123056 Diversity and complexity of HIV-1 drug resistance: A bioinformatics approach to predicting phenotype from genotype Niko Beerenwinkel, Barbara Schmidt, Hauke Walter, Rolf Kaiser, Thomas Lengauer, Daniel Hoffmann, Klaus Korn, and Joachim Selbig Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8271–8276. doi: 10.1073/pnas.112177799.PMCID: PMC123057 The endocytic catalysts, Rab5a and Rab7, are tandem regulators of thyroid hormone production Karine Croizet-Berger, Chantal Daumerie, Marianne Couvreur, Pierre J. Courtoy, and Marie-France van den Hove Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8277–8282. Published online 2002 May 28. doi: 10.1073/pnas.122187699.PMCID: PMC123058 PML/RARα and FLT3-ITD induce an APL-like disease in a mouse model Louise M. Kelly, Jeffrey L. Kutok, Ifor R. Williams, Christina L. Boulton, Sonia M. Amaral, David P. Curley, Timothy J. Ley, and D. Gary Gilliland Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8283–8288. doi: 10.1073/pnas.122233699.PMCID: PMC123059 A critical concentration of neutrophils is required for effective bacterial killing in suspension Yongmei Li, Arthur Karlin, John D. Loike, and Samuel C. Silverstein Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8289–8294. doi: 10.1073/pnas.122244799.PMCID: PMC123060 Transduction of human NOD/SCID-repopulating cells with both lymphoid and myeloid potential by foamy virus vectors Neil C. Josephson, George Vassilopoulos, Grant D. Trobridge, Greg V. Priestley, Brent L. Wood, Thalia Papayannopoulou, and David W. Russell Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8295–8300. doi: 10.1073/pnas.122131099.PMCID: PMC123061 3-Hydroxy-3-methylglutaryl CoA reductase inhibitors prevent high glucose-induced proliferation of mesangial cells via modulation of Rho GTPase/ p21 signaling pathway: Implications for diabetic nephropathy Farhad R. Danesh, Mehran M. Sadeghi, Nail Amro, Carrie Philips, Lixia Zeng, Sun Lin, Atul Sahai, and Yashpal S. Kanwar Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8301–8305. Published online 2002 June 4. doi: 10.1073/pnas.122228799.PMCID: PMC123062 From the Cover: Identification of the enzymatic mechanism of nitroglycerin bioactivation Zhiqiang Chen, Jian Zhang, and Jonathan S. Stamler Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8306–8311. Published online 2002 June 4. doi: 10.1073/pnas.122225199.PMCID: PMC123063 Microbiology Effects of the twin-arginine translocase on secretion of virulence factors, stress response, and pathogenesis Urs A. Ochsner, Aleksandra Snyder, Adriana I. Vasil, and Michael L. Vasil Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8312–8317. Published online 2002 May 28. doi: 10.1073/pnas.082238299.PMCID: PMC123064 Of the three tegument proteins that package mRNA in herpes simplex virions, one (VP22) transports the mRNA to uninfected cells for expression prior to viral infection Maria Teresa Sciortino, Brunella Taddeo, Alice P. W. Poon, Antonio Mastino, and Bernard Roizman Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8318–8323. doi: 10.1073/pnas.122231699.PMCID: PMC123065 Novel kingdom-level eukaryotic diversity in anoxic environments Scott C. Dawson and Norman R. Pace Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8324–8329. doi: 10.1073/pnas.062169599.PMCID: PMC123066 Reduced immunopathology and mortality despite tissue persistence in a Mycobacterium tuberculosis mutant lacking alternative σ factor, SigH Deepak Kaushal, Benjamin G. Schroeder, Sandeep Tyagi, Tetsuyuki Yoshimatsu, Cherise Scott, Chiew Ko, Liane Carpenter, Jyoti Mehrotra, Yukari C. Manabe, Robert D. Fleischmann, and William R. Bishai Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8330–8335. doi: 10.1073/pnas.102055799.PMCID: PMC123067 Direct biochemical evidence for type III secretion-dependent translocation of the AvrBs2 effector protein into plant cells Catharina Casper-Lindley, Douglas Dahlbeck, Eszter T. Clark, and Brian J. Staskawicz Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8336–8341. doi: 10.1073/pnas.122220299.PMCID: PMC123068 An expanded view of bacterial DNA replication Marie-Françoise Noirot-Gros, Etienne Dervyn, Ling Juan Wu, Peggy Mervelet, Jeffery Errington, S. Dusko Ehrlich, and Philippe Noirot Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8342–8347. doi: 10.1073/pnas.122040799.PMCID: PMC123069 Cowpox virus encodes a fifth member of the tumor necrosis factor receptor family: A soluble, secreted CD30 homologue Joanne Fanelli Panus, Craig A. Smith, Caroline A. Ray, Terri Davis Smith, Dhavalkumar D. Patel, and David J. Pickup Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8348–8353. Published online 2002 May 28. doi: 10.1073/pnas.122238599.PMCID: PMC123070 Rapid genetic analysis of Helicobacter pylori gastric mucosal colonization in suckling mice Betty P. Guo and John J. Mekalanos Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8354–8359. doi: 10.1073/pnas.122244899.PMCID: PMC123071 Neurobiology Identification of gene expression profile of dorsal root ganglion in the rat peripheral axotomy model of neuropathic pain Hua-Sheng Xiao, Qiu-Hua Huang, Fang-Xiong Zhang, Lan Bao, Ying-Jin Lu, Chao Guo, Liang Yang, Wein-Jing Huang, Gang Fu, Shu-Hua Xu, Xi-Ping Cheng, Qing Yan, Zhi-Dong Zhu, Xin Zhang, Zhu Chen, Ze-Guang Han, and Xu Zhang Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8360–8365. doi: 10.1073/pnas.122231899.PMCID: PMC123072 Dendritic K+ channels contribute to spike-timing dependent long-term potentiation in hippocampal pyramidal neurons Shigeo Watanabe, Dax A. Hoffman, Michele Migliore, and Daniel Johnston Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8366–8371. Published online 2002 June 4. doi: 10.1073/pnas.122210599.PMCID: PMC123073 All-trans-retinal shuts down rod cyclic nucleotide-gated ion channels: A novel role for photoreceptor retinoids in the response to bright light? Dylan M. Dean, Wang Nguitragool, Andrew Miri, Sarah L. McCabe, and Anita L. Zimmerman Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8372–8377. Published online 2002 May 28. doi: 10.1073/pnas.122681899.PMCID: PMC123074 Single-neuron correlates of subjective vision in the human medial temporal lobe Gabriel Kreiman, Itzhak Fried, and Christof Koch Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8378–8383. Published online 2002 May 28. doi: 10.1073/pnas.072194099.PMCID: PMC123075 Endogenous cannabinoids mediate long-term synaptic depression in the nucleus accumbens David Robbe, Manfred Kopf, Anne Remaury, Joel Bockaert, and Olivier J. Manzoni Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8384–8388. doi: 10.1073/pnas.122149199.PMCID: PMC123076 A new form of cerebellar long-term potentiation is postsynaptic and depends on nitric oxide but not cAMP Varda Lev-Ram, Scott T. Wong, Daniel R. Storm, and Roger Y. Tsien Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8389–8393. Published online 2002 June 4. doi: 10.1073/pnas.122206399.PMCID: PMC123077 A missense mutation in human fatty acid amide hydrolase associated with problem drug use Jack C. Sipe, Kyle Chiang, Alexandra L. Gerber, Ernest Beutler, and Benjamin F. Cravatt Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8394–8399. doi: 10.1073/pnas.082235799.PMCID: PMC123078 An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors Susan M. Huang, Tiziana Bisogno, Marcello Trevisani, Abdulmonem Al-Hayani, Luciano De Petrocellis, Filomena Fezza, Michele Tognetto, Timothy J. Petros, Jocelyn F. Krey, Constance J. Chu, Jeffrey D. Miller, Stephen N. Davies, Pierangelo Geppetti, J. Michael Walker, and Vincenzo Di Marzo Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8400–8405. doi: 10.1073/pnas.122196999.PMCID: PMC123079 From the Cover: Cerebellar role in fear-conditioning consolidation Benedetto Sacchetti, Elisabetta Baldi, Carlo Ambrogi Lorenzini, and Corrado Bucherelli Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8406–8411. Published online 2002 May 28. doi: 10.1073/pnas.112660399.PMCID: PMC123080 From the Cover: Gangliosides are functional nerve cell ligands for myelin-associated glycoprotein (MAG), an inhibitor of nerve regeneration Alka A. Vyas, Himatkumar V. Patel, Susan E. Fromholt, Marija Heffer-Lauc, Kavita A. Vyas, Jiyoung Dang, Melitta Schachner, and Ronald L. Schnaar Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8412–8417. doi: 10.1073/pnas.072211699.PMCID: PMC123081 Pharmacology Developmental expression of functional cyclooxygenases in zebrafish Tilo Grosser, Shamila Yusuff, Ellina Cheskis, Michael A. Pack, and Garret A. FitzGerald Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8418–8423. Published online 2002 May 14. doi: 10.1073/pnas.112217799.PMCID: PMC123082 Physiology Mechanism of calcium/calmodulin inhibition of rod cyclic nucleotide-gated channels Matthew C. Trudeau and William N. Zagotta Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8424–8429. Published online 2002 June 4. doi: 10.1073/pnas.122015999.PMCID: PMC123083 A glutamate residue at the C terminus regulates activity of inward rectifier K+ channels: Implication for Andersen's syndrome Lei Chen, Takeharu Kawano, Sibinka Bajic, Yoshito Kaziro, Hiroshi Itoh, Jonathan J. Art, Yasuko Nakajima, and Shigehiro Nakajima Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8430–8435. Published online 2002 May 28. doi: 10.1073/pnas.122682899.PMCID: PMC123084 Plant Biology Regulation of SOS1, a plasma membrane Na+/H+ exchanger in Arabidopsis thaliana, by SOS2 and SOS3 Quan-Sheng Qiu, Yan Guo, Margaret A. Dietrich, Karen S. Schumaker, and Jian-Kang Zhu Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8436–8441. Published online 2002 May 28. doi: 10.1073/pnas.122224699.PMCID: PMC123085 Population Biology Life-long sustained mortality advantage of siblings of centenarians Thomas T. Perls, John Wilmoth, Robin Levenson, Maureen Drinkwater, Melissa Cohen, Hazel Bogan, Erin Joyce, Stephanie Brewster, Louis Kunkel, and Annibale Puca Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8442–8447. doi: 10.1073/pnas.122587599.PMCID: PMC123086 Psychology Evidence for a dysfunctional prefrontal circuit in patients with an impulsive aggressive disorder Mary Best, J. Michael Williams, and Emil F. Coccaro Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8448–8453. Published online 2002 May 28. doi: 10.1073/pnas.112604099.PMCID: PMC123087 Social Sciences Anthropology Paranasal sinus anatomy of Aegyptopithecus: Implications for hominoid origins James B. Rossie, Elwyn L. Simons, Suellen C. Gauld, and D. Tab Rasmussen Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8454–8456. doi: 10.1073/pnas.092258699.PMCID: PMC123088 Corrections Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8457. doi: 10.1073/pnas.122227499.PMCID: PMC122969 Corrects: S. Rashkova, et al. Element-specific localization of Drosophila retrotransposon Gag proteins occurs in both nucleus and cytoplasm. Proc Natl Acad Sci U S A. 2002 March 19; 99(6): 3621–3626. Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8457. Published online 2002 June 4. doi: 10.1073/pnas.122227999.PMCID: PMC122970 Corrects: Catherine H. Régnier, et al. Impaired neural tube closure, axial skeleton malformations, and tracheal ring disruption in TRAF4-deficient mice. Proc Natl Acad Sci U S A. 2002 April 16; 99(8): 5585–5590. Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8458. Published online 2002 June 4. doi: 10.1073/pnas.112186899.PMCID: PMC122971 Corrects: Xiaoping Shao, et al. Regulatory DNA required for vnd/NK-2 homeobox
gene expression pattern in neuroblasts. Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 113–117. Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8460. Published online 2002 June 4. doi: 10.1073/pnas.122227199.PMCID: PMC122972 Corrects: Qing Zhao, et al. Identification of genes expressed with temporal-spatial restriction to developing cerebellar neuron precursors by a functional genomic approach. Proc Natl Acad Sci U S A. 2002 April 16; 99(8): 5704–5709. |