| | This journal provides immediate access to some articles. Biochemistry INAUGURAL ARTICLE by a Recently Elected Academy Member: Zinc finger as distance determinant in the flexible linker of intron endonuclease I- TevI Amy B. Dean, Matt J. Stanger, John T. Dansereau, Patrick Van Roey, Victoria Derbyshire, and Marlene Belfort Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8554–8561. Published online 2002 June 19. doi: 10.1073/pnas.082253699.PMCID: PMC124309 Commentaries Microbial subversion of the immune response P. J. Lachmann Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8461–8462. Published online 2002 June 19. doi: 10.1073/pnas.132284499.PMCID: PMC124270 A new type of photoreceptor in algae Thomas G. Ebrey Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8463–8464. doi: 10.1073/pnas.142293599.PMCID: PMC124272 Might a vanguard of mRNAs prepare cells for the arrival of herpes simplex virus? Thomas Shenk Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8465–8466. doi: 10.1073/pnas.152301499.PMCID: PMC124273 Physical Sciences Applied Mathematics The p53MH algorithm and its application in detecting p53-responsive genes J. Hoh, S. Jin, T. Parrado, J. Edington, A. J. Levine, and J. Ott Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8467–8472. Published online 2002 June 19. doi: 10.1073/pnas.132268899.PMCID: PMC124275 Structure theorems for game trees Srihari Govindan and Robert Wilson Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 9077–9080. Published online 2002 June 11. doi: 10.1073/pnas.082249599.PMCID: PMC124887 Applied Physical Sciences Inverting dynamic force microscopy: From signals to time-resolved interaction forces Martin Stark, Robert W. Stark, Wolfgang M. Heckl, and Reinhard Guckenberger Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8473–8478. Published online 2002 June 17. doi: 10.1073/pnas.122040599.PMCID: PMC124277 Design of protein struts for self-assembling nanoconstructs Paul Hyman, Regina Valluzzi, and Edward Goldberg Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8488–8493. Published online 2002 June 17. doi: 10.1073/pnas.132544299.PMCID: PMC124284 Chemistry Liquid–liquid separation in solutions of normal and sickle cell hemoglobin Oleg Galkin, Kai Chen, Ronald L. Nagel, Rhoda Elison Hirsch, and Peter G. Vekilov Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8479–8483. Published online 2002 June 17. doi: 10.1073/pnas.122055299.PMCID: PMC124280 Physics Contactless experiments on individual DNA molecules show no evidence for molecular wire behavior C. Gómez-Navarro, F. Moreno-Herrero, P. J. de Pablo, J. Colchero, J. Gómez-Herrero, and A. M. Baró Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8484–8487. Published online 2002 June 17. doi: 10.1073/pnas.122610899.PMCID: PMC124282 Biological Sciences Applied Biological Sciences Design of protein struts for self-assembling nanoconstructs Paul Hyman, Regina Valluzzi, and Edward Goldberg Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8488–8493. Published online 2002 June 17. doi: 10.1073/pnas.132544299.PMCID: PMC124284 Biochemistry Omnipotent decoding potential resides in eukaryotic translation termination factor eRF1 of variant-code organisms and is modulated by the interactions of amino acid sequences within domain 1 Koichi Ito, Ludmila Frolova, Alim Seit-Nebi, Andrey Karamyshev, Lev Kisselev, and Yoshikazu Nakamura Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8494–8499. doi: 10.1073/pnas.142690099.PMCID: PMC124286 From the Cover: trilogy: Discovery of sequence–structure patterns across diverse proteins Philip Bradley, Peter S. Kim, and Bonnie Berger Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8500–8505. doi: 10.1073/pnas.112221999.PMCID: PMC124288 All intermediates of the arsenate reductase mechanism, including an intramolecular dynamic disulfide cascade Joris Messens, José C. Martins, Karolien Van Belle, Elke Brosens, Aline Desmyter, Marjan De Gieter, Jean-Michel Wieruszeski, Rudolph Willem, Lode Wyns, and Ingrid Zegers Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8506–8511. Published online 2002 June 18. doi: 10.1073/pnas.132142799.PMCID: PMC124290 Identification of a gene encoding MGAT1, a monoacylglycerol acyltransferase Chi-Liang Eric Yen, Scot J. Stone, Sylvaine Cases, Ping Zhou, and Robert V. Farese, Jr. Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8512–8517. Published online 2002 June 19. doi: 10.1073/pnas.132274899.PMCID: PMC124292 The rate-limiting step in the folding of a large ribozyme without kinetic traps X.-W. Fang, P. Thiyagarajan, T. R. Sosnick, and T. Pan Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8518–8523. doi: 10.1073/pnas.142288399.PMCID: PMC124294 Specificity and affinity motifs for Grb2 SH2-ligand interactions Helmut W. H. G. Kessels, Alister C. Ward, and Ton N. M. Schumacher Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8524–8529. doi: 10.1073/pnas.142224499.PMCID: PMC124298 Isolation of receptor–ligand pairs by capture of long-lived multivalent interaction complexes Ruud M. T. de Wildt, Ian M. Tomlinson, Jennifer L. Ong, and Philipp Holliger Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8530–8535. doi: 10.1073/pnas.132008499.PMCID: PMC124300 Autoregulation of a bacterial σ factor explored by using segmental isotopic labeling and NMR Julio A. Camarero, Alexander Shekhtman, Elizabeth A. Campbell, Mark Chlenov, Tanja M. Gruber, Donald A. Bryant, Seth A. Darst, David Cowburn, and Tom W. Muir Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8536–8541. doi: 10.1073/pnas.132033899.PMCID: PMC124302 Interactions of mutant and wild-type flap endonucleases with oligonucleotide substrates suggest an alternative model of DNA binding Joe J. Dervan, Min Feng, Dipak Patel, Jane A. Grasby, Peter J. Artymiuk, Thomas A. Ceska, and Jon R. Sayers Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8542–8547. doi: 10.1073/pnas.082241699.PMCID: PMC124304 Gene activation by interaction of an inhibitor with a cytoplasmic signaling protein Gang Peng and James E. Hopper Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8548–8553. doi: 10.1073/pnas.142100099.PMCID: PMC124307 INAUGURAL ARTICLE by a Recently Elected Academy Member: Zinc finger as distance determinant in the flexible linker of intron endonuclease I- TevI Amy B. Dean, Matt J. Stanger, John T. Dansereau, Patrick Van Roey, Victoria Derbyshire, and Marlene Belfort Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8554–8561. Published online 2002 June 19. doi: 10.1073/pnas.082253699.PMCID: PMC124309 Kinetic analysis of estrogen receptor/ligand interactions Rebecca L. Rich, Lise R. Hoth, Kieran F. Geoghegan, Thomas A. Brown, Peter K. LeMotte, Samuel P. Simons, Preston Hensley, and David G. Myszka Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8562–8567. Published online 2002 June 19. doi: 10.1073/pnas.142288199.PMCID: PMC124311 Sequence determinants of the energetics of folding of a transmembrane four-helix-bundle protein Kathleen P. Howard, James D. Lear, and William F. DeGrado Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8568–8572. doi: 10.1073/pnas.132266099.PMCID: PMC124313 Characterization of an orphan G protein-coupled receptor localized in the dorsal root ganglia reveals adenine as a signaling molecule Eckhard Bender, Arjan Buist, Mirek Jurzak, Xavier Langlois, Geert Baggerman, Peter Verhasselt, Martine Ercken, Hong-Qing Guo, Cindy Wintmolders, Ilse Van den Wyngaert, Irma Van Oers, Liliane Schoofs, and Walter Luyten Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8573–8578. doi: 10.1073/pnas.122016499.PMCID: PMC124315 Ebselen: A substrate for human thioredoxin reductase strongly stimulating its hydroperoxide reductase activity and a superfast thioredoxin oxidant Rong Zhao, Hiroyuki Masayasu, and Arne Holmgren Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8579–8584. Published online 2002 June 17. doi: 10.1073/pnas.122061399.PMCID: PMC124318 Hsp90 enables Ctf13p/Skp1p to nucleate the budding yeast kinetochore Olaf Stemmann, Anke Neidig, Thomas Köcher, Matthias Wilm, and Johannes Lechner Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8585–8590. doi: 10.1073/pnas.082223899.PMCID: PMC124320 A target essential for the activity of a nonacidic yeast transcriptional activator Zhen Lu, Aseem Z. Ansari, Xiangyang Lu, Anuja Ogirala, and Mark Ptashne Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8591–8596. doi: 10.1073/pnas.092263499.PMCID: PMC124323 Employing Escherichia coli to functionally express, purify, and characterize a human transporter Matthias Quick and Ernest M. Wright Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8597–8601. Published online 2002 June 19. doi: 10.1073/pnas.132266599.PMCID: PMC124325 NTP-sensing by rRNA promoters in Escherichia coli is direct David A. Schneider, Tamas Gaal, and Richard L. Gourse Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8602–8607. Published online 2002 June 11. doi: 10.1073/pnas.132285199.PMCID: PMC124327 Overexpression, purification, and site-directed spin labeling of the Nramp metal transporter from Mycobacterium leprae Ian Reeve, David Hummell, Nathan Nelson, and John Voss Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8608–8613. Published online 2002 June 19. doi: 10.1073/pnas.142287699.PMCID: PMC124330 Biophysics Specific zinc-finger architecture required for HIV-1 nucleocapsid protein's nucleic acid chaperone function Mark C. Williams, Robert J. Gorelick, and Karin Musier-Forsyth Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8614–8619. doi: 10.1073/pnas.132128999.PMCID: PMC124332 How to describe protein motion without amino acid sequence and atomic coordinates Dengming Ming, Yifei Kong, Maxime A. Lambert, Zhong Huang, and Jianpeng Ma Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8620–8625. doi: 10.1073/pnas.082148899.PMCID: PMC124334 Using deeply trapped intermediates to map the cytochrome c folding landscape F. Akif Tezcan, William M. Findley, Brian R. Crane, Scott A. Ross, Julia G. Lyubovitsky, Harry B. Gray, and Jay R. Winkler Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8626–8630. doi: 10.1073/pnas.132254499.PMCID: PMC124336 A possible evolutionary origin for the Mn4 cluster of the photosynthetic water oxidation complex from natural MnO2 precipitates in the early ocean Kenneth Sauer and Vittal K. Yachandra Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8631–8636. Published online 2002 June 19. doi: 10.1073/pnas.132266199.PMCID: PMC124339 Topological determinants of protein folding Nikolay V. Dokholyan, Lewyn Li, Feng Ding, and Eugene I. Shakhnovich Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8637–8641. doi: 10.1073/pnas.122076099.PMCID: PMC124342 Hidden Markov models from molecular dynamics simulations on DNA Kelly M. Thayer and D. L. Beveridge Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8642–8647. Published online 2002 June 18. doi: 10.1073/pnas.132148699.PMCID: PMC124344 Probing solvent accessibility of amyloid fibrils by solution NMR spectroscopy Johannes H. Ippel, Anders Olofsson, Jürgen Schleucher, Erik Lundgren, and Sybren S. Wijmenga Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8648–8653. Published online 2002 June 18. doi: 10.1073/pnas.132098999.PMCID: PMC124346 Tuning the membrane surface potential for efficient toxin import Stanislav D. Zakharov, Tatyana I. Rokitskaya, Vladimir L. Shapovalov, Yuri N. Antonenko, and William A. Cramer Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8654–8659. Published online 2002 June 11. doi: 10.1073/pnas.122613099.PMCID: PMC124348 Cell Biology The p53MH algorithm and its application in detecting p53-responsive genes J. Hoh, S. Jin, T. Parrado, J. Edington, A. J. Levine, and J. Ott Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8467–8472. Published online 2002 June 19. doi: 10.1073/pnas.132268899.PMCID: PMC124275 Dome formation in cell cultures as expression of an early stage of lactogenic differentiation of the mammary gland I. Zucchi, L. Bini, D. Albani, R. Valaperta, S. Liberatori, R. Raggiaschi, C. Montagna, L. Susani, O. Barbieri, V. Pallini, P. Vezzoni, and R. Dulbecco Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8660–8665. Published online 2002 June 19. doi: 10.1073/pnas.132259399.PMCID: PMC124351 Presenilin and nicastrin regulate each other and determine amyloid β-peptide production via complex formation Dieter Edbauer, Edith Winkler, Christian Haass, and Harald Steiner Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8666–8671. Published online 2002 June 4. doi: 10.1073/pnas.132277899.PMCID: PMC124353 Activation of Cdc2/cyclin B and inhibition of centrosome amplification in cells depleted of Plk1 by siRNA Xiaoqi Liu and Raymond L. Erikson Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8672–8676. Published online 2002 June 19. doi: 10.1073/pnas.132269599.PMCID: PMC124355 An ectopic human XIST gene can induce chromosome inactivation in postdifferentiation human HT-1080 cells Lisa L. Hall, Meg Byron, Kosuke Sakai, Laura Carrel, Huntington F. Willard, and Jeanne B. Lawrence Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8677–8682. Published online 2002 June 18. doi: 10.1073/pnas.132468999.PMCID: PMC124357 Subcellular distribution of Wnt pathway proteins in normal and neoplastic colon Christine B. Anderson, Kristi L. Neufeld, and Raymond L. White Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8683–8688. Published online 2002 June 18. doi: 10.1073/pnas.122235399.PMCID: PMC124359 From the Cover: Two rhodopsins mediate phototaxis to low- and high-intensity light in Chlamydomonas reinhardtii Oleg A. Sineshchekov, Kwang-Hwan Jung, and John L. Spudich Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8689–8694. Published online 2002 June 11. doi: 10.1073/pnas.122243399.PMCID: PMC124360 Methylation of histone H3 Lys 4 in coding regions of active genes Bradley E. Bernstein, Emily L. Humphrey, Rachel L. Erlich, Robert Schneider, Peter Bouman, Jun S. Liu, Tony Kouzarides, and Stuart L. Schreiber Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8695–8700. Published online 2002 June 11. doi: 10.1073/pnas.082249499.PMCID: PMC124361 Evidence that subcellular localization of a bacterial membrane protein is achieved by diffusion and capture David Z. Rudner, Qi Pan, and Richard M. Losick Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8701–8706. Published online 2002 June 11. doi: 10.1073/pnas.132235899.PMCID: PMC124362 Developmental Biology Previously uncharacterized histone acetyltransferases implicated in mammalian spermatogenesis Bruce T. Lahn, Zhao Lan Tang, Jianxin Zhou, Robert J. Barndt, Martti Parvinen, C. David Allis, and David C. Page Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8707–8712. Published online 2002 June 18. doi: 10.1073/pnas.082248899.PMCID: PMC124363 From the Cover: Bone patterning is altered in the regenerating zebrafish caudal fin after ectopic expression of sonic hedgehog and bmp2b or exposure to cyclopamine Elizabeth Quint, Amanda Smith, Fabien Avaron, Lynda Laforest, Jennifer Miles, William Gaffield, and Marie-Andrée Akimenko Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8713–8718. Published online 2002 June 11. doi: 10.1073/pnas.122571799.PMCID: PMC124364 Mutually regulated expression of Pax6 and Six3 and its implications for the Pax6 haploinsufficient lens phenotype Guy Goudreau, Petros Petrou, Lixing W. Reneker, Jochen Graw, Jana Löster, and Peter Gruss Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8719–8724. Published online 2002 June 18. doi: 10.1073/pnas.132195699.PMCID: PMC124365 Ecology From the Cover: The etiology of white pox, a lethal disease of the Caribbean elkhorn coral, Acropora palmata Kathryn L. Patterson, James W. Porter, Kim B. Ritchie, Shawn W. Polson, Erich Mueller, Esther C. Peters, Deborah L. Santavy, and Garriet W. Smith Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8725–8730. Published online 2002 June 19. doi: 10.1073/pnas.092260099.PMCID: PMC124366 Increased competition may promote species coexistence J. Vandermeer, M. A. Evans, P. Foster, T. Höök, M. Reiskind, and M. Wund Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8731–8736. Published online 2002 June 17. doi: 10.1073/pnas.142073599.PMCID: PMC124367 Evolution SOS-induced DNA polymerases enhance long-term survival and evolutionary fitness Bethany Yeiser, Evan D. Pepper, Myron F. Goodman, and Steven E. Finkel Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8737–8741. Published online 2002 June 11. doi: 10.1073/pnas.092269199.PMCID: PMC124368 On the evolution of cells Carl R. Woese Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8742–8747. Published online 2002 June 19. doi: 10.1073/pnas.132266999.PMCID: PMC124369 Microsatellite evolution inferred from human– chimpanzee genomic sequence alignments Matthew T. Webster, Nick G. C. Smith, and Hans Ellegren Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8748–8753. Published online 2002 June 17. doi: 10.1073/pnas.122067599.PMCID: PMC124370 Quantitative evolutionary design of nutrient processing: Glucose Anthony C. Steyermark, Mandy M. Lam, and Jared Diamond Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8754–8759. Published online 2002 June 19. doi: 10.1073/pnas.132277799.PMCID: PMC124371 Genetics The aspartate-257 of presenilin 1 is indispensable for mouse development and production of β-amyloid peptides through β-catenin-independent mechanisms Xuefeng Xia, Pei Wang, Xiaoyan Sun, Salvador Soriano, Wan-Kyng Shum, Haruyasu Yamaguchi, Myrna E. Trumbauer, Akihiko Takashima, Edward H. Koo, and Hui Zheng Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8760–8765. Published online 2002 June 17. doi: 10.1073/pnas.132045399.PMCID: PMC124372 TRAF6-deficient mice display hypohidrotic ectodermal dysplasia Asuka Naito, Hisahiro Yoshida, Eri Nishioka, Mizuho Satoh, Sakura Azuma, Tadashi Yamamoto, Shin-ichi Nishikawa, and Jun-ichiro Inoue Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8766–8771. Published online 2002 June 11. doi: 10.1073/pnas.132636999.PMCID: PMC124373 Short inverted repeats initiate gene amplification through the formation of a large DNA palindrome in mammalian cells Hisashi Tanaka, Stephen J. Tapscott, Barbara J. Trask, and Meng-Chao Yao Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8772–8777. Published online 2002 June 11. doi: 10.1073/pnas.132275999.PMCID: PMC124374 Transcriptional response of Saccharomyces cerevisiae to DNA-damaging agents does not identify the genes that protect against these agents Geoff W. Birrell, James A. Brown, H. Irene Wu, Guri Giaever, Angela M. Chu, Ronald W. Davis, and J. Martin Brown Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8778–8783. Published online 2002 June 19. doi: 10.1073/pnas.132275199.PMCID: PMC124375 Polynucleotide phosphorylase is a global regulator of virulence and persistency in Salmonella enterica Mark O. Clements, Sofia Eriksson, Arthur Thompson, Sacha Lucchini, Jay C. D. Hinton, Staffan Normark, and Mikael Rhen Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8784–8789. Published online 2002 June 18. doi: 10.1073/pnas.132047099.PMCID: PMC124376 Binding sites of different geometries for the 16-3 phage repressor Péter P. Papp, Tibor Nagy, Szilamér Ferenczi, Péter Élõ, Zsolt Csiszovszki, Zsuzsanna Buzás, András Patthy, and László Orosz Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8790–8795. doi: 10.1073/pnas.132275399.PMCID: PMC124377 Transcriptional collision between convergent genes in budding yeast Elizabeth M. Prescott and Nick J. Proudfoot Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8796–8801. Published online 2002 June 19. doi: 10.1073/pnas.132270899.PMCID: PMC124378 A cytosine methyltransferase homologue is essential for repeat-induced point mutation in Neurospora crassa Michael Freitag, Rebecca L. Williams, Gregory O. Kothe, and Eric U. Selker Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8802–8807. Published online 2002 June 18. doi: 10.1073/pnas.132212899.PMCID: PMC124379 Immunology From the Cover: Variola virus immune evasion design: Expression of a highly efficient inhibitor of human complement Ariella M. Rosengard, Yu Liu, Zhiping Nie, and Robert Jimenez Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8808–8813. Published online 2002 May 28. doi: 10.1073/pnas.112220499.PMCID: PMC124380 Genome expression analysis of Anopheles gambiae: Responses to injury, bacterial challenge, and malaria infection George Dimopoulos, George K. Christophides, Stephan Meister, Jörg Schultz, Kevin P. White, Carolina Barillas-Mury, and Fotis C. Kafatos Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8814–8819. Published online 2002 June 19. doi: 10.1073/pnas.092274999.PMCID: PMC124381 Alternate interactions define the binding of peptides to the MHC molecule IAb Xinqi Liu, Shaodong Dai, Frances Crawford, Rachel Frugé, Philippa Marrack, and John Kappler Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8820–8825. doi: 10.1073/pnas.132272099.PMCID: PMC124382 Recognition of a virus-encoded ligand by a natural killer cell activation receptor Hamish R. C. Smith, Jonathan W. Heusel, Indira K. Mehta, Sungjin Kim, Brigitte G. Dorner, Olga V. Naidenko, Koho Iizuka, Hiroshi Furukawa, Diana L. Beckman, Jeanette T. Pingel, Anthony A. Scalzo, Daved H. Fremont, and Wayne M. Yokoyama Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8826–8831. Published online 2002 June 11. doi: 10.1073/pnas.092258599.PMCID: PMC124383 CD25+CD4+ T cells contribute to the control of memory CD8+ T cells Masaaki Murakami, Akemi Sakamoto, Jeremy Bender, John Kappler, and Philippa Marrack Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8832–8837. doi: 10.1073/pnas.132254399.PMCID: PMC124384 Identification of gene function by cyclical packaging rescue of retroviral cDNA libraries Deepta Bhattacharya, Eric C. Logue, Sonia Bakkour, James DeGregori, and William C. Sha Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8838–8843. doi: 10.1073/pnas.132274799.PMCID: PMC124385 Distinct recognition by two subsets of T cells of an MHC class II-peptide complex Zheng Pu, Javier A. Carrero, and Emil R. Unanue Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8844–8849. doi: 10.1073/pnas.092260499.PMCID: PMC124386 MHC class I-dependent Vγ4+ pulmonary T cells regulate αβ T cell-independent airway responsiveness Michael Lahn, Arihiko Kanehiro, Katsuyuki Takeda, Jennifer Terry, Youn-Soo Hahn, M. Kemal Aydintug, Anatole Konowal, Koichi Ikuta, Rebecca L. O'Brien, Erwin W. Gelfand, and Willi K. Born Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8850–8855. Published online 2002 June 17. doi: 10.1073/pnas.132519299.PMCID: PMC124387 The myelin basic protein gene is expressed in differentiated blood cell lineages and in hemopoietic progenitors M. C. Marty, F. Alliot, J. Rutin, R. Fritz, D. Trisler, and B. Pessac Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8856–8861. doi: 10.1073/pnas.122079599.PMCID: PMC124388 Urokinase–urokinase receptor interaction mediates an inhibitory signal for HIV-1 replication Massimo Alfano, Nicolai Sidenius, Barbara Panzeri, Francesco Blasi, and Guido Poli Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8862–8867. doi: 10.1073/pnas.142078099.PMCID: PMC124389 Medical Sciences Blockade of vascular endothelial growth factor receptor-3 signaling inhibits fibroblast growth factor-2-induced lymphangiogenesis in mouse cornea Hajime Kubo, Renhai Cao, Ebba Bräkenhielm, Taija Mäkinen, Yihai Cao, and Kari Alitalo Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8868–8873. Published online 2002 June 17. doi: 10.1073/pnas.062040199.PMCID: PMC124390 Stable expression of calpain 3 from a muscle transgene in vivo: Immature muscle in transgenic mice suggests a role for calpain 3 in muscle maturation M. J. Spencer, J. R. Guyon, H. Sorimachi, A. Potts, I. Richard, M. Herasse, J. Chamberlain, I. Dalkilic, L. M. Kunkel, and J. S. Beckmann Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8874–8879. Published online 2002 June 19. doi: 10.1073/pnas.132269299.PMCID: PMC124391 Conditional mutation of the ErbB2 (HER2) receptor in cardiomyocytes leads to dilated cardiomyopathy Cemil Özcelik, Bettina Erdmann, Bernhard Pilz, Nina Wettschureck, Stefan Britsch, Norbert Hübner, Kenneth R. Chien, Carmen Birchmeier, and Alistair N. Garratt Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8880–8885. Published online 2002 June 18. doi: 10.1073/pnas.122249299.PMCID: PMC124392 Transformation of follicular lymphoma to diffuse large-cell lymphoma: Alternative patterns with increased or decreased expression of c-myc and its regulated genes Izidore S. Lossos, Ash A. Alizadeh, Maximilian Diehn, Roger Warnke, Yvonne Thorstenson, Peter J. Oefner, Patrick O. Brown, David Botstein, and Ronald Levy Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8886–8891. Published online 2002 June 19. doi: 10.1073/pnas.132253599.PMCID: PMC124393 Inhibition of mitochondrial respiration by endogenous nitric oxide: A critical step in Fas signaling Belén Beltrán, Marisol Quintero, Eugenia García-Zaragozá, Enrique O'Connor, Juan V. Esplugues, and Salvador Moncada Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8892–8897. Published online 2002 June 19. doi: 10.1073/pnas.092259799.PMCID: PMC124394 In vivo properties of an anti-GnRH Spiegelmer: An example of an oligonucleotide-based therapeutic substance class Britta Wlotzka, Susanne Leva, Bernd Eschgfäller, Jens Burmeister, Frank Kleinjung, Christine Kaduk, Peter Muhn, Holger Hess-Stumpp, and Sven Klussmann Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8898–8902. Published online 2002 June 17. doi: 10.1073/pnas.132067399.PMCID: PMC124395 Role of Lkb1, the causative gene of Peutz–Jegher's syndrome, in embryogenesis and polyposis Kou-ichi Jishage, Jun-ichi Nezu, Yosuke Kawase, Takamitsu Iwata, Miho Watanabe, Akio Miyoshi, Asuka Ose, Kiyoshi Habu, Takei Kake, Nobuo Kamada, Otoya Ueda, Michiko Kinoshita, Dieter E. Jenne, Miyuki Shimane, and Hiroshi Suzuki Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8903–8908. Published online 2002 June 11. doi: 10.1073/pnas.122254599.PMCID: PMC124396 Adeno-associated virus type-2 expression of pigmented epithelium-derived factor or Kringles 1–3 of angiostatin reduce retinal neovascularization Brian J. Raisler, Kenneth I. Berns, Maria B. Grant, Denis Beliaev, and William W. Hauswirth Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8909–8914. Published online 2002 June 18. doi: 10.1073/pnas.122247299.PMCID: PMC124397 Bucillamine, a thiol antioxidant, prevents transplantation-associated reperfusion injury Farin Amersi, Sally K. Nelson, Xiu Da Shen, Hirohisa Kato, Judy Melinek, Jerzy W. Kupiec-Weglinski, Lawrence D. Horwitz, Ronald W. Busuttil, and Marcus A. Horwitz Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8915–8920. doi: 10.1073/pnas.132026099.PMCID: PMC124398 A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression Kazuhiro Ito, Sam Lim, Gaetano Caramori, Borja Cosio, K. Fan Chung, Ian M. Adcock, and Peter J. Barnes Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8921–8926. Published online 2002 June 17. doi: 10.1073/pnas.132556899.PMCID: PMC124399 Intestinal adenomas can develop with a stable karyotype and stable microsatellites Kevin M. Haigis, James G. Caya, Mark Reichelderfer, and William F. Dove Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8927–8931. Published online 2002 June 11. doi: 10.1073/pnas.132275099.PMCID: PMC124400 Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: Implications for cell therapy of bone Edwin M. Horwitz, Patricia L. Gordon, Winston K. K. Koo, Jeffrey C. Marx, Michael D. Neel, Rene Y. McNall, Linda Muul, and Ted Hofmann Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8932–8937. doi: 10.1073/pnas.132252399.PMCID: PMC124401 Important role of hypothalamic Y2 receptors in body weight regulation revealed in conditional knockout mice Amanda Sainsbury, Christoph Schwarzer, Michelle Couzens, Serguei Fetissov, Sabine Furtinger, Arthur Jenkins, Helen M. Cox, Günther Sperk, Tomas Hökfelt, and Herbert Herzog Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8938–8943. Published online 2002 June 18. doi: 10.1073/pnas.132043299.PMCID: PMC124402 Microbiology DNA containing CpG motifs induces angiogenesis Mei Zheng, Dennis M. Klinman, Malgorzata Gierynska, and Barry T. Rouse Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8944–8949. Published online 2002 June 11. doi: 10.1073/pnas.132605599.PMCID: PMC124403 Emergence of multiple genotypes of H5N1 avian influenza viruses in Hong Kong SAR Y. Guan, J. S. M. Peiris, A. S. Lipatov, T. M. Ellis, K. C. Dyrting, S. Krauss, L. J. Zhang, R. G. Webster, and K. F. Shortridge Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8950–8955. Published online 2002 June 19. doi: 10.1073/pnas.132268999.PMCID: PMC124404 Evolutionary genomics of Salmonella: Gene acquisitions revealed by microarray analysis Steffen Porwollik, Rita Mei-Yi Wong, and Michael McClelland Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8956–8961. Published online 2002 June 18. doi: 10.1073/pnas.122153699.PMCID: PMC124405 Assembling the glycopeptide antibiotic scaffold: The biosynthesis of from Streptomyces toyocaensis NRRL15009 Jeff Pootoolal, Michael G. Thomas, C. Gary Marshall, John M. Neu, Brian K. Hubbard, Christopher T. Walsh, and Gerard D. Wright Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8962–8967. Published online 2002 June 11. doi: 10.1073/pnas.102285099.PMCID: PMC124406 Neurobiology Human α-synuclein-harboring familial Parkinson's disease-linked Ala-53 → Thr mutation causes neurodegenerative disease with α-synuclein aggregation in transgenic mice Michael K. Lee, Wanda Stirling, Yanqun Xu, Xueying Xu, Dike Qui, Allen S. Mandir, Ted M. Dawson, Neal G. Copeland, Nancy A. Jenkins, and Don L. Price Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8968–8973. doi: 10.1073/pnas.132197599.PMCID: PMC124407 Computational subunits of visual cortical neurons revealed by artificial neural networks Brian Lau, Garrett B. Stanley, and Yang Dan Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8974–8979. Published online 2002 June 11. doi: 10.1073/pnas.122173799.PMCID: PMC124408 Trace fear conditioning involves hippocampal α5 GABAA receptors F. Crestani, R. Keist, J.-M. Fritschy, D. Benke, K. Vogt, L. Prut, H. Blüthmann, H. Möhler, and U. Rudolph Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8980–8985. doi: 10.1073/pnas.142288699.PMCID: PMC124409 Altered accumbens neural response to prediction of reward associated with place in dopamine D2 receptor knockout mice Anh Hai Tran, Ryoi Tamura, Teruko Uwano, Tsuneyuki Kobayashi, Motoya Katsuki, Gen Matsumoto, and Taketoshi Ono Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8986–8991. doi: 10.1073/pnas.132284599.PMCID: PMC124410 A role for ASIC3 in the modulation of high-intensity pain stimuli Chih-Cheng Chen, Anne Zimmer, Wei-Hsin Sun, Jennifer Hall, Michael J. Brownstein, and Andreas Zimmer Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8992–8997. Published online 2002 June 11. doi: 10.1073/pnas.122245999.PMCID: PMC124411 Deciphering peripheral nerve myelination by using Schwann cell expression profiling Rakesh Nagarajan, Nam Le, Heather Mahoney, Toshiyuki Araki, and Jeffrey Milbrandt Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8998–9003. doi: 10.1073/pnas.132080999.PMCID: PMC124412 Local circuit neurons in the striatum regulate neural and behavioral responses to dopaminergic stimulation E. Saka, M. Iadarola, D. J. Fitzgerald, and A. M. Graybiel Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 9004–9009. Published online 2002 June 11. doi: 10.1073/pnas.132212499.PMCID: PMC124413 Amyotrophic lateral sclerosis: A proposed mechanism Ayako Okado-Matsumoto and Irwin Fridovich Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 9010–9014. Published online 2002 June 11. doi: 10.1073/pnas.132260399.PMCID: PMC124414 Leukemia inhibitory factor inhibits neuronal terminal differentiation through STAT3 activation Cheil Moon, Joo-Yeon Yoo, Valéry Matarazzo, Young Kwan Sung, Esther J. Kim, and Gabriele V. Ronnett Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 9015–9020. doi: 10.1073/pnas.132131699.PMCID: PMC124415 Time-critical integration of formants for perception of communication calls in mice Diana B. Geissler and Günter Ehret Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 9021–9025. Published online 2002 June 17. doi: 10.1073/pnas.122606499.PMCID: PMC124416 Cocaine sensitization and reward are under the influence of circadian genes and rhythm Carolina Abarca, Urs Albrecht, and Rainer Spanagel Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 9026–9030. doi: 10.1073/pnas.142039099.PMCID: PMC124417 Inosine induces axonal rewiring and improves behavioral outcome after stroke Peng Chen, David E. Goldberg, Bryan Kolb, Marc Lanser, and Larry I. Benowitz Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 9031–9036. doi: 10.1073/pnas.132076299.PMCID: PMC124418 Total arrest of spontaneous and evoked synaptic transmission but normal synaptogenesis in the absence of Munc13-mediated vesicle priming Frederique Varoqueaux, Albrecht Sigler, Jeong-Seop Rhee, Nils Brose, Carsten Enk, Kerstin Reim, and Christian Rosenmund Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 9037–9042. Published online 2002 June 17. doi: 10.1073/pnas.122623799.PMCID: PMC124419 Plant Biology Semidwarf (sd-1), “green revolution” rice, contains a defective gibberellin 20-oxidase gene Wolfgang Spielmeyer, Marc H. Ellis, and Peter M. Chandler Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 9043–9048. Published online 2002 June 19. doi: 10.1073/pnas.132266399.PMCID: PMC124420 Two immediate-early pathogen-responsive members of the AtCMPG gene family in Arabidopsis thaliana and the W-box-containing elicitor-response element of AtCMPG1 Andreas Heise, Bernadette Lippok, Christoph Kirsch, and Klaus Hahlbrock Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 9049–9054. doi: 10.1073/pnas.132277699.PMCID: PMC124421 Suppression and acceleration of cell elongation by integration of xyloglucans in pea stem segments Takumi Takeda, Yuzo Furuta, Tatsuya Awano, Koichi Mizuno, Yasushi Mitsuishi, and Takahisa Hayashi Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 9055–9060. doi: 10.1073/pnas.132080299.PMCID: PMC124422 Reconstitution in yeast of the Arabidopsis SOS signaling pathway for Na+ homeostasis Francisco J. Quintero, Masaru Ohta, Huazhong Shi, Jian-Kang Zhu, and Jose M. Pardo Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 9061–9066. Published online 2002 June 17. doi: 10.1073/pnas.132092099.PMCID: PMC124423 Population Biology Disease surveillance in recombining pathogens: Multilocus genotypes identify sources of human Coccidioides infections Matthew C. Fisher, Bruce Rannala, Vishnu Chaturvedi, and John W. Taylor Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 9067–9071. doi: 10.1073/pnas.132178099.PMCID: PMC124424 Psychology Early experience is associated with the development of categorical representations for facial expressions of emotion Seth D. Pollak and Doris J. Kistler Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 9072–9076. Published online 2002 June 18. doi: 10.1073/pnas.142165999.PMCID: PMC124425 Social Sciences Economic Sciences Structure theorems for game trees Srihari Govindan and Robert Wilson Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 9077–9080. Published online 2002 June 11. doi: 10.1073/pnas.082249599.PMCID: PMC124887 Corrections Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 9081. Published online 2002 June 11. doi: 10.1073/pnas.132227099.PMCID: PMC124261 Corrects: Eugene W. Myers, et al. On the sequencing and assembly of the human genome. Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4145–4146. Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 9081. doi: 10.1073/pnas.132249099.PMCID: PMC124263 Corrects: Andrea G. Cochran, et al. Tryptophan zippers: Stable, monomeric β-hairpins. Proc Natl Acad Sci U S A. 2001 May 8; 98(10): 5578–5583. Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 9081. Published online 2002 June 11. doi: 10.1073/pnas.132280599.PMCID: PMC124264 Corrects: Shinya Inoué, et al. Fluorescence polarization of green fluorescence protein. Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4272–4277. Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 9081. Published online 2002 June 11. doi: 10.1073/pnas.122187999.PMCID: PMC124266 Corrects: Helen R. Moinova, et al. HLTF gene silencing in human colon cancer. Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4562–4567. Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 9081. doi: 10.1073/pnas.122187899.PMCID: PMC124267 Corrects: Cristine Alves da Costa, et al. Wild-type and mutated presenilins 2 trigger p53-dependent apoptosis and down-regulate presenilin 1 expression in HEK293 human cells and in murine neurons. Proc Natl Acad Sci U S A. 2002 March 19; 99(6): 4043–4048. Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 9081. Published online 2002 June 11. doi: 10.1073/pnas.132281199.PMCID: PMC124269 Corrects: Cristina R. Artalejo, et al. Sustained stimulation shifts the mechanism of endocytosis from dynamin-1-dependent rapid endocytosis to clathrin- and dynamin-2-mediated slow endocytosis in chromaffin cells. Proc Natl Acad Sci U S A. 2002 April 30; 99(9): 6358–6363. |