| | This journal provides immediate access to some articles. From the Academy Modeling attacks on the food supply Bruce Alberts Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9737–9738. Published online 2005 June 28. doi: 10.1073/pnas.0504944102.PMCID: PMC1175018 In This Issue Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9735–9736. doi: 10.1073/iti2805102.PMCID: PMC1175019 Commentary Efficient hepatitis C virus cell culture system: What a difference the host cell makes Ralf Bartenschlager and Thomas Pietschmann Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9739–9740. Published online 2005 July 5. doi: 10.1073/pnas.0504296102.PMCID: PMC1175013 Physical Sciences Chemistry Initial synthesis and structure of an all-ferrous analogue of the fully reduced [Fe4S4]0 cluster of the nitrogenase iron protein Thomas A. Scott, Curtis P. Berlinguette, Richard H. Holm, and Hong-Cai Zhou Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9741–9744. Published online 2005 June 28. doi: 10.1073/pnas.0504258102.PMCID: PMC1175011 Fisher's theorems for multivariable, time- and space-dependent systems, with applications in population genetics and chemical kinetics Marcel O. Vlad, Stefan E. Szedlacsek, Nader Pourmand, L. Luca Cavalli-Sforza, Peter Oefner, and John Ross Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9848–9853. Published online 2005 June 30. doi: 10.1073/pnas.0504073102.PMCID: PMC1175005 Engineering A modular microfluidic architecture for integrated biochemical analysis Kashan A. Shaikh, Kee Suk Ryu, Edgar D. Goluch, Jwa-Min Nam, Juewen Liu, C. Shad Thaxton, Thomas N. Chiesl, Annelise E. Barron, Yi Lu, Chad A. Mirkin, and Chang Liu Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9745–9750. Published online 2005 June 28. doi: 10.1073/pnas.0504082102.PMCID: PMC1161008 Geophysics Iron-rich silicates in the Earth's D″ layer Wendy L. Mao, Yue Meng, Guoyin Shen, Vitali B. Prakapenka, Andrew J. Campbell, Dion L. Heinz, Jinfu Shu, Razvan Caracas, Ronald E. Cohen, Yingwei Fei, Russell J. Hemley, and Ho-kwang Mao Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9751–9753. Published online 2005 June 30. doi: 10.1073/pnas.0503737102.PMCID: PMC1174998 Biological Sciences Biochemistry Systematically perturbed folding patterns of amyotrophic lateral sclerosis (ALS)-associated SOD1 mutants Mikael J. Lindberg, Roberth Byström, Niklas Boknäs, Peter M. Andersen, and Mikael Oliveberg Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9754–9759. Published online 2005 June 29. doi: 10.1073/pnas.0501957102.PMCID: PMC1174986 Isolation and functional expression of an animal geranyl diphosphate synthase and its role in bark beetle pheromone biosynthesis Anna B. Gilg, Jeremy C. Bearfield, Claus Tittiger, William H. Welch, and Gary J. Blomquist Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9760–9765. Published online 2005 June 27. doi: 10.1073/pnas.0503277102.PMCID: PMC1174994 Sequential phosphorylation of CCAAT enhancer-binding protein β by MAPK and glycogen synthase kinase 3β is required for adipogenesis Qi-Qun Tang, Mads Grønborg, Haiyan Huang, Jae-Woo Kim, Tamara C. Otto, Akhilesh Pandey, and M. Daniel Lane Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9766–9771. Published online 2005 June 28. doi: 10.1073/pnas.0503891102.PMCID: PMC1175002 Soluble epoxide hydrolase is a therapeutic target for acute inflammation Kara R. Schmelzer, Lukas Kubala, John W. Newman, In-Hae Kim, Jason P. Eiserich, and Bruce D. Hammock Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9772–9777. Published online 2005 June 30. doi: 10.1073/pnas.0503279102.PMCID: PMC1168955 Telomerase can act as a template- and RNA-independent terminal transferase Neal F. Lue, Dimitry Bosoy, Tara J. Moriarty, Chantal Autexier, Brian Altman, and Siyang Leng Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9778–9783. Published online 2005 June 30. doi: 10.1073/pnas.0502252102.PMCID: PMC1174988 From the Cover: Evolution of 3-deoxy-d-arabino-heptulosonate-7-phosphate synthase-encoding genes in the yeast Saccharomyces cerevisiae Kerstin Helmstaedt, Axel Strittmatter, William N. Lipscomb, and Gerhard H. Braus Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9784–9789. Published online 2005 June 29. doi: 10.1073/pnas.0504238102.PMCID: PMC1175010 Biophysics On soliton propagation in biomembranes and nerves Thomas Heimburg and Andrew D. Jackson Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9790–9795. Published online 2005 July 1. doi: 10.1073/pnas.0503823102.PMCID: PMC1175000 Single-molecule studies of repressor–DNA interactions show long-range interactions Y. M. Wang, Jonas O. Tegenfeldt, W. Reisner, R. Riehn, Xiao-Juan Guan, Ling Guo, Ido Golding, Edward C. Cox, James Sturm, and Robert H. Austin Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9796–9801. Published online 2005 June 30. doi: 10.1073/pnas.0502917102.PMCID: PMC1168954 Cell Biology The structural basis of androgen receptor activation: Intramolecular and intermolecular amino–carboxy interactions Fred Schaufele, Xavier Carbonell, Martin Guerbadot, Sabine Borngraeber, Mark S. Chapman, Aye Aye K. Ma, Jeffrey N. Miner, and Marc I. Diamond Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9802–9807. Published online 2005 July 1. doi: 10.1073/pnas.0408819102.PMCID: PMC1168953 Stochastic model for Soj relocation dynamics in Bacillus subtilis Konstantin Doubrovinski and Martin Howard Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9808–9813. Published online 2005 July 5. doi: 10.1073/pnas.0500529102.PMCID: PMC1174977 Cell junction-associated proteins IQGAP1, MAGI-2, CASK, spectrins, and α-actinin are components of the nephrin multiprotein complex Sanna Lehtonen, Jennifer J. Ryan, Krystyna Kudlicka, Noriaki Iino, Huilin Zhou, and Marilyn G. Farquhar Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9814–9819. Published online 2005 July 1. doi: 10.1073/pnas.0504166102.PMCID: PMC1175008 Eph kinases and ephrins support thrombus growth and stability by regulating integrin outside-in signaling in platelets Nicolas Prévost, Donna S. Woulfe, Hong Jiang, Timothy J. Stalker, Patrizia Marchese, Zaverio M. Ruggeri, and Lawrence F. Brass Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9820–9825. Published online 2005 July 1. doi: 10.1073/pnas.0404065102.PMCID: PMC1174973 Ecology Estimating the total genetic diversity of a spatial field population from a sample and implications of its dependence on habitat area Erik M. Rauch and Yaneer Bar-Yam Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9826–9829. Published online 2005 July 5. doi: 10.1073/pnas.0408471102.PMCID: PMC1174974 Evolution Annotation of cis-regulatory elements by identification, subclassification, and functional assessment of multispecies conserved sequences Jim R. Hughes, Jan-Fang Cheng, Nicki Ventress, Shyam Prabhakar, Kevin Clark, Eduardo Anguita, Marco De Gobbi, Pieter de Jong, Eddy Rubin, and Douglas R. Higgs Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9830–9835. doi: 10.1073/pnas.0503401102.PMCID: PMC1174996 Replication-associated strand asymmetries in mammalian genomes: Toward detection of replication origins Marie Touchon, Samuel Nicolay, Benjamin Audit, Edward-Benedict Brodie of Brodie, Yves d'Aubenton-Carafa, Alain Arneodo, and Claude Thermes Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9836–9841. Published online 2005 June 28. doi: 10.1073/pnas.0500577102.PMCID: PMC1174978 Genetics Stable barley chromosomes without centromeric repeats S. Nasuda, S. Hudakova, I. Schubert, A. Houben, and T. R. Endo Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9842–9847. Published online 2005 July 5. doi: 10.1073/pnas.0504235102.PMCID: PMC1175009 Fisher's theorems for multivariable, time- and space-dependent systems, with applications in population genetics and chemical kinetics Marcel O. Vlad, Stefan E. Szedlacsek, Nader Pourmand, L. Luca Cavalli-Sforza, Peter Oefner, and John Ross Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9848–9853. Published online 2005 June 30. doi: 10.1073/pnas.0504073102.PMCID: PMC1175005 APOBEC3G hypermutates genomic DNA and inhibits Ty1 retrotransposition in yeast April J. Schumacher, Dwight V. Nissley, and Reuben S. Harris Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9854–9859. Published online 2005 July 6. doi: 10.1073/pnas.0501694102.PMCID: PMC1172225 Immunology Gut mucosal T cell responses and gene expression correlate with protection against disease in long-term HIV-1-infected nonprogressors Sumathi Sankaran, Moraima Guadalupe, Elizabeth Reay, Michael D. George, Jason Flamm, Thomas Prindiville, and Satya Dandekar Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9860–9865. Published online 2005 June 24. doi: 10.1073/pnas.0503463102.PMCID: PMC1159164 Control of T helper 2 cell function and allergic airway inflammation by PKCζ Pilar Martin, Ricardo Villares, Sandra Rodriguez-Mascarenhas, Angel Zaballos, Michael Leitges, Judit Kovac, Irene Sizing, Paul Rennert, Gabriel Márquez, Carlos Martínez-A, María T. Diaz-Meco, and Jorge Moscat Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9866–9871. Published online 2005 June 29. doi: 10.1073/pnas.0501202102.PMCID: PMC1174981 Inducible costimulator is required for type 2 antibody isotype switching but not T helper cell type 2 responses in chronic nematode infection P'ng Loke, Xingxing Zang, Lisa Hsuan, Rebecca Waitz, Richard M. Locksley, Judith E. Allen, and James P. Allison Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9872–9877. Published online 2005 July 1. doi: 10.1073/pnas.0503961102.PMCID: PMC1175004 Medical Sciences From the Cover: Kinetic suppression of microtubule dynamic instability by griseofulvin: Implications for its possible use in the treatment of cancer Dulal Panda, K. Rathinasamy, Manas K. Santra, and Leslie Wilson Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9878–9883. Published online 2005 June 28. doi: 10.1073/pnas.0501821102.PMCID: PMC1174985 Endothelial expression of constitutively active Notch4 elicits reversible arteriovenous malformations in adult mice Timothy R. Carlson, Yibing Yan, Xiaoqing Wu, Michael T. Lam, Gale L. Tang, Levi J. Beverly, Louis M. Messina, Anthony J. Capobianco, Zena Werb, and Rong Wang Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9884–9889. Published online 2005 June 30. doi: 10.1073/pnas.0504391102.PMCID: PMC1175015 The ErbB3-binding protein Ebp1 suppresses androgen receptor-mediated gene transcription and tumorigenesis of prostate cancer cells Yuexing Zhang, Xin-Wei Wang, Danijela Jelovac, Takeo Nakanishi, Myoung-hee Yu, Damilola Akinmade, Olga Goloubeva, Douglas D. Ross, Angela Brodie, and Anne W. Hamburger Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9890–9895. Published online 2005 June 30. doi: 10.1073/pnas.0503829102.PMCID: PMC1175001 The binding of the ubiquitous transcription factor Sp1 at the locus control region represses the expression of β-like globin genes Dongxiao Feng and Yuet Wai Kan Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9896–9900. Published online 2005 July 5. doi: 10.1073/pnas.0502041102.PMCID: PMC1174987 An integrated functional genomics and metabolomics approach for defining poor prognosis in human neuroendocrine cancers Joseph E. Ippolito, Jian Xu, Sanjay Jain, Krista Moulder, Steven Mennerick, Jan R. Crowley, R. Reid Townsend, and Jeffrey I. Gordon Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9901–9906. Published online 2005 July 5. doi: 10.1073/pnas.0500756102.PMCID: PMC1169236 Microbiology From the Cover: Nonmetabolizable analogue of 2-oxoglutarate elicits heterocyst differentiation under repressive conditions in Anabaena sp. PCC 7120 Sophie Laurent, Han Chen, Sylvie Bédu, Fabio Ziarelli, Ling Peng, and Cheng-Cai Zhang Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9907–9912. Published online 2005 June 28. doi: 10.1073/pnas.0502337102.PMCID: PMC1174989 Interferon prevents formation of replication-competent hepatitis B virus RNA-containing nucleocapsids Stefan F. Wieland, Angelina Eustaquio, Christina Whitten-Bauer, Bryan Boyd, and Francis V. Chisari Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9913–9917. Published online 2005 July 1. doi: 10.1073/pnas.0504273102.PMCID: PMC1175012 A tumor necrosis factor receptor family protein serves as a cellular receptor for the macrophage-tropic equine lentivirus Baoshan Zhang, Sha Jin, Jing Jin, Feng Li, and Ronald C. Montelaro Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9918–9923. Published online 2005 June 28. doi: 10.1073/pnas.0501560102.PMCID: PMC1174982 The phagosomal transporter A couples threonine acquisition to differentiation and replication of Legionella pneumophila in macrophages John-Demian Sauer, Michael A. Bachman, and Michele S. Swanson Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9924–9929. Published online 2005 July 5. doi: 10.1073/pnas.0502767102.PMCID: PMC1174991 A secreted regulatory protein couples transcription to the secretory activity of the Pseudomonas aeruginosa type III secretion system Mark L. Urbanowski, Guinevere L. Lykken, and Timothy L. Yahr Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9930–9935. Published online 2005 June 28. doi: 10.1073/pnas.0504405102.PMCID: PMC1175016 Neuroscience Peroxynitrite generated by inducible nitric oxide synthase and NADPH oxidase mediates microglial toxicity to oligodendrocytes Jianrong Li, Olivier Baud, Timothy Vartanian, Joseph J. Volpe, and Paul A. Rosenberg Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9936–9941. Published online 2005 July 5. doi: 10.1073/pnas.0502552102.PMCID: PMC1174990 From the Cover: Neuropeptide B-deficient mice demonstrate hyperalgesia in response to inflammatory pain Michele A. Kelly, Carsten T. Beuckmann, S. Clay Williams, Christopher M. Sinton, Toshiyuki Motoike, James A. Richardson, Robert E. Hammer, Mary G. Garry, and Masashi Yanagisawa Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9942–9947. Published online 2005 June 27. doi: 10.1073/pnas.0503795102.PMCID: PMC1174999 Synchronous neural activity in scale-free network models versus random network models Geoffrey Grinstein and Ralph Linsker Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9948–9953. Published online 2005 July 5. doi: 10.1073/pnas.0504127102.PMCID: PMC1175007 Physiology Phosphorylation-regulated endoplasmic reticulum retention signal in the renal outer-medullary K+ channel (ROMK) Anthony D. O'Connell, Qiang Leng, Ke Dong, Gordon G. MacGregor, Gerhard Giebisch, and Steven C. Hebert Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9954–9959. Published online 2005 June 29. doi: 10.1073/pnas.0504332102.PMCID: PMC1175014 Variation in commercial rodent diets induces disparate molecular and physiological changes in the mouse uterus Haibin Wang, Susanne Tranguch, Huirong Xie, Gregory Hanley, Sanjoy K. Das, and Sudhansu K. Dey Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9960–9965. Published online 2005 June 29. doi: 10.1073/pnas.0501632102.PMCID: PMC1174983 Plant Biology HOS10 encodes an R2R3-type MYB transcription factor essential for cold acclimation in plants Jianhua Zhu, Paul E. Verslues, Xianwu Zheng, Byeong-ha Lee, Xiangqiang Zhan, Yuzuki Manabe, Irina Sokolchik, Yanmei Zhu, Chun-Hai Dong, Jian-Kang Zhu, Paul M. Hasegawa, and Ray A. Bressan Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9966–9971. Published online 2005 July 1. doi: 10.1073/pnas.0503960102.PMCID: PMC1175003 Agrobacterium tumefaciens increases cytokinin production in plastids by modifying the biosynthetic pathway in the host plant Hitoshi Sakakibara, Hiroyuki Kasahara, Nanae Ueda, Mikiko Kojima, Kentaro Takei, Shojiro Hishiyama, Tadao Asami, Kazunori Okada, Yuji Kamiya, Tomoyuki Yamaya, and Shinjiro Yamaguchi Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9972–9977. Published online 2005 July 5. doi: 10.1073/pnas.0500793102.PMCID: PMC1174980 Psychology Hypnotic suggestion reduces conflict in the human brain Amir Raz, Jin Fan, and Michael I. Posner Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9978–9983. Published online 2005 June 30. doi: 10.1073/pnas.0503064102.PMCID: PMC1174993 Social Sciences Social Sciences Analyzing a bioterror attack on the food supply: The case of botulinum toxin in milk Lawrence M. Wein and Yifan Liu Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9984–9989. Published online 2005 June 28. doi: 10.1073/pnas.0408526102.PMCID: PMC1161865 Correction Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9990. doi: 10.1073/pnas.0504835102.PMCID: PMC1175017 Corrects: Jonathan M. Jeschke, et al. From the Cover: Invasion success of vertebrates in Europe and North America. Proc Natl Acad Sci U S A. 2005 May 17; 102(20): 7198–7202. |