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Volume 97(22);  October 24, 2000
Colloquium Papers
Auditory neuroscience: Development, transduction, and integration
A. J. Hudspeth and Masakazu Konishi
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11690–11691.
PMCID: PMC34336
Notch signaling in the development of the inner ear: Lessons from Drosophila
Mark Eddison, Isabelle Le Roux, and Julian Lewis
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11692–11699.
PMCID: PMC34337
Molecular genetics of pattern formation in the inner ear: Do compartment boundaries play a role?
John V. Brigande, Amy E. Kiernan, Xiaoying Gao, Laurie E. Iten, and Donna M. Fekete
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11700–11706.
PMCID: PMC34338
Patterning of the mammalian cochlea
Raquel Cantos, Laura K. Cole, Dario Acampora, Antonio Simeone, and Doris K. Wu
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11707–11713.
PMCID: PMC34339
Cellular studies of auditory hair cell regeneration in birds
Jennifer S. Stone and Edwin W Rubel
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11714–11721.
PMCID: PMC34340
Hair cell recovery in mitotically blocked cultures of the bullfrog saccule
Richard A. Baird, Miriam D. Burton, David S. Fashena, and Rebecca A. Naeger
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11722–11729.
PMCID: PMC34341
Two mechanisms for transducer adaptation in vertebrate hair cells
Jeffrey R. Holt and David P. Corey
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11730–11735.
PMCID: PMC34342
Cochlear mechanisms from a phylogenetic viewpoint
Geoffrey A. Manley
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11736–11743.
PMCID: PMC34343
Mechanical bases of frequency tuning and neural excitation at the base of the cochlea: Comparison of basilar-membrane vibrations and auditory-nerve-fiber responses in chinchilla
Mario A. Ruggero, S. Shyamla Narayan, Andrei N. Temchin, and Alberto Recio
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11744–11750.
PMCID: PMC34344
The spatial and temporal representation of a tone on the guinea pig basilar membrane
K. E. Nilsen and I. J. Russell
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11751–11758.
PMCID: PMC34345
Molecular mechanisms of sound amplification in the mammalian cochlea
Jonathan F. Ashmore, Gwénaëlle S. G. Géléoc, and Lene Harbott
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11759–11764.
PMCID: PMC34346
Putting ion channels to work: Mechanoelectrical transduction, adaptation, and amplification by hair cells
A. J. Hudspeth, Y. Choe, A. D. Mehta, and P. Martin
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11765–11772.
PMCID: PMC34347
Detection of synchrony in the activity of auditory nerve fibers by octopus cells of the mammalian cochlear nucleus
Donata Oertel, Ramazan Bal, Stephanie M. Gardner, Philip H. Smith, and Philip X. Joris
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11773–11779.
PMCID: PMC34348
Linear and nonlinear pathways of spectral information transmission in the cochlear nucleus
Jane J. Yu and Eric D. Young
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11780–11786.
PMCID: PMC34349
Cellular mechanisms for resolving phase ambiguity in the owl's inferior colliculus
José Luis Peña and Masakazu Konishi
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11787–11792.
PMCID: PMC34350
Subdivisions of auditory cortex and processing streams in primates
Jon H. Kaas and Troy A. Hackett
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11793–11799.
PMCID: PMC34351
Mechanisms and streams for processing of “what” and “where” in auditory cortex
Josef P. Rauschecker and Biao Tian
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11800–11806.
PMCID: PMC34352
The corticofugal system for hearing: Recent progress
Nobuo Suga, Enquan Gao, Yunfeng Zhang, Xiaofeng Ma, and John F. Olsen
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11807–11814.
PMCID: PMC34353
Traces of learning in the auditory localization pathway
Eric I. Knudsen, Weimin Zheng, and William M. DeBello
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11815–11820.
PMCID: PMC34354
Plasticity in the neural coding of auditory space in the mammalian brain
Andrew J. King, Carl H. Parsons, and David R. Moore
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11821–11828.
PMCID: PMC34355
Spatial processing in the auditory cortex of the macaque monkey
Gregg H. Recanzone
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11829–11835.
PMCID: PMC34356
Song selectivity and sensorimotor signals in vocal learning and production
Michele M. Solis, Michael S. Brainard, Neal A. Hessler, and Allison J. Doupe
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11836–11842.
PMCID: PMC34357
On cortical coding of vocal communication sounds in primates
Xiaoqin Wang
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11843–11849.
PMCID: PMC34358
A new view of language acquisition
Patricia K. Kuhl
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11850–11857.
PMCID: PMC34178
Commentaries
The self-same beat of time's wide wings
Vincent M. Cassone
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11677–11679.
PMCID: PMC34331
Can allosteric regulation be predicted from structure?
Ernesto Freire
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11680–11682.
PMCID: PMC34332
Channel structure and drug-induced cardiac arrhythmias
Robert S. Kass and Candido Cabo
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11683–11684.
PMCID: PMC34333
Facilitating structural transitions in DNA
Michael Waring
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11685–11687.
PMCID: PMC34334
Ecological mechanisms of extinction
Steven R. Beissinger
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11688–11689.
PMCID: PMC34335
Physical Sciences
Applied Physical Sciences
Attributes of an alluvial river and their relation to water policy and management
William J. Trush, Scott M. McBain, and Luna B. Leopold
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11858–11863.
PMCID: PMC17259
Chemistry
Atmospheric aerosols as prebiotic chemical reactors
Christopher M. Dobson, G. Barney Ellison, Adrian F. Tuck, and Veronica Vaida
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11864–11868. Published online 2000 October 17.
PMCID: PMC17260
Neuromelanin biosynthesis is driven by excess cytosolic catecholamines not accumulated by synaptic vesicles
David Sulzer, Johanna Bogulavsky, Kristin E. Larsen, Gerald Behr, Erdem Karatekin, Mark H. Kleinman, Nicholas Turro, David Krantz, Robert H. Edwards, Lloyd A. Greene, and Luigi Zecca
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11869–11874.
PMCID: PMC17261
Geology
Fossilized high pressure from the Earth's deep interior: The coesite-in-diamond barometer
Nikolai V. Sobolev, Boris A. Fursenko, Sergei V. Goryainov, Jinfu Shu, Russell J. Hemley, Ho-kwang Mao, and Francis R. Boyd
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11875–11879. Published online 2000 October 17.
PMCID: PMC17262
Geophysics
Atmospheric aerosols as prebiotic chemical reactors
Christopher M. Dobson, G. Barney Ellison, Adrian F. Tuck, and Veronica Vaida
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11864–11868. Published online 2000 October 17.
PMCID: PMC17260
The magnitude distribution of declustered earthquakes in Southern California
Leon Knopoff
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11880–11884. Published online 2000 October 17.
PMCID: PMC17263
Statistics
Bounds for cell entries in contingency tables given marginal totals and decomposable graphs
Adrian Dobra and Stephen E. Fienberg
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11885–11892.
PMCID: PMC17264
Biological Sciences
Applied Biological Sciences
Cytoplasmic catalytic subunit of protein kinase A mediates cross-repression by NF-κB and the glucocorticoid receptor
Vassilis Doucas, Yanhong Shi, Shigeki Miyamoto, Andrew West, Inder Verma, and Ronald M. Evans
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11893–11898. Published online 2000 October 10.
PMCID: PMC17265
Biochemistry
How important are entropic contributions to enzyme catalysis?
J. Villà, M. Štrajbl, T. M. Glennon, Y. Y. Sham, Z. T. Chu, and A. Warshel
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11899–11904.
PMCID: PMC17266
Furin-mediated processing in the early secretory pathway: Sequential cleavage and degradation of misfolded insulin receptors
Joseph Bass, Christopher Turck, Mathias Rouard, and Donald F. Steiner
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11905–11909.
PMCID: PMC17267
A census of glutamine/asparagine-rich regions: Implications for their conserved function and the prediction of novel prions
Melissa D. Michelitsch and Jonathan S. Weissman
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11910–11915.
PMCID: PMC17268
Demonstration of the in vivo interaction of key cell death regulators by structure-based design of second-site suppressors
Jay Parrish, Helen Metters, Lin Chen, and Ding Xue
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11916–11921. Published online 2000 October 10.
PMCID: PMC17269
Miniaturized metalloproteins: Application to iron–sulfur proteins
Angela Lombardi, Daniela Marasco, Ornella Maglio, Luigi Di Costanzo, Flavia Nastri, and Vincenzo Pavone
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11922–11927.
PMCID: PMC17270
Cytochrome c binding to Apaf-1: The effects of dATP and ionic strength
Cherie Purring-Koch and George McLendon
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11928–11931. Published online 2000 October 17.
PMCID: PMC17271
Molecular basis for modulation of biological function by alternate splicing of the Wilms' tumor suppressor protein
John H. Laity, H. Jane Dyson, and Peter E. Wright
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11932–11935.
PMCID: PMC17272
Phosphorylation of murine p53 at Ser-18 regulates the p53 responses to DNA damage
Connie Chao, Shin'ichi Saito, Carl W. Anderson, Ettore Appella, and Yang Xu
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11936–11941. Published online 2000 October 17.
PMCID: PMC17273
Deoxysugars in glycopeptide antibiotics: Enzymatic synthesis of TDP-l-epivancosamine in chloroeremomycin biosynthesis
Huawei Chen, Michael G. Thomas, Brian K. Hubbard, Heather C. Losey, Christopher T. Walsh, and Michael D. Burkart
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11942–11947. Published online 2000 October 17.
PMCID: PMC17274
A single amino acid substitution (F363I) converts the regiochemistry of the spearmint (−)-limonene hydroxylase from a C6- to a C3-hydroxylase
Michel Schalk and Rodney Croteau
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11948–11953.
PMCID: PMC17275
The complex ATP–Fe2+ serves as a specific affinity cleavage reagent in ATP-Mg2+ sites of Na,K-ATPase: Altered ligation of Fe2+ (Mg2+) ions accompanies the E1P→E2P conformational change
Guy Patchornik, Rivka Goldshleger, and Steven J. D. Karlish
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11954–11959. Published online 2000 October 17.
PMCID: PMC17276
Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A
Xianjun Fang, Shuang Xing Yu, Yiling Lu, Robert C. Bast, Jr., James R. Woodgett, and Gordon B. Mills
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11960–11965. Published online 2000 October 17.
PMCID: PMC17277
Polynucleotide phosphorylase functions both as a 3′ → 5′ exonuclease and a poly(A) polymerase in Escherichia coli
Bijoy K. Mohanty and Sidney R. Kushner
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11966–11971. Published online 2000 October 17.
PMCID: PMC17278
Dual roles of the 11S regulatory subcomplex in condensin functions
Keiji Kimura and Tatsuya Hirano
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11972–11977. Published online 2000 October 10.
PMCID: PMC17279
Unique progressive cleavage mechanism of HIV reverse transcriptase RNase H
Michele Wisniewski, Mini Balakrishnan, C. Palaniappan, Philip J. Fay, and Robert A. Bambara
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11978–11983. Published online 2000 October 17.
PMCID: PMC17280
Biochemistry, mutagenesis, and oligomerization of DsRed, a red fluorescent protein from coral
Geoffrey S. Baird, David A. Zacharias, and Roger Y. Tsien
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11984–11989.
PMCID: PMC17281
The structure of the chromophore within DsRed, a red fluorescent protein from coral
Larry A. Gross, Geoffrey S. Baird, Ross C. Hoffman, Kim K. Baldridge, and Roger Y. Tsien
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11990–11995.
PMCID: PMC17282
Biophysics
Molecular spectroscopy and dynamics of intrinsically fluorescent proteins: Coral red (dsRed) and yellow (Citrine)
Ahmed A. Heikal, Samuel T. Hess, Geoffrey S. Baird, Roger Y. Tsien, and Watt W. Webb
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11996–12001.
PMCID: PMC17283
Replication by a single DNA polymerase of a stretched single-stranded DNA
Berenike Maier, David Bensimon, and Vincent Croquette
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12002–12007.
PMCID: PMC17284
Mass spectrometry and immobilized enzymes for the screening of inhibitor libraries
Mark T. Cancilla, Michael D. Leavell, Jason Chow, and Julie A. Leary
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12008–12013. Published online 2000 October 17.
PMCID: PMC17285
Nonglassy kinetics in the folding of a simple single-domain protein
Blake Gillespie and Kevin W. Plaxco
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12014–12019.
PMCID: PMC17286
From the Cover:
Binding sites in Escherichia coli dihydrofolate reductase communicate by modulating the conformational ensemble
Hong Pan, J. Ching Lee, and Vincent J. Hilser
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12020–12025. Published online 2000 October 17.
PMCID: PMC17287
Negative hair-bundle stiffness betrays a mechanism for mechanical amplification by the hair cell
P. Martin, A. D. Mehta, and A. J. Hudspeth
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12026–12031. Published online 2000 October 10.
PMCID: PMC17288
From the Cover:
Allosteric, chiral-selective drug binding to DNA
Xiaogang Qu, John O. Trent, Izabela Fokt, Waldemar Priebe, and Jonathan B. Chaires
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12032–12037. Published online 2000 October 10.
PMCID: PMC17289
Anatomy of protein structures: Visualizing how a one-dimensional protein chain folds into a three-dimensional shape
Chung-Jung Tsai, Jacob V. Maizel, Jr., and Ruth Nussinov
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12038–12043.
PMCID: PMC17290
Cell Biology
Receptor-mediated endocytosis of soluble and membrane-tethered Sonic hedgehog by Patched-1
John P. Incardona, Ju Ho Lee, Christie P. Robertson, Kristi Enga, Raj P. Kapur, and Henk Roelink
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12044–12049. Published online 2000 October 10.
PMCID: PMC17291
Peg3/Pw1 promotes p53-mediated apoptosis by inducing Bax translocation from cytosol to mitochondria
Yibin Deng and Xiangwei Wu
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12050–12055.
PMCID: PMC17292
Hematopoietic reconstitution of SLP-76 corrects hemostasis and platelet signaling through αIIbβ3 and collagen receptors
Barbi A. Judd, Peggy S. Myung, Lijun Leng, Achim Obergfell, Warren S. Pear, Sanford J. Shattil, and Gary A. Koretzky
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12056–12061.
PMCID: PMC17293
Creatine kinase, an ATP-generating enzyme, is required for thrombin receptor signaling to the cytoskeleton
Vinit B. Mahajan, Karnire S. Pai, Alice Lau, and Dennis D. Cunningham
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12062–12067.
PMCID: PMC17294
A viral member of the ERV1/ALR protein family participates in a cytoplasmic pathway of disulfide bond formation
Tatiana G. Senkevich, Christine L. White, Eugene V. Koonin, and Bernard Moss
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12068–12073. Published online 2000 October 17.
PMCID: PMC17295
Skeletal muscle deformity and neuronal disorder in Trio exchange factor-deficient mouse embryos
Stephen P. O'Brien, Katja Seipel, Quintus G. Medley, Roderick Bronson, Rosalind Segal, and Michel Streuli
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12074–12078.
PMCID: PMC17296
Coupled two-way clustering analysis of gene microarray data
Gad Getz, Erel Levine, and Eytan Domany
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12079–12084. Published online 2000 October 17.
PMCID: PMC17297
Adenomatous polyposis coli protein contains two nuclear export signals and shuttles between the nucleus and cytoplasm
Kristi L. Neufeld, David A. Nix, Hal Bogerd, Yibin Kang, Mary C. Beckerle, Bryan R. Cullen, and Raymond L. White
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12085–12090. Published online 2000 October 17.
PMCID: PMC17298
Phosphorylation-dependent targeting of cAMP response element binding protein to the ubiquitin/proteasome pathway in hypoxia
Cormac T. Taylor, Glenn T. Furuta, Kristin Synnestvedt, and Sean P. Colgan
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12091–12096. Published online 2000 October 17.
PMCID: PMC17299
Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXRα
Asha Venkateswaran, Bryan A. Laffitte, Sean B. Joseph, Puiying A. Mak, Damien C. Wilpitz, Peter A. Edwards, and Peter Tontonoz
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12097–12102. Published online 2000 October 17.
PMCID: PMC17300
Insulin-like growth factor 1 regulates the location, stability, and transcriptional activity of β-catenin
Martin P. Playford, David Bicknell, Walter F. Bodmer, and Valentine M. Macaulay
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12103–12108. Published online 2000 October 17.
PMCID: PMC17301
Direct genetic demonstration of Gα13 coupling to the orphan G protein-coupled receptor G2A leading to RhoA-dependent actin rearrangement
Janusz H. S. Kabarowski, Jamison D. Feramisco, Lu Q. Le, Jennifer L. Gu, Shiuh-Wen Luoh, Melvin I. Simon, and Owen N. Witte
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12109–12114.
PMCID: PMC17302
Localizing proteins in the cell from their phylogenetic profiles
Edward M. Marcotte, Ioannis Xenarios, Alexander M. van der Bliek, and David Eisenberg
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12115–12120. Published online 2000 October 17.
PMCID: PMC17303
Developmental Biology
Antagonistic role of vega1 and bozozok/dharma homeobox genes in organizer formation
Atsuo Kawahara, Thomas Wilm, Lilianna Solnica-Krezel, and Igor B. Dawid
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12121–12126.
PMCID: PMC17304
Parameters of self-organization in Hydra aggregates
Ulrich Technau, Christoph Cramer von Laue, Fabian Rentzsch, Susanne Luft, Bert Hobmayer, Hans R. Bode, and Thomas W. Holstein
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12127–12131.
PMCID: PMC17305
Clonogenic hepatoblasts, common precursors for hepatocytic and biliary lineages, are lacking classical major histocompatibility complex class I antigen
Hiroshi Kubota and Lola M. Reid
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12132–12137.
PMCID: PMC17306
Quantitative transcript imaging in normal and heat-shocked Drosophila embryos by using high-density oligonucleotide arrays
Ronny Leemans, Boris Egger, Thomas Loop, Lars Kammermeier, Haiqiong He, Beate Hartmann, Ulrich Certa, Frank Hirth, and Heinrich Reichert
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12138–12143. Published online 2000 October 17.
PMCID: PMC17307
Ecology
From the Cover:
Ecological basis of extinction risk in birds: Habitat loss versus human persecution and introduced predators
Ian P. F. Owens and Peter M. Bennett
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12144–12148. Published online 2000 September 26.
PMCID: PMC17308
Evolution
Social enhancement of fitness in yellow-bellied marmots
Kenneth B. Armitage and Orlando A. Schwartz
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12149–12152. Published online 2000 October 17.
PMCID: PMC17309
Origin of mitochondria in relation to evolutionary history of eukaryotic alanyl-tRNA synthetase
Joseph W. Chihade, James R. Brown, Paul R. Schimmel, and Lluís Ribas de Pouplana
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12153–12157. Published online 2000 October 17.
PMCID: PMC17310
Genetics
Coupled two-way clustering analysis of gene microarray data
Gad Getz, Erel Levine, and Eytan Domany
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12079–12084. Published online 2000 October 17.
PMCID: PMC17297
A Saccharomyces gene family involved in invasive growth, cell–cell adhesion, and mating
Bing Guo, Cora A. Styles, Qinghua Feng, and Gerald R. Fink
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12158–12163. Published online 2000 October 10.
PMCID: PMC17311
SBE-TAGS: An array-based method for efficient single-nucleotide polymorphism genotyping
Joel N. Hirschhorn, Pamela Sklar, Kerstin Lindblad-Toh, Yin-Mei Lim, Melisa Ruiz-Gutierrez, Stacey Bolk, Bradley Langhorst, Steven Schaffner, Ellen Winchester, and Eric S. Lander
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12164–12169. Published online 2000 October 17.
PMCID: PMC17312
DNA microarray analysis of gene expression in response to physiological and genetic changes that affect tryptophan metabolism in Escherichia coli
Arkady B. Khodursky, Brian J. Peter, Nicholas R. Cozzarelli, David Botstein, Patrick O. Brown, and Charles Yanofsky
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12170–12175. Published online 2000 October 10.
PMCID: PMC17313
From the Cover:
Genome sequence of Halobacterium species NRC-1
Wailap Victor Ng, Sean P. Kennedy, Gregory G. Mahairas, Brian Berquist, Min Pan, Hem Dutt Shukla, Stephen R. Lasky, Nitin S. Baliga, Vesteinn Thorsson, Jennifer Sbrogna, Steven Swartzell, Douglas Weir, John Hall, Timothy A. Dahl, Russell Welti, Young Ah Goo, Brent Leithauser, Kim Keller, Randy Cruz, Michael J. Danson, David W. Hough, Deborah G. Maddocks, Peter E. Jablonski, Mark P. Krebs, Christine M. Angevine, Heather Dale, Thomas A. Isenbarger, Ronald F. Peck, Mechthild Pohlschroder, John L. Spudich, Kwang-Hwan Jung, Maqsudul Alam, Tracey Freitas, Shaobin Hou, Charles J. Daniels, Patrick P. Dennis, Arina D. Omer, Holger Ebhardt, Todd M. Lowe, Ping Liang, Monica Riley, Leroy Hood, and Shiladitya DasSarma
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12176–12181. Published online 2000 October 3.
PMCID: PMC17314
Discovering functional relationships between RNA expression and chemotherapeutic susceptibility using relevance networks
Atul J. Butte, Pablo Tamayo, Donna Slonim, Todd R. Golub, and Isaac S. Kohane
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12182–12186. Published online 2000 October 10.
PMCID: PMC17315
The pachytene checkpoint prevents accumulation and phosphorylation of the meiosis-specific transcription factor Ndt80
Kuei-Shu Tung, Eun-Jin Erica Hong, and G. Shirleen Roeder
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12187–12192. Published online 2000 October 17.
PMCID: PMC17316
Immunology
X-ray crystal structure of an anti-Buckminsterfullerene antibody Fab fragment: Biomolecular recognition of C60
Bradford C. Braden, Fernando A. Goldbaum, Bi-Xing Chen, Austin N. Kirschner, Stephen R. Wilson, and Bernard F. Erlanger
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12193–12197. Published online 2000 October 17.
PMCID: PMC17317
Induction of primary NY-ESO-1 immunity: CD8+ T lymphocyte and antibody responses in peptide-vaccinated patients with NY-ESO-1+ cancers
Elke Jäger, Sacha Gnjatic, Yasuhiro Nagata, Elisabeth Stockert, Dirk Jäger, Julia Karbach, Antje Neumann, Julia Rieckenberg, Yao-Tseng Chen, Gerd Ritter, Eric Hoffman, Michael Arand, Lloyd J. Old, and Alexander Knuth
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12198–12203. Published online 2000 October 10.
PMCID: PMC17318
Pinpointing when T cell costimulatory receptor CTLA-4 must be engaged to dampen diabetogenic T cells
Fred Lühder, Cynthia Chambers, James P. Allison, Christophe Benoist, and Diane Mathis
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12204–12209. Published online 2000 October 17.
PMCID: PMC17319
Antimicrobial activity of MHC class I-restricted CD8+ T cells in human tuberculosis
Sungae Cho, Vijay Mehra, Sybille Thoma-Uszynski, Steffen Stenger, Natalya Serbina, Richard J. Mazzaccaro, JoAnne L. Flynn, Peter F. Barnes, Scott Southwood, Esteban Celis, Barry R. Bloom, Robert L. Modlin, and Alessandro Sette
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12210–12215. Published online 2000 October 17.
PMCID: PMC17320
Medical Sciences
PCGEM1, a prostate-specific gene, is overexpressed in prostate cancer
Vasantha Srikantan, Zhiqiang Zou, Gyorgy Petrovics, Linda Xu, Meena Augustus, Leland Davis, Jeffrey R. Livezey, Theresa Connell, Isabell A. Sesterhenn, Kiyoshi Yoshino, Gregory S. Buzard, F. K. Mostofi, David G. McLeod, Judd W. Moul, and Shiv Srivastava
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12216–12221.
PMCID: PMC17321
Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation
Xue-Liang Du, Diane Edelstein, Luciano Rossetti, Ivan George Fantus, Howard Goldberg, Fuad Ziyadeh, Jie Wu, and Michael Brownlee
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12222–12226.
PMCID: PMC17322
Suppression of angiogenesis by lentiviral delivery of PEX, a noncatalytic fragment of matrix metalloproteinase 2
Alexander Pfeifer, Torsten Kessler, Steve Silletti, David A. Cheresh, and Inder M. Verma
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12227–12232. Published online 2000 October 17.
PMCID: PMC17323
BCR/ABL inhibition by an escort/phosphatase fusion protein
Young-Mi Lim, Stephane Wong, Gary Lau, Owen N. Witte, and John Colicelli
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12233–12238. Published online 2000 October 10.
PMCID: PMC17324
Frataxin activates mitochondrial energy conversion and oxidative phosphorylation
Michael Ristow, Markus F. Pfister, Andrew J. Yee, Markus Schubert, Laura Michael, Chen-Yu Zhang, Kojhiro Ueki, M. Dodson Michael, II, Bradford B. Lowell, and C. Ronald Kahn
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12239–12243. Published online 2000 October 17.
PMCID: PMC17325
Human lung cancer and p53: The interplay between mutagenesis and selection
Sergei N. Rodin and Andrew S. Rodin
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12244–12249. Published online 2000 October 17.
PMCID: PMC17326
Tonsillar memory B cells, latently infected with Epstein–Barr virus, express the restricted pattern of latent genes previously found only in Epstein–Barr virus-associated tumors
Gregory J. Babcock and David A. Thorley-Lawson
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12250–12255. Published online 2000 October 17.
PMCID: PMC17327
Prostate formation in a marsupial is mediated by the testicular androgen 5α-androstane-3α,17β-diol
Geoffrey Shaw, Marilyn B. Renfree, Michael W. Leihy, Cedric H. L. Shackleton, Esther Roitman, and Jean D. Wilson
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12256–12259. Published online 2000 October 17.
PMCID: PMC17328
Hematopoietic progenitor cells grow on 3T3 fibroblast monolayers that overexpress growth arrest-specific gene-6 (GAS6)
Shane P. Dormady, Xin-Min Zhang, and Ross S. Basch
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12260–12265.
PMCID: PMC17329
Intracellular antibody-caspase-mediated cell killing: An approach for application in cancer therapy
Eric Tse and Terence H. Rabbitts
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12266–12271.
PMCID: PMC17330
Regulation of T cell activation, anxiety, and male aggression by RGS2
Antonio J. Oliveira-dos-Santos, Goichi Matsumoto, Bryan E. Snow, Donglin Bai, Frank P. Houston, Ian Q. Whishaw, Sanjeev Mariathasan, Takehiko Sasaki, Andrew Wakeham, Pamela S. Ohashi, John C. Roder, Carol A. Barnes, David P. Siderovski, and Josef M. Penninger
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12272–12277. Published online 2000 October 10.
PMCID: PMC17331
Visualizing gene expression by whole-body fluorescence imaging
Meng Yang, Eugene Baranov, A. R. Moossa, Sheldon Penman, and Robert M. Hoffman
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12278–12282.
PMCID: PMC17332
Microbiology
A viral member of the ERV1/ALR protein family participates in a cytoplasmic pathway of disulfide bond formation
Tatiana G. Senkevich, Christine L. White, Eugene V. Koonin, and Bernard Moss
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12068–12073. Published online 2000 October 17.
PMCID: PMC17295
A secreted Salmonella protein induces a proinflammatory response in epithelial cells, which promotes neutrophil migration
Catherine A. Lee, Milton Silva, Andrew M. Siber, Aaron J. Kelly, Edouard Galyov, and Beth A. McCormick
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12283–12288.
PMCID: PMC17333
The Ebola virus VP35 protein functions as a type I IFN antagonist
Christopher F. Basler, Xiuyan Wang, Elke Mühlberger, Victor Volchkov, Jason Paragas, Hans-Dieter Klenk, Adolfo García-Sastre, and Peter Palese
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12289–12294. Published online 2000 October 10.
PMCID: PMC17334
A conserved mechanism of retrovirus restriction in mammals
Greg Towers, Michael Bock, Samia Martin, Yasuhiro Takeuchi, Jonathan P. Stoye, and Olivier Danos
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12295–12299. Published online 2000 October 10.
PMCID: PMC17335
Neurobiology
Neuromelanin biosynthesis is driven by excess cytosolic catecholamines not accumulated by synaptic vesicles
David Sulzer, Johanna Bogulavsky, Kristin E. Larsen, Gerald Behr, Erdem Karatekin, Mark H. Kleinman, Nicholas Turro, David Krantz, Robert H. Edwards, Lloyd A. Greene, and Luigi Zecca
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11869–11874.
PMCID: PMC17261
Functional switching of GABAergic synapses by ryanodine receptor activation
Miao-Kun Sun, Thomas J. Nelson, and Daniel L. Alkon
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12300–12305. Published online 2000 October 10.
PMCID: PMC17336
Reduction of axonal caliber does not alleviate motor neuron disease caused by mutant superoxide dismutase 1
Minh Dang Nguyen, Roxanne C. Larivière, and Jean-Pierre Julien
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12306–12311.
PMCID: PMC17337
Development and persistence of kindling epilepsy are impaired in mice lacking glial cell line-derived neurotrophic factor family receptor α2
Avtandil Nanobashvili, Matti S. Airaksinen, Merab Kokaia, Jari Rossi, Fredrik Asztély, Klara Olofsdotter, Paul Mohapel, Mart Saarma, Olle Lindvall, and Zaal Kokaia
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12312–12317.
PMCID: PMC17338
Constitutive expression of the neuron-restrictive silencer factor (NRSF)/REST in differentiating neurons disrupts neuronal gene expression and causes axon pathfinding errors in vivo
Alice J. Paquette, Sharon E. Perez, and David J. Anderson
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12318–12323.
PMCID: PMC17339
Photoperiodic information acquired and stored in vivo is retained in vitro by a circadian oscillator, the avian pineal gland
Roland Brandstätter, Vinod Kumar, Ute Abraham, and Eberhard Gwinner
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12324–12328. Published online 2000 September 26.
PMCID: PMC17340
Pharmacology
A structural basis for drug-induced long QT syndrome
John S. Mitcheson, Jun Chen, Monica Lin, Chris Culberson, and Michael C. Sanguinetti
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12329–12333. Published online 2000 September 26.
PMCID: PMC17341
Physiology
Inhibition of cardiac L-type calcium channels by protein kinase C phosphorylation of two sites in the N-terminal domain
Damian McHugh, Elizabeth M. Sharp, Todd Scheuer, and William A. Catterall
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12334–12338. Published online 2000 October 17.
PMCID: PMC17342
A metabolic defect promotes obesity in mice lacking melanocortin-4 receptors
Linda Ste. Marie, Grant I. Miura, Donald J. Marsh, Keith Yagaloff, and Richard D. Palmiter
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12339–12344. Published online 2000 October 10.
PMCID: PMC17343
Plant Biology
Role of microtubules in the intracellular distribution of tobacco mosaic virus movement protein
Paloma Más and Roger N. Beachy
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12345–12349.
PMCID: PMC17344
Substrate-dependent mutant complementation to select fatty acid desaturase variants for metabolic engineering of plant seed oils
Edgar B. Cahoon and John Shanklin
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12350–12355. Published online 2000 October 10.
PMCID: PMC17345
Altered selectivity in an Arabidopsis metal transporter
Elizabeth E. Rogers, David J. Eide, and Mary Lou Guerinot
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12356–12360. Published online 2000 October 17.
PMCID: PMC17346
ABA activates multiple Ca2+ fluxes in stomatal guard cells, triggering vacuolar K+(Rb+) release
Enid A. C. MacRobbie
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12361–12368. Published online 2000 October 10.
PMCID: PMC17347
Population Biology
Manifold anomalies in gene expression in a vineyard isolate of Saccharomyces cerevisiae revealed by DNA microarray analysis
Duccio Cavalieri, Jeffrey P. Townsend, and Daniel L. Hartl
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12369–12374. Published online 2000 October 17.
PMCID: PMC17348
Psychology
The visual paired-comparison task as a measure of declarative memory
Joseph R. Manns, Craig E. L. Stark, and Larry R. Squire
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12375–12379. Published online 2000 October 10.
PMCID: PMC17349
Failure to handle more than one internal representation in visual detection tasks
Andrei Gorea and Dov Sagi
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12380–12384.
PMCID: PMC17350
Social Sciences
Social Sciences
From the Cover:
Prostitution and the sex discrepancy in reported number of sexual partners
Devon D. Brewer, John J. Potterat, Sharon B. Garrett, Stephen Q. Muth, John M. Roberts, Jr., Danuta Kasprzyk, Daniel E. Montano, and William W. Darrow
Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12385–12388. Published online 2000 October 10.
PMCID: PMC17351
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