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Volume 97(23);  November 7, 2000
From the Academy
Japanese-American Frontiers of Science Symposium
Introduction to the Japanese–American Frontiers of Science
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12402. Published online 2000 October 17.
PMCID: PMC34059
Learning and memory
Hideyuki Okano, Tomoo Hirano, and Evan Balaban
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12403–12404. Published online 2000 October 17.
PMCID: PMC34060
Extrasolar planets
Jack J. Lissauer, Geoffrey W. Marcy, and Shigeru Ida
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12405–12406. Published online 2000 October 17.
PMCID: PMC34061
Aging mechanisms
Yoshiko Takahashi, Makoto Kuro-o, and Fuyuki Ishikawa
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12407–12408. Published online 2000 October 17.
PMCID: PMC34062
Mantle dynamics and seismic tomography
Toshiro Tanimoto and Thorne Lay
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12409–12410. Published online 2000 October 17.
PMCID: PMC34063
Emerging viral diseases
Stuart T. Nichol, Jiro Arikawa, and Yoshihiro Kawaoka
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12411–12412. Published online 2000 October 17.
PMCID: PMC34064
Commentaries
From mouse to human: Fine mapping of quantitative trait loci in a model organism
Mary Sara McPeek
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12389–12390. Published online 2000 October 24.
PMCID: PMC34053
Are denatured proteins ever random coils?
Robert L. Baldwin and Bruno H. Zimm
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12391–12392.
PMCID: PMC34054
Can neural stem cells be used to track down and destroy migratory brain tumor cells while also providing a means of repairing tumor-associated damage?
Mark Noble
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12393–12395.
PMCID: PMC34055
Pausing to decide
Maho Niwa and Peter Walter
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12396–12397. Published online 2000 October 31.
PMCID: PMC34056
Natural selection and speciation
Christopher J. Schneider
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12398–12399. Published online 2000 October 31.
PMCID: PMC34057
Anti-inflammatories for cardiovascular disease
Jaime L. Masferrer and Philip Needleman
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12400–12401. Published online 2000 October 31.
PMCID: PMC34058
Physical Sciences
Applied Physical Sciences
Remarkable statistical behavior for truncated Burgers–Hopf dynamics
Andrew J. Majda and Ilya Timofeyev
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12413–12417. Published online 2000 October 24.
PMCID: PMC18776
Chemistry
Emergent mechanical properties of self-assembled polymeric capsules
Ronald K. Castellano, Ross Clark, Stephen L. Craig, Colin Nuckolls, and Julius Rebek, Jr.
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12418–12421.
PMCID: PMC18777
Condensed complexes, rafts, and the chemical activity of cholesterol in membranes
Arun Radhakrishnan, Thomas G. Anderson, and Harden M. McConnell
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12422–12427. Published online 2000 October 24.
PMCID: PMC18778
Geology
Impact of a Permo-Carboniferous high O2 event on the terrestrial carbon cycle
D. J. Beerling and R. A. Berner
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12428–12432. Published online 2000 October 24.
PMCID: PMC18779
Geophysics
Geophysical, archaeological, and historical evidence support a solar-output model for climate change
Charles A. Perry and Kenneth J. Hsu
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12433–12438. Published online 2000 October 24.
PMCID: PMC18780
Mathematics
Prime type III factors
Dimitri Shlyakhtenko
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12439–12441. Published online 2000 October 31.
PMCID: PMC18781
Biological Sciences
Biochemistry
Single 8-oxo-guanine and 8-oxo-adenine lesions induce marked changes in the backbone structure of a 25-base DNA strand
Donald C. Malins, Nayak L. Polissar, Gary K. Ostrander, and Mark A. Vinson
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12442–12445. Published online 2000 October 31.
PMCID: PMC18782
Role of C/EBP homologous protein (CHOP-10) in the programmed activation of CCAAT/enhancer-binding protein-β during adipogenesis
Qi-Qun Tang and M. Daniel Lane
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12446–12450. Published online 2000 October 24.
PMCID: PMC18783
Polymerization of nontemplate bases before transcription initiation at the 3′ ends of templates by an RNA-dependent RNA polymerase: An activity involved in 3′ end repair of viral RNAs
Hancheng Guan and Anne E. Simon
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12451–12456.
PMCID: PMC18784
The semaphorin receptor plexin-B1 specifically interacts with active Rac in a ligand-dependent manner
Haris G. Vikis, Weiquan Li, Zhigang He, and Kun-Liang Guan
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12457–12462. Published online 2000 October 17.
PMCID: PMC18785
The x-ray structure of d-amino acid oxidase at very high resolution identifies the chemical mechanism of flavin-dependent substrate dehydrogenation
Stephan Umhau, Loredano Pollegioni, Gianluca Molla, Kay Diederichs, Wolfram Welte, Mirella S. Pilone, and Sandro Ghisla
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12463–12468.
PMCID: PMC18786
A unique loop in the DNA-binding crevice of bacteriophage T7 DNA polymerase influences primer utilization
Kajal Chowdhury, Stanley Tabor, and Charles C. Richardson
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12469–12474. Published online 2000 October 24.
PMCID: PMC18787
Regulation of the antioxidant response element by protein kinase C-mediated phosphorylation of NF-E2-related factor 2
H.-C. Huang, Truyen Nguyen, and Cecil B. Pickett
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12475–12480. Published online 2000 October 17.
PMCID: PMC18788
Synthesis and characterization of selenotrisulfide-derivatives of lipoic acid and lipoamide
William T. Self, Lin Tsai, and Thressa C. Stadtman
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12481–12486. Published online 2000 October 24.
PMCID: PMC18789
Combinatorial peptide libraries reveal the ligand-binding mechanism of the oligopeptide receptor OppA of Lactococcus lactis
Frank J. M. Detmers, Frank C. Lanfermeijer, Rupert Abele, Ralph W. Jack, Robert Tampé, Wil N. Konings, and Bert Poolman
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12487–12492. Published online 2000 October 24.
PMCID: PMC18790
2′-Hydroxylation of nicotine by cytochrome P450 2A6 and human liver microsomes: Formation of a lung carcinogen precursor
Stephen S. Hecht, J. Bradley Hochalter, Peter W. Villalta, and Sharon E. Murphy
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12493–12497. Published online 2000 October 24.
PMCID: PMC18791
Vigilin binding selectively inhibits cleavage of the vitellogenin mRNA 3′-untranslated region by the mRNA endonuclease polysomal ribonuclease 1
Kristopher S. Cunningham, Robin E. Dodson, Maria A. Nagel, David J. Shapiro, and Daniel R. Schoenberg
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12498–12502. Published online 2000 October 24.
PMCID: PMC18792
Self-organizing biochemical cycles
Leslie E. Orgel
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12503–12507. Published online 2000 October 31.
PMCID: PMC18793
Unusual DNA structure of the diabetes susceptibility locus IDDM2 and its effect on transcription by the insulin promoter factor Pur-1/MAZ
Amy Lew, William J. Rutter, and Giulia C. Kennedy
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12508–12512.
PMCID: PMC18794
Repression of human papillomavirus oncogenes in HeLa cervical carcinoma cells causes the orderly reactivation of dormant tumor suppressor pathways
Edward C. Goodwin and Daniel DiMaio
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12513–12518.
PMCID: PMC18795
Sequential repression and activation of the CCAAT enhancer-binding protein-α (C/EBPα) gene during adipogenesis
Man-Shiow Jiang and M. Daniel Lane
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12519–12523. Published online 2000 October 24.
PMCID: PMC18796
Dimerization and N-terminal domain proximity underlie the function of the molecular chaperone heat shock protein 90
Ahmed Chadli, Ilham Bouhouche, William Sullivan, Bridget Stensgard, Nancy McMahon, Maria G. Catelli, and David O. Toft
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12524–12529. Published online 2000 October 24.
PMCID: PMC18797
Active acetyl-CoA synthase from Clostridium thermoaceticum obtained by cloning and heterologous expression of acsAB in Escherichia coli
Huay-Keng Loke, George N. Bennett, and Paul A. Lindahl
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12530–12535. Published online 2000 October 24.
PMCID: PMC18798
Endogenously expressed estrogen receptor and coactivator AIB1 interact in MCF-7 human breast cancer cells
Minna K. Tikkanen, Damien J. Carter, Alana M. Harris, Hung M. Le, David O. Azorsa, Paul S. Meltzer, and Fern E. Murdoch
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12536–12540. Published online 2000 October 24.
PMCID: PMC18799
Chimeric double-stranded RNA-specific adenosine deaminase ADAR1 proteins reveal functional selectivity of double-stranded RNA-binding domains from ADAR1 and protein kinase PKR
Yong Liu, Ming Lei, and Charles E. Samuel
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12541–12546.
PMCID: PMC18800
MDM2 inhibits p300-mediated p53 acetylation and activation by forming a ternary complex with the two proteins
Eric Kobet, Xiaoya Zeng, Yong Zhu, David Keller, and Hua Lu
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12547–12552.
PMCID: PMC18801
Chimeras of Dictyostelium myosin II head and neck domains with Acanthamoeba or chicken smooth muscle myosin II tail domain have greatly increased and unregulated actin-dependent MgATPase activity
Xiong Liu, Shi Shu, Roxanne A. Yamashita, Yuhui Xu, and Edward D. Korn
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12553–12558. Published online 2000 October 31.
PMCID: PMC18802
Coevolution of head, neck, and tail domains of myosin heavy chains
Edward D. Korn
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12559–12564. Published online 2000 October 31.
PMCID: PMC18803
Biophysics
Condensed complexes, rafts, and the chemical activity of cholesterol in membranes
Arun Radhakrishnan, Thomas G. Anderson, and Harden M. McConnell
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12422–12427. Published online 2000 October 24.
PMCID: PMC18778
From the Cover:
The Flory isolated-pair hypothesis is not valid for polypeptide chains: Implications for protein folding
Rohit V. Pappu, Rajgopal Srinivasan, and George D. Rose
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12565–12570.
PMCID: PMC18804
Cell Biology
Formation of high molecular weight complexes of mutant Cu,Zn-superoxide dismutase in a mouse model for familial amyotrophic lateral sclerosis
Jennifer A. Johnston, Muffie J. Dalton, Mark E. Gurney, and Ron R. Kopito
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12571–12576. Published online 2000 October 24.
PMCID: PMC18805
Phosphorylation near nuclear localization signal regulates nuclear import of adenomatous polyposis coli protein
Fang Zhang, Raymond L. White, and Kristi L. Neufeld
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12577–12582. Published online 2000 October 24.
PMCID: PMC18806
Interaction of yeast kinetochore proteins with centromere–protein/transcription factor Cbf1
Peter Hemmerich, Tanja Stoyan, Gerhard Wieland, Marianne Koch, Johannes Lechner, and Stephan Diekmann
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12583–12588.
PMCID: PMC18807
Peripheral Golgi protein GRASP65 is a target of mitotic polo-like kinase (Plk) and Cdc2
Chin-Yo Lin, Matthew L. Madsen, Frederic R. Yarm, Young-Joo Jang, Xiaoqi Liu, and Raymond L. Erikson
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12589–12594. Published online 2000 October 24.
PMCID: PMC18808
Timing of hepatocyte entry into DNA synthesis after partial hepatectomy is cell autonomous
Teresa C. Weglarz and Eric P. Sandgren
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12595–12600. Published online 2000 October 24.
PMCID: PMC18809
Genetic mosaic analysis based on Cre recombinase and navigated laser capture microdissection
Melissa H. Wong, Jennifer R. Saam, Thaddeus S. Stappenbeck, Charles H. Rexer, and Jeffrey I. Gordon
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12601–12606. Published online 2000 October 24.
PMCID: PMC18810
The classical progesterone receptor mediates Xenopus oocyte maturation through a nongenomic mechanism
Mustafa Bayaa, Ronald A. Booth, Yinglun Sheng, and X. Johné Liu
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12607–12612. Published online 2000 October 24.
PMCID: PMC18811
Regulation of β-catenin transformation by the p300 transcriptional coactivator
Yongnian Sun, Frank T. Kolligs, Michael O. Hottiger, Rashid Mosavin, Eric R. Fearon, and Gary J. Nabel
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12613–12618. Published online 2000 October 24.
PMCID: PMC18812
RNA polymerase III transcription factor TFIIIC2 is overexpressed in ovarian tumors
Andrew G. Winter, George Sourvinos, Simon J. Allison, Kerrie Tosh, Pamela H. Scott, Demetrios A. Spandidos, and Robert J. White
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12619–12624. Published online 2000 October 31.
PMCID: PMC18813
PERK mediates cell-cycle exit during the mammalian unfolded protein response
Joseph W. Brewer and J. Alan Diehl
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12625–12630. Published online 2000 October 17.
PMCID: PMC18814
Two tandem verprolin homology domains are necessary for a strong activation of Arp2/3 complex-induced actin polymerization and induction of microspike formation by N-WASP
Hideki Yamaguchi, Hiroaki Miki, Shiro Suetsugu, Le Ma, Marc W. Kirschner, and Tadaomi Takenawa
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12631–12636. Published online 2000 October 31.
PMCID: PMC18815
Evolution
From the Cover:
Nonrandom mating in Drosophila melanogaster laboratory populations derived from closely adjacent ecologically contrasting slopes at “Evolution Canyon”
Abraham Korol, Eugenia Rashkovetsky, Konstantin Iliadi, Pawel Michalak, Yefim Ronin, and Eviatar Nevo
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12637–12642. Published online 2000 October 24.
PMCID: PMC18816
Postsegregational killing does not increase plasmid stability but acts to mediate the exclusion of competing plasmids
Tim F. Cooper and Jack A. Heinemann
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12643–12648. Published online 2000 October 31.
PMCID: PMC18817
Genetics
From the Cover:
A method for fine mapping quantitative trait loci in outbred animal stocks
Richard Mott, Christopher J. Talbot, Maria G. Turri, Allan C. Collins, and Jonathan Flint
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12649–12654. Published online 2000 October 24.
PMCID: PMC18818
Detection of mutations in transgenic fish carrying a bacteriophage λcII transgene target
Richard N. Winn, Michelle B. Norris, Kathryn J. Brayer, Cecilia Torres, and Stacy L. Muller
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12655–12660. Published online 2000 October 17.
PMCID: PMC18819
Quantifying genetic and nongenetic contributions to malarial infection in a Sri Lankan population
Margaret J. Mackinnon, D. M. Gunawardena, Jagath Rajakaruna, Sudath Weerasingha, Kamini N. Mendis, and Richard Carter
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12661–12666. Published online 2000 October 17.
PMCID: PMC18820
Zidovudine–didanosine coexposure potentiates DNA incorporation of zidovudine and mutagenesis in human cells
Quanxin Meng, Dale M. Walker, Ofelia A. Olivero, Xiaochu Shi, Brendan B. Antiochos, Miriam C. Poirier, and Vernon E. Walker
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12667–12671. Published online 2000 October 31.
PMCID: PMC18821
TEP1, the yeast homolog of the human tumor suppressor gene PTEN/MMAC1/TEP1, is linked to the phosphatidylinositol pathway and plays a role in the developmental process of sporulation
Jennifer Heymont, Ludmilla Berenfeld, Jennifer Collins, Alexandra Kaganovich, Bradford Maynes, Aaron Moulin, Irina Ratskovskaya, Pak P. Poon, Gerald C. Johnston, Margarita Kamenetsky, John DeSilva, Hong Sun, Gregory A. Petsko, and JoAnne Engebrecht
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12672–12677.
PMCID: PMC18822
SOS mutator activity: Unequal mutagenesis on leading and lagging strands
Magdalena Maliszewska-Tkaczyk, Piotr Jonczyk, Malgorzata Bialoskorska, Roel M. Schaaper, and Iwona J. Fijalkowska
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12678–12683. Published online 2000 October 24.
PMCID: PMC18823
RaSH, a rapid subtraction hybridization approach for identifying and cloning differentially expressed genes
Hongping Jiang, Dong-chul Kang, Deborah Alexandre, and Paul B. Fisher
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12684–12689. Published online 2000 October 31.
PMCID: PMC18824
Identification of human chromosome 22 transcribed sequences with ORF expressed sequence tags
Sandro J. de Souza, Anamaria A. Camargo, Marcelo R. S. Briones, Fernando F. Costa, Maria Aparecida Nagai, Sergio Verjovski-Almeida, Marco A. Zago, Luis Eduardo C. Andrade, Helaine Carrer, Hamza F. A. El-Dorry, Enilza M. Espreafico, Angelita Habr-Gama, Daniel Giannella-Neto, Gustavo H. Goldman, Arthur Gruber, Christine Hackel, Edna T. Kimura, Rui M. B. Maciel, Suely K. N. Marie, Elizabeth A. L. Martins, Marina P. Nóbrega, Maria Luisa Paçó-Larson, Maria Inês M. C. Pardini, Gonçalo G. Pereira, João Bosco Pesquero, Vanderlei Rodrigues, Silvia R. Rogatto, Ismael D. C. G. da Silva, Mari C. Sogayar, Maria de Fátima Sonati, Eloiza H. Tajara, Sandro R. Valentini, Marcio Acencio, Fernando L. Alberto, Maria Elisabete J. Amaral, Ivy Aneas, Mário Henrique Bengtson, Dirce M. Carraro, Alex F. Carvalho, Lúcia Helena Carvalho, Janete M. Cerutti, Maria Lucia C. Corrêa, Maria Cristina R. Costa, Cyntia Curcio, Tsieko Gushiken, Paulo L. Ho, Elza Kimura, Luciana C. C. Leite, Gustavo Maia, Paromita Majumder, Mozart Marins, Adriana Matsukuma, Analy S. A. Melo, Carlos Alberto Mestriner, Elisabete C. Miracca, Daniela C. Miranda, Ana Lucia T. O. Nascimento, Francisco G. Nóbrega, Élida P. B. Ojopi, José Rodrigo C. Pandolfi, Luciana Gilbert Pessoa, Paula Rahal, Claudia A. Rainho, Nancy da Ro's, Renata G. de Sá, Magaly M. Sales, Neusa P. da Silva, Tereza C. Silva, Wilson da Silva, Jr., Daniel F. Simão, Josane F. Sousa, Daniella Stecconi, Fernando Tsukumo, Valéria Valente, Heloisa Zalcberg, Ricardo R. Brentani, Luis F. L. Reis, Emmanuel Dias-Neto, and Andrew J. G. Simpson
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12690–12693.
PMCID: PMC18825
Immunology
Coexpression of the chemokines ELC and SLC by T zone stromal cells and deletion of the ELC gene in the plt/plt mouse
Sanjiv A. Luther, H. Lucy Tang, Paul L. Hyman, Andrew G. Farr, and Jason G. Cyster
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12694–12699.
PMCID: PMC18826
A targeted mutation in the IL-4Rα gene protects mice against autoimmune diabetes
Dorel L. Radu, Nancy Noben-Trauth, Jane Hu-Li, William E. Paul, and Constantin A. Bona
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12700–12704. Published online 2000 October 24.
PMCID: PMC18827
Selective requirement for c-Rel during IL-12 P40 gene induction in macrophages
Shomyseh Sanjabi, Alexander Hoffmann, Hsiou-Chi Liou, David Baltimore, and Stephen T. Smale
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12705–12710. Published online 2000 October 31.
PMCID: PMC18828
Cytotoxic T lymphocyte antigen-4 (CTLA-4) regulates the size, reactivity, and function of a primed pool of CD4+ T cells
Michael S. Kuhns, Victoria Epshteyn, Raymond A. Sobel, and James P. Allison
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12711–12716. Published online 2000 October 24.
PMCID: PMC18829
Beryllium presentation to CD4+ T cells underlies disease-susceptibility HLA-DP alleles in chronic beryllium disease
Andrew P. Fontenot, Michaelann Torres, William H. Marshall, Lee S. Newman, and Brian L. Kotzin
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12717–12722. Published online 2000 October 24.
PMCID: PMC18830
An essential amino acid induces epithelial β-defensin expression
Pascale Fehlbaum, Meena Rao, Michael Zasloff, and G. Mark Anderson
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12723–12728. Published online 2000 October 31.
PMCID: PMC18831
Medical Sciences
Increased adipose tissue in male and female estrogen receptor-α knockout mice
P. A. Heine, J. A. Taylor, G. A. Iwamoto, D. B. Lubahn, and P. S. Cooke
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12729–12734.
PMCID: PMC18832
Aromatase-deficient (ArKO) mice have a phenotype of increased adiposity
Margaret E. E. Jones, Anne W. Thorburn, Kara L. Britt, Kylie N. Hewitt, Nigel G. Wreford, Joseph Proietto, Orhan K. Oz, Brian J. Leury, Kirsten M. Robertson, Shenggen Yao, and Evan R. Simpson
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12735–12740.
PMCID: PMC18833
Increased resistance to acetaminophen hepatotoxicity in mice lacking glutathione S-transferase Pi
Colin J. Henderson, C. Roland Wolf, Neil Kitteringham, Helen Powell, Diana Otto, and B. Kevin Park
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12741–12745. Published online 2000 October 31.
PMCID: PMC18834
Myocardial extracellular matrix remodeling in transgenic mice overexpressing tumor necrosis factor α can be modulated by anti-tumor necrosis factor α therapy
Y. Y. Li, Y. Q. Feng, T. Kadokami, C. F. McTiernan, R. Draviam, S. C. Watkins, and A. M. Feldman
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12746–12751.
PMCID: PMC18835
Linking immune-mediated arterial inflammation and cholesterol-induced atherosclerosis in a transgenic mouse model
Burkhard Ludewig, Stefan Freigang, Martin Jäggi, Michael O. Kurrer, Yao-Chang Pei, Lenka Vlk, Bernhard Odermatt, Rolf M. Zinkernagel, and Hans Hengartner
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12752–12757. Published online 2000 October 24.
PMCID: PMC18836
Bestrophin, the product of the Best vitelliform macular dystrophy gene (VMD2), localizes to the basolateral plasma membrane of the retinal pigment epithelium
Alan D. Marmorstein, Lihua Y. Marmorstein, Mary Rayborn, Xinxing Wang, Joe G. Hollyfield, and Konstantin Petrukhin
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12758–12763. Published online 2000 October 24.
PMCID: PMC18837
Sulindac inhibits neointimal formation after arterial injury in wild-type and apolipoprotein E-deficient mice
Ernane D. Reis, Mercè Roqué, Hayes Dansky, John T. Fallon, Juan J. Badimon, Carlos Cordon-Cardo, Steven J. Shiff, and Edward A. Fisher
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12764–12769. Published online 2000 October 10.
PMCID: PMC18838
Increased p53 mutation load in nontumorous human liver of Wilson disease and hemochromatosis: Oxyradical overload diseases
S. Perwez Hussain, Kamran Raja, Paul A. Amstad, Mark Sawyer, Laura J. Trudel, Gerald N. Wogan, Lorne J. Hofseth, Peter G. Shields, Timothy R. Billiar, Christian Trautwein, Thomas Höhler, Peter R. Galle, David H. Phillips, Rodney Markin, Aizen J. Marrogi, and Curtis C. Harris
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12770–12775. Published online 2000 October 24.
PMCID: PMC18839
Altered HOX and WNT7A expression in human lung cancer
Roser Calvo, James West, Wilbur Franklin, Paul Erickson, Lynne Bemis, Efang Li, Barbara Helfrich, Paul Bunn, Joelle Roche, Elisabeth Brambilla, Rafael Rosell, Robert M. Gemmill, and Harry A. Drabkin
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12776–12781.
PMCID: PMC18840
The antiangiogenic agent TNP-470 requires p53 and p21CIP/WAF for endothelial cell growth arrest
Jing-Ruey J. Yeh, Royce Mohan, and Craig M. Crews
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12782–12787.
PMCID: PMC18841
Microbiology
Identification of alternative splicing and negative splicing activity of a nonsegmented negative-strand RNA virus, Borna disease virus
Keizo Tomonaga, Takeshi Kobayashi, Byeong- Jae Lee, Makiko Watanabe, Wataru Kamitani, and Kazuyoshi Ikuta
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12788–12793.
PMCID: PMC18842
Cooperative subunit interactions within the oligomeric envelope glycoprotein of HIV-1: Functional complementation of specific defects in gp120 and gp41
Karl Salzwedel and Edward A. Berger
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12794–12799. Published online 2000 October 24.
PMCID: PMC18843
Molecular identification by “suicide PCR” of Yersinia pestis as the agent of Medieval Black Death
Didier Raoult, Gérard Aboudharam, Eric Crubézy, Georges Larrouy, Bertrand Ludes, and Michel Drancourt
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12800–12803. Published online 2000 October 31.
PMCID: PMC18844
Neurobiology
Sparing of neuronal function postseizure with gene therapy
John McLaughlin, Benno Roozendaal, Theodore Dumas, Anurag Gupta, Olusola Ajilore, Joseph Hsieh, Dora Ho, Matthew Lawrence, James L. McGaugh, and Robert Sapolsky
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12804–12809. Published online 2000 October 31.
PMCID: PMC18845
Endogenous regulators of G protein signaling proteins regulate presynaptic inhibition at rat hippocampal synapses
Huanmian Chen and Nevin A. Lambert
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12810–12815. Published online 2000 October 24.
PMCID: PMC18846
A membrane-associated progesterone-binding protein, 25-Dx, is regulated by progesterone in brain regions involved in female reproductive behaviors
Christopher J. Krebs, Erich D. Jarvis, Johnny Chan, John P. Lydon, Sonoko Ogawa, and Donald W. Pfaff
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12816–12821.
PMCID: PMC18847
Presenilin-1 regulates the neuronal threshold to excitotoxicity both physiologically and pathologically
M. Grilli, E. Diodato, G. Lozza, R. Brusa, M. Casarini, D. Uberti, R. Rozmahel, D. Westaway, P. St George-Hyslop, M. Memo, and E. Ongini
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12822–12827.
PMCID: PMC18848
“Kiss and run” exocytosis at hippocampal synapses
Charles F. Stevens and James H. Williams
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12828–12833. Published online 2000 October 24.
PMCID: PMC18849
From the Cover:
An empirical explanation of color contrast
R. Beau Lotto and Dale Purves
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12834–12839. Published online 2000 October 31.
PMCID: PMC18850
Amplification of dopaminergic signaling by a positive feedback loop
Akinori Nishi, James A. Bibb, Gretchen L. Snyder, Hideho Higashi, Angus C. Nairn, and Paul Greengard
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12840–12845. Published online 2000 October 24.
PMCID: PMC18851
From the Cover:
Neural stem cells display extensive tropism for pathology in adult brain: Evidence from intracranial gliomas
Karen S. Aboody, Alice Brown, Nikolai G. Rainov, Kate A. Bower, Shaoxiong Liu, Wendy Yang, Juan E. Small, Ulrich Herrlinger, Vaclav Ourednik, Peter McL. Black, Xandra O. Breakefield, and Evan Y. Snyder
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12846–12851.
PMCID: PMC18852
Behavioral insensitivity to restraint stress, absent fear suppression of behavior and impaired spatial learning in transgenic rats with hippocampal neuropeptide Y overexpression
A. Thorsell, M. Michalkiewicz, Y. Dumont, R. Quirion, L. Caberlotto, R. Rimondini, A. A. Mathé, and M. Heilig
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12852–12857. Published online 2000 October 31.
PMCID: PMC18853
Long-term regulation of neuronal high-affinity glutamate and glutamine uptake in Aplysia
Jonathan Levenson, Shogo Endo, Lorna S. Kategaya, Raymond I. Fernandez, David G. Brabham, Jeannie Chin, John H. Byrne, and Arnold Eskin
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12858–12863. Published online 2000 October 24.
PMCID: PMC18854
Sensory deprivation without competition yields modest alterations of short-term synaptic dynamics
Gerald T. Finnerty and Barry W. Connors
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12864–12868. Published online 2000 October 31.
PMCID: PMC18855
Functional mosaic organization of mouse olfactory receptor neurons
Minghong Ma and Gordon M. Shepherd
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12869–12874. Published online 2000 October 24.
PMCID: PMC18856
Statistics of lateral geniculate nucleus (LGN) activity determine the segregation of ON/OFF subfields for simple cells in visual cortex
Ann B. Lee, Brian Blais, Harel Z. Shouval, and Leon N Cooper
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12875–12879.
PMCID: PMC18857
Effects of environmental enrichment on gene expression in the brain
Claire Rampon, Cecilia H. Jiang, Helin Dong, Ya-Ping Tang, David J. Lockhart, Peter G. Schultz, Joe Z. Tsien, and Yinghe Hu
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12880–12884.
PMCID: PMC18858
Pharmacology
Neuronal death enhanced by N-methyl-d-aspartate antagonists
Chrysanthy Ikonomidou, Vanya Stefovska, and Lechoslaw Turski
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12885–12890. Published online 2000 October 31.
PMCID: PMC18859
Cloning and characterization of two splice variants of human phosphodiesterase 11A
Joanna M. Hetman, Nicola Robas, Rhona Baxendale, Mark Fidock, Stephen C. Phillips, Scott H. Soderling, and Joseph A. Beavo
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12891–12895. Published online 2000 October 24.
PMCID: PMC18860
Physiology
A dibasic motif involved in parathyroid hormone-induced down-regulation of the type IIa NaPi cotransporter
Zoubida Karim-Jimenez, Nati Hernando, Jürg Biber, and Heini Murer
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12896–12901. Published online 2000 October 24.
PMCID: PMC18861
Plant Biology
LEUNIG, a putative transcriptional corepressor that regulates AGAMOUS expression during flower development
Joann Conner and Zhongchi Liu
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12902–12907. Published online 2000 October 31.
PMCID: PMC18862
The Arabidopsis aldehyde oxidase 3 (AAO3) gene product catalyzes the final step in abscisic acid biosynthesis in leaves
Mitsunori Seo, Anton J. M. Peeters, Hanae Koiwai, Takayuki Oritani, Annie Marion-Poll, Jan A. D. Zeevaart, Maarten Koornneef, Yuji Kamiya, and Tomokazu Koshiba
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12908–12913. Published online 2000 October 24.
PMCID: PMC18863
Purification, molecular cloning, and sequence analysis of sucrose-6F-phosphate phosphohydrolase from plants
John E. Lunn, Anthony R. Ashton, Marshall D. Hatch, and Hans W. Heldt
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12914–12919. Published online 2000 October 24.
PMCID: PMC18864
Potentiation of pathogen-specific defense mechanisms in Arabidopsis by β-aminobutyric acid
Laurent Zimmerli, Gabor Jakab, Jean-Pierre Métraux, and Brigitte Mauch-Mani
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12920–12925. Published online 2000 October 31.
PMCID: PMC18865
Social Sciences
Anthropology
The transition from quantity to quality: A neglected causal mechanism in accounting for social evolution
Robert L. Carneiro
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12926–12931. Published online 2000 October 24.
PMCID: PMC18866
Correction
Correction
Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12932.
PMCID: PMC56149
Corrects: Rong Xiang, et al. An autologous oral DNA vaccine protects against murine melanoma. Proc Natl Acad Sci U S A. 2000 May 9; 97(10): 5492–5497.
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