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SCSRPC Home
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SCSRPC
Coordinator
Thomas H. Terrill
Fort
Valley State Univ, GA
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SCSRPC
Participants
Gareth F. Bath
South Africa
Joan M. Burke
USDA, ARS,
Booneville, AR
Linda
Coffey
NCAT, ATTRA, Fayetteville, AR
Will R. Getz
Fort
Valley State Univ, GA
Margo Hale
NCAT, ATTRA, Fayetteville, AR
Steve Hart
Langston Univ, OK
Sue Howell
University of Georgia, Athens,
GA
Dahlia
Jackson
Delaware State Univ., CARS
Ray M. Kaplan
Univ
of Georgia
Jean-Marie Luginbuhl
North Carolina State Univ
James E. Miller
Louisiana State Univ
Byeng R. Min
Texas A&M Univ
Seyedmehdi Mobini
Fort
Valley State Univ, GA
Jorge Mosjidis
Auburn Univ, AL
Jim Muir
Texas A&M
Bob Storey
Univ
of Georgia
Thomas H. Terrill
Fort
Valley State Univ, GA
Elide Valencia
Univ
of Puerto Rico
Jan A. Van Wyk
South Africa
Adriano Vatta
Onderstepoort Veterinary Institute -South Africa
Stuart Weiss
Univ
of Virgin Islands
Niki
Whitley
North Carolina A&T State Univ
Stephan Wildeus
Virginia State Univ
Lisa H. Williamson
Univ
of Georgia
Anne Zajac
Virginia Tech
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Ray M. Kaplan
(contact information
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Ray M. Kaplan, DVM, PhD,
DipEVPC
Associate Professor
Department of Infectious Diseases
College of Veterinary Medicine
University of Georgia
Athens, Georgia 30602
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Full curriculum vitae and contact
information
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Dr. Kaplan is
an Associate Professor in the Department of
Infectious Diseases in the College of Veterinary
Medicine at the University of Georgia. Prior to
his position at University of Georgia, Dr.
Kaplan served in the Army Veterinary Corps at
the Walter Reed Army Institute of Research where
he was Chief of Parasite Biology in the Division
of Experimental Therapeutics. Dr. Kaplan
received his bachelor’s degree from Virginia
Tech and his DVM from Virginia-Maryland Regional
College of Veterinary Medicine. He worked as a
clinical veterinarian in a mixed-species private
practice in Pennsylvania for several years
before leaving practice for the University of
Florida where he earned a PhD in Veterinary
Parasitology. Since 1998 he has been in his
current position where he teaches and performs
research in veterinary and human medical
parasitology. Dr. Kaplan is principal
investigator and director of the Filariasis
Research Reagent Resource Center (FR3), and is
director of the Athens Parasitology Diagnostic
Laboratory.
The primary
research focus of his laboratory is to measure,
understand, and solve the problems presented by
drug-resistant parasites. Over the past forty
years, the availability of cheap and effective
anthelmintic drugs has led to an almost complete
reliance on these chemicals for parasite control
in animals. Chemical-based parasite control was
extremely effective for many years, but we now
know that this strategy has turned out to be
shortsighted and unsustainable. Parasite drug
resistance is now recognized globally as one of
the greatest health threats to grazing
livestock. Also, in recent years there has been
a dramatic increase in the use of mass drug
administration to reduce the morbidity
associated with helminth parasite infections of
humans, raising the likelihood that anthelmintic
resistance may become a public health concern in
the near future.
To address
these problems, Dr. Kaplan’s laboratory pursues
research projects with several different areas
of emphasis:
1. Measuring
the prevalence of drug resistance
2. Studying the molecular basis of anthelmintic
resistance
3. Developing molecular diagnostic assays to
detect emerging resistance in nematode
populations
4. Developing and optimizing in vitro diagnostic
assays to detect and measure clinically relevant
levels of anthelmintic resistance
5. Studying and developing novel and sustainable
approaches to parasite control that deemphasize
chemical control
6. Developing improved methods for evaluating
and understanding fecal egg count data,
especially as relating to diagnosing resistance
using the fecal egg count reduction test
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Recent Publications |
Mortensen, L.L.,
L.H. Williamson , T.H. Terrill, R. Kircher, M.
Larsen and R.M. Kaplan.
2003. Evaluation of prevalence and clinical
implications of anthelmintic resistance in
gastrointestinal nematodes of goats. JAVMA,
223(4):495-500.
Terrill, T.H., M. Larsen, O. Samples, S. Husted,
J.E. Miller, R.M. Kaplan,
S. Gelaye. 2004. Capability of the
nematode-trapping fungus Duddingtonia flagrans
to reduce infective larvae of gastrointestinal
nematodes in goat feces in the southeastern
United States: dose titration and dose time
interval studies, Veterinary Parasitology, 120,
(4), 285-96.
Tandon, R., and R.M. Kaplan.
2004. Evaluation of a larval development assay
(DrenchRite®) for the detection of anthelmintic
resistance in cyathostomin nematodes of horses.
Veterinary Parasitology, 121: 125-142.
Kaplan, R.M.,
T.R. Klei, E.T. Lyons, G.D. Lester, D.D. French,
S.C. Tolliver, C.H. Courtney, Y. Zhao, and A.
Vidyashankar. 2004. Prevalence of anthelmintic
resistant cyathostomes on horse farms. JAVMA,
225(6): 903-910.
Kaplan, R.M.,
and J.B. Mathews. 2004. Equine Cyathostomins,
in (Eds.) Williams, J.C., Gasser, R., and
Malone, J.B., Diversity and Progress of
Veterinary Parasitology Research in the 21st
Century. A selection of presentations given
during the 19th International Conference of the
World Association for the Advancement of
Veterinary Parasitology (WAAVP): Veterinary
Parasitology,125 (1-2): 203-220.
Kaplan, R.M.,
J.M. Burke, T.H. Terrill, J.E. Miller, W.R.
Getz, S. Mobini, E. Valencia, M.J.Williams, L.H.
Williamson, M. Larsen, and A.F. Vatta. 2004.
Validation of the FAMACHA© eye color chart for
detecting clinical anemia in sheep and goats on
farms in the southern United States. Veterinary
Parasitology 123: 105-120.
Kaplan, R.M.
2004. Drug resistance in nematodes of veterinary
importance: a status report. Trends in
Parasitology 20(10): 477-481. [Identified by
Essential Science Indicators to be one of the
most cited papers in the research area of “DRUG
RESISTANCE.”
(see
http://sciencewatch.com/sciencewatch/dr/erf/2008/08aprerf/08aprerfKap/])
Stuedemann, J.A., R.M. Kaplan,
H. Ciordia, A. J. Franzluebbers, T. B. Stewart,
and D. H. Seman. 2004. Bermudagrass management
in the Southern Piedmont USA: V.
Gastrointestinal parasite control in cattle.
Veterinary Parasitology, 126: 375-385.
Clark, H.J., R.M. Kaplan,
J.B. Matthews and J.E. Hodgkinson 2005.
Isolation and characterisation of a beta tubulin
isotype 2 gene from two species of cyathostomin.
International Journal for Parasitology 35:4,
349-358.
Tandon, R., E. T. Lyons, Tolliver, S.C.,
Kaplan, R.M.
2005. Effect of moxidectin selection on the
genetic variation within Cylicocyclus nassatus
based on amplified fragment length polymorphism
(AFLP). International Journal for Parasitology
35(7): 813-819.
Fleming, S A.,T. Craig, R.M.
Kaplan,
J. E. Miller, C. Navarre, M. Rings. 2006.
Consensus Statement on: Anthelmintic resistance
of gastrointestinal parasites in small
ruminants. Journal of Veterinary Internal
Medicine, 20:435–444.
Shaika, S.A., T.H. Terrill, J.E. Miller, B.
Kouakou, G. Kannan, R.M. Kaplan,
J. Burke, and J. Mosjidis 2006. Use of sericea
lespedeza hay as a natural deworming agent in
goats infected with Haemonchus contortus.
Veterinary Parasitology, 139:150–157.
van Wyk, J.A,. H. Hoste, R.M.
Kaplan,
R.B. Besier 2006. Targeted selective treatment
for worm management - how do we sell rational
programs to farmers? Veterinary
Parasitology,139:336-346.
Tandon, R., K.T. LePage, and
R.M. Kaplan
2006. Cloning and characterization of genes
encoding alpha and beta subunits of
glutamate-gated chloride channel protein in
Cylicocyclus nassatus. Molecular and Biochemical
Parasitology, 150:46-55.
Schwenkenbecher, J.M. and
Kaplan, R.M.
2007. Development and characterization of
microsatellite markers for the canine hookworm,
Ancylostoma caninum. Parasitology Research,
100:1015-1021.
Kaplan, R.M.,
A. N. Vidyashankar, S.B. Howell, J.M. Neiss, L.H.
Williamson, and T.H. Terrill. 2007. A novel
approach for combining the use of in vitro and
in vivo data to measure and detect emerging
moxidectin resistance in gastrointestinal
nematodes of goats. International Journal for
Parasitology, 37:795-804.
Burke, J.M., R.M. Kaplan,
J.E. Miller, T.H. Terrill, W.R. Getz, S. Mobini,
E. Valencia, M.J. Williams, L.H. Williamson and
A.F. Vatta. 2007. Accuracy of the FAMACHA
system for on-farm use by sheep and goat
producers in the southeastern United States.
Veterinary Parasitology 147:89-95.
Nielsen, M.K., R.M. Kaplan,
S.M.Thamsborg, J. Monrad, and S.N. Olsen. 2007.
Climatic influences on development and survival
of free-living stages of equine strongyles:
Implications for worm control strategies and
managing anthelmintic resistance. The
Veterinary Journal, 174:23-32.
Schwenkenbecher, J.M., M. Albonico, B. Quentin,
R.M. Kaplan.
2007. Characterization of beta-tubulin genes in
hookworms and investigation of
resistance-associated mutations using real-time
PCR. Molecular and Biochemical Parasitology,
156:167-174.
Vidyashankar, A.N., R.M. Kaplan,
S. Chan. 2007. Statistical approach to measure
efficacy of anthelmintic treatment on horse
farms, Parasitology, 134:2027-2039.
Nielsen, M.K., D.S. Peterson, J. Monrad, S.M.
Thamsborg, SN. Olsen, R.M.
Kaplan.
2008. Detection and semi-quantification of
Strongylus vulgaris DNA in equine faeces by
real-time PCR. International Journal for
Parasitology, 38:443-453.
Hodgkinson, J.E., H. J. Clark,
R.M. Kaplan,
S.L.Lake, J.B. Matthews. 2008. The role of
polymorphisms at beta tubulin isotype 1 codons
167 and 200 in benzimidazole resistance in
cyathostomins, International Journal for
Parasitology, 38:1149-1160.
Howell, S.B., J.M. Burke, J.E. Miller, T.H.
Terrill, E. Valencia , M.J. Williams, L.H.
Williamson, A.M. Zajac, R.M.
Kaplan.
2008. Anthelmintic resistance on sheep and goat
farms in the southeastern United States, JAVMA,
accepted. |
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