| | This journal provides immediate access to some articles. Perspective A Careful Look at Binding Site Reorganization in the even-skipped Enhancers of Drosophila and Sepsids Emily E. Hare, Brant K. Peterson, and Michael B. Eisen PMCID: PMC2582681 Spindle Positioning, Meiotic Nonreduction, and Polyploidy in Plants Sebastien Andreuzza and Imran Siddiqi PMCID: PMC2582683 A Closer Look at the eve Stripe 2 Enhancers of Drosophila and Themira Justin Crocker and Albert Erives PMCID: PMC2583955 Research Articles A Glial Variant of the Vesicular Monoamine Transporter Is Required To Store Histamine in the Drosophila Visual System Rafael Romero-Calderón, Guido Uhlenbrock, Jolanta Borycz, Anne F. Simon, Anna Grygoruk, Susan K. Yee, Amy Shyer, Larry C. Ackerson, Nigel T. Maidment, Ian A. Meinertzhagen, Bernhard T. Hovemann, and David E. Krantz PMCID: PMC2570955 Mutations in the SLC2A9 Gene Cause Hyperuricosuria and Hyperuricemia in the Dog Danika Bannasch, Noa Safra, Amy Young, Nili Karmi, R. S. Schaible, and G. V. Ling PMCID: PMC2573870 Silent but Not Static: Accelerated Base-Pair Substitution in Silenced Chromatin of Budding Yeasts Leonid Teytelman, Michael B. Eisen, and Jasper Rine PMCID: PMC2570616 High-Resolution Copy-Number Variation Map Reflects Human Olfactory Receptor Diversity and Evolution Yehudit Hasin, Tsviya Olender, Miriam Khen, Claudia Gonzaga-Jauregui, Philip M. Kim, Alexander Eckehart Urban, Michael Snyder, Mark B. Gerstein, Doron Lancet, and Jan O. Korbel PMCID: PMC2570968 The Impact of the Nucleosome Code on Protein-Coding Sequence Evolution in Yeast Tobias Warnecke, Nizar N. Batada, and Laurence D. Hurst PMCID: PMC2570795 The Evolutionary Dynamics of the Lion Panthera leo Revealed by Host and Viral Population Genomics Agostinho Antunes, Jennifer L. Troyer, Melody E. Roelke, Jill Pecon-Slattery, Craig Packer, Christiaan Winterbach, Hanlie Winterbach, Graham Hemson, Laurence Frank, Philip Stander, Ludwig Siefert, Margaret Driciru, Paul J. Funston, Kathy A. Alexander, Katherine C. Prager, Gus Mills, David Wildt, Mitch Bush, Stephen J. O'Brien, and Warren E. Johnson PMCID: PMC2572142 Functional Polymorphisms in PRODH Are Associated with Risk and Protection for Schizophrenia and Fronto-Striatal Structure and Function Lucas Kempf, Kristin K. Nicodemus, Bhaskar Kolachana, Radhakrishna Vakkalanka, Beth A. Verchinski, Michael F. Egan, Richard E. Straub, Venkata A. Mattay, Joseph H. Callicott, Daniel R. Weinberger, and Andreas Meyer-Lindenberg PMCID: PMC2573019 p8/TTDA Overexpression Enhances UV-Irradiation Resistance and Suppresses TFIIH Mutations in a Drosophila Trichothiodystrophy Model Javier Aguilar-Fuentes, Mariana Fregoso, Mariana Herrera, Enrique Reynaud, Cathy Braun, Jean Marc Egly, and Mario Zurita PMCID: PMC2576456 Genetic Control of Variegated KIR Gene Expression: Polymorphisms of the Bi-Directional KIR3DL1 Promoter Are Associated with Distinct Frequencies of Gene Expression Hongchuan Li, Véronique Pascal, Maureen P. Martin, Mary Carrington, and Stephen K. Anderson PMCID: PMC2575236 Exploring Microbial Diversity and Taxonomy Using SSU rRNA Hypervariable Tag Sequencing Susan M. Huse, Les Dethlefsen, Julie A. Huber, David Mark Welch, David A. Relman, and Mitchell L. Sogin PMCID: PMC2577301 Synonymous Genes Explore Different Evolutionary Landscapes Guillaume Cambray and Didier Mazel PMCID: PMC2575237 CTCF cis-Regulates Trinucleotide Repeat Instability in an Epigenetic Manner: A Novel Basis for Mutational Hot Spot Determination Randell T. Libby, Katharine A. Hagerman, Victor V. Pineda, Rachel Lau, Diane H. Cho, Sandy L. Baccam, Michelle M. Axford, John D. Cleary, James M. Moore, Bryce L. Sopher, Stephen J. Tapscott, Galina N. Filippova, Christopher E. Pearson, and Albert R. La Spada PMCID: PMC2573955 Bidirectional Transcription Directs Both Transcriptional Gene Activation and Suppression in Human Cells Kevin V. Morris, Sharon Santoso, Anne-Marie Turner, Chiara Pastori, and Peter G. Hawkins PMCID: PMC2576438 Murine Dishevelled 3 Functions in Redundant Pathways with Dishevelled 1 and 2 in Normal Cardiac Outflow Tract, Cochlea, and Neural Tube Development S. Leah Etheridge, Saugata Ray, Shuangding Li, Natasha S. Hamblet, Nardos Lijam, Michael Tsang, Joy Greer, Natalie Kardos, Jianbo Wang, Daniel J. Sussman, Ping Chen, and Anthony Wynshaw-Boris PMCID: PMC2576453 Dissection of a QTL Hotspot on Mouse Distal Chromosome 1 that Modulates Neurobehavioral Phenotypes and Gene Expression Khyobeni Mozhui, Daniel C. Ciobanu, Thomas Schikorski, Xusheng Wang, Lu Lu, and Robert W. Williams PMCID: PMC2577893 Zebrafish Mutants calamity and catastrophe Define Critical Pathways of Gene–Nutrient Interactions in Developmental Copper Metabolism Erik C. Madsen and Jonathan D. Gitlin PMCID: PMC2576455 The Coordination of Centromere Replication, Spindle Formation, and Kinetochore–Microtubule Interaction in Budding Yeast Hong Liu, Fengshan Liang, Fengzhi Jin, and Yanchang Wang PMCID: PMC2577889 Aging Predisposes Oocytes to Meiotic Nondisjunction When the Cohesin Subunit SMC1 Is Reduced Vijayalakshmi V. Subramanian and Sharon E. Bickel PMCID: PMC2577922 Hypermutability of Damaged Single-Strand DNA Formed at Double-Strand Breaks and Uncapped Telomeres in Yeast Saccharomyces cerevisiae Yong Yang, Joan Sterling, Francesca Storici, Michael A. Resnick, and Dmitry A. Gordenin PMCID: PMC2577886 A Motor Function for the DEAD-Box RNA Helicase, Gemin3, in Drosophila Ruben J. Cauchi, Kay E. Davies, and Ji-Long Liu PMCID: PMC2577925 A Role for Oxidized DNA Precursors in Huntington's Disease–Like Striatal Neurodegeneration Gabriele De Luca, Maria Teresa Russo, Paolo Degan, Cecilia Tiveron, Andrea Zijno, Ettore Meccia, Ilenia Ventura, Elisabetta Mattei, Yusaku Nakabeppu, Marco Crescenzi, Rita Pepponi, Antonella Pèzzola, Patrizia Popoli, and Margherita Bignami PMCID: PMC2580033 Indistinguishable Landscapes of Meiotic DNA Breaks in rad50+ and rad50S Strains of Fission Yeast Revealed by a Novel rad50+ Recombination Intermediate Randy W. Hyppa, Gareth A. Cromie, and Gerald R. Smith PMCID: PMC2580034 A RAC/CDC-42–Independent GIT/PIX/PAK Signaling Pathway Mediates Cell Migration in C. elegans Mark Lucanic and Hwai-Jong Cheng PMCID: PMC2581894 Cell Cycle– and Chaperone-Mediated Regulation of H3K56ac Incorporation in Yeast Tommy Kaplan, Chih Long Liu, Judith A. Erkmann, John Holik, Michael Grunstein, Paul D. Kaufman, Nir Friedman, and Oliver J. Rando PMCID: PMC2581598 Gene Regulation in Primates Evolves under Tissue-Specific Selection Pressures Ran Blekhman, Alicia Oshlack, Adrien E. Chabot, Gordon K. Smyth, and Yoav Gilad PMCID: PMC2581600 Gamma-Linolenic and Stearidonic Acids Are Required for Basal Immunity in Caenorhabditis elegans through Their Effects on p38 MAP Kinase Activity Madhumitha Nandakumar and Man-Wah Tan PMCID: PMC2581601 Mutations in AtPS1 (Arabidopsis thaliana Parallel Spindle 1) Lead to the Production of Diploid Pollen Grains Isabelle d'Erfurth, Sylvie Jolivet, Nicole Froger, Olivier Catrice, Maria Novatchkova, Mathieu Simon, Eric Jenczewski, and Raphaël Mercier PMCID: PMC2581889 AML1/ETO Oncoprotein Is Directed to AML1 Binding Regions and Co-Localizes with AML1 and HEB on Its Targets Alessandro Gardini, Matteo Cesaroni, Lucilla Luzi, Akiko J. Okumura, Joseph R. Biggs, Simone P. Minardi, Elisa Venturini, Dong-Er Zhang, Pier Giuseppe Pelicci, and Myriam Alcalay PMCID: PMC2577924 A PI3-Kinase–Mediated Negative Feedback Regulates Neuronal Excitability Eric Howlett, Curtis Chun-Jen Lin, William Lavery, and Michael Stern PMCID: PMC2581892 An Ancient Duplication of Exon 5 in the Snap25 Gene Is Required for Complex Neuronal Development/Function Jenny U. Johansson, Jesper Ericsson, Juliette Janson, Simret Beraki, Davor Stanić, Slavena A. Mandic, Martin A. Wikström, Tomas Hökfelt, Sven Ove Ögren, Björn Rozell, Per-Olof Berggren, and Christina Bark PMCID: PMC2581893 SRA-Domain Proteins Required for DRM2-Mediated De Novo DNA Methylation Lianna M. Johnson, Julie A. Law, Anuj Khattar, Ian R. Henderson, and Steven E. Jacobsen PMCID: PMC2582956 Hypermutable Non-Synonymous Sites Are under Stronger Negative Selection Steffen Schmidt, Anna Gerasimova, Fyodor A. Kondrashov, Ivan A. Adzuhbei, Alexey S. Kondrashov, and Shamil Sunyaev PMCID: PMC2583910 Genetics Meets Metabolomics: A Genome-Wide Association Study of Metabolite Profiles in Human Serum Christian Gieger, Ludwig Geistlinger, Elisabeth Altmaier, Martin Hrabé de Angelis, Florian Kronenberg, Thomas Meitinger, Hans-Werner Mewes, H.-Erich Wichmann, Klaus M. Weinberger, Jerzy Adamski, Thomas Illig, and Karsten Suhre PMCID: PMC2581785 Profiling Synaptic Proteins Identifies Regulators of Insulin Secretion and Lifespan QueeLim Ch'ng, Derek Sieburth, and Joshua M. Kaplan PMCID: PMC2582949 Chemical–Genetic Profiling of Imidazo[1,2-a]pyridines and -Pyrimidines Reveals Target Pathways Conserved between Yeast and Human Cells Lisa Yu, Andres Lopez, Abderrahmane Anaflous, Brahim El Bali, Abdellah Hamal, Elke Ericson, Lawrence E. Heisler, Angus McQuibban, Guri Giaever, Corey Nislow, Charles Boone, Grant W. Brown, and Mohammed Bellaoui PMCID: PMC2583946 Field-Caught Permethrin-Resistant Anopheles gambiae Overexpress CYP6P3, a P450 That Metabolises Pyrethroids Pie Müller, Emma Warr, Bradley J. Stevenson, Patricia M. Pignatelli, John C. Morgan, Andrew Steven, Alexander E. Yawson, Sara N. Mitchell, Hilary Ranson, Janet Hemingway, Mark J. I. Paine, and Martin J. Donnelly PMCID: PMC2583951 Genetic Analysis of Human Traits In Vitro: Drug Response and Gene Expression in Lymphoblastoid Cell Lines Edwin Choy, Roman Yelensky, Sasha Bonakdar, Robert M. Plenge, Richa Saxena, Philip L. De Jager, Stanley Y. Shaw, Cara S. Wolfish, Jacqueline M. Slavik, Chris Cotsapas, Manuel Rivas, Emmanouil T. Dermitzakis, Ellen Cahir-McFarland, Elliott Kieff, David Hafler, Mark J. Daly, and David Altshuler PMCID: PMC2583954 Corrections Correction: The Challenge of Regulation in a Minimal Photoautotroph: Non-Coding RNAs in Prochlorococcus Claudia Steglich, Matthias E. Futschik, Debbie Lindell, Bjoern Voss, Sallie W. Chisholm, and Wolfgang R. Hess PMCID: PMC2599920 Corrects: Claudia Steglich, et al. The Challenge of Regulation in a Minimal Photoautotroph: Non-Coding RNAs in Prochlorococcus. PLoS Genet. 2008 August; 4(8): e1000173. Correction: ZHP-3 Acts at Crossovers to Couple Meiotic Recombination with Synaptonemal Complex Disassembly and Bivalent Formation in C. elegans Needhi Bhalla, David J. Wynne, Verena Jantsch, and Abby F. Dernburg PMCID: PMC2598017 Corrects: Needhi Bhalla, et al. ZHP-3 Acts at Crossovers to Couple Meiotic Recombination with Synaptonemal Complex Disassembly and Bivalent Formation in C. elegans. PLoS Genet. 2008 October; 4(10): e1000235. |
