| | This journal provides immediate access to some articles. Perspective Genetical Genomics: Spotlight on QTL Hotspots Rainer Breitling, Yang Li, Bruno M. Tesson, Jingyuan Fu, Chunlei Wu, Tim Wiltshire, Alice Gerrits, Leonid V. Bystrykh, Gerald de Haan, Andrew I. Su, and Ritsert C. Jansen PMCID: PMC2563687 Leaving the Past Behind E. Jean Finnegan and Emma Whitelaw PMCID: PMC2569149 Interview Curling Up with a Story: An Interview with Sean Carroll Jane Gitschier PMCID: PMC2570611 Research Articles Context-Dependent Requirement for dE2F during Oncogenic Proliferation Brandon N. Nicolay and Maxim V. Frolov PMCID: PMC2542417 Zebrafish eda and edar Mutants Reveal Conserved and Ancestral Roles of Ectodysplasin Signaling in Vertebrates Matthew P. Harris, Nicolas Rohner, Heinz Schwarz, Simon Perathoner, Peter Konstantinidis, and Christiane Nüsslein-Volhard PMCID: PMC2542418 A Myo6 Mutation Destroys Coordination between the Myosin Heads, Revealing New Functions of Myosin VI in the Stereocilia of Mammalian Inner Ear Hair Cells Ronna Hertzano, Ella Shalit, Agnieszka K. Rzadzinska, Amiel A. Dror, Lin Song, Uri Ron, Joshua T. Tan, Alina Starovolsky Shitrit, Helmut Fuchs, Tama Hasson, Nir Ben-Tal, H. Lee Sweeney, Martin Hrabe de Angelis, Karen P. Steel, and Karen B. Avraham PMCID: PMC2543112 Mutability and Importance of a Hypermutable Cell Subpopulation that Produces Stress-Induced Mutants in Escherichia coli Caleb Gonzalez, Lilach Hadany, Rebecca G. Ponder, Mellanie Price, P. J. Hastings, and Susan M. Rosenberg PMCID: PMC2543114 Mutation and Evolutionary Rates in Adélie Penguins from the Antarctic Craig D. Millar, Andrew Dodd, Jennifer Anderson, Gillian C. Gibb, Peter A. Ritchie, Carlo Baroni, Michael D. Woodhams, Michael D. Hendy, and David M. Lambert PMCID: PMC2546446 High-Throughput Phenotypic Characterization of Pseudomonas aeruginosa Membrane Transport Genes Daniel A. Johnson, Sasha G. Tetu, Katherine Phillippy, Joan Chen, Qinghu Ren, and Ian T. Paulsen PMCID: PMC2542419 Efficient and Accurate Construction of Genetic Linkage Maps from the Minimum Spanning Tree of a Graph Yonghui Wu, Prasanna R. Bhat, Timothy J. Close, and Stefano Lonardi PMCID: PMC2556103 A TRPV Channel Modulates C. elegans Neurosecretion, Larval Starvation Survival, and Adult Lifespan Brian H. Lee and Kaveh Ashrafi PMCID: PMC2556084 High-Resolution Mapping of Expression-QTLs Yields Insight into Human Gene Regulation Jean-Baptiste Veyrieras, Sridhar Kudaravalli, Su Yeon Kim, Emmanouil T. Dermitzakis, Yoav Gilad, Matthew Stephens, and Jonathan K. Pritchard PMCID: PMC2556086 Cooperation of Sumoylated Chromosomal Proteins in rDNA Maintenance Yoshimitsu Takahashi, Stanimir Dulev, Xianpeng Liu, Natalie Jasmin Hiller, Xiaolan Zhao, and Alexander Strunnikov PMCID: PMC2563031 A Position Effect on the Heritability of Epigenetic Silencing Jaswinder Singh, Michael Freeling, and Damon Lisch PMCID: PMC2563033 Drosophila Kismet Regulates Histone H3 Lysine 27 Methylation and Early Elongation by RNA Polymerase II Shrividhya Srinivasan, Kristel M. Dorighi, and John W. Tamkun PMCID: PMC2563034 Genetic Association and Expression Studies Indicate a Role of
Toll-Like Receptor 8 in Pulmonary Tuberculosis Sonia Davila, Martin L. Hibberd, Ranjeeta Hari Dass, Hazel E. E. Wong, Edhyana Sahiratmadja, Carine Bonnard, Bachti Alisjahbana, Jeffrey S. Szeszko, Yanina Balabanova, Francis Drobniewski, Reinout van Crevel, Esther van de Vosse, Sergey Nejentsev, Tom H. M. Ottenhoff, and Mark Seielstad PMCID: PMC2568981 Time-Lapse Analysis and Mathematical Characterization Elucidate Novel Mechanisms Underlying Muscle Morphogenesis Chelsi J. Snow, Michelle Goody, Meghan W. Kelly, Emma C. Oster, Robert Jones, Andre Khalil, and Clarissa A. Henry PMCID: PMC2543113 Identification and Replication of Three Novel Myopia Common Susceptibility Gene Loci on Chromosome 3q26 using Linkage and Linkage Disequilibrium Mapping Toby Andrew, Nikolas Maniatis, Francis Carbonaro, S. H. Melissa Liew, Winston Lau, Tim D. Spector, and Christopher J. Hammond PMCID: PMC2556391 Mechanisms Underlying Hypoxia Tolerance in Drosophila melanogaster: hairy as a Metabolic Switch Dan Zhou, Jin Xue, James C. K. Lai, Nicholas J. Schork, Kevin P. White, and Gabriel G. Haddad PMCID: PMC2556400 The HLH-6 Transcription Factor Regulates C. elegans Pharyngeal Gland Development and Function Ryan B. Smit, Ralf Schnabel, and Jeb Gaudet PMCID: PMC2563036 Variations in Stress Sensitivity and Genomic Expression in Diverse
S. cerevisiae Isolates Daniel J. Kvitek, Jessica L. Will, and Audrey P. Gasch PMCID: PMC2562515 Regulatory Network Analyses Reveal Genome-Wide Potentiation of LIF Signaling by Glucocorticoids and Define an Innate Cell Defense Response David Langlais, Catherine Couture, Aurélio Balsalobre, and Jacques Drouin PMCID: PMC2562516 Diverse Splicing Patterns of Exonized Alu Elements in Human Tissues Lan Lin, Shihao Shen, Anne Tye, James J. Cai, Peng Jiang, Beverly L. Davidson, and Yi Xing PMCID: PMC2562518 Effects of Aneuploidy on Genome Structure, Expression, and Interphase
Organization in Arabidopsis thaliana Bruno Huettel, David P. Kreil, Marjori Matzke, and Antonius J. M. Matzke PMCID: PMC2562519 Depletion of Human Histone H1 Variants Uncovers Specific Roles in Gene Expression and Cell Growth Mónica Sancho, Erika Diani, Miguel Beato, and Albert Jordan PMCID: PMC2563032 Condensin II Resolves Chromosomal Associations to Enable Anaphase I Segregation in Drosophila Male Meiosis Tom A. Hartl, Sarah J. Sweeney, Peter J. Knepler, and Giovanni Bosco PMCID: PMC2562520 The Anticonvulsant Ethosuximide Disrupts Sensory Function to Extend C. elegans Lifespan James J. Collins, Kimberley Evason, Christopher L. Pickett, Daniel L. Schneider, and Kerry Kornfeld PMCID: PMC2565500 Predicting Unobserved Phenotypes for Complex Traits from Whole-Genome SNP Data Sang Hong Lee, Julius H. J. van der Werf, Ben J. Hayes, Michael E. Goddard, and Peter M. Visscher PMCID: PMC2565502 Evolution and Dynamics of Regulatory Architectures Controlling Polymyxin B Resistance in Enteric Bacteria Alexander Y. Mitrophanov, Mollie W. Jewett, Tricia J. Hadley, and Eduardo A. Groisman PMCID: PMC2565834 Genetic Networks Controlling Structural Outcome of Glucosinolate Activation across Development Adam M. Wentzell, Ian Boeye, Zhiyong Zhang, and Daniel J. Kliebenstein PMCID: PMC2565841 ZHP-3 Acts at Crossovers to Couple Meiotic Recombination with Synaptonemal Complex Disassembly and Bivalent Formation in C. elegans Needhi Bhalla, David J. Wynne, Verena Jantsch, and Abby F. Dernburg PMCID: PMC2567099 Two Pathways Recruit Telomerase to Saccharomyces cerevisiae Telomeres Angela Chan, Jean-Baptiste Boulé, and Virginia A. Zakian PMCID: PMC2567097 Numt-Mediated Double-Strand Break Repair Mitigates Deletions during Primate Genome Evolution Einat Hazkani-Covo and Shay Covo PMCID: PMC2567098 The Novel Mouse Mutation Oblivion Inactivates the PMCA2 Pump and Causes Progressive Hearing Loss Sarah L. Spiden, Mario Bortolozzi, Francesca Di Leva, Martin Hrabé de Angelis, Helmut Fuchs, Dmitry Lim, Saida Ortolano, Neil J. Ingham, Marisa Brini, Ernesto Carafoli, Fabio Mammano, and Karen P. Steel PMCID: PMC2568954 Genetic and Linguistic Coevolution in Northern Island Melanesia Keith Hunley, Michael Dunn, Eva Lindström, Ger Reesink, Angela Terrill, Meghan E. Healy, George Koki, Françoise R. Friedlaender, and Jonathan S. Friedlaender PMCID: PMC2570610 Mutation of the Zebrafish Nucleoporin elys Sensitizes Tissue Progenitors to Replication Stress Gangarao Davuluri, Weilong Gong, Shamila Yusuff, Kristin Lorent, Manimegalai Muthumani, Amy C. Dolan, and Michael Pack PMCID: PMC2570612 Essential Role of Chromatin Remodeling Protein Bptf in Early Mouse Embryos and Embryonic Stem Cells Joseph Landry, Alexei A. Sharov, Yulan Piao, Lioudmila V. Sharova, Hua Xiao, Eileen Southon, Jennifer Matta, Lino Tessarollo, Ying E. Zhang, Minoru S. H. Ko, Michael R. Kuehn, Terry P. Yamaguchi, and Carl Wu PMCID: PMC2570622 Genomewide Analysis of PRC1 and PRC2 Occupancy Identifies Two Classes of Bivalent Domains Manching Ku, Richard P. Koche, Esther Rheinbay, Eric M. Mendenhall, Mitsuhiro Endoh, Tarjei S. Mikkelsen, Aviva Presser, Chad Nusbaum, Xiaohui Xie, Andrew S. Chi, Mazhar Adli, Simon Kasif, Leon M. Ptaszek, Chad A. Cowan, Eric S. Lander, Haruhiko Koseki, and Bradley E. Bernstein PMCID: PMC2567431 Adaptive Copy Number Evolution in Malaria Parasites Shalini Nair, Becky Miller, Marion Barends, Anchalee Jaidee, Jigar Patel, Mayfong Mayxay, Paul Newton, François Nosten, Michael T. Ferdig, and Tim J. C. Anderson PMCID: PMC2570623 Modifier Effects between Regulatory and Protein-Coding Variation Antigone S. Dimas, Barbara E. Stranger, Claude Beazley, Robert D. Finn, Catherine E. Ingle, Matthew S. Forrest, Matthew E. Ritchie, Panos Deloukas, Simon Tavaré, and Emmanouil T. Dermitzakis PMCID: PMC2570624 Corrections Correction: A Mouse Model of Harlequin Ichthyosis Delineates a Key Role for Abca12 in Lipid Homeostasis Ian Smyth, Douglas F. Hacking, Adrienne A. Hilton, Nigora Mukhamedova, Peter J. Meikle, Sarah Ellis, Keith Slatterley, Janelle E. Collinge, Carolyn A. de Graaf, Melanie Bahlo, Dmitri Sviridov, Benjamin T. Kile, and Douglas J. Hilton PMCID: PMC2597898 Corrects: Ian Smyth, et al. A Mouse Model of Harlequin Ichthyosis Delineates a Key Role for Abca12 in Lipid Homeostasis. PLoS Genet. 2008 September; 4(9): e1000192. Correction: Adaptive Stress Response in Segmental Progeria Resembles Long-Lived Dwarfism and Calorie Restriction in Mice Marieke van de Ven, Jaan-Olle Andressoo, Valerie B Holcomb, Marieke von Lindern, Willeke M. C Jong, Chris I. De Zeeuw, Yousin Suh, Paul Hasty, Jan H. J Hoeijmakers, Gijsbertus T. J van der Horst, and James R Mitchell PMCID: PMC2645274 Corrects: Marieke van de Ven, et al. Adaptive Stress Response in Segmental Progeria Resembles Long-Lived Dwarfism and Calorie Restriction in Mice. PLoS Genet. 2006 December; 2(12): e192. Correction: Motility Screen Identifies Drosophila IGF-II mRNA-Binding Protein, a Zipcode-Binding Protein Acting in Oogenesis and Synaptogenesis Jennifer J. Jordan, Daniel Menendez, Alberto Inga, Maher Noureddine, Douglas A. Bell, and Michael A. Resnick PMCID: PMC2553204 Corrects: Jennifer J. Jordan, et al. Noncanonical DNA Motifs as Transactivation Targets by Wild Type and Mutant p53. PLoS Genet. 2008 June; 4(6): e1000104. |
