Recent Additions

23 December 2005

The Summary of n-Hexane has been revised and an updated Toxicological Review (PDF) (210 pages, 2.3Mb) has been added to the IRIS Web site.

23 September 2005

The Summary of Toluene has been revised and an updated Toxicological Review (PDF) (179 pages, 1.8 Mb) has been added to the IRIS Web site.

26 August 2005

Publication: Final Report for the 2005 Peer Consultation Workshop on Research Needs Related to the IRIS Draft Toxicological Review of Naphthalene . This document is the final report for the 2005 peer consultation workshop to seek expert opinion on research needs related to the mode of action of the inhalation carcinogenicity of naphthalene. A panel of expert participants met to discuss their responses to the charge questions on April 7, 2005. This report is a summary of the main points of presentations and highlights discussions among the participants.

15 August 2005

IRIS Literature Screen Verification
The IRIS Program added statements to certain existing IRIS Summaries confirming that the health effects information upon which the assessment was based is still current. This is to follow up on our February 9, 2004 FR notice (69 FR 5971) announcing the annual IRIS agenda. In that notice, EPA announced that we would use findings from our recent IRIS literature screening project (the results of which were added to IRIS in 2003) as the basis for a systematic update of the IRIS database. We explained that we would begin performing a more in-depth review of the extant health literature to confirm results from the literature screen. For those substances confirmed to be without new health effects information likely to change an existing assessment, we stated that we would update IRIS Summaries to indicate this finding. Also, in the FR notice we sought submission of scientific information from the public to confirm the results of the literature screen review. Confirmatory statements for 12 substances have been added to IRIS Summaries. Statements for Chloromethyl methyl ether, Ammonium acetate, Bromochloromethane, Crotonaldehyde, Pentachlorocyclopentadiene, Diethylene glycol dinitrate, p,p'-Dibromodiphenyl ether, Dibromodichloromethane, o-Dinitrobenzene, Acetyl chloride, 1-Chlorobutane and Acetonitrile were added to the respective IRIS summaries on 08/15/2005. This will be an on-going project.

03 August 2005

The Summary of Zinc and Compounds has been revised and an updated Toxicological Review (PDF) (83 pages, 518 Kb) has been added to the IRIS Web site.

14 July 2005

The IRIS Program is updating the IRIS Glossary by adopting the revised definitions for the reference dose (RfD) and reference concentration (RfC) to implement the recommendations of the RfD/RfC Technical Panel as provided in the report, "A Review of the Reference Dose and Reference Concentration Processes (PDF)," (192 pages, 2.8 Mb) EPA/630/P-02/002F (U.S. EPA, 2002).

11 July 2005

The summary for Barium and compounds has been revised, and an updated Toxicological Review (PDF) (87 pages, 258 Kb) has been added to the IRIS Web site. The oral reference dose (RfD) was revised in response to a Request for Correction (RFC #2293) (PDF) (77 pages, 307 Kb) submitted to EPA. The noncancer inhalation and cancer assessments were not revised.

22 June 2005

IRIS Literature Screen Verification
The IRIS Program added statements to certain existing IRIS Summaries confirming that the health effects information upon which the assessment was based is still current. This is to follow up on our February 9, 2004 FR notice (69 FR 5971) announcing the annual IRIS agenda. In that notice, EPA announced that we would use findings from our recent IRIS literature screening project (the results of which were added to IRIS in 2003) as the basis for a systematic update of the IRIS database. We explained that we would begin performing a more in-depth review of the extant health literature to confirm results from the literature screen. For those substances confirmed to be without new health effects information likely to change an existing assessment, we stated that we would update IRIS Summaries to indicate this finding. Also, in the FR notice we sought submission of scientific information from the public to confirm the results of the literature screen review. Confirmatory statements for 24 substances have been added to IRIS Summaries. Statements for 2,6-Dimethylphenol, 3,4-Dimethylphenol, beta-Chloronaphthalene, Copper cyanide, Dichlorodifluoromethane, Hexabromobenzene, 1,1-Difluoroethane, 1-Chloro-1,1-difluoroethane, Phosphoric acid, Propylene glycol monoethyl ether, Triethylene glycol monobutyl ether, and Triethylene glycol monoethyl ether were added on March 3, 2005. Statements for 2,4-Dinitrophenol, Chlorine cyanide, 1,4-Dithiane, Glycidaldehyde, Isopropyl methyl phosphonic acid, m-Dinitrobenzene, Monochloramine, p-Chlorophenyl methyl sulfide, Selenious acid, 1,1-Dichloroethylene, Chlorite (sodium salt), and 2-Chlorobutane were added on June 22, 2005. This will be an on-going project.

31 May 2005

Publication: Final Report for the 2005 External Peer Review of the Toxicological Review and IRIS Summary for N-Hexane. This document is the final report for the 2005 external peer review for the IRIS Reassessment of n-hexane, prepared by the U.S. Environmental Protection Agency (EPA), National Center for Environmental Assessment (NCEA), for the Integrated Risk Information System (IRIS). A panel of external peer reviewers met to discuss their responses to the charge questions on March 30, 2005. This document contains the final written comments of the external peer reviewers.

08 March 2005

Notice of a Peer Consultation Workshop on Research Needs Related to the IRIS Draft Toxicological Review of Naphthalene
Environmental Protection Agency (EPA) is announcing a workshop to seek expert opinion on the research needs related to the mode of action of the inhalation carcinogenicity of naphthalene. EPA will consider the comments and recommendations from the expert panel in determining a future course of action for assessing potential health risks associated with naphthalene exposure. The workshop will begin on April 7, 2005.

07 March 2005

EPA's announcement of IRIS 2005 program agenda and request for scientific information on human health effects that may result from exposure to substances was published in the Federal Register on March 4, 2005 [70 FR 42] (PDF) (5 pages, 99 Kb).

18 February 2005

A new summary for Perchlorate and Perchlorate Salts has been added to the IRIS Web site. The summary is based on "Health Implications of Perchlorate Ingestion " by the National Research Council of the National Academies (NRC, 2005).

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