About NEJMEditors and Publishers
A publication of NEJM Group — Owned & Published by the MASSACHUSETTS MEDICAL SOCIETY
James S. Gessner, M.D., President
Lois Dehls Cornell, Executive Vice President
THE COMMITTEE ON PUBLICATIONS OF THE MASSACHUSETTS MEDICAL SOCIETY
Lynda M. Young, M.D., Chair
Stuart B. Mushlin, M.D., Vice Chair
Edward W. Boyer, M.D., Nicholas Chiu, Paul M. Copeland, M.D., James A. Feldman, M.D., Subramanyan Jayasankar, M.D., Marek M. Kowalski, Paul M. Ridker, M.D., Lakshmana Swamy, M.D., John B. Wong, M.D., Beverly Woo, M.D., Joseph C. Bergeron, Jr., M.D., ex officio,Alain A. Chaoui, M.D., ex officio, Corey E. Collins, D.O., ex officio, Henry L. Dorkin, M.D., ex officio, James S. Gessner, M.D., ex officio
EDITORS
Jeffrey M. Drazen, M.D., Editor-in-Chief
Edward W. Campion, M.D., Executive Editor and Online Editor
Mary Beth Hamel, M.D., M.P.H., Executive Deputy Editor
Deputy Editors
Lindsey R. Baden, M.D., Julie R. Ingelfinger, M.D., John A. Jarcho, M.D., Dan L. Longo, M.D., Elizabeth G. Phimister, Ph.D., Allan H. Ropper, M.D., Caren G. Solomon, M.D., M.P.H.
Associate Editors
Arnold M. Epstein, M.D., M.A.,Michael F. Greene, M.D., John F. Keaney, Jr., M.D., Thomas LaMont, M.D., Clifford J. Rosen, M.D., Eric J. Rubin, M.D., Ph.D., David R. Spriggs, M.D., Gary Wong, M.D., F.R.C.P.C., Rui‑Ping Xiao, M.D., Ph.D.
Stephen Morrissey, Ph.D., Managing Editor
Ralph B. D’Agostino, Sr., Ph.D., Constantine Gatsonis, Ph.D.,David Harrington, Ph.D., David J. Hunter, M.B.B.S., M.P.H., Sc.D., Sharon‑Lise T. Normand, Ph.D., Statistical Consultants
Debra Malina, Ph.D., Perspective Editor
John K. Iglehart, Lisa S. Rosenbaum, M.D., National Correspondents
Charlotte J. Haug, M.D., Ph.D., International Correspondent
Carla S. Rothaus, M.D., CME Editor
Chana A. Sacks, M.D., Images Editor
Joseph Loscalzo, M.D., Ph.D., Richard P. Wenzel, M.D., M.Sc., Editors-at-Large
Rebecca E. Berger, M.D., Ramya Ramaswami, M.B.B.S., M.R.C.P., M.P.H., Editorial Fellows
EDITORIAL BOARD
Salim S. Abdool Karim, M.B., Ch.B., Ph.D., Durban
David Blumenthal, M.D., M.P.P., New York
Michele K. Evans, M.D., Bethesda
Jeremy J. Farrar, M.D., Ph.D., London
Harvey V. Fineberg, M.D., Ph.D., San Francisco
Thomas H. Lee, M.D., Boston
Jeffrey A. Lieberman, M.D., New York
John McMurray, M.D., Glasgow
Trevor Mundel, M.D., Ph.D., Seattle
Richard L. Schilsky, M.D., Alexandria
Christine Van Broeckhoven, Ph.D., D.Sc., Antwerp
Erika von Mutius, M.D., Munich
Janet Woodcock, M.D., Rockville
EDITORIAL SYSTEMS
Sarah Fishkin, Director of Editorial Systems
Karen Daly, Manager of Editorial Office Services, Lauren Lindenfelser, Manager of Editorial Administration, Neil Galloway, Pamela Miller, Assistants to the Editor, Briana Doherty, Senior Editorial Coordinator, Jennifer Lewis, Editorial Coordinator, Grace Hansen-Dewar, Senior Editorial Assistant, Alex Marie Lombino, Andrew Ochrymowych, Jacqueline Ruzicka, Editorial Assistants
ONLINE EDITORIAL GROUP
Lisa Scott, Assistant Managing Editor, Online
Andrea Graham, Manager of Online Editorial Production, David Lyons, Electronic Content Specialist, Julie Evers, Web Production Specialist
MANUSCRIPT EDITING
Margaret Perkins, Director of Manuscript Editing
Deborah Moskowitz, Manager of Manuscript Editing, Deborah Stone, Quality Assurance Manager, Cynthia Hastings, Senior Manuscript and Production Editor, India Koopman, Senior Multimedia Editor, Dan Fields, Sharon Hogan, Elizabeth Laurençot, Mary Prince, Leahanne Sarlo, Senior Manuscript Editors, Lindsay Guth, William Oppenheimer, Amy Schulz, Donald Smith, Manuscript Editors, Claudette Dawes, Senior Production Coordinator, Jessica Derby, Pamela Stryjewski, Editorial Copy Specialists, Jeffrey Allen, Ethel Garvin, Senior Proofreaders
GRAPHIC ARTS
Kathy Stern, Graphic Arts Director
Jennifer Moses, Manager of Editorial Premedia, Timothy Vining, Manager of Medical and Scientific Illustration, Alison E. Burke, Kimberly Knoper, Scott Leighton, Lori Messenger, Scott Williams, Senior Scientific/Medical Illustrators, Daniel Müller, Interactive Medical Media Designer, Natalie Koscal, Medical Illustrator, Tomoko Shibusawa, Senior Information Graphics Specialist, Jeff Seals, Interactive Medical Visualization Developer,,Michael Tomases, Media Specialist, Darah Whelihan, XML Content Producer, Richard Waring, Senior Layout Artist
EDITORIAL PRODUCTION TECHNOLOGY
John E. Muenning, Director of Editorial Production Technology
Ellen Duff, Editorial Metadata Manager, Elizabeth Quilty, Manager of Editorial Scheduling and Tracking
PERSPECTIVE GROUP
Debra Malina, Ph.D., Stephen Morrissey, Ph.D.
Genevra Pittman, Assistant Perspective Editor
Perspective Advisory Board: John Z. Ayanian, M.D., M.P.P., David S. Jones, M.D., Ph.D., Aaron S. Kesselheim, M.D., J.D., M.P.H., Ph.D.,Debra F. Weinstein, M.D.,Rebecca L. Weintraub, M.D.
Christopher R. Lynch, Vice President for Publishing