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QUICK TAKE
Mass Intoxication with a Synthetic Cannabinoid
Mass Intoxication with a Synthetic Cannabinoid
In July 2016, emergency services in Brooklyn responded to a scene of mass intoxication of 33 persons who had been exposed to an “herbal incense” product. How was the cause of their zombielike behavior identified? New research findings are summarized in a short video.
January 19, 2017
Free
Images in Clinical Medicine
Swirl Sign — Intestinal Volvulus after Roux-en-Y Gastric Bypass
A 56-year-old man presented after a day and a half of midabdominal pain, nausea, and bilious emesis. The patient had undergone Roux-en-Y gastric bypass 7 years earlier. During the physical examination, tachycardia and tachypnea were noted. The abdominal examination showed a distended, tympanic…
- Free Full Text
Perspective
Transparency and Trust — Online Patient Reviews of Physicians
Example of Patient Ratings and Comments from the University of Utah Health Care Website.
- Free Full Text
Original Article
Ocrelizumab versus Placebo in Primary Progressive Multiple Sclerosis
Primary and Key Secondary Clinical Outcomes (Intention-to-Treat Population).
Panel A (primary end point) and Panel B (first secondary end point) show the cumulative probability of clinical disability progression (as defined by an increase in the score on the Expanded Disability Status Scale) that was confirmed after at least 12 weeks and at least 24 weeks, respectively, in…
- CME
Original Article
Ocrelizumab versus Placebo in Primary Progressive Multiple Sclerosis
MRI End Points (Intention-to-Treat Population).
Panel A shows the percent change in the total volume of brain lesions on T2-weighted MRI from baseline to week 120 (third secondary end point). The P value was calculated with the use of a ranked analysis of covariance. Panel B shows the percent change on MRI scans in brain volume from week 24 to…
- CME
Original Article
Ocrelizumab versus Placebo in Primary Progressive Multiple Sclerosis
Baseline Demographic and Disease Characteristics (Intention-to-Treat Population).
- CME
Original Article
Ocrelizumab versus Placebo in Primary Progressive Multiple Sclerosis
Primary and Secondary End Points, According to Hierarchical Order in the Statistical Analysis (Intention-to-Treat Population).
- CME
Original Article
Ocrelizumab versus Placebo in Primary Progressive Multiple Sclerosis
Adverse Events (Safety Population).
- CME
Original Article
Transmission of Extensively Drug-Resistant Tuberculosis in South Africa
Geospatial Coordinates of Participants with Extensively Drug-Resistant (XDR) Tuberculosis in KwaZulu-Natal Province, South Africa.
Panel A shows the homes (red dots) of all 404 enrolled participants. Panel B shows the 53 hospitals (blue squares) where the participants were admitted before or after XDR tuberculosis was diagnosed.
- Free Full Text
Original Article
Transmission of Extensively Drug-Resistant Tuberculosis in South Africa
Single-Nucleotide Polymorphism (SNP)–Based Maximum Likelihood Phylogenetic Tree.
Isolates are labeled according to study identification number and color coded according to restriction-fragment–length polymorphism (RFLP) group. Single-isolate RFLP groups are shown in black. The tree is rooted to the lineage 7 isolate Percy256. L2 denotes lineage 2, and L4 lineage 4. The other…
- Free Full Text
Original Article
Transmission of Extensively Drug-Resistant Tuberculosis in South Africa
Social Networks in Homes and Communities, Derived from Name-Based Person-to-Person Links.
A social network of 59 participants with direct person-to-person links is shown. Large black circles indicate study participants. Small circles indicate 450 close contacts named by participants. Lines between two large circles indicate 2 study participants who named each other as a close contact.…
- Free Full Text
Original Article
Transmission of Extensively Drug-Resistant Tuberculosis in South Africa
Baseline Characteristics of the Participants with Extensively Drug-Resistant Tuberculosis in KwaZulu-Natal Province, South Africa, According to a Clinical Case Definition of Acquired or Transmitted Resistance.
- Free Full Text
Case Records of the Massachusetts General Hospital
Case 2-2017 — An 18-Year-Old Woman with Acute Liver Failure
Abdominal Ultrasound Images.
Grayscale ultrasound images show mildly echogenic parenchyma of the liver (Panel A) and distention of the gallbladder, with layering sludge, wall edema, and a small amount of pericholecystic fluid (Panel B). A color Doppler ultrasound image shows that the common bile duct is normal in diameter…
- CME
Case Records of the Massachusetts General Hospital
Case 2-2017 — An 18-Year-Old Woman with Acute Liver Failure
Causes of Acute Liver Failure in Children and Adults.
Data are adapted from Lee et al.1 and Squires and Alonso.3 The numbers shown are percentages. Among children older than 10 years of age, Wilson’s disease accounted for 90% of metabolic disease.
- CME
Case Records of the Massachusetts General Hospital
Case 2-2017 — An 18-Year-Old Woman with Acute Liver Failure
Explanted Liver.
A photograph of the cut surface of the liver shows a mottled appearance, with several regenerative nodules that vary in color from tannish-brown to yellow (Panel A). Hematoxylin and eosin staining shows that the parenchyma has a nodular appearance and widespread inflammation (Panel B). At higher…
- CME
Case Records of the Massachusetts General Hospital
Case 2-2017 — An 18-Year-Old Woman with Acute Liver Failure
Laboratory Data.
- CME
Review Article
Mechanisms, Pathophysiology, and Management of Obesity
Some Pathways through Which Excess Adiposity Leads to Major Risk Factors and Common Chronic Diseases.
Common chronic diseases are shown in red boxes. The dashed arrow denotes an indirect association.
- CME
Review Article
Mechanisms, Pathophysiology, and Management of Obesity
Weight Loss at 1 Year with High-Intensity Lifestyle Interventions or Pharmacotherapy Combined with Low-to-Moderate-Intensity Lifestyle Counseling.
Shown are the percentages of participants in randomized, controlled trials who had weight loss of at least 5% or at least 10% of their initial weight at 1 year after a high-intensity lifestyle intervention or pharmacotherapy that typically was combined with low-to-moderate-intensity lifestyle…
- CME
Review Article
Mechanisms, Pathophysiology, and Management of Obesity
Weight Loss at 1 Year with Bariatric Surgery and Lifestyle Interventions as Compared with Lifestyle Interventions Alone.
Shown are categorical weight losses at 1 year in persons with overweight or obesity and type 2 diabetes who participated in randomized, controlled trials evaluating laparoscopic adjustable gastric banding (LAGB) combined with medical therapy and a lifestyle intervention (MT/LI) as compared with…
- CME