Sharing Tools and Resources

Frederick National Laboratory for Cancer Research

Research Collaboration Page

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The Frederick National Laboratory for Cancer Research (FNLCR), formerly NCI-Frederick, is home to many talented scientific researchers. The STAR page at the Scientific Library is dedicated to them, and to the scientific resources they have created, and is open to all FNLCR researchers who wish to share the resources they have developed with the rest of FNLCR, as well as with a larger, world-wide community of researchers, in the spirit of collaboration that moves research forward and makes breakthroughs more likely to happen. Please contact the Scientific Library for more information on how you can have your resource represented on the STAR page.

We invite all STAR participants to link back to the list to encourage ease of access to all these valuable resources. .

Current Research Initiatives:

AVIA-Automated Variation and Impact Analysis – AVIA is a web based resource for variant detection (Sanger Sequencing) as well as impact analysis. This resource allows users to interrogate specific genomic coordinates and determine the impact of the mutation based on public information as well as user specified data from their own experiments.

bioDBnet-biological DataBase network – bioDBnet is an application integrating a wide range of biological databases and providing an easy interface for researchers to annotate and convert between various biological identifiers like genes to pathways, mouse genes to human genes, SNPs to genes.

CyloFold – CyloFold addresses the single-sequence RNA structure prediction problem with pseudoknots.

DAVID Bioinformatics Resource – DAVID (the Database for Annotation, Visualization and Integrated Discovery) is a free online bioinformatics resource aimed to provide functional interpretation of large lists of genes derived from genomic studies, e.g. microarray and proteomics studies.

KNetFold – KNetFold is the method of choice for RNA secondary structure prediction if an alignment of RNA sequences is available.

Metagenomic Pipelines at ABCC – The computational pipelines were developed for analysis of the environmental samples. Two major areas will be discussed: (i) identification of the foreign DNA in the sequences of the mammalian origin and (ii) resources available at ABCC for microbiome analysis. Access Request Form

NanoFolder – NanoFolder predicts the RNA secondary structure of a set of RNA strands (possibly forming a complex).

NCI @ NIH Fellows and Young Investigators (NCI FYI) Mobile App – The NCI FYI mobile application offers a centralized source of available resources to fellows and trainees working on the NIH main Campus in Bethesda, MD, off campus in the surrounding area in Rockville, MD and Frederick, MD.

NCI @ NIH Summer Interns Program (NCI SIP) Mobile App – The NCI SIP mobile application provides summer interns a source for accessing activities and resources available during their eight week tenure working at the NIH main campus in Bethesda, MD, off campus in the surrounding area in Rockville, MD and Frederick, MD.

NCI CADD Group's Chemical Structure Web Services – Web services allowing you to (a) find chemical structures and information about where these molecules occur in the ~140 small molecule databases aggregated by the NCI CADD Group into a collection of approx. 120 million chemical structure records representing about approx. 70 million unique chemical structures, (b) convert your chemical structures from one format into another, and (c) integrate these resources into your own web site.

Frederick National Lab in Print – The NCI-Frederick-in-Print database is a collection of citations for publications authored by employees and contractors of the National Cancer Institute at Frederick from 1997 through the present.

non-B DB, a database of predicted non-B DNA-forming motifs in mammalian genomes and the non-B DNA Motif Search Tool (nBMST) – non-B DB web resource allows users to query pre-computed non-B DNA motifs in several mammalian species and to submit their favorite DNA sequences for custom non-B DNA search.

PHL Murine Immunohistochemistry Database – This database features 250 different immunohistochemical techniques optimized in mouse tissues. It may be searched by Antibody, Manufacturer, and Fixative.

RNA2D3D – RNA2D3D is a graphical, interactive system for rapid conversion of RNA 2D structures to 3D models and interactive 3D model refinement.

StructureLab – StructureLab is a software workbench for prediction and analysis of 2D RNA structures. It provides interactive GUI-based data mining of the solution spaces produced by the secondary structure prediction programs.

Tissue Sample and Usage Inventory – A software in development to track mouse tissue collections from Pathology Histotechnology Laboratory (or similar source) and the usage of tissues by molecular and immunostaining procedure.

Tools for Studying the Biological Effects of Nitric Oxide (NO) and Nitroxyl (HNO) – Caged nitric oxide (NO) prodrugs as research tools and for use in designing advances in clinical practice.

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