| CONGRESS | NAME OF SENATOR | TERM BEGAN | TERM ENDED | COMMENTS |
|---|---|---|---|---|
| Class 1 | ||||
| 1st | Tristram Dalton (PRO-ADMIN) | Mar. 4, 1789 | Mar. 3, 1791 | |
| 2nd - 4th | George Cabot (PRO-ADMIN, F) | Mar. 4, 1791 | Jun. 9, 1796 | Resigned |
| 4th - 6th | Benjamin Goodhue (F) | Jun. 11, 1796 | Nov. 8, 1800 | Resigned |
| 6th - 7th | Jonathan Mason (F) | Nov. 14, 1800 | Mar. 3, 1803 | |
| 8th - 10th | John Quincy Adams (F) | Mar. 4, 1803 | Jun. 8, 1808 | Resigned |
| 10th - 13th | James Lloyd (F) | Jun. 9, 1808 | May 1, 1813 | Resigned |
| 13th - 14th | Christopher Gore (F) | May 5, 1813 | May 30, 1816 | Appointed then elected; Resigned |
| 14th - 15th | Eli P. Ashmun (F) | Jun. 12, 1816 | May 10, 1818 | Resigned |
| 15th - 16th | Prentiss Mellen (F) | Jun. 5, 1818 | May 15, 1820 | Resigned |
| 16th - 19th | Elijah H. Mills (F, ADAMS-CLAY F, ADAMS) | Jun. 12, 1820 | Mar. 3, 1827 | |
| 20th - 26th | Daniel Webster (ADAMS, AJ, W) | May 30, 1827 | Feb. 22, 1841 | Resigned |
| 26th - 28th | Rufus Choate (W) | Feb. 23, 1841 | Mar. 3, 1845 | |
| 29th - 31st | Daniel Webster (W) | Mar. 4, 1845 | Jul. 22, 1850 | Resigned |
| 31st | Robert C. Winthrop (W) | Jul. 30, 1850 | Feb. 1, 1851 | Appointed |
| 31st | Robert Rantoul Jr. (D) | Feb. 1, 1851 | Mar. 3, 1851 | |
| 32nd - 43rd | Charles Sumner (FS, OP, R, LR) | Mar. 4, 1851 | Mar. 11, 1874 | Died |
| 43rd | William B. Washburn (R) | Apr. 17, 1874 | Mar. 3, 1875 | |
| 44th - 52nd | Henry L. Dawes (R) | Mar. 4, 1875 | Mar. 3, 1893 | |
| 53rd - 69th | Henry Cabot Lodge (R) | Mar. 4, 1893 | Nov. 9, 1924 | Died |
| 69th | William M. Butler (R) | Nov. 13, 1924 | Dec. 5, 1926 | Appointed |
| 69th - 79th | David I. Walsh (D) | Dec. 6, 1926 | Jan. 3, 1947 | |
| 80th - 82nd | Henry Cabot Lodge Jr. (R) | Jan. 3, 1947 | Jan. 3, 1953 | |
| 83rd - 87th | John F. Kennedy (D) | Jan. 3, 1953 | Dec. 22, 1960 | Resigned |
| 87th | Benjamin A. Smith II (D) | Dec. 27, 1960 | Nov. 6, 1962 | Appointed |
| 87th - 111th | Edward M. Kennedy (D) | Nov. 7, 1962 | Aug. 25, 2009 | Died |
| 111th | Paul G. Kirk Jr. (D) | Sept. 24, 2009 | Feb. 4, 2010 | Appointed |
| 111th - 112th | Scott P. Brown (R) | Feb. 4, 2010 | Jan. 3, 2013 | |
| 113th - | Elizabeth Warren (D) | Jan. 3, 2013 | Present | |
| Class 2 | ||||
| 1st - 4th | Caleb Strong (PRO-ADMIN, F) | Mar. 4, 1789 | Jun. 1, 1796 | Resigned |
| 4th - 5th | Theodore Sedgwick (F) | Jun. 11, 1796 | Mar. 3, 1799 | |
| 6th | Samuel Dexter (F) | Mar. 4, 1799 | May 30, 1800 | Resigned |
| 6th - 8th | Dwight Foster (F) | Jun. 6, 1800 | Mar. 3, 1803 | Resigned |
| 8th - 11th | Thomas Pickering (F) | Mar. 4, 1803 | Mar. 3, 1811 | |
| 12th - 14th | Joseph B. Varnum (R) | Jun. 8, 1811 | Mar. 3, 1817 | |
| 15th - 17th | Harrison Gray Otis (F) | Mar. 4, 1817 | May 30, 1822 | Resigned |
| 17th - 19th | James Lloyd (F, ADAMS-CLAY F, ADAMS) | Jun. 5, 1822 | May 23, 1826 | Resigned |
| 19th - 23rd | Nathaniel Silsbee (ADAMS, AJ) | May 31, 1826 | Mar. 3, 1835 | |
| 24th - 26th | John Davis (AJ, W) | Mar. 4, 1835 | Jan. 5, 1841 | Resigned |
| 26th - 29th | Issac C. Bates (W) | Jan. 13, 1841 | Mar. 16, 1845 | Died |
| 29th - 32nd | John Davis (W) | Mar. 24, 1845 | Mar. 3, 1853 | |
| 33rd | Edward Everett (W) | Mar. 4, 1853 | Jun. 1, 1854 | Resigned |
| 33rd | Julius Rockwell (W) | Jun. 3, 1854 | Jan. 31, 1855 | Appointed |
| 33rd - 43rd | Henry Wilson (AM, OP, R) | Jan. 31, 1855 | Mar. 3, 1873 | Resigned |
| 43rd - 44th | George S. Boutwell (R) | Mar. 12, 1873 | Mar. 3, 1877 | |
| 45th - 58th | George F. Hoar (R) | Mar. 4, 1877 | Sept. 30, 1904 | Died |
| 58th - 62nd | Winthrop M. Crane (R) | Oct. 12, 1904 | Mar. 3, 1913 | Appointed, the elected |
| 63rd - 65th | John W. Weeks (R) | Mar. 4, 1913 | Mar. 3, 1919 | |
| 66th - 68th | David I. Walsh (D) | Mar. 4, 1919 | Mar. 3, 1925 | |
| 69th - 71st | Fredrick H. Gillett (R) | Mar. 4, 1925 | Mar. 3, 1931 | |
| 72nd - 74th | Marcus A. Coolidge (D) | Mar. 4, 1931 | Jan. 3, 1937 | |
| 75th - 78th | Henry Cabot Lodge Jr. (R) | Jan. 3, 1937 | Feb. 3, 1944 | Resigned |
| 78th | Sinclair Weeks (R) | Feb. 8, 1944 | Dec. 19, 1944 | Appointed |
| 78th - 89th | Leverett Saltonstall1 (R) | Jan. 4, 1945 | Jan. 3, 1967 | Appointed |
| 90th - 95th | Edward W. Brooke III (R) | Jan. 3, 1967 | Jan. 3, 1979 | |
| 96th - 98th | Paul E. Tsongas (D) | Jan. 3, 1979 | Jan. 3, 1985 | |
| 99th - | John F. Kerry (D) | Jan. 3, 1985 | Present | |
1. Elected Nov. 7, 1944. Took oath of office Jan. 10, 1945. Governor during interim.
