Directions to the Natchez Trace Parkway vary greatly depending on what part of the tri-state Parkway you are trying to reach. There are more than 50 roads that access the Parkway in Tennessee, Alabama, and Mississippi. For specific questions concerning how to get to a certain portion of the Parkway, please call the Visitor Center at 1-800-305-7417. Below are listed some of the more common ways that travelers may access the Parkway.

In Natchez, Mississippi - The southern terminus of the Parkway is accessed off of Liberty Road in Natchez, Mississippi. Technically, this is starting your trip from the historical "beginning" of the Old Trace, in Natchez, at milepost zero.

In Jackson, Mississippi - There are two major access points in the Jackson area. One access is from I-20, and the other from I-55.

In Tupelo, Mississippi - U.S. Highway 78 (future I-22) accesses the Parkway.

In Cherokee, Alabama - U.S. Highway 72 accesses the Parkway.

Southwest of Nashville, Tennessee - The northern terminus of the Parkway (milepost 444) intersects with Tennessee Highway 100 about 17 miles southwest of downtown Nashville. Travelers can also follow I-40 west of Nashville to exit 192, McCrory Lane. Travel on McCrory Lane for about 5 miles to the entrance to the Natchez Trace Parkway.

It should be noted that the list above is only meant to highlight some of the more popular access points to the Parkway. Please keep in mind that there are over 50 roads that access the Parkway.