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In this issue... Also available in pdf. 1997 Santa Fe Highlights Human Genome Project Administration In the News Publications Software and the Internet Funding Meeting Calendars & Acronyms |
Eyes on the Prize: Deliver the SequenceComplete, Accurate Sequence Most Important, Patrinos SaysThe message delivered by Ari Patrinos last November at the Sixth DOE Human Genome Program Contractor-Grantee meeting in Santa Fe was clear and unequivocal: The Human Genome Project needs to stay focused on the commitment to obtain a highly accurate, complete human DNA sequence by 2005 (see New 5-Year Plan). More than 400 genome program grantees, managers, and guests attended the workshop in the city of the "holy faith", high above the southwestern desert. Patrinos, associate director of the DOE Office of Biological and Environmental Research (OBER), explained the rationale for dramatically increasing support for large-scale sequencing at the expense of other projects in the genome program. It's simple, he said. "We need to take our human genome goals seriously, or public support may evaporate and bring potentially serious budgetary repercussions." OBER's decisions, Patrinos continued, are aimed specifically toward DOE's pledge to complete at least human chromosomes 5, 16, and 19 (about 340 Mb or 10% of the genome) over the next 7 years. He then outlined the steps DOE is taking toward its daunting goal. Sequencing Factory on Track "The only way to do production sequencing on the required competitive scale is with a factory approach," Patrinos asserted. Work on JGI's new Production Sequencing Facility (PSF) began in January in Walnut Creek, California, about 35 minutes from LLNL and LBNL. With PSF operations scheduled to begin in late fall 1998, Patrinos said he felt "very optimistic." He credited the hard work and strong support of principal scientists, senior management at the three laboratories, and DOE advisors, many of whom were at the meeting. Sequence quality generated by JGI will conform to or exceed community standards (see Bermuda-Quality Sequence) and include full and immediate data release. JGI will be held to the highest standards of quality assurance and control and database sharing. Expectations are for strong academic collaborations with sequencing centers funded under the NIH National Human Genome Research Institute, Patrinos said. Informatics and Technology Development Preparing for the Future Fifty Years of BER Progress
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