FYI from the NHLBI Index

May 2008: Vol. 9, Issue 1
Research and Resources

NHLBI Research Initiatives

• Research on the Economics of Diet, Activity and Energy Balance (R21/R01)
• The Effect of Racial and Ethnic Discrimination/Bias on Health Care Delivery (R01/R21)
• Novel Approaches to Study Polymicrobial Diseases (R01/R21)
• Rare Diseases Clinical Research Consortia (RDCRC) for the Rare Diseases Clinical Research Network (U54)
• Administrative Supplements for Making Knockout Mice
• Molecular Phenotypes for Lung Diseases (R01)
• Small Grants for Lung Tissue Research (R03)
• Immunomodulatory, Inflammatory, and Vasoregulatory Properties of Transfused Red Blood Cell Units as a Function of Preparation and Storage (R01)
• New Technologies for Transient Molecular Complex Characterization (SBIR [R43/R44])
• Targeted Approaches to Weight Control for Young Adults (U01)
• Enhancing Zebrafish Research with Research Tools and Techniques (R01) and Genetic Screens to Enhance Zebrafish Research (R01)

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NHLBI Research Initiatives

From time to time, the NHLBI invites investigators to submit grant applications or contract proposals for specific research programs. We are soliciting applications for the new programs described below. Please visit the URL listed with each program to obtain information about important application dates and deadlines. For full details of these and other current research initiatives, visit www.nhlbi.nih.gov/funding/inits/index.htm.

Research on the Economics of Diet, Activity and Energy Balance (R21/R01)

• Initiative Number: PA-08-077 and PA-08-078
• Objective: Apply the tools of health economics, health services research, and econometric modeling to the study of energy balance in order to better understand the causes of obesity.

The Effect of Racial and Ethnic Discrimination/Bias on Health Care Delivery (R01/R21)

• Initiative Number: PA-08-083 and PA-08-084
• Objective: Enhance understanding of the influence of racial and ethnic discrimination and bias in health care delivery systems in the United States and their association with disparities in disease incidence, treatment, and outcomes among disadvantaged racial and ethnic minority groups.

Novel Approaches to Study Polymicrobial Diseases (R01/R21)

• Initiative Number: PA-08-091 and PA-08-092
• Objective: Understand the mechanisms that influence the virulence of infections involving two or more microorganisms or strains of microorganisms (with the exception of HIV).

Rare Diseases Clinical Research Consortia (RDCRC) for the Rare Diseases Clinical Research Network (U54)

• Initiative Number: RFA-OD-08-001
• Objective: Participate in a network of research centers conducting collaborative clinical research in rare diseases, including longitudinal studies of individuals with rare diseases, clinical studies, and/or clinical trials.

Administrative Supplements for Making Knockout Mice

• Initiative Number: NOT-HG-08-002
• Objective: Generate knockout mice from mutant embryonic stem cell lines for use in ongoing NHLBI-supported research studies.

Molecular Phenotypes for Lung Diseases (R01)

• Initiative Number: RFA-HL-08-006
• Objective: Re-define major categories of lung diseases using molecular phenotypes based on RNA and DNA extracted from clinically phenotyped patients and controls.

Small Grants for Lung Tissue Research (R03)

• Initiative Number: RFA-HL-08-008
• Objective: Use biospecimens and clinical data collected by the NHLBI Lung Tissue Research Consortium in studies that will correlate lung molecular characteristics with phenotypic manifestations of COPD.

Immunomodulatory, Inflammatory, and Vasoregulatory Properties of Transfused Red Blood Cell Units as a Function of Preparation and Storage (R01)

• Initiative Number: RFA-HL-08-005
• Objective: Improve red blood cell transfusion therapies by conducting basic and translational research to identify the molecular and cellular changes that occur during blood preparation and storage, and evaluate the effects of those changes on the blood vessel wall, host cells, and tissue oxygenation.

New Technologies for Transient Molecular Complex Characterization (SBIR [R43/R44])

• Initiative Number: PA-08-110
• Objective: Encourage small businesses to develop technologies, tools, and/or processes for the study of transient molecular complexes by creating new methods or extending existing technologies.

Targeted Approaches to Weight Control for Young Adults (U01)

• Initiative Number: HL-08-007
• Objective: Conduct clinical research studies to develop, refine, and test innovative behavioral and/or environmental approaches for weight control in young adults (18-35 years of age) at high risk for weight gain.

Enhancing Zebrafish Research with Research Tools and Techniques (R01) and Genetic Screens to Enhance Zebrafish Research (R01)

• Initiative Number: PAR-08-138 and PAR-08-139
• Objective: Develop new tools or genetic or genomic resources that will advance the detection and characterization of genes, pathways, and phenotypes of interest in development and aging, organ formation, behavior, sensory processing, normal physiological processes, and disease processes.

Need More Information?

We are always interested in receiving comments and suggestions from the community. If you or your organizations have questions for me or for the Institute, please contact me at nabele@nhlbi.nih.gov or Dr. Carl Roth at rothc@nhlbi.nih.gov.

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