To visit this center's site, go to http://www.mmi.pitt.edu/mdcrc/
Center Abstract
Project 1: Developing Clinical Outcomes for Gene Transfer
PI: Jerry Mendell, M.D. Project Abstract
Project 2: Preclinical Gene Therapy in a Large Animal Model of DMD
PI: Xiao Xiao, Ph.D. Project Abstract
Project 3: Muscle Stem Cell-based Therapies for Cardiomyopathy
PI: Johnny Huard, Ph.D. Project Abstract
Project 4: Functional Genomics Studies of Early Myogenic Differentiation
PI: Joseph Glorioso, Ph.D. Project Abstract
Core A: Administrative and Training Core
PIs: Joseph C. Glorioso, Ph.D.; Paula Clemens, M.D. Core Abstract
Core B: Human Gene Therapy Applications Laboratory (HGTAL)
PI: David M. Krisky Core Abstract
Core C: Large Animal Core
PI: Joe N. Kornegay, D.V.M., Ph.D. Core Abstract
Core D: Biologic Imaging Core
Simon C. Watkins, Ph.D. Core Abstract
Publications
Draviam RA, Wang B, Li J, Xiao X, Watkins SC. Mini-dystrophin efficiently incorporates into the dystrophin protein complex in living cells. J Muscle Res Cell Motil 27(1): 53-67, 2006. Oshima H, Payne TR, Urish KL, Sakai T, Ling Y, Gharaibeh B, Tobita K, Keller BB, Cummins JH, and J Huard. Differential myocardial infarct repair with muscle stem cells compared to myoblasts. Mol Ther 12: 1130-41, 2005. Payne TR, Oshima H, Sakai T, Ling Y, Gharaibeh B, Cummins J, and J Huard. Regeneration of dystrophin-expressing myocytes in the mdx heart by skeletal muscle stem cells. Gene Ther 12: 1264-74, 2005. Qiao C, Li J, Zhu T, Draviam R, Watkins S, Ye X, Chen C, Li J, and X Xiao. Amelioration of laminin-alpha2-deficient congenital muscular dystrophy by somatic gene transfer of miniagrin. Proc Natl Acad Sci USA 102: 11999-2004, 2005.
Draviam RA, Wang B, Li J, Xiao X, Watkins SC. Mini-dystrophin efficiently incorporates into the dystrophin protein complex in living cells. J Muscle Res Cell Motil 27(1): 53-67, 2006.
Oshima H, Payne TR, Urish KL, Sakai T, Ling Y, Gharaibeh B, Tobita K, Keller BB, Cummins JH, and J Huard. Differential myocardial infarct repair with muscle stem cells compared to myoblasts. Mol Ther 12: 1130-41, 2005.
Payne TR, Oshima H, Sakai T, Ling Y, Gharaibeh B, Cummins J, and J Huard. Regeneration of dystrophin-expressing myocytes in the mdx heart by skeletal muscle stem cells. Gene Ther 12: 1264-74, 2005.
Qiao C, Li J, Zhu T, Draviam R, Watkins S, Ye X, Chen C, Li J, and X Xiao. Amelioration of laminin-alpha2-deficient congenital muscular dystrophy by somatic gene transfer of miniagrin. Proc Natl Acad Sci USA 102: 11999-2004, 2005.