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Sponsored by: |
Yonsei University |
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Information provided by: | Yonsei University |
ClinicalTrials.gov Identifier: | NCT00808717 |
Although statin prior to PCI has favorable effects in stable angina and ACS except ST elevation MI (STEMI), there have been few studies for STEMI. Celik T et al. reported in patients with STEMI that prior statin use may improve coronary blood flow after PCI in patients with AMI, possibly by its beneficial effects on microvascular function. But this study was retrospective, non-randomized study and evaluated the effects for chronic statin therapy not acute high dose effect. Therefore, the investigators investigated whether acute high-dose statin prior to primary PCI in ST segment elevation myocardial infarction can have beneficial effect or not for periprocedural period and 30 days-cardiac events.
Condition | Intervention | Phase |
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Myocardial Infarction Angioplasty Percutaneous Coronary |
Drug: Atorvastatin |
Phase IV |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Open Label, Dose Comparison, Parallel Assignment, Efficacy Study |
Official Title: | Efficacy of High Dose Atorvastatin Loading in ST Elevation Myocardial Infarction |
Estimated Enrollment: | 170 |
Study Start Date: | July 2007 |
Estimated Primary Completion Date: | December 2008 (Final data collection date for primary outcome measure) |
Arms | Assigned Interventions |
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High dose Atorvastatin 80 mg: Experimental
Administered Atorvastatin 80 mg before intervention
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Drug: Atorvastatin
Atorvastatin 10 mg vs. 80 mg before intervention
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Control: Active Comparator
Administered Atorvastatin 10 mg before intervention
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Drug: Atorvastatin
Atorvastatin 10 mg vs. 80 mg before intervention
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Ages Eligible for Study: | 18 Years to 80 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Contact: Donghoon Choi, MD, Ph D | 02-2228-8460 | cdhlyg@yuhs.ac |
Contact: Jung Youn Bae, MS, RN | 02-2228-8317 | recath@yuhs.ac |
Korea, Republic of | |
Severance Hospital | Recruiting |
Seoul, Korea, Republic of, 120-752 | |
Contact: Donghoon Choi, MD, Ph D 02-2228-8460 cdhlyg@yuhs.ac | |
Principal Investigator: Donghoon Choi, MD, Ph D | |
Sub-Investigator: Jung-Sun Kim, MD, Ph D | |
Principal Investigator: Sung Jin Oh, MD | |
Principal Investigator: Jung Rae Cho, MD | |
Principal Investigator: Deok-Kyu Cho, MD |
Responsible Party: | Cardiology, Yonsei University ( Donghoon Choi ) |
Study ID Numbers: | 4-2007-0156 |
Study First Received: | December 15, 2008 |
Last Updated: | December 15, 2008 |
ClinicalTrials.gov Identifier: | NCT00808717 |
Health Authority: | South Korea: Institutional Review Board |
Myocardial Infarction Coronary Angioplasty Myocardial infarction, Angioplasty, Transluminal, Percutaneous Coronary |
Necrosis Heart Diseases Myocardial Ischemia Vascular Diseases |
Ischemia Infarction Myocardial Infarction Atorvastatin |
Antimetabolites Pathologic Processes Molecular Mechanisms of Pharmacological Action Therapeutic Uses Antilipemic Agents |
Enzyme Inhibitors Cardiovascular Diseases Anticholesteremic Agents Hydroxymethylglutaryl-CoA Reductase Inhibitors Pharmacologic Actions |