Available
in PDF
In this issue...
Genome Project
U.S.
HGP on Fast Track
DOE
Joint Genome Institute Exceeds Goal
New
5-Year Goals
Faster
Sequencing with BACs
Mapping
with STCs and STSs
Availability
of BAC Clones and STC Data
BAC
Related Websites
BAC
Resource Success Story
Scientists
Hunt SNPs for Variation, Disease
Who's
Sequencing the Human Genome?
Genomics
Progress in Science
EMSL
Promotes Remote Access to Instrumentation
Second
Private-Sector Sequencing Project
GeneMap'98
In the News
Team
Delivers C. elegans Sequence
Why
Sequence Entire Genomes? Worm's Eye View
Embnet.news on
Web
European
Biotech Program
DOE
BER Research Update
Hollaender
Fellows Named
SBIR
1998 Human Genome Awards Announced
Mouse
Resources
Mouse
Consortium for Functional Genomics
Chlamydia Genome
Analysis
HUGO
Merges Offices, Web Sites
Microbial Genomics
Superbug Deinococcus
radiodurans
Unfinished
Microbial Genomes Searchable
TIGR
Releases Chlorobium tepidum Sequence
DOE
MGP Abstracts Online
Microbial
TV Series
Ethical, Legal, and Social Issues
and Educational Resources
Cambridge
ELSI Symposium
Eric
Lander, Genetics in the 21st Century
Mark
Rothstein, Genetic Privacy
James
Wilson, Gene Therapy Present & Future
LeRoy
Walters, Ethical Issues in Gene Therapy
DNA
Files on NPR, Internet
Innovative
Biotechnology Curriculum
Short
Course for Biology Teachers
Microbial
TV Series
Proteomics
Looking
at Proteins to Understand Expression
2-DGE: Protein
Visualization, Modification
Tool
for Protein Analysis
TREMBL
Release 6
R&D
100 Award Goes to LANL's SOLVE
NIH
Awards Proteomics Grant to Axys
E.
coli Proteome Database
Genetics in Medicine
National
Organization for Rare Disorders
Translation
of Genetics to Medicine: New Website
Cancer
Genetics Web Site
HuGem
Website Offers Education in New Genetics
Calculation
of Genetic Risks 2nd Edition
New Genetics
Manual Offered
Mutation
Research Genomics Online
Informatics
GDB
Database Operations Restored
In
Silico Biology: Bioinformatics Journal
Computational
Methods Book Available
Bioinformatics
Guide
BioToolKit
Gene-Finding
Programs at Sanger
New
Sequin Version
Tandem
Repeat Tool
Sequence
Viewer
SmithKline
Licenses Gene Logic Software
Influenza
Database at LANL
TRANSFAC
Database
p53
Mutation Database
TBASE
at Jackson Laboratory
Intein
Database on Web
System
Identifies Polymorphisms
Web, Other Resources, Publications
1999
Oakland Workshop Website
Launchpad
to Human Chromosomes
Nature
Genetics Supplement
Funding
DOE
Office of Science Grants and Contracts
NHGRI
National Service Award Fellowships
NCI
Technologies for Molecular Analysis
NIH:
Netork for Large-Scale Mouse Sequencing
NHGRI:
Genomic Technology Development
US
Genome Research Funding
Meeting Calendars & Acronyms
Genome
and Biotechnology Meetings
Training
Courses and Workshops
Acronyms
HGN archives
and subscriptions
HGP
Information home
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Five-Year Research Goals of the U.S. Human Genome Project
October 1, 1998 to September 30, 2003
Note: For more on the Five Year Research Goals, see the website.
Human DNA Sequence
- Achieve coverage of at least 90% of the genome in a working draft based on mapped clones by the end of 2001.
- Finish one-third of the human DNA sequence by the end of 2001.
- Finish the complete human genome sequence by the end of 2003.
- Make the sequence totally and freely accessible.
Sequencing Technology
- Continue to increase the throughput and reduce the cost of current sequencing technology.
- Support research on novel technologies that can lead to significant improvements in sequencing technology.
- Develop effective methods for the advanced development and introduction of new sequencing technologies into the sequencing process.
Human Genome Sequence Variation
- Develop technologies for rapid, large-scale identification and/or scoring of single nucleotide polymorphisms and other DNA sequence variants.
- Identify common variants in the coding regions of the majority of identified genes during this five-year period.
- Create a SNP map of at least 100,000 markers.
- Develop the intellectual foundations for studies of sequence variation.
- Create public resources of DNA samples and cell lines.
Functional Genomics Technology
- Generate sets of full-length cDNA clones and sequences that represent human genes and model organisms.
- Support research on methods for studying functions of nonprotein-coding sequences.
- Develop technology for comprehensive analysis of gene expression.
- Improve methods for genome-wide mutagenesis.
- Develop technology for large-scale protein analyses.
Comparative Genomics
- Complete the sequence of the roundworm C. elegans genome by 1998.
- Complete the sequence of the fruitfly Drosophila genome by 2002.
- Develop an integrated physical and genetic map for the mouse, generate additional mouse cDNA resources, and complete the sequence of the mouse genome by 2008.
- Identify other useful model organisms and support appropriate genomic studies.
Ethical, Legal, and Social Issues
- Examine issues surrounding the completion of the human DNA sequence and the study of human genetic variation.
- Examine issues raised by the integration of genetic technologies and information into health care and public health activities.
- Examine issues raised by the integration of knowledge about genomics and gene-environment interactions in non-clinical settings.
- Explore how new genetic knowledge may interact with a variety of philosophical, theological, and ethical perspectives.
- Explore how racial, ethnic, and socioeconomic factors affect the use, understanding, and interpretation of genetic information; the use of genetic services; and the development of policy.
Bioinformatics and Computational Biology
- Improve content and utility of databases.
- Develop better tools for data generation, capture, and annotation.
- Develop and improve tools and databases for comprehensive functional studies.
- Develop and improve tools for representing and analyzing sequence similarity and variation.
- Create mechanisms to support effective approaches for producing robust, exportable software that can be widely shared.
Training and Manpower
- Nurture the training of scientists skilled in genomics research.
- Encourage the establishment of academic career paths for genomic scientists.
- Increase the number of scholars who are knowledgeable in both genomic and genetic sciences and in ethics, law, or the social sciences.
The electronic form of the newsletter may be cited in the following style:
Human Genome Program, U.S. Department of Energy, Human Genome News (v10n1-2).
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