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Sponsored by: |
TNO Quality of Life |
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Information provided by: | TNO Quality of Life |
ClinicalTrials.gov Identifier: | NCT00221052 |
Overweight increases the risk to develop chronic diseases including type-2 diabetes and cardiovascular disease.
The low-grade inflammatory status often seen in overweight subjects is thought to play an important role in disease development.
The purpose of this study is to determine the role of inflammation on glucose metabolism and insulin resistance.
In this study the effect of the anti-inflammatory treatment diclofenac on markers of inflammation and on parameters of glucose metabolism will be studied.
Condition | Intervention |
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Overweight Obesity Inflammation |
Drug: Diclofenac |
Study Type: | Interventional |
Study Design: | Randomized, Double-Blind, Placebo Control, Parallel Assignment |
Official Title: | Relation Between Reduction of the Inflammatory Status and Glucose Metabolism in Healthy Overweight Men |
Ages Eligible for Study: | 18 Years to 60 Years |
Genders Eligible for Study: | Male |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Study ID Numbers: | TNO-P6374 |
Study First Received: | September 13, 2005 |
Last Updated: | October 10, 2006 |
ClinicalTrials.gov Identifier: | NCT00221052 History of Changes |
Health Authority: | Netherlands: Medical Ethics Review Committee (METC) |
Anti-Inflammatory Agents Obesity Cyclooxygenase Inhibitors Diclofenac Overweight Healthy Inflammation Body Weight |
Signs and Symptoms Analgesics, Non-Narcotic Nutrition Disorders Overnutrition Anti-Inflammatory Agents, Non-Steroidal Peripheral Nervous System Agents Analgesics Antirheumatic Agents |
Anti-Inflammatory Agents Obesity Molecular Mechanisms of Pharmacological Action Cyclooxygenase Inhibitors Physiological Effects of Drugs Diclofenac Enzyme Inhibitors Overweight Pharmacologic Actions Inflammation Body Weight Signs and Symptoms |
Pathologic Processes Analgesics, Non-Narcotic Sensory System Agents Therapeutic Uses Nutrition Disorders Overnutrition Anti-Inflammatory Agents, Non-Steroidal Peripheral Nervous System Agents Analgesics Antirheumatic Agents Central Nervous System Agents |