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Sponsored by: |
National Cancer Institute (NCI) |
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Information provided by: | National Cancer Institute (NCI) |
ClinicalTrials.gov Identifier: | NCT00899067 |
RATIONALE: Studying samples of blood in the laboratory from patients with cancer or an immunodeficiency disorder may help doctors learn more about the immune response.
PURPOSE: This research study is evaluating immune response in healthy volunteers and patients with cancer or an immunodeficiency disorder.
Condition | Intervention |
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Unspecified Adult Solid Tumor, Protocol Specific Unspecified Childhood Solid Tumor, Protocol Specific |
Other: laboratory biomarker analysis |
Study Type: | Observational |
Official Title: | Collection of Blood, Bone Marrow, and Tissue Samples for the Investigation of the Human Immune Response, Lymphoma Biology and HTLV-1 Infection |
Estimated Enrollment: | 1000 |
Study Start Date: | June 1998 |
OBJECTIVES:
OUTLINE: Patients and participants have blood drawn for determination of serum immunoglobulin and circulating antibody levels, Southern blot analysis of circulating lymphocytes (to test for clonal gene rearrangements), and studies of intracellular signaling pathways. Patients also undergo skin hypersensitivity tests and parenteral antigen tests. Selected patients undergo apheresis and/or skin biopsy.
PROJECTED ACCRUAL: At least 1,000 patients will be accrued in this study.
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
DISEASE CHARACTERISTICS:
One of the following groups:
Known or potential carriers of genetically determined immunodeficiency disease
PATIENT CHARACTERISTICS:
Age
Performance status
Life expectancy
Hematopoietic
Hepatic
Renal
Cardiovascular
Patients with any of the following are not eligible for the apheresis part of the study:
Other
PRIOR CONCURRENT THERAPY:
Biologic therapy
Chemotherapy
Endocrine therapy
Radiotherapy
Surgery
United States, Maryland | |
Warren Grant Magnuson Clinical Center - NCI Clinical Trials Referral Office | Recruiting |
Bethesda, Maryland, United States, 20892-1182 | |
Contact: Patient Recruitment 888-NCI-1937 |
Study Chair: | John E. Janik, MD | NCI - Metabolism Branch;MET |
Study ID Numbers: | CDR0000078571, NCI-97-C-0143, NCI-77-C-0066, NCI-82-C-0044 |
Study First Received: | May 9, 2009 |
Last Updated: | July 21, 2009 |
ClinicalTrials.gov Identifier: | NCT00899067 History of Changes |
Health Authority: | Unspecified |
unspecified adult solid tumor, protocol specific unspecified childhood solid tumor, protocol specific |
Human T Cell Leukemia Virus 1 Healthy Lymphoma Immunologic Deficiency Syndromes |