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Sponsored by: |
M.D. Anderson Cancer Center |
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Information provided by: | M.D. Anderson Cancer Center |
ClinicalTrials.gov Identifier: | NCT00038883 |
High dose chemotherapy followed by transplantation of allogeneic hematopoietic stem cell with the use of Campath-1h, a monoclonal antibody that have a synergistic effect to chemotherapy with minimal toxicity. In addition Campath-1H can improve engraftment of donor cells through its immunosuppressive properties.
Condition | Intervention |
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Leukemia, Lymphocytic, Chronic Leukemia, Lymphocytic, Acute Lymphoma, Low-Grade Lymphoma, T-Cell Lymphoma, B-Cell |
Drug: Campath-1H |
Study Type: | Interventional |
Study Design: | Treatment, Non-Randomized, Open Label, Uncontrolled, Single Group Assignment, Efficacy Study |
Official Title: | Campath-1H Snd Allogeneic Blood Stem Cell Transplantation for Lymphoid Malignancies |
Ages Eligible for Study: | 15 Years to 60 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Study ID Numbers: | ID99-410 |
Study First Received: | June 5, 2002 |
Last Updated: | June 23, 2005 |
ClinicalTrials.gov Identifier: | NCT00038883 History of Changes |
Health Authority: | United States: Food and Drug Administration |
Lymphoid Malignancies Chronic Lymphocytic Leukemia Acute Lymphoblastic Leukemia Low grade Lymphoma B and T cell Lymphoma of the intermediate and high grade |
Leukemia, Lymphoid Precursor Cell Lymphoblastic Leukemia-Lymphoma Immunoproliferative Disorders Lymphoma, B-Cell Leukemia Lymphatic Diseases Chronic Lymphocytic Leukemia B-cell Lymphomas Leukemia, Lymphocytic, Chronic, B-Cell |
Alemtuzumab Lymphoma, T-Cell Leukemia, B-cell, Chronic Leukemia, B-Cell Lymphoma, Non-Hodgkin Lymphoproliferative Disorders Lymphoma Acute Lymphoblastic Leukemia |
Leukemia, Lymphoid Immunoproliferative Disorders Precursor Cell Lymphoblastic Leukemia-Lymphoma Neoplasms by Histologic Type Immune System Diseases Antineoplastic Agents Pharmacologic Actions Lymphoma, B-Cell Leukemia Lymphatic Diseases |
Neoplasms Leukemia, Lymphocytic, Chronic, B-Cell Therapeutic Uses Alemtuzumab Lymphoma, T-Cell Leukemia, B-Cell Lymphoma, Non-Hodgkin Lymphoproliferative Disorders Lymphoma |