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Sponsors and Collaborators: |
Johns Hopkins University UCB |
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Information provided by: | Johns Hopkins University |
ClinicalTrials.gov Identifier: | NCT00370838 |
The goal of this study is to confirm that levetiracetam has a better tic-suppressing profile than that of the widely used tic-suppressing medication, clonidine. More specifically, we hypothesize that in a 15 week placebo run-in, double-blind, medication cross-over trial; levetiracetam will be more effective and have fewer side-effects than clonidine.
Condition | Intervention | Phase |
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Tic Disorders Tourette Syndrome |
Drug: levetiracetam and clonidine |
Phase IV |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Double-Blind, Active Control, Crossover Assignment, Safety/Efficacy Study |
Official Title: | Comparison of Keppra and Clonidine in the Treatment of Tics in Children With Tourette Syndrome |
Estimated Enrollment: | 20 |
Study Start Date: | February 2007 |
Ages Eligible for Study: | 7 Years to 19 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Patients will be included in this study if they meet the following criteria:
Exclusion Criteria:
Exclusion criteria include the following:
Contact: Harvey S Singer, MD | 410-955-7212 | hsinger@jhmi.edu |
United States, Maryland | |
Johns Hopkins Hospital | Recruiting |
Baltimore, Maryland, United States, 21287 | |
Contact: Harvey S Singer, MD | |
Principal Investigator: Harvey S Singer, MD |
Principal Investigator: | Harvey S Singer, MD | Johns Hopkins University |
Study ID Numbers: | TSkepclon |
Study First Received: | August 30, 2006 |
Last Updated: | April 5, 2007 |
ClinicalTrials.gov Identifier: | NCT00370838 History of Changes |
Health Authority: | United States: Institutional Review Board |
Tics Tourette syndrome levetiracetam clonidine |
Neurotransmitter Agents Adrenergic Agents Basal Ganglia Diseases Brain Diseases Neurodegenerative Diseases Adrenergic Agonists Tics Signs and Symptoms Heredodegenerative Disorders, Nervous System Mental Disorders Movement Disorders Mental Disorders Diagnosed in Childhood Analgesics Nootropic Agents |
Ganglion Cysts Adrenergic alpha-Agonists Clonidine Central Nervous System Diseases Tourette Syndrome Cardiovascular Agents Tic Disorders Antihypertensive Agents Dyskinesias Genetic Diseases, Inborn Neurologic Manifestations Etiracetam Peripheral Nervous System Agents Anticonvulsants |
Neurotransmitter Agents Molecular Mechanisms of Pharmacological Action Adrenergic Agents Physiological Effects of Drugs Basal Ganglia Diseases Brain Diseases Neurodegenerative Diseases Adrenergic Agonists Tics Signs and Symptoms Pathologic Processes Heredodegenerative Disorders, Nervous System Sensory System Agents Mental Disorders Movement Disorders |
Therapeutic Uses Syndrome Mental Disorders Diagnosed in Childhood Analgesics Nootropic Agents Sympatholytics Disease Adrenergic alpha-Agonists Nervous System Diseases Clonidine Central Nervous System Diseases Tourette Syndrome Cardiovascular Agents Tic Disorders Antihypertensive Agents |