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Sponsored by: |
Department of Veterans Affairs |
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Information provided by: | Department of Veterans Affairs |
ClinicalTrials.gov Identifier: | NCT00018499 |
Genetic differences in response to brain injury may reasonably be expected to play a role in the initial consequences of traumatic brain injury and in the rate of recovery from such injury.
Condition |
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Brain Injury |
Study Type: | Observational |
Official Title: | The Influence of APOE Genotype on Recovery After Traumatic Brain Injury |
Study Start Date: | October 1998 |
Estimated Study Completion Date: | October 2001 |
Polymorphisms in the Apolipoprotein E gene encode functional variants which differentially determine the rate at which neuronal repair can occur, and are associated with differences in expression of neurodegenerative processes, including traumatic brain injury. It is proposed that the accuracy of prediction of outcome after head injury will be significantly increased by inclusion of APOE genotype alone, or in combination with other variables such as severity of head injury, cognitive, electroencephalographic or neuroradiologic measures, or treatment strategies.
Ages Eligible for Study: | 17 Years to 55 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Patients enrolled in the DVHIP are subject to the following recruitment criteria:
Mild, moderate or severe closed head injury, where the cut off between mild and moderate is defined by GCS<12. PTA>24 hrs or - foca cerebral contusion on CT/MRI or Loss of Consciousness (LOC) > 12 hours.
Note: the definition of mild, moderate or severe head injury differs widely between centers and is absolutely not critical for the work proposed as we will use continuous measures of severity throughout.
Exclusion Criteria:
United States, Florida | |
James A. Haley Veterans' Hospital | |
Tampa, Florida, United States, 33612 |
Investigator: | Fiona Crawford, Ph.D. | |
Investigator: | Rodney Vanderploeg, Ph.D. | |
Investigator: | Robert Thatcher, Ph.D. | |
Investigator: | Andres Salazar, M.D. |
Study ID Numbers: | EPID-030-98S |
Study First Received: | July 3, 2001 |
Last Updated: | January 20, 2009 |
ClinicalTrials.gov Identifier: | NCT00018499 History of Changes |
Health Authority: | United States: Federal Government |
Traumatic Brain Injury |
Craniocerebral Trauma Wounds and Injuries Disorders of Environmental Origin Central Nervous System Diseases |
Trauma, Nervous System Brain Diseases Brain Injuries |
Craniocerebral Trauma Nervous System Diseases Wounds and Injuries Disorders of Environmental Origin |
Central Nervous System Diseases Trauma, Nervous System Brain Diseases Brain Injuries |