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Sponsors and Collaborators: |
University of Sao Paulo Fundação de Amparo à Pesquisa do Estado de São Paulo |
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Information provided by: | University of Sao Paulo |
ClinicalTrials.gov Identifier: | NCT00849602 |
The objective of this study was to evaluate the effect of chloroquine in the treatment of patients with dengue.
Condition | Intervention | Phase |
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Dengue |
Drug: Placebo Drug: Chloroquine |
Phase I Phase II |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Double Blind (Subject, Investigator), Parallel Assignment, Safety/Efficacy Study |
Official Title: | The Effect of Chloroquine in the Treatment of Patients With Dengue |
Estimated Enrollment: | 132 |
Study Start Date: | February 2008 |
Estimated Study Completion Date: | June 2009 |
Estimated Primary Completion Date: | May 2008 (Final data collection date for primary outcome measure) |
Arms | Assigned Interventions |
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1: Placebo Comparator |
Drug: Placebo
Placebo bid for three days
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2: Active Comparator |
Drug: Chloroquine
Chloroquine bid for three days
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Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Patients were included in the study if they presented with fever and at least two other symptoms, such as:
Exclusion Criteria:
Brazil, SP | |
São Paulo University Medical School at Ribeirão Preto | |
Ribeirão Preto, SP, Brazil, 14048.900 |
Principal Investigator: | Benedito AL Fonseca, PhD | São Paulo University Medical School at Ribeirão Preto |
Responsible Party: | São Paulo University Medical School at Ribeirão Preto ( Benedito Antonio Lopes da Fonseca ) |
Study ID Numbers: | BALF-01 |
Study First Received: | February 23, 2009 |
Last Updated: | February 23, 2009 |
ClinicalTrials.gov Identifier: | NCT00849602 History of Changes |
Health Authority: | Brazil: Ethics Committee |
Anti-Inflammatory Agents Anti-Infective Agents Dengue Fever Chloroquine Anthelmintics Dengue Hemorrhagic Fever Fever Virus Diseases Antimalarials Hemorrhagic Fevers, Viral |
Analgesics, Non-Narcotic Dengue Chloroquine diphosphate Viral Hemorrhagic Fever Anti-Inflammatory Agents, Non-Steroidal Peripheral Nervous System Agents Analgesics Arbovirus Infections Hemorrhagic Fever Antirheumatic Agents |
Anti-Inflammatory Agents Anti-Infective Agents Antiprotozoal Agents Flaviviridae Infections Physiological Effects of Drugs Antimalarials Antiparasitic Agents Hemorrhagic Fevers, Viral Dengue Sensory System Agents Therapeutic Uses Anti-Inflammatory Agents, Non-Steroidal Amebicides Analgesics Antinematodal Agents |
RNA Virus Infections Flavivirus Infections Filaricides Chloroquine Anthelmintics Pharmacologic Actions Dengue Hemorrhagic Fever Virus Diseases Analgesics, Non-Narcotic Chloroquine diphosphate Arbovirus Infections Peripheral Nervous System Agents Antirheumatic Agents Central Nervous System Agents |