Neuroimaging the Effects of Intravenous Anesthetic on Amygdala Dependent Memory Processes

This study is currently recruiting participants.

Verified by Weill Medical College of Cornell University, February 2008

First Received: July 19, 2007 Last Updated: March 20, 2008 History of Changes

Sponsored by:	Weill Medical College of Cornell University
Information provided by:	Weill Medical College of Cornell University
ClinicalTrials.gov Identifier:	NCT00504894

Purpose

This study involves 54 healthy volunteers aged between 18 and 50 recruited from the general community. It involves doing a set of simple memory tests while inside a fMRI machine. The subject is given a very low dose of an anesthetic drug intravenously while in the scanner. The subject then sees a sequence of pictures on a screen, and presses a button if they remember seeing the picture before. While this is happening, the scanner will be capturing images that tell us what parts of the brain are active. Hypothesis: patterns of hippocampal and amygdala activation during the encoding and retrieval of memory,as measured by fMRI, will be altered by intravenous anesthetics such that suppression of hippocampal and amygdala activities will be dissociable. This dissociation pattern will be different between the drugs propofol and thiopental

Condition	Intervention	Phase
Healthy	Drug: Thiopental Drug: Propofol	Phase IV

Study Type:	Interventional
Study Design:	Randomized, Single Blind (Subject), Parallel Assignment
Official Title:	Neuroimaging the Effects of Intravenous Anesthetic on Amygdala Dependent Memory Processes

Resource links provided by NLM:

MedlinePlus related topics: Anesthesia Memory

Drug Information available for: Thiopental sodium Thiopental Propofol

U.S. FDA Resources

Further study details as provided by Weill Medical College of Cornell University:

Primary Outcome Measures:

Performance on memory tasks [ Time Frame: 2 hours after MRI ] [ Designated as safety issue: No ]

Estimated Enrollment:	90
Study Start Date:	March 2007
Estimated Primary Completion Date:	December 2010 (Final data collection date for primary outcome measure)

Arms	Assigned Interventions
A: Placebo Comparator Drug given in low dose to gauge subject's responses to visual stimuli.	Drug: Thiopental A low dose given intravenously one time for just under an hour while the subject is shown visually stimulating images in an MRI machine.
B: Placebo Comparator Thiopental administration	Drug: Propofol A low dose given intravenously while the subject is shown visually stimulating images in an MRI machine.

Eligibility

Ages Eligible for Study:	18 Years to 50 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

age b/w 18 and 50
right-handed
minimum of high school education
fluent in English
normal vocabulary

Exclusion Criteria:

any significant medical/psychiatric comorbidity
deficit in vision or hearing that would impede the study
allergies to any of the study drugs, to soybeans, or eggs.
history of head trauma
family history of major psychiatric illness
body mass index > 30 kg/m2
claustrophobia
prior exposure to IAPS pictures
pregnancy
permanent metal objects anywhere in the body
a personal/family history of any porphyria

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00504894

Contacts

Contact: Jackie Bogan, BA	212-746-2952	jab2035@med.cornell.edu
Contact: Kane Pryor, M.D.

Locations

United States, New York
Weill Cornell Medical College	Recruiting
New York, New York, United States, 10065
Principal Investigator: Kane Pryor, M.D.

Sponsors and Collaborators

Weill Medical College of Cornell University

Investigators

Principal Investigator:

Kane Pryor, M.D.

Weill Cornell Medical College

More Information

No publications provided

Responsible Party:	WCMC ( Kane Pryor, MD )
Study ID Numbers:	0701008933
Study First Received:	July 19, 2007
Last Updated:	March 20, 2008
ClinicalTrials.gov Identifier:	NCT00504894 History of Changes
Health Authority:	United States: Institutional Review Board

Keywords provided by Weill Medical College of Cornell University:

N/A healthy volunteers

Study placed in the following topic categories:

Anesthetics, Intravenous
Neurotransmitter Agents
Anesthetics, General
Thiopental
Hypnotics and Sedatives

Central Nervous System Depressants
Anesthetics
Healthy
Propofol
Anticonvulsants

Additional relevant MeSH terms:

Anesthetics, Intravenous
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Thiopental
GABA Modulators
Physiological Effects of Drugs
Anesthetics
Central Nervous System Depressants

Pharmacologic Actions
Anesthetics, General
Therapeutic Uses
Hypnotics and Sedatives
GABA Agents
Central Nervous System Agents
Anticonvulsants

ClinicalTrials.gov processed this record on September 11, 2009